................................................................................................................................................... 1 ............................................................................................................................................... 1 ............................................................................................................................................... 2 ....................................................................................................................................... 2 ................................................................................................................... 3 ................................................................................................................................................... 4 ................................................................................................................................................... 6 ....................................................................................................................... 6 ................................................................................................................... 7 Vitalsail ........................................................................................................ 7 ....................................................................................................................... 8 ................................................................................................................................... 8 ............................................................................................................................................... 8 ................................................................................................................................................. 16

Antrodia camphorata 1990 ( 600 ) 450 2,000 Cinnamomum kanehirai Hay( Cinnamomum micranthum Hay ) 1

polysaccharide Triterpenoids superoxide dismutase SODadenosine nucleic acid sterol ... -D- B 199019911991 19941999 -D- B Triterpenoids Superoxide DismutaseSOD Adenosine -D-glucan Immunity Protein Vitamin-B Ergosterol Nucleic Acid Amino Acid Lectin Lignin Antrodia Acid

: CalciumPhosphorousGermanium

2

(Triterpenoids) Angiotensin Converting Enzyme(ACE) polysaccharides-D- (-D-glucan) -D- (-D-glucan) -D-glucan T B Mizuno1995 -D-glucan -D- glucan -1-3 -1-6 X-ray -13 D-Glucan (SOD:Superoxide Dismutase) (ROS:Reactive Oxygen Species ) DNA (SOD) Nucleic Acid (Adenosine) Nucleic Acid(Adenosine)(RNA)(Adenine) (Uracil) 1. 2. 3. 4. 5. -D- 1. 2. 3

3. 4. 1. 2. 3. 4. 1. 2. 3. 4

2% ( ) DNA indole lanostane Angiotensin converting enzymeACE Cytotoxic Histamine Angiotensin converting enzymeACE -D-glucan glucan 5

ergosterol D D O 1 2

6

/ 4 2 / 4 / 42 / 64 / 96 / 64 / 42 / 4 / 64 / 96 / 219 / 96 / 219 / 5121 / 8151

ELS CB CB L/UI 021 TPGTOG L/UI 021 TPGTOG Vitalsail

250

715

7

ABCD 1. 2. 3. 300 cc 4. 5. 1 2 3 8

Antrodia camphorata Ganaderma sp. 4

50 200 1~3% 1~2%

200 10~45% 1~2%

() 5 () 6 7

450~2000 8 9

9 10 GPT 12 13 10~20 3~8 2~2.5 14 1~1.5 4 5 15 10

11

16 histamine 17 18 lanostane Angiotensin converting enzyme ACE Cytotoxic Histamine 19 Angiotensin converting enzymeACE 20 -D-glucan 21 glucan 22 23 24 ergosterol D D 25 26 insulin 11

27 -D-glucan T B glucan C-6 1-3 --D-glucopyranosyl -(1-3)-A- D-glucopyranosyl Polyol 1-3 28 An5 HeLaAGSMCF-7Hep G2 29 -D-glucan 30 -D-glucan T B 31

1.2.3. 4. 5. 6. 33 34 35 polysaccharides - triterpenoids superoxide dismutaseSOD adenosine 12

B ergosterol antrodia acid -D-glucan 36 Grifola frondosa Cherng 1995 ergostane antcin Aantcin Bantcin C antcin4 7-dimethoxy-5methy-1 3-benzodioxole 22'55'-teramethoxy-3 37 43' 4'-bi-methylenedioxy- 66'-dimethyl- biphenyl 1996 Cherng antcin Eantcin Fmethyl antcinate G methyl antcinate H Yang 1996 ergostane zhankuic acid Dzhankuic acid E lanostane 15 -acetyl-dehydrosulphurenic aciddehydroeburicoic aciddehydrasulphurenic acid 38 200 50 10~45% 1~3% 39 200 10~45% 50 200 1~3%

40 A () 41 13

superoxide dismutaseSOD 42 SOD CuZnSODMnSOD FeSOD 43 44 : 2Ol/ml FEMA ; 60l/ml FEMA 3000mg/kg 14 45 :(500mg/kg/day) (25mg/kg/day) 20 ICR 48 46 ; 72 (CHL) : 47 3 P-388 U-937 49 14

48

50 1.: 2.: 3. : 4.: 51 5.: 6.: 7.: 8.: 9.: 2% 52 ( ) DNA 15

indole 1: 2: 3: LD50 53 4: 5: 6: 1 2 54 3 4 5 : 16

1) 2) 92% ( )

17

() () () () () () () () 18

""?? ""?? ~ () """" ""? () () "" () ? () () "" 1"""" 2"" 3 X CTB 19

"" 1- 2 3 " """" ()

20