New Patents v

X is cis or trans -CH double bondCH or - CH2CH2-, n is 1 or 2, Y is a saturated hetero- cyclic amino group having 5-8 ring members, and R2 is unsubstituted or substituted phenylalkyl, thienzlalkyl, naphthylalkyl or cin- namyl, and their salts and solvates. These com- pounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and antiasthmatic agents.

4482552

TRIAZOLE COMPOUNDS AND THEIR PHARMACEUTICAL USE

John Clitherow, Hertfordshire, United King- dom assigned to Glaxo Group Limited

R3\ N ~ A

RIR2N'--Alk~Q~X~(Clt2)nY(CH2)mNH--~ \\ B N /

0)

Compounds of the general formula (I) See Pa- tent for Chemical Structure (I) and phys- iologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H2-antagonists. The substituents in Formula (I) are defined in the specification.

with a more than equimolar amount of an or- ganic base of the general formula: See Patent for Tabular Presentation PS in which R is a hydro- gen atom or an alkyl radical containing up to 6 carbon atoms and n is 3 or 4.

4482563

NITRO PYRROLS AND THEIR PHARMACEUTICAL USE

Michael L Roantree, Rodney Young, Welwyn Garden City, United Kingdom assigned to Smith Kline & French Laboratories Limited

O2 N R 3

CH NH ~ R 4 Het--(CH2)mZ( 2)n N H

Structure 1

3-Nitro-2-substituted aminopyrroles are histamine H2- receptor antagonists. The 2- posi- tion substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5- positions of the pyrrole ring can also be substituted.

4482554

PHARMACEUTICAL COMPOSITIONS CONTAINING

OXICAM DERIVATIVES AND PROCESS FOR THEIR

PREPARATION

Uwe Gebhardt, Helmut Augart, Adolf Knecht, Waldkirch, Federal Republic Of Germany as- signed to Warner-Lambert Company

OH X ~ C O ~ N t { ~ R

Y O,...S.~ ' ' ~ - -"oN~-cH3

The present invention provides a pharma- ceutical composition containing at least one ox- icam derivative of the general formula: See Patent for Chemical Structure (I) in which R is a heterocyclic ring and X together with Y represent a condensed aromatic ring, together

4482569

PLATINUM (IV)-DIAMINE COMPLEXES, A PROCESS FOR

THE PREPARATION OF PHARMACEUTICAL

COMPOSITIONS AND A METHOD OF TREATING

MALIGNANT TUMORS IN MICE

Eric J Bulten, Francoi Verbeek, Bilthoven, Netherlands assigned to Nederlandse Centrale Organisatie Voor Toegepastnatuurweten- Schappelijk Onderzoek

~ Clt2_NH2 ~:l/ON o Pt S

. 1 1 \ /% CH2--NH2 CI O O

This invention relates to novel-platinum (IV)- diamine complexes, a pharmaceutical composi- tion using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.