4-th INTERNATIONAL CONFERENCE ON

TRANSLATIONAL MEDICINEOCTOBER 26-28, 2015 BALTIMORE, MARYLAND, USA

Translational medicine – our

approach.ALEXANDER V MELERZANOV MD PHD

DEAN OF BIOLOGICAL AND MEDICAL PHYSICS DEPARTMENT

MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY

(STATE UNIVERSITY)

MIPT HISTORY

For the time of MIPT’s existence 8 Nobel prize winners were its professors and founders

2 Nobel prize laureates for graphene in 2010 are MIPT graduates

MIPT ADVISORY BOARD

MIPT –LEADING RUSSIAN TECH UNIVERSITY

EDUCATIONAL MISSION: Cross-disciplinary training of highly qualified specialists

based on mandatory participation of all students in research practice ;

STRATEGICAL GOAL: Elaboration and transfer of new technologies into industry

FOR REFERENCE: 1st among high schools by average exam score of entrants; 1st place among RUS technical universities ; 2-3d place in the RUS universities rating; ~ 3000 undergraduates ~ 2500 graduates

FOR less then 65-YEARS HISTORY: 10 Nobel prize laureates ~150 Members of Russian Academy of Sciences; ~ 6000 Doctors of Science;

NEW DEFINITIONS FOR MEDICINETRANSLATIONAL MEDICINE is a discipline within biomedical and public health research that aims to improve the health of individuals and the community by "translating" findings into diagnostic tools, medicines, procedures, policies and education.

PREVENTIVE MEDICINE consists of measures taken for disease prevention, as opposed to disease treatment. Just as health encompasses a variety of physical and mental states, so do disease and disability, which are affected by environmental factors, genetic predisposition, disease agents, and lifestyle choices.

PERSONALIZED MEDICINE is a medical model that proposes the customization of healthcare - with medical decisions, practices, and/or products being tailored to the individual patient. In this model, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient’s genetic content or other molecular or cellular analysis. Wikipedia

NEW HEALTHCARE MODEL

TRANSLATIONAL MEDICINE - PREVENTIVE MEDICINE

PERSONALIZED MEDICINE

PERSONALIZED HEALTH PRODUCT

PERSONAL DATA BASED RECOMMENDATIONS

FUNDAMENTAL AND APPLIED RESEARCH

FEATURES, OUTCOMES AND GOALS OF THE NEW MODEL

OF HEALTHCARE

PREVENTIONEARLY DIAGNOSTICSTARGETED THERAPYDIRECT ECONOMICAL EFFECTINDIRECT ECONOMICAL EFFECT

HEALTHIER POPULATIONPRODUCTIVE LOGEVITY

SHORT HISTORICAL REVIEWPREVENTION starts with parents genetic testing and family consulting and continues with regular check-ups and biobanking NIKOLAY A. SEMASHKO (1874-1949) PREVENTION MEDICINE AS A SYSTEM, MOSCOW, 1926

EARLY DIAGNOSTICS including microbiome EVGENIY I. CHAZOV EARLY DIAGNOSTICS AT A NATIONAL LEVEL, USSR, 1970-s “REGULAR CHECK-UP SYSTEM”

TARGETED THERAPY “Targeted therapy is one of the major modalities of medical treatment” Wiki V. Craig Jordan and Elwood V. Jensen on the occasion of learning they were going to be the inaugural recipients of the Dorothy P. Landon/AACR Prize (2002) for Translational Research. “Tamoxifen: catalyst for the change to targeted therapy” V. Craig Jordan Eur J Cancer. Author manuscript; available in PMC 2009 Jan 1.Published in final edited form as: Eur J Cancer. 2008 Jan; 44(1): 30–38. doi: 10.1016/j.ejca.2007.11.002

ECONOMICS

PRODUCTIVE LOGEVITY IS THE ONLY WAY

TO OVERCOME ECONOMICAL CRISIS

OF THE AGING WORLD

What do we need to make Translation Medicine happen?

1. Understanding by society2. Funds3. Change of law and regulations including insurance

coverage4. Freedom for physicians in taking decisions5. Deep patient’s involvement through the education

and mass-media6. Multidisciplinary trained professionals and joined

teams

Who is the translational medicine specialist?

TEAM OF MULTIDISCIPLINARY TRAINED PROFESSIONALS

PHYSICIST BIOTECHNOLOGIST(ACCORDING TO THE EXISTING REGULATION)

PHYSICIAN

RESEARCHER

X XANALYST

X X

GENERAL TRAINING (APPLIED PHYSICS) (BS)

TRANSLATIONAL MEDICINE (MS)BS DEGREE: 4 YEARS OF PHYSICS, 4 YEARS OF MATH, 3-4 YEARS OF CHEMISTRY, 2-3 YEARS OF BIOLOGY AND HUMAN PHYSIOLOGY4 YEARS OF LAB WORK1 YEAR OF RESEARCHMS:1 YEAR OF PHYSICS1 YEAR OF CHEMISTRY1 YEAR GxP and ROSZDRAVNADZOR “Russian FDA” regulations2 YEARS OF RESEARCHOPTIONS:DRUG DESIGN AND DEVELOPMENTMEDICAL EQUIPMENT RESEARHOMICS TECHNOLOGUESBIOINFORMATICSBIOCHEMISTRYBIOPHYSICS

PHYSICIANS TRAINING (PLAN)CERTIFICATION COURSES FOR BASIC SCIENCE AND FOR OMICS TECHNOLOGIES SEVERAL “MODULES” 16 HOURS EACH ACCORDING TO A NEW SYSTEM OF CONTINIOUS EDUCATION CREDUTS TO BE IMPLEMENTED FROM 2016 IN RUSSIA.

THEORETICAL COURSES FOR THE WHOLE VARIETY PRESENTED IN MIPT AT THE CHAIR OF MOLECULAR AND BIOLOGICAL PHYSICS AND CHAIR OF THE INNOVATIVE PHARMACEUTICALS AND BIOTECHNOLOGIES

LAB PRACTICE:STEM CELLS LABGENOMICS LABTRANCRIPTOMICS LABPROTEOMICS LABBIOINFORMATICSBIOANALITICS LAB (METABOLOMICS)

STAKEHOLDERS IN RUSSIA

FEDERAL MEDICO-BIOLOGICAL AGENCYFEDERAL CLINICAL RESEARCH CENTER FOR PEDIATRIC HAEMATOLOGY,ONCOLOGY AND IMMUNOLOGYHEALTHCARE SYSTEM OF PRESIDENTIAL AFFAIRSNATIONAL SPACE AGENCYMOSCOW RESEARCH INSTITUTE OF EMERGENCY CAREMOSCOW RESEARCH INSTITUTE FOR ONCOLOGYCENTER FOR HEAMATOLOGYRESEARCH INSTITUTE FOR CLINICAL CARDIOLOGYBIOPHARMCLUSTER “NORTHEN” AND PARTHERS

EXAMPLES OF 3 CNETERS PLANNED BY MIPT IN COLLABORATION WITH HOSPITALS AND VENDORS:

TRANSLATIONAL MEDICINE CENTER WITHOUT OMICS TECHNOLOGIES

UNITED CENTER OF

MIPT, FMSMU ANDGEORGE

WASINGTON UNIVERSITY

FORTRANSLATIONAL

MEDICINE

Application is pending

Russian SpeakingAcademic Science

Association

Translational medicine center

No omics, only math modeling, radiology and interventional cardiologyThe idea behind is an establishing of the classification of human hearts by sizes and shapes for further design of a custom-made cardiac flexible electronics.At a moment center is about to start getting statistics.

ANGIOSURGERY PROGNOSIS

Virtual Fractional Flow Reserve Assessment

TRANSLATIONAL MEDICINE CENTER FOR ONCOLOGY

data is provided by courtesy of R.G.C.C. and Natalilab

Clinical data response in 254 cases complete response partial responsestable diseaseprogress of disease Response Number Percent Complete Regression 31 254 12,2 % Partial Regression 103 254 40,6% Minor Response 33 254 12,9 % Stable Disease 34 254 13,4 % Progression 26 254 10,2 % Treatment not started 27 254 10,7 % Response was assessed according to RECIST criteria after 2 years of follow up

CENTER FOR PERSONALIZED MEDICINE FMBA-MIPT

PERSONALIZED ANTI-AGEING RESEARCHNUTRIGENETICSREGENERATIVE MEDICINE AND COSMETOLOGYTELMEDICINE

News of the dayMinistry of Education and Science of Russia

has just accepted our application for the first in Russia translational medicine program.

26-th of October 2015

THANK YOU FOR YOUR ATTENTION