3-P1-01 Poster Sessions Human mesenchymal stem cells ......Phar maceutical Sci., Sanyo-Onoda City Univ., 2Dept. Pharmacotherapy, Grad. Sch. Biomed. Development of drugs for anticancer

3-P1-01

Human mesenchymal stem cells from adipose tissue and umbilical cordimproved neuropathic pain by regulating inflammation and recovery of thedemyelination of sciatic nerve in rats

Kanako Miyano1,2, Minori Ikehata3, Kaori Ohshima2,4, Yuki Yoshida5, Yasuhiro Nose3, Sei-ichi Yoshihara3, Katsuyuki Oki3, Seiji Shiraishi6, Miaki Uzu7, Miki Nonaka2, Yoshikazu Higami5,Minoru Narita1,8, Yasuhito Uezono2

1Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst.,2Dept. Pain & Cont. Res., The Jikei Univ. Sch. of Med., 3R&DDept. Biomimetics Sympathies Inc., 4Pathol., Immunol. and Microbiol., Grad. Sch. of Med., The Univ. of Tokyo.,5Lab. Mol. Pathol. and Metab. Disease, Faculty of Pharm. Sci., Tokyo Univ. of Sci.,6Div. Cancer Pathophysiol.,Natl. Hosp. Org. Kure Med., 7Vitrigel Prj., Inst. of Agrobiol. Sci., NARO., 8Dept. Pharmacol., Hoshi Univ. Sch. ofPharm. and Pharma. Sci.

Poster Sessions

Copyright © The Japanese Pharmacological Society

3-P1-02

KCNQ (Kv7) K+ channel opener retigabine inhibits pain and itch.

Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe

Lab. of Pharmacol., Sch. of Pharmacy, Kitasato Univ.

Poster Sessions


3-P1-03

Mechanisms of hyperalgesia in dry eye model rats: involvement of the glialcells and the voltage-gated Ca2+ channel α2δ subunit in the trigeminalnucleus

Yuto Tei1,2, Yoshinori Mikami1, Masanori Ito1, Taichiro Tomida1, Daisuke Ohshima1, Yuichi Hori2,Satomi Adachi-Akahane1

1Department of Physiology, Faculty of Medicine, Toho University,2Department of Ophthalmology, Faculty ofMedicine, Toho University

Poster Sessions


3-P1-04

TRPV1 and TRPA1 are cooperatively involved in the tooth movement-relatedpain.

Kazunori Adachi1, Misato Yugawa2

1Div. Pharmacol. Meikai Univ. Schol. Dent., 2Div. Orthodont. Meikai Univ. Schol. Dent.

Poster Sessions


3-P1-05

Implicated in spinal cholecystokinin-8 and hemokinin-1 in type 1 diabetesallodynia in mice

Takafumi Hayashi1, Chizuko Watanabe2, Syu-ichi Kanno3, Masaru Yoshizumi2,Yasuyuki Agatsuma1, Akiyoshi Hara3, Shinobu Sakurada4

1Lab. Pharmaceut. Sci., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.,2Dept. Physiol. Anato., Fac.Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.,3Dept. Clin. Pharmacotherap., Fac. Pharmaceut. Sci., TohokuMed. Pharmaceut. Univ., 4Tohoku Med. Pharmaceut. Univ.

Poster Sessions


3-P1-06

Two-way association between sleep disturbance and persistent pain

Yabe Shuhei1, Yusuke Hamada1,2, Kenichi Tanaka1, Yoshiyuki Yamabe1, Michiko Narita2,3,Naoko Kuzumaki1, Minoru Narita1,2

1Dept. Pharmacol., Hoshi Univ., Tokyo, Japan,2Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan,3Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan

Poster Sessions


3-P1-07

Comparison of the effects of Goreisan and loxoprofen on cerebral bloodflow dynamics in meteoropathy model mice

Sumika Ryu1, Yuki Kurauchi1,2, Risako Tanaka1, Makito Haruta3, Kiyotaka Sasagawa3,Takahiro Seki1,2, Jun Ohta3, Hiroshi Katsuki1,2

1Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, 2Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci,Kumamoto Univ, 3Division of Materials Science, Graduate School of Science and Technology, Nara Institute ofScience and Technology

Poster Sessions


3-P1-08

Itch and pain caused by intradermal injection of sulfides in mouse cheek:Effect of genetic deletion of Cav3.2 T-type calcium channels

Shotaro Kurahashi1, Iyo Nishiyama1, Rina Minamino1, Hiroyuki Nishikawa1,2, Fumiko Sekiguchi1,Maho Tsubota1, Atsufumi Kawabata1

1Laboratory of Pharmacology & Pathophysiology, Faculty of Pharmacy, Kindai University,2Fuso PharmaceuticalIndustries, Ltd.

Poster Sessions


3-P1-09

Phenotypic examination of the endocannabinoid-degrading enzymealpha/beta-hydrolase domain containing 6 (ABHD6) knockout rat

Katsuhiko Noguchi1, Kimio Sugaya1, Saori Nishijima1, Mayuko Sakanashi2, Katsumi Kadekawa1,Shiho Okitsu3, Sayomi Nakamine3, Hidetsugu Torihara3, Hideyuki Yamamoto3

1Southern Knights’ Laboratory Co., Ltd., 2Dept. Pharmacy, Col. Pharmacy, Kinjo Gakuin University,3Dept.Biochemistry, Grad. Sch. Med., Univ. the Ryukyus

Poster Sessions


3-P1-10

MicroRNA expression profiling in ethanol dependence in mice

Keisuke Mizuo, Tomoka Yamaguchi, Satoshi Watanabe

Dept. of Legal Med. Sapporo Med. Univ. Sch. of Med.

Poster Sessions


3-P1-11

Inhibitory effect of SB216763, a selective glycogen synthase kinase-3inhibitor, on morphine-induced Straub’s tail reaction in mice

Junichi Kitanaka1, Nobue Kitanaka1, Utau Horie1, Yumi Kawasaki1, Takashi Sakamoto1,Junya Yashiro1, Koh-ichi Tanaka2, Kento Igarashi2,3, Kazuo Tomita2,3, Ami Shiomoto4,Kaname Watabe4, Kiyoshi Nakano4, Hitoshi Takahashi4, Nobuyoshi Nishiyama2, Tomoaki Sato3,Motohiko Takemura1

1Dept. Pharmacol., Hyogo Col. Med., 2Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci.,3Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 4Muromachi Kikai, Co., Ltd.

Poster Sessions


3-P1-12

Analysis of the tendency of dependence for various targets based on thepsychological characteristic in undergraduate students

Ken-ichi Tanaka, Michiko Konno

Sch. Health Social Services, Saitama Pref. Univ.

Poster Sessions


3-P1-13

Chronic pain-induced neuronal plasticity in the extended amygdala causesmaladaptive anxiety

Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami

Dept Pharmacol Grad Sch Pharm Sci, Hokkaido Univ

Poster Sessions


3-P1-14

Histological analyses of CRF mRNA expression in the dorsolateral bednucleus of the stria terminalis of chronic pain model rats

Saya Arakaki, Daiki Takahashi, Yuta Asaoka, Keisuke Kimura, Ryuto Hara, Keisuke Sakasai,Hiroe Suzuki, Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University.

Poster Sessions


3-P1-15

Development of a novel stress model using a video-recorded scene of thesocial defeat stress in mice

Yuko Nakatake1,2, Hiroki Furuie2, Masatoshi Ukezono3, Misa Yamada2, Kazumi Yoshizawa1,Mitsuhiko Yamada2

1Lab. Pharmacol. Therap., Grad. Sch. Pharmaceut. Sci., Tokyo Univ. Sci.,2Dept. Neuropsychopharmacol., Natl.Inst. Mental Health, Natl. Center Neurol. Psychiat., 3RIKEN

Poster Sessions


3-P1-17

Social stress induces subcellular degeneration preceding dendritic loss ofprefrontal pyramidal neurons in mice

Chisato Numa1, Hirotaka Nagai1, Midori Nagai1, Nobuhiko Ohno2, Yuko Mimori-Kiyosue3,Yosky Kataoka4, Tomoyuki Furuyashiki1

1Dept. Med. Div. Pharmacol., 2Jichi Med. Univ. Div. Hist. & Cell Biol. Dept. Anat.,3RIKEN BDR Lab. Mol. & Cell.Dyn., 4RIKEN BDR Lab. Cell. Funct. Img.

Poster Sessions


3-P1-18

Left-right asymmetry in chronic stress-induced neuroinflammation

Kazutoshi Matsushita, Masayuki Taniguchi, Tomoyuki Furuyashiki

Div. Pharmacol., Grad. Sch. Med., Kobe Univ.

Poster Sessions


3-P1-19

Role of Microsomal prostaglandin E synthase-1 in acute stress

Kawabata Yuta1, Asumi Doumae1, Hiromi Hirata1, Aki Sakahara1, Satoshi Uematsu2,Shizuo Akira3, Tatsuo Takahashi1, Yuri Ikeda-Matsuo1

1Lab. Pharmacol., Dept. Clin. Pharmacy, Fac. Pharmac. Sci., Hokuriku Univ., 2Dept. Immunol. Genomics, OsakaCity Univ. Grad. Sch. Med., 3Lab. Host Defense, WPI Immunol. Front. Res. Ctr, Osaka Univ.

Poster Sessions


3-P1-20

Loss of function in mouse GAD67 leads to emotional impairments

Shigeo Miyata1, Toshikazu Kakizaki1, Kazuyuki Fujihara1, Hideru Obinata2, Touko Hirano2,Junichi Nakai3, Mika Tanaka4, Shigeyoshi Itohara4, Kenji Tanaka5, Masahiko Watanabe6,Manabu Abe7, Kenji Sakimura7, Yuchio Yanagawa1

1Dept. Gen. Behav. Neurosci., Grad. Sch. Med., Gunma Univ.,2Lab. Anal. Instr., Grad. Sch. Med., Gunma Univ.,3Div. Oral Physiol., Dept. Oral Funct. Mor., Grad. Sch. Dent., Tohoku Univ.,4Lab. Behav. Gen., RIKEN Brain Sci.Inst., 5Dept. Neuropsychiat., Sch. Med., Keio Univ., 6Dept. Anat., Fac. Med., Hokkaido Univ., 7Dept. Anim. Mod.Devel., Brain Res. Inst., Niigata Univ.

Poster Sessions


3-P1-21

Glutamatergic neurons from medial prefrontal cortex to dorsal raphenucleus regulates maternal aggression in mice

Yoshikage Muroi, Toshiaki Ishi

Dep. Vet. Med., Obihiro Univ.

Poster Sessions


3-P1-22

The amygdalohippocampal area that projects to the medial preoptic areamediates aggression toward the infant

Keiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Masabumi Minami, Taiju Amano

Dept. of Pharmacol, Grad. Sch. of Pharmaceut. Sci. Hokkaido Univ.

Poster Sessions


3-P1-23

Synaptic inputs derived from the central nucleus of amygdala thatsuppresses neurons in the rhomboid nucleus of the bed nucleus of the striaterminals of paternal mice

Shunsaku Murakawa, Haruka Uki, Masabumi Minami, Taiju Amano

Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Science, Hokkaido Univ, Hokkaido, Japan

Poster Sessions


3-P1-24

Long-term administration of D2 receptor blocker sulpiride changes socialbehavioral pattern in male mice

Hamasaki Yumi, Masabumi Minami, Taiju Amano

Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Sciences, Hokkaido Univ, Hokkaido, Japan

Poster Sessions


3-P1-25

Blonanserin and 1-(2-Pyriidinyl)-piperazine suppress impulsive action in rats

Hitomi Sasamori1, Naoya Nishitani2, Yu Ohmura1, Mitsuhiro Yoshioka1

1Dept. Neuropharmacol. Hokkaido Univ., 2Lab. Mol. Pharmacol. Kanazawa Univ.

Poster Sessions


3-P1-26

Serotonergic activity in the dorsal raphe nucleus is required for model-based decision making

Yu Ohmura1, Kentaro Iwami2, Hitomi Sasamori1, Chiaki Sugiura1, Youcef Bouchekioua1,Mitsuhiro Yoshioka1

1Dept Neuropharmacol, Hokkaido Univ, Hokkaido, Japan, 2Hokkaido Univ Sch Med, Hokkaido, Japan

Poster Sessions


3-P1-27

Behavioral Characterization of Dopamine D5 Receptor Knockout(D5KO) Mice

Chiaki Sugiura

Dept. Neuropharmacol. Hokkaido Univ.

Poster Sessions


3-P1-28

Ameliorating effects of guanfacine, an adrenergic α2A receptor agonist, onAD/HD-like behaviors in an AD/HD model rat, male adolescent SHRSP/Ezo

Taku Yamaguchi, Ryosuke Shinozaki, Tatsuya Oka

Dept. Pharmacother. and Neuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

Poster Sessions


3-P1-29

Inhibitory effects of local anesthetics on muscarinic receptors: effects onthe Ca2+ release from intracellular store and recruitment of beta-arrestin.

Shimatani Mari1, Akihiro Nezu2, Akihiko Taimura2

1Div. Reconstructive Surg Oral Maxillofac Reg., Health Sci. Univ. Hokkaido, Sch. of Dent.,2Div. Pharmacol.,Health Sci. Univ. Hokkaido, Sch. of Dent.

Poster Sessions


3-P1-30

Annexin A2 is involved in activation of AKT upon endothelin-1 stimulation inmelanoma cells

Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa

Dept. Cell. Pharm., Grad. Sch. Med., Hokkaido Univ.

Poster Sessions


3-P1-31

Localization analysis of several NCKX2-NCLX chimeras into plasmamembrane/mitochondrial inner membrane

Takayuki Nemoto1, Tomo Kita1, Hideaki Tagashira1, Satomi Kita1,2, Takahiro Iwamoto1

1Dept. Pharmacol., Fac. Med., Fukuoka Univ., 2Dept. Pharmacol., Fac. Pharma. Sci., Tokushima Bunri Univ.

Poster Sessions


3-P1-32

Distribution of mammal-like melanin concentrating hormone type 1 and 2receptor expressing neurons in the brain of a basal actinopterygian fish,Polypterus senegalus

Morio Azuma, Taka-aki Koshimizu

Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

Poster Sessions


3-P1-33

Receptor functional analysis of leptin resistance by adenosine- BRETanalysis

Toru Hosoi1, Takenori Matsuura3, Anisia Silva4, Momoe Wada3, Syu Matsuzaki3,Michitaka Sugiyama2, Naoshi Kodama2, Ralf Jockers4, Julie Dam4, Koichiro Ozawa2

1Dept. Clin. Pharmacology, Facul. Pharmaceutical Sci., Sanyo-Onoda City Univ., 2Dept. Pharmacotherapy, Grad.Sch. Biomed. Health Sci., Hiroshima Univ., 3Dept. Pharmacotherapy, Sch. Pharm. Hiroshima Univ.,4Inserm U1016,Institut Cochin, Dept Endocrinology, Metabolism and Diabetes, Paris, France

Poster Sessions


3-P1-34

Collapsin response mediator protein 2 was one of targets for 15-deoxy -Δ12,14-prostaglandin J2

Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma

Dept. Pharmaceutic. Health, Himeji Dokkyo Univ.

Poster Sessions


3-P1-35

Differentiation-inducing factor 1 activates AMP-regulated kinase/Cofilinpathway to regulate the actin cytoskeleton.

Koichi Miura, Takeru Inoue, Ruzhe Han, Toshiyuki Sasaguri

Kyushu Univ., Fac. of Med. Sci.

Poster Sessions


3-P1-36

Development of Histamine N-methyltransferase Inhibitors for BrainDisorders

Takeo Yoshikawa, Rina Otsuka, Yuki Sato, Kazuhiko Yanai

Dept Pharmacol Tohoku Univ Grad Sch Med

Poster Sessions


3-P1-37

The development of miR-96-5p gene knock out technique by CRISPR/Cas9system

Nobuko Matsumura1, Chisato Kinoshita1, Toshio Nakaki2, Koji Aoyama1

1Dept. Pharmacol., Teikyo Univ. Sch. Med.,2Fac. Pharma-Sci., Teikyo Univ.

Poster Sessions


3-P1-38

Evaluation of seizure sensitivity and potential excitation foci in Phf24-KOrats

Naofumi Kunisawa1, Hiroaki Hisadumi1, Masaki Kato1, Saki Shimizu1, Kazuaki Sato2,Masato Kinboshi1, Masao Matsuhashi3, Akio Ikeda3, Tadao Serikawa1, Yukihiro Ohno1

1Dept. Pharmacol., Osaka Univ. Pharmaceut. Sci., 2Dept. neurol., Ijinkai takeda general Hosp., 3Dept. Epilepsy,Mov. Dis. and Physiol., Kyoto Univ.

Poster Sessions


3-P1-39

Lifelong measurement of locomotor activity and body temperature in group-housed laboratory mice by wireless power transmission

Kazuhiko Yanai1, Takeo Yoshikawa1, Kenichi Sagara2, Shu Sasaki2

1Tohoku Univ. Sch. Med. Dept. Pharmacol.,2HIKARIDENSHI, CO., LTD

Poster Sessions


3-P1-40

Our preclinical support of neurological research approaches usingcerebrospinal fluid

Kohei Araki, Keita Saito, Kotaro Suzuki, Toru Nonomura, Noriyuki Yamazaki

New Drug Research Center, Inc.

Poster Sessions


3-P1-41

Efforts for promotion of Use of Radioisotopes (RI) -RI ExperimentalProtocols for Beginners-

Rikako Azuma1, Hiroyuki Tsunokuni1, Keiichi Matsunami2, Masayuki Hara3, Shinsuke Katoh4,Hiroyuki Iizuka5

1Japan Radioisotope Association, 2Grad. Sch. of Medicine, Juntendo Univ., 3Res. Core, Inst. of Res., Tokyo Medicaland Dental Univ., 4Dept. of Health Pharm., Yokohama Univ. of Pharm.,5Sch. of Eng. Environ. Health and SafetyOffice., Univ. of Tokyo

Poster Sessions


3-P1-42

Structure prediction of the N-terminal regulatory domain of the humantryptophan hydroxylase 2

Masanori Ootaki1, Tomoko Hiroi2, Yuki Ohta1, Yuko Takeba1, Keisuke Kida1, Hiroaki Matsui2,Naoki Matsumoto1

1St. Marianna Univ. Sch. Med. Dept. Pharmacol., 2Inst. Radioisotope Res. St. Marianna Univ. Grad. Sch. Med.

Poster Sessions


3-P1-43

Comparison of medication self-management for older adults supported bynurses at general hospitals and home-visit nursing stations

Kanako Sakane1, Yuta Kobayashi1, Mayumi Miyamoto1, Miki Fukuma1, Yuko Tsumoto1,Hiromi Uchida2

1Shimane Uni., Fac. Med., Dept. Nursing, 2Tenri Helth Care Uni.

Poster Sessions


3-P1-44

Integrated safety evaluation of benzodiazepines using human iPS celltechnology

Tsunemoto Kazunobu1, Shigeru Yamada1,2, Yasunari Kanda1

1Div. Pharmacol, NIHS, 2PEIJ

Poster Sessions


3-P1-45

Antioxidative activity of fructose 1,6-bisphosphate as a direct free radicalscavenger

Kazue Ogata1, Kahona Ono2, Osamu Tokumaru1

1Department of Physiology, Facalty of Welfare and Health Sciences, Oita University,2Medical student, School ofMedicine, Oita University Faculty of Medicine

Poster Sessions


3-P2-01

ATX- increases intracellular Na+ and Ca2+ concentration in pulmonary veincardiomyocytes by activating reverse-mode Na+/Ca2+ exchanger

Taro Saito, Aiko Ohba, Yuta Takano, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka

Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.

Poster Sessions


3-P2-02

Elucidation of mechanisms that trigger torsades de pointes in drug-inducedlong QT syndrome: a simulation study

Kunichika Tsumoto1, Takao Shimamoto2, Akira Amano2, Yuhichi Kuda1, Mamoru Tanida1,Yasutaka Kurata1

1Dept. Physiol, Kanazawa Med. Univ., 2Dept. Bioinfo, Ritumeikan Univ.

Poster Sessions


3-P2-03

Different modulatory effects of isoflurane and halothane onarrhythmogenesis elicited by dofetilide in rabbits.

Satoshi Kawakami, Yoshinobu Nagasawa, Megumi Aimoto, Akira Takahara

Dept. Pharmacol. Therap., Fac. Pharmaceut. Sci. Toho Univ.

Poster Sessions


3-P2-04

Dulaglutide inhibited perilipin 2-induced atrial fibrillation through theimprovement of atrial impulse conduction slowing in transgenic mice

Nanae Ishida1, Shogo Yukawa1, Satsuki Sato2, Jinya Suzuki2, Eiichi Taira3, Masamichi Hirose1

1Dept. Pathophysiol. and Pharmacol., Iwate Medical Univ., 2Third Dept. Internal Med., Univ. of Fukui, 3Dept. ofPharmacol., Iwate Medical Univ.

Poster Sessions


3-P2-05

Manifestation of proarrhythmic properties of IKACh blocker tertiapin in the ratdilated atria caused by chronic volume overload

Megumi Aimoto, Ryohei Suzuki, Yuka Taneichi, Yoshinobu Nagasawa, Akira Takahara

Dept. Pharmacol. Ther., Fdt. Pharmaceut. Sci. Toho Univ.

Poster Sessions


3-P2-06

Comprehensive and rigorous analysis of drug-induced QT intervalprolongation in anesthetized guinea pigs using 11 antihistamines withclinical reports on adverse drug reactions

Yoshinobu Nagasawa1, Miki Shimizu1, Misa Oshiba1, Go Minemoto1, Yuichi Kenmotsu1,Kengo Kimura1, Kensuke Omura1, Naoki Omuro1, Kaori Fujiwara1, Haruka Matsuzaki1,Kazuko Kobayashi1,2, Satoshi Kawakami1, Megumi Aimoto1, Akira Takahara1

1Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci. Toho Univ.,2Dept. Pharm. Toho Univ. Ohashi Med. Ctr.

Poster Sessions


3-P2-07

Characteristics of sudden death in cardiac-specific conditional NCX1knockout mice

Hideaki Tagashira1, Satomi Kita1,2, Takahiro Iwamoto1

1Dept. Pharmacol., Fac. of Med., Fukuoka Univ., 2Dept. Pharmacol., Fac. of Pharma. Sci., Tokushima Bunri Univ.

Poster Sessions


3-P2-08

Hsp90 contributes to cardiac hypertrophy in the development of heart failurevia regulating c-Raf.

Takumi Itoh, Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka

Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

Poster Sessions


3-P2-09

Pathophysiological role of Ca2+ permeable TRPV2 channel in myocardialischemia reperfusion injury

Yuko Iwata1, Shigeo Wakabayashi2, James Pearson1

1NCVC, Cardiac Physiology, 2Osaka Aoyama Univ., Health Science

Poster Sessions


3-P2-10

Gender differences in the effect of spontaneous exercise on heart failure inDCM model mice

Masami Sugihara1, Ryo Kakigi2, Takashi Murayama3, Takashi Miida1, Takashi Sakurai3,Sachio Morimoto4, Nagomi Kurebayashi3

1Dept.Clin.Lab.and Med.,Juntendo Univ., 2Fac. Mgmt. & Info. Sci., Josai Int. Univ., 3Dept.Phamacol.,JuntendoUniv., 4Dept. Health Sci. at Fukuoka, IUHW

Poster Sessions


3-P2-11

Development of drugs for anticancer drug-induced cardiotoxicity using acylghrelin and des-acyl ghrelin extracted from the stomach of salmon and tuna

Toshiki Kawashima1,2, Miki Nonaka2, Minoru Kihara3, Hidekazu Katayama4, Kaori Ohshima2,5,Kanako Miyano6, Kazumi Yoshizawa1, Yasuhito Uezono2,7

1Lab. of Pharmacol. and Ther., Dept. of Pharm., Fac. of Pharmaceut. Sci., Tokyo Univ. of Sci., Chiba, Japan,2Dept.of Pain Control Res., The Jikei Univ. Sch. of Med., Tokyo, Japan,3Dep. of Mar. Biol. and Sci., Sch. of Biol. Sci.,Tokai Univ., Hokkaido, Japan,4Dep. of Appl. Biochem., Sch. of Eng., Tokai Univ., Kanagawa, Japan,5Patho.,Immunol. & Microbiol., Grad. Sch. of Med., Univ. of Tokyo, Tokyo, Japan,6Div. of Cancer Pathol., Natl. CancerCtr. Res. Inst., Tokyo, Japan,7Div. of Support. Care Res., Explor. Oncol. Res. & Clin. Trial Ctr., Natl. Cancer Ctr.Res. Inst., Tokyo, Japan

Poster Sessions


3-P2-12

Arresten, a cleaved fragment of type IV collagen α1 chain, regulatesfunctions of cardiac fibroblasts and left atria

Akira Sugiyama, Shiho Tajima, Riki Yamamoto, Kosuke Otani, Muneyoshi Okada,Hideyuki Yamawaki

Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

Poster Sessions


3-P2-13

Chronic toxicity assessment of nilotinib using human-induced pluripotentstem cell-derived cardiomyocytes

Hayashi Sayo, Ayano Satsuka, Shota Yanagida, Yasunari Kanda

Div. Pharmacol, NIHS

Poster Sessions


3-P2-14

Assessment of drug-induced contractility in iPS-CMs by cell motion imagingand cell-induced electrical impedance monitoring.

Satsuka Ayano, Sayo Hayashi, Yasunari Kanda

Div. Pharmacol, NIHS

Poster Sessions


3-P2-15

Tanshinone VI promotes the differentiation of cardiosphere-derived cellsinto cardiomyocytes.

Tetsuro Marunouchi, Minami Ikoshi, Emi Yano, Kouichi Tanonaka

Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

Poster Sessions


3-P2-16

The effect of chemical sympathetic dennervation on the postnatal heartdevelopment.

Takuro Numaga-Tomita1, Hiroyuki Kawagishi1, Tsutomu Nakada2, Mitsuhiko Yamada1

1Dept Mol Pharamcol, Sch Med, Shinshu Univ, 2Res Center Supp Adv Sci, Shinshu Univ

Poster Sessions


3-P2-17

A novel intracellular drug-delivery system specific for cardiomyocytes usingRNA aptamer

Takeshi Honda1, Hiroki Sakai1, Makoto Inui1,2

1Dept. Pharmacol. Grad. Sch. Med., 2YIC Rehab. Col.

Poster Sessions


3-P2-18

Analysis of the molecular mechanism of compensatory hypertrophy-associated enhancement of salivary secretion using the intravital Ca2+

imaging and gene analysis.

Akihiro Nezu1, Shigeru Takahashi2, Takao Morita3, Akihiko Tanimura1

1Div. Pharmacol, Health Sci. Univ. Hokkaido Sch. Dent., 2Dept. Oral Functional. Anat., Hokkaido Univ. Grad. Sch.Dent. Med., 3Dept. Biochem., Nippon Dent. Univ. at Niigata

Poster Sessions


3-P2-19

Cdc42-deficiency induces salivary hyposecretion and maintains lacrimalsecretion in mice.

Nagase Haruna, Akiko Shitara, Yuta Ohno, Masanori Kashimata

Asahi Univ., Dent., Pharmacol.

Poster Sessions


3-P2-20

Regulation by purinergic signal of glucose-induced insulin secretion fromiGL insulinoma cells.

Masa-aki Ito, Chinatsu Machida, Kazuki Yoshida, Isao Matsuoka

Lab. Pharmacol., Fac. Pharm, Takasaki Univ. Health and Welfare

Poster Sessions


3-P2-21

Effect of sucrose beverage intake on blood glucose level and insulinsecretion

Sato Sachiko, Yukiko Kondo, Eiichi Taira

Dept. of Pharmacol., Iwate Med. Univ., Morioka, Japan

Poster Sessions


3-P2-22

Thyrotropin receptor antibodies (TRAbs) induced by Epstein-Barr virusreactivation: Significance on Graves’ disease

Nagata Keiko1, Kazuhiko Hayashi2, Yukio Satoh3, Mitsuhiko Osaki4, Junichiro Miake1,Yoshinori Ichihara1, Tatsuya Sawano1, Yuhang Zhou1, Agung Priyono1, Kazuhiko Matsuzawa1,Takeshi Imamura1

1Div. Pharmacol. Fac. Med. Tottori Univ.,2Pathol.Dept. Fac. Med. Tottori Univ.,3Div. Developmental Biol. Sch.Life Sci. Fac. Med. Tottori UNiv.,4Div. Exp. Pathol Sch. Life Sci. Fac. Med. Tottori Univ.

Poster Sessions


3-P2-23

Possible roles of autophagy related proteins ATG2A and ATG7 in thedifferentiation of human endometrial stromal cells

Saito Yuri1, Junya Kojima2, Atsuya Tsuru1, Mikihiro Yoshie1, Kazuya Kusama1, Kazuhiro Tamura1,Hirotaka Nishi2

1Dept. Endocrine Pharmacol.,Tokyo Univ. Pharm. & Life Sci.,2Dept. Obstet. & Gynecol., Tokyo Med. Univ.

Poster Sessions


3-P2-24

Effect of adipose tissue-derived stem/stromal cells on muscle atrophy

Yuki Ohta1, Tsukasa Kobayashi1, Yuko Takeba1, Masanori Ootaki1, Keisuke Kida1,Minoru Watanabe2, Taroh Iiri1, Mitsuko Takenaga3, Naoki Matsumoto1

1Dept. of Pharmacol., St Marianna Univ. Sch. of Med., 2Inst. for Anim. Exp., St. Marianna Univ. Grad. Sch. of Med.,3Inst. of Med. Sci., St Marianna Univ. Sch. of Med.

Poster Sessions


3-P2-25

17β-estradiol attenuates sepsis-induced myopathy in mice

Shunya Takeshita, Chihiro Hibi, Kazuho Sakamoto, Junko Kurokawa

Dept. Bio-Info. Pharmacol., Univ. Shizuoka

Poster Sessions


3-P2-26

Identification of binding site for a novel RyR1-selective inhibitor

Takashi Murayama1, Nagomi Kurebayashi1, Takuya Kobayashi1, Haruo Ogawa2,Masami Kodama2, Shuichi Mori3, Hiroyuki Kagechika3, Takashi Sakurai1

1Dept. Pharmacol., Juntendo Univ. Sch. Med., 2IQB, Univ. Tokyo,3IBB, Tokyo Med. Dent. Univ.

Poster Sessions


3-P2-27

Characterization of novel RyR1 selective inhibitors identified by ER Ca2+

measurements

Matsukawa Hiroyuki1, Takashi Murayama1, Takuya Kobayashi1, Nagomi Kurebayashi1,Toshiko Yamazawa2, Mari Ikegami-Yuasa3, Shuichi Mori3, Hiroyuki Kagechika3, Takashi Sakurai1

1Dept. Pharmacol., Juntendo Univ. Sch. Med., 2Dept. Mol. Physiol., Jikei Univ. Sch. Med., 3IBB, Tokyo Med. Dent.Univ.

Poster Sessions


3-P2-28

Effects of Palmitoleic acids on skeletal muscle differentiation inhyperglycemic environment.

Yayoi Tokunaga1, Hitomi Yoshizaki2, Akiyo Toriumi2, Chisato Ishida3, Ritsuko Kawaharada4,Masatoshi Hori1, Akio Nakmura2

1Lab. of Veterinary Pharmacol., Grad. Sch. of Agr. and Life Sci., Tokyo Univ.,2Department of Food and HealthSciences, Jissen Women’s University, Hino, Japan,3Department of nutrition, Japanese Haramachi Red CrossHospital, Japan, 4Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki, Japan

Poster Sessions


3-P2-29

Evaluation of the usefulness of three-dimensional organoid culture in thedrug screening of non-alcoholic steatohepatitis (NASH) disease

Yamamoto Haru1, Megumi Yamanaka1, Elbadawy Mohamed2, Tatsuya Usui1, Kazuaki Sasaki1

1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, TokyoUniversity of Agriculture and Technology,2Department of Pharmacology, Faculty of Veterinary Medicine, BenhaUniversity

Poster Sessions


3-P2-30

Disruption of steroidogenic acute regulatory protein-related lipid transferdomain containing 10 (STARD10) prevents the development of nonalcoholicsteatohepatitis (NASH)

Masanori Ito, Daisuke Ohshima, Yoshinori Mikami, Taichiro Tomida, Satomi Adachi-Akahane

Department of Physiology, Faculty of Medicine, Toho University

Poster Sessions


3-P2-31

Effects of Bezafibrate on Carbon Tetrachloride and T0901317-InducedNonalcoholic Steatohepatitis Model

Yukiko Kawasaki, Shoko Otsu, Yuri Noda, Takahito Imaizumi, Hisami Matsushita, Katsumi Endo,Yasushi Hirasawa

Nihon Bioresearch Inc.

Poster Sessions


3-P2-32

Roles of heparan sulfate against CCl4 cytotoxicity in HepG2 cells

Takuro Matsuzawa, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa

Dept Pharmacol. Tohoku Univ Grad Sch Med

Poster Sessions


3-P2-33

Platelets attenuate monocrotaline-induced liver injury

Fumisato Otaka1,2, Yoshiya Ito1,2, Kanako Hosono1,2, Kou Hatanaka1,2, Wasaburo Koizumi3,Hideki Amano1,2

1Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, 2Departmentof Pharmacology, Kitasato University School of Medicine, 3Department of Gastroenterology, Kitasato UniversitySchool of Medicine

Poster Sessions


3-P2-34

Expression of the growth-related factors in the liver of fetal rats

Tsukasa Kobayashi1, Yuko Takeba1, Yuki Ohta1, Masanori Ootaki1, Keisuke Kida1,Minoru Watanabe2, Taroh Iiri1, Naoki Matsumoto1

1Department of Pharmacology, St Marianna University School of Medicine, 2Institute for Animal Experimentation,St Marianna University Graduate School of Medicine

Poster Sessions


3-P2-35

CRAC channel blockers attenuate the activation of human hepatic stellatecells

Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura

Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Poster Sessions


3-P2-36

The alternation of adenosine-related genes likely progress HSC activation ininflammatory condition.

Naoki Dohi1, Momoka Yamaguchi1, Sin-ya Saito1,2, Tomohisa Ishikawa1

1Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, 2Fac. Vet. Med., Okayama Univ. Sci.

Poster Sessions


3-P2-37

The formation of lymphatic vessels and macrophages contribute to liverrepair after liver injury

Shuji Nakamoto1,2,3, Yoshiya Ito1,2, Takuya Goto1,2,3, Kanako Hosono1,2, Ko Hatanaka1,2,Masataka Majima1,2,4, Hideki Amano1,2

1Dept. Mol. Pharmacol., Kitasato Univ. Grad. Sch. Med., 2Dept. Pharmacol., Kitasato Univ. Sch. Med., 3Dept.Surg., Kitasato Univ. Sch. Med., 4Dept. Med. Therap., Kanagawa Inst. Tech.

Poster Sessions


3-P2-38

In vivo S-allyl-L-cysteine and some analogues accelerates liver regenerationin 70% partially hepatectomized rats.

Kazuki Kurihara1, Hajime Moteki1, Hideshi Natsume2, Masahiko Ogihara1, Mitsutoshi Kimura1

1Dept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ., 2Dept. pharmaceutics, Fac. Pharma. Sci., Josai Univ.

Poster Sessions


3-P2-39

Functional analysis of FSGS-associated TRPC6 channels and itsrelationship to early-onset and late-onset of the renal disease

Ryo Okada1, Tatsuya Komaki1,2, Onur K. Polat3,4, Hideyuki Kobayashi1, Takanori Kihara2,Masayuki X. Mori1

1Bio-materer. Chem., Sch. Med., UOEH,2Graduate School of Environmental Engineering, The University ofKitakyushu, 3Dept. Synth. Chem. Biol. Chem., Grad. Sch. Eng., Kyoto Univ., 4Rush Univ., Chicago, USA

Poster Sessions


3-P2-40

Inhibition of CRAC channel current by TRPV1 channel agonist andantagonist in RBL cells

Ayumi Nakayama, Minoru Wakamori

Div. Mol. Pharmacol. Cell Biophys., Grad. Sch. Dent., Tohoku Univ.

Poster Sessions


3-P2-41

Role of TRPM7 channel in pancreatic cancer

Hosokoshi Atsuki1, Nobuaki Takahashi2, Reiko Sakaguchi1, Atsusi Masamune3, Hiroshi Harada4,Yasuo Mori1

1Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ, 2The Hakubi Cent., Kyoto Univ, 3Dept.Gastroente., Grad. Sch. Med., Tohoku Univ,4Dept. Genome Dynamics., Radiation Biology Cent., Grad. Sch. Bio.,Kyoto Univ

Poster Sessions


3-P2-42

TRPC channels selective compounds for novel fibrotic disease treatmentand trafficking of antisense oligonucleotides

Tomorrow Amatani1, Yuuya Kasahara2, Masahito Shimojo3, Motohiro Nishida4,5, Ryu Nagata3,Satoshi Obika2,3, Yasuo Mori1

1Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ, 2Natl. Inst. Biomed. Innov. Health. & Nut.(NIBIOHN), 3Dept. Bioorg. & Chem., Grad. Sch. Pharmaceut. Sci., Osaka Univ, 4Dept. Pharm., Grad. Sch., KyushuUniv, 5Nat. Ins. Physiol. Sci. (NIPS), Nat. Ins. Natural Sci. (NINS)

Poster Sessions


3-P2-43

Regulation of mitochondrial activities by TRPA1 channel

Yoshiaki Hasegawa1, Satoru Hamano1, Yasuo Mori1, Nobuaki Takahashi1,2

1Lab. Mol. Biol. Grad. Sch. Eng. Kyoto Univ., 2The Hakubi Cent., Kyoto Univ.

Poster Sessions


3-P2-44

Different Zinc sensitivity of TRPA1 between human and chicken.

Masaki Matsubara, Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki

Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University

Poster Sessions


3-P2-45

C-terminal domain regulates the plasma membrane localization of aquaporin-5

Shin-ichi Muroi, Yoichiro Isohama

Lab. Appl. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. of Sci.

Poster Sessions


3-P2-46

Characterization of G-protein coupled receptors selectively localized inprimary cilia in ciliated cellular models

Yuki Kobayashi1, Nobuya Nishimura1, Yuki Tokubaga1, Tatsuo Miyamoto2, Yumiko Saito1

1Hiroshima Univ. Grad. Sch. Integrate Sci. Life, 2Hiroshima Univ. Res. Inst. Radiobiol.

Poster Sessions


3-P2-47

A dual prokaryotic (E. coli) expression system (pdMAX)

Manabu Murakami1, Agnieszka Murakami1, Shirou Itagaki2

1Department of Pharmacology, Hirosaki University Graduate School of Medicine, Hirosaki, 2Collaboration Centerfor Community and Industry, Sapporo Medical University

Poster Sessions


Documents

3-P1-01 Poster Sessions Human mesenchymal stem cells ......Phar maceutical Sci., Sanyo-Onoda City Univ., 2Dept. Pharmacotherapy, Grad. Sch. Biomed. Development of drugs for anticancer