3 Learning Objectives

7/25/2019 3 Learning Objectives

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Lecture 22-23(Hollow Fibers Biomaterials in Nephrology)

Within the context of biomaterials, what is meant by the term hollow fiber!"

#ist se$eral important biome%ical applications of hollow fibers"

What is meant by the terms semipermeable or selecti$ely permeable!"

How are hollow fibers &se% in ner$e repair"

Within the context of cell encaps&lation, what is meant by the term

imm&noisolation!"

What is meant by the term phase in$ersion!"

How are hollow fibers ma%e"

What types of reagents are re'&ire% for fabricating a hollow fiber"

What is meant by the term ann&lar spinneret!"

How is the perm-selecti$e sin of a hollow fiber create%"

Why %o many types of hollow fibers ha$e an anisotropic wall architect&re"

What %oes the &ltra-topography of the inner sin loo lie an% why %oes it

ha$e this characteristic str&ct&re"

How %oes one characterie the sie$ing or filtration properties of a hollow fiber

membrane"

What is meant by the term *olec&lar Weight +&t-off (*W+)"

What is meant by the term hin%ere% %iff&sion"

escribe how a hemo%ialyer is constr&cte% an% how it f&nctions"

What are the primary iss&es that %etermine hemo%ialysis biocompatibility"

What is the chemical nat&re of +&prophane"

What are the clinical symptoms most fre'&ently obser$e% after the &se of

c&prophan heom%ialyers"

#ect&re 2. (Hy%rogels) /ro$i%e a complete %efinition of the term hy%rogel!"

escribe the $ario&s chemical schemes that can participate in the

constr&ct&ion of a hy%rogel networ"

What is meant by the phrase hy%rogel water content can $ary from 01-

4!5"

How is swell beha$ior characterie% empirically5"

What is meant by the term s&pramacromolec&le!5

What two characteristics %etermine the sie of a swollen hy%rogel networ5"

What is meant by the term xerogel!5"

What is the chemical nat&re of chitosan an% where is ti %eri$e%5" How are xerogels an% hy%rogels &se% in %r&g %eli$ery applications"

#ist fi$e nat&rally occ&rring hy%rogels"

#ist the f&nctions of biological hy%rogels"

#ist fi$e synthetic hy%rogels"

What are the common chemical attrib&tes of h%rogels5


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What is meant by the term polyelectrolyte hy%rogels6 an% how are they

&se%5"

ifferentiate between hyla&ronic aci% an% alginic aci% in terms of str&ct&re

an% f&nction"

escribe a scheme for encaps&lating cells in a biocompatible hy%rogel coating

&sing polyelectrolytes"

#ect&re 2-(7pplications in pthalmology)

escribe the chemical nat&re of polyacrylates!"

How are poly(acrylates) synthesie%"

escribe fo&r significant e$ents in the historical %e$elopment of contact lens"

escribe why the original /**7 contact lens were not as biocompatible as

pH8*7 lens"

ifferentiate p**7 an% pH8*7"

#ist the properties that mae pH8*7 &sef&l as a contact lens material"

#ist three ways by which contact lens can be fabricate%" What is a cataract"

What is meant my the term 9#!"

#ist the common materials &se% for maing intraoc&lar lens"

What was the firs materials &se% for maing 9#6s an% why was it chosen:"

What are the most common complications with 9#6s"

What animal mo%el is generally &se% in the %e$elopment of 9#6s an% why is

it &se%"

What is meant by the term calification!"

What type of a%%iti$es are a%%e% to 9#6s to protect the retina"

What are the two ma;or ca&ses of lens opacification5" What is meant by a 3-pience lens!"

What is the chemical nat&re of the calcification"

Lecture 2 7pplications)

n a broa% le$el, list the $ario&s types of biomaterials"

From an engineering perspecti$e, what are the a%$antages of &sing metals as

biomaterials"

#ist . applications of metals an% pro$i%e specific examples of %e$ices an% their

&ses"

#ist se$eral physical properties that are characteristics of metals"

#ist se$eral chemical properties that are characteristics of metals"

/ro$i%e a simple chemical %efinition of metals"

#ist three common lattice types an% %escribe how they are relate% to mechanical

properties"

What is meant by the statement the %etails of the processing can strongly affect

the mechanical properties of a metal!"


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What is meant by the term grain formation!"

From a str&ct&ral perspecti$e, what is meant by the term phase!"

escribe two %efects in lattice architect&re an% pro$i%e an explanation of how

they affect mechanical beha$ior of the soli%"

What is meant by the term fatig&e fail&re!" How are the mechanical properties of the metal relate% to its internal str&ct&re5"

escribe two metho%s of increasing the strength of a metal"

What is meant by the term alloy!"

What are the two principle types of alloys"

#ist se$eral important alloys an% their &ses"

What is meant by the term strain har%ening!"

#ist three common metals &se% as biomaterials"

For long term &se, What metals are preferre% an% why"

escribe the principal components of the total artificial nee an% pro$i%e a list of

materials"

escribe the ma;or ca&se of re$ision s&rgery with the ?@A

Lecture 29 (Ceramics and glasses)

ifferentiate the terms ceramic an% glass!"

How %o metals compare with ceramics in terms of physical properties5"

What are the generally accepte% a%$antages an% %isa%$antages of &sing ceramics

as biomaterials5"

#ist se$eral orthope%ic applications of ceramics" #ist se$eral %ental applications of ceramics"

What are the fo&r most commonly s&e% ceramics5"

What is meant by the term osteintegration! an% how is it achie$e%"

escribe the $ario&s possible concept&al interactions of ceramics an% tiss&e"

escribe a generic processing scheme for processing a ceramic implant"

#ist two commonly &se% str&ct&ral bioceramics"

/ro$i%e two common fail&re mechanisms of the total artificial hip"

What is the composition of %ental porcelain5"

What is meant by the term calci&m phosphates!"

What is the inorganic component of bones an% teeth5" #ist se$eral ways that calci&m hy%roxyapatite is in the biome%ical %e$ice

in%&stry"

What is meant by the term bioceramic coating!5 an%, what is a rationale for their

&se5"

What is meant by the term tiss&e engineering!"

escribe a tiss&e engineering scheme to replace bone in a %efecti$e man%ible


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Lecture 30 (Adhesives and Sealents)

efine the terms a%hesion! an% a%hesi$e!"

What is meant by the term sealant!"

How are a%hesi$es an% sealants &se% as biomaterials5"

#ist se$eral ways that can be &se% to classify a%hesi$e materials" 7s an %esign engineer, what generally nee%s to be consi%ere% in the selection of a

partic&lar a%hesi$e5"

#ist the factors that %etermine the breaing strength of an a%hesi$e ;oint"

#ist fo&r common a%hesi$es"

ifferentiate between %ifferent bon%ing mechanisms"

What is meant by the term s&rface treatment! an% how %o the $ario&s treatments

increase a%hesi$e bon% strength"

ifferentiate between the $ario&s terms &se% in fail&re analysis"

ifferentiate between the two ma;or types of a%hesi$es an% pro$i%e an example of

each" What is meant by the term light c&re% system!"

escribe some of the f&n%amental characteristics of light c&re a%hesi$es"

What are some of the typical applications of light c&re a%hesi$es"

From an biome%ical engineering perspecti$e, what are the benefits of a%hesi$es"

From an biome%ical engineering perspecti$e, what are the limitations of

a%hesi$es"

n the basis of their limitations, %ifferentiate between cyanacrylate a%hesi$es,

light c&re% acrylate a%hesi$es" epoxy a%hesi$es" an% poly&rethane a%hesi$es"

Lecture 31 (Biomaterials in Dentistr)

What is meant by the term a%hesi$e %entistry!5"

escribe how sealants are &se%"

What is a glass ionomer cement an% how is it &se%"

Class ionomer restorations are bacteriostatic- explain"

Class iomers are composites-explain"

What is the most common %ental resin &se% in composite restorations5"

What is meant by the term inorganic filler!5"

How are restorations lie s&staine% release! form&lations5

Lecture 32-33 (!iodegrada!le materials) Dsing graphical representation, show what is meant by the term polymer

%egra%ation!"

/ro$i%e a rationale for the &se of %egra%able materials in orthope%ic me%icine"

#ist se$eral a%$antages for the &se of bio%egra%able implants"

/ro$i%e fo&r general str&ct&ral form&las %epicting %egra%able f&nctional gro&ps"

Be able to i%entify the most liely hy%rolytic sites in common str&ct&ral form&lae"


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#ist se$eral nat&ral an% se$eral synthetic %egra%able polymers &se% in me%ical

applications"

What are the a%$antages of synthetic %egra%able polymers o$er nat&ral ones5"

&tline the synthesis of poly(glycolic aci%)"

With a graph, %escribe how $arying the ratio of /C7 to /#7 infl&ences the time of

%egra%ation of the co-polymer" What are the two most common mechanisms of bio%egra%ation5"

With respect to biome%ical %e$ice %esign, %ifferentiate between s&rface an% b&l

%egra%ation"

#ist the most important factors that affect the beha$ior of %egra%able polymers"

#ist fi$e common metho%s for st&%ying polymer %egra%ation"

What wo&l% a comparison of ?gs tell yo& abo&t the %egra%ation of two %ifferent

/C#7 copolymers"

How is a$erage molec&lar weight infl&ence% o$er time5"

What metho%s wo&l% yo& &se to st&%y how a$erage molec&lar weight is affecte% o$er

time" #ist se$eral me%ical specialties which mae &se of %egra%able materials an% pro$i%e

specific examples of their applications"

Lecture 3" (#$ and Biomaterial %rocessing)

What is meant by the term tiss&e engineering scaffol%!"

escribe how a poro&s scaffol% wo&l% be prepare% &sing the sol$ent casting metho%"

ifferentiate between the terms particle leaching, ball leaching an% filament leaching"

What are the ma;or consi%eration when &sing a leaching process to create a poro&s

scaffol% or s&bstrate"

What are the ma;or metho%s for creating poro&s tiss&e engineering scaffol%s"

What is the %ifference between melt spinning an% electrospinning processes"

escribe a simple way to create a scaffol% &sing thermoplastic filaments"

9n the f&t&re, how is it en$isione% that imaging can be integrate% into the man&fact&re

of tiss&es for therape&tic &se5"

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3 Learning Objectives