ISSN 0036-8075

22 June 1984Volume 224, No. 4655

LETTERS Groundwater Contamination: J. D. Bredehoeft and T. M. Usselman; NAS andthe Soviet Academy: E. R. Piore; Sex Differences Among theMathematically Precocious: L. H. Fox; Biological Diversity:P. F. Brussard; D. Jablonski et al. ......................................

EDITORIAL Chemistry Without Test Tubes ..............................................

ARTICLES Computer Vision and Natural Constraints: C. M. Brown .......................

Strategic Command, Control, Communications, and Intelligence: C. A. Zraket....

The Interleukin-2 T-Cell System: A New Cell Growth Model: D. A. Cantrelland K. A. Smith .......................................................

NEWS AND COMMENT

RESEARCH NEWS

A Political Push for Scientific Cooperation ..................................

IBM's Bloch Named to Lead NSF...........................................

Lab Break-In Stirs Animal Welfare Debate ...................................

A "Prolife" Population Delegation9 ........................................

Congress Turns Cold on Fusion .............................................Briefing: Academy Cancels Visit to Soviet Union; Environment 1984 Gets Mixed

Marks by Report; Melmon Resigns Stanford Chairmanship .................

New Neurons Form in Adulthood ...........................................

Why Is Development So Illogical? ..........................................

Unusual Bimetallic Catalyst Synthesized .....................................

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BOOK REVIEWS The Development of Political Organization in Native North America,reviewed by J. G. Jorgensen; Limitations to Efficient Water Use inCrop Production, R. P. Patterson; Rock and Mineral Magnetism,D. J. Dunlop; Books Received .......................................... 1331

REPORTS Paleoceanographic Events and Deep-Sea Ostracodes: R. H. Benson,R. E. Chapman, L. T. Deck ............................................. 1334

Community Recovery After Storm Damage: A Case of Facilitation in PrimarySuccession: L. G. Harris et al. .........1................................ 336

Bishop Tuff Revisited: New Rare Earth Element Data Consistent with CrystalFractionation: K. L. Cameron ........................................... 1338

The Association of Iron and Manganese with Bacteria on Marine MacroparticulateMaterial: J. P. Cowen and M. W. Silver .................................. 1340

Adenovirus Ela Gene Product Expressed at High Levels in Escherichia coliIs Functional: B. Ferguson et al. ........ ............................... 1343

Potentiation of Bleomycin Lethality by Anticalmodulin Drugs: A Role forCalmodulin in DNA Repair: J. G. Chafouleas, W. E. Bolton,A. R. Means ........... ............................................... 1346 V

Autoantibodies to a 64-Kilodalton Islet Cell Protein Precede the Onsetof Spontaneous Diabetes in the BB Rat: S. Baekkeskov, T. Dyrberg,A. Lernmark . 1348

Wolves, Moose, and the Allometry of Population Cycles: R. 0. Peterson,R. E. Page, K. M. Dodge ............................................... 1350

Competition Controls the Growth of an Identified Axonal Arborization:R. K. Murphey and C. A. Lemere ........ ............................... 1352

Is There an Evoked Vascular Response?: C. A. Sandman, J. P. O'Halloran,R. Isenhart .1355

Predator-Induced Defense in a Marine Bryozoan: C. D. Harvell ................. 1357

Decreased Neuronal Inhibition in Vitro After Long-Term Administration ofEthanol: D. Durand and P. L. Carlen ....... ............................. 1359

COVER

(Left) Optic flow images (retinal pat-tern velocities caused by scene motion)from a rotating sphere and cylinder.(Right) Shapes causing the images, asderived by a computational visionprocess. Such processes use mathe-matical models of physical laws andassumptions about nature to recoverphysical information about scenes frominput images. See page 1299. [JohnAloimonos, Computer Science Depart-ment, University of Rochester, Roch-ester, New York 15627]

22 June 1984, Volume 224, Number 4655

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SCIENCE

hmistry Without Test Tubesthose whose experience in chemical research laboratories was 20ago or more the modern counterpart is a strange place. New

imentation with electronic components has revolutionized analytical)ilities. It has also made accessible crucial experiments and theoreticallations that could not previously be performed. Some present-dayarements can be made with speeds and sensitivities that are five to tens of magnitude better than those of two decades ago.a symposium at the recent AAAS meeting in New York and in an

r report,* leading chemists were enthusiastic about new opportunitiessearch that have been created. They emphasized three major frontiers.irst is the opportunity to understand, in the most fundamental sense,ical reactivity and how to control it. The second is to improve-standing of catalyses. The third is to extend to the molecular levelstanding of life processes. A few examples are appropriate.- study of why and how chemical changes take place has beenially facilitated by new instrumentation. Lasers, computers, moleculars, ion cyclotron resonance, and many more tools have opened andEated new research approaches. Of these, lasers have been particularlyil. Their short pulse durations permit probing of chemical reactions inranging from 10-6 to 10- 12 seconds. Lasers also provide tunable,nely narrow, frequency light sources and thus greater diagnostic:ivity and selectivity. With high-power sharply tunable lasers it isble to excite one particular degree of freedom of many molecules in a

le. During the interval in which these excited states persist, such-ules react as if that particular degree of freedom is at a highZrature while all the rest of the degrees offreedom of the molecule are

Today we know much about the chemistry of molecules at the groundThe study of their behavior under excitation will greatly improve our

standing and ability to devise important applications.:alysts are already important technologically. It is estimated that 20nt of the gross national product is generated through their use. Muchpresent art was developed through empirical research. New equip-

facilitating fundamental studies of processes on a molecular level isavailable. One result is the rapid development of surface science.ise of the unsatisfied bonding capability of atoms at surfaces, theistry there is different from that of reactants brought together in solu-tras gases. When chemists are able to identify molecular structures onirfaces they will be able to understand and control events there.ier frontiers of research include homogeneous catalyses, metal clusteristry, and stereoselective catalysts. An important branch of homoge-catalysis has developed from research in organometallic chemistry.:ample is rhodium dicarbonyl diiodide employed in the commercialction of acetic acid from methanol and carbon monoxide. Stereoselec-atalysts now being discovered will surely have important applicationssynthesis of biological molecules. If a complex molecule has manycarbon atoms and a synthetic process produces all of them, only a

raction of the product is likely to have the desired biological activity.chemists state, and rightly so, that their science has been underfund-lative to other major disciplines. They point to many new researchtunities and to the needs of the $175-billion chemical industry for newledge and trained people. They remind us that although chemicals nowIce a favorable balance of payments of $12 billion a year, leadership inareas of research has moved to other countries. Their pleas for fundsable them to purchase state of the art instrumentation should bed, and their efforts to support training of the next generation ofists supported.-PHILIP H. ABELSON

rch Briefing Panel on Selected Opportunities in Chemistry, in Research Briefings 1983ial Academy Press, Washington, D.C., 1983).

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