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2. Synthetic Utilization of pentafulvenes. NIIST. 2. Development of Synthetic Methodologies towards Fused Cyclooctanoids. Some of the Biologically active cyclooctanoids. Developed a Novel Methodology for the synthesis of 5-8 fused Cyclooctanoids. Tet. Lett . 2005, 46, 4785-4788. NIIST. - PowerPoint PPT Presentation
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2. Synthetic Utilization of pentafulvenes
2. Development of Synthetic Methodologies towards Fused Cyclooctanoids2. Development of Synthetic Methodologies towards Fused CyclooctanoidsNIIST
OH
H OH
OHHO
HO
H
H
H
OHOH
Dactylol Kalmanol
OO
O
H
Asteriscanolide
H
OO
O
O
O
HO H
HO
O
HH
O
OH
Anti-HIV activeLancifodilactone G
H
Some of the Biologically active cyclooctanoidsSome of the Biologically active cyclooctanoids
O
O
AcO Et3N
CHCl3
R1R
O
O
R1R
O
O
[6+3]
Developed a Novel Methodology for the synthesis of 5-8 fused CyclooctanoidsDeveloped a Novel Methodology for the synthesis of 5-8 fused Cyclooctanoids
Tet. LettTet. Lett. 2005, 46, 4785-4788
O
O
N Bn
N Bn
O
O
N
O
O
Ph
O
O
AcO R2
TFA
Et3N
O
ON
O
O
Ph
H
H
H
Toluene, RT
O
O
O
O
OO
OO
R2
R1R1
R2
Syn-anti Syn-syn
Utilization of the Developed Synthetic MethodologyNIIST
Tet. LettTet. Lett. 2005, 46, 4785-4788
TetrahedronTetrahedron, 2006, 5952-5961
Tetrahedron,Tetrahedron, 2006, 62, 12345;
SynthesisSynthesis, 2006,11, 1811-1818
Eur. J. Org. Chem. Eur. J. Org. Chem. 2007, 5847, 5847
O
OOH
H
O
H
H
O
O
O OR
RuCl3.3H2O
H2
O
O
R
O
O
R
O
O
AcO
NaIO4
O
O
O
i. CPD, base
ii.
Pd/C
Neodolabellane
R
Novel route to eleven membered rings and spirocyclic cyclooctanoidsNovel route to eleven membered rings and spirocyclic cyclooctanoidsNIIST
“Heterocycles via Pyrylium and Pyridinium Betaines”,”, K. V. Radhakrishnan,
Topics in Heterocyclic Chemistry, Vol. Synthesis of Heterocycles via Cycloadditions, 13, 2008,
pages-71-98., Springer.
Eur. J. Org. ChemEur. J. Org. Chem. .
2007, 5847, 5847
Synthesis, 2008, 13, 2134
O
Br
R-OH
OBz
O
O
O
Ph
OR
BzO
2,6-Lutidine
[bmim]PF6
N
N
H3C
PF6
[bmim]PF6
NIIST
3. Synthetic Carbohydrate Chemistry
1,2-Orthoesters- Important Intermediates in Synthetic Carbohydrate Chemistry
For eg: n-Pentenyl Orthoesters as Glycoside Donors
Design, Synthesis and Host-Guest Evaluation of NeoglycoconjugatesDesign, Synthesis and Host-Guest Evaluation of Neoglycoconjugates
Ionic liquid [bmim]PFIonic liquid [bmim]PF66 Mediated Synthesis of 1,2-Orthoesters of Carbohydrates Mediated Synthesis of 1,2-Orthoesters of Carbohydrates
We have developed a facile and environmentally benign method for the We have developed a facile and environmentally benign method for the
synthesis of 1,2- orthoesters of carbohydrates and Glycosidation reactions ofsynthesis of 1,2- orthoesters of carbohydrates and Glycosidation reactions of
NPOE in ionic liquid [bmim]PFNPOE in ionic liquid [bmim]PF66..
The method is much simpler and the solvent can be reused several timesThe method is much simpler and the solvent can be reused several times
Synlett, 2005, 6, 997Bull. Chem. Soc. Jpn. 2007, 553.
Synthesis and Study of Carbohydrate Appended Mutivalent ligands
Synthesis of higher order glycoconjugates as
probes to define the molecular nature of
carbohydrate-receptor interactions
Interaction of metal ions with carbohydrates is an important element for
biochemical processes
Metal complexes involving carbohydrates clarify many functions of
carbohydrates in natural systems
Carbohydrates as Scaffolds by attaching
a chelating ligand for cation and anion binding
Able to encapsulate guest molecules
Synthesis and study of Carbohydrate-coated Nanocapsules
Target selective nanocarriers
Labelling specific protein
Sensing of a range of pathogens.
Vesicles
Nanorods
NIIST Photochromic nanocapsules Multivalent nanoscaffolds for selective
interactions
