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7/24/2019 2 Haramati Slides 2015
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Movement Across a
Semi-permeable Membrane
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Osmosis
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Osmotic Pressure depends on
Concentration of Particles
= cRT
Jacobus Henricus Vant Hoff1852-1911
= icRT
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Effective Osmotic Pressure depends on
Concentration of ImpermeantSolutes
= icRT
= icRT
= Reflection coefficient( 0 - 1 )
permeable - impermeable
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Reflection Coefficient (
)Permeability of a membrane to a particularsolute, compared to water
= 1-P solute
P water
Effective Osmotic Pressure = Tonicity
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HydrostaticPressure
Water Movement
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Osmotic Pressure
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Osmoles = # of Active Particles
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Osmotic Composition of Body Fluids
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Osmotic Pressure
mmHg = osmolarity x 19.3
= cRT
300 mOsm/Lx 19.35790 mmHg =
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Volume of a Compartment is
determined by the # of Osmoles
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What Drives Fluid Movement?Intracellular Extracellular
Interstitial
Plasma
in Osmolarity
inPressures
CellMembrane
CapillaryWall
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Pressures Across Capillary
Jv = Kfx net filtration pressure
Jv = Kfx (HPc-HPi)-(c- i) Kf= S.A. x Lp
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