$506 Friday, November 11, 2005 Poster Abstracts

evaluation. We performed an extensive neuropsychological assessment with MRI, CI', SPECT, EEG and an audiological study. Results: a patient with a mild depression experienced U M H and the neuropsychological evaluation showed a mild cognitive decline and language impairment. Neuroradiological studies showed a cortical atrophy with asimetry on the right temporal lobe and the presence of infarction in the fight middle temporal gyrus. Audiometry showed mild hearing loss. Conclusion: U M H are rare and not well known. We describe a case report with an extensive neuropsychological and neuroradiological study and we assmne a correlation with an infarction in the right temporal area and this symptom, giving the opportunity to review different mechanisms to explain UMH.

1597 Behavioural Improvement, Reactive Gliosis anti Lesioned area in rodent model of Cerebral Isdieiilia following stein cell treahnent

Bulawina, L z, Boltze, j i , Kamprad, M i, Hfirtig, W 2, Paulke, B-R 3, Grosche, j2, Arendt, T a and Elrmlrich, F ~. 1Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany; 2Paul Flechsig Institute of Brain Research, University of Leipzig, Germany; 3Fraunhofer Institut Angewan&e Polymerforschung, Golm, Germany

It was shown recently that stem/progenitor cell subpopulations may be beneficial for a treatment of different neurological disorders, including stroke, although the mechanisms of a therapeutic effect are not well knowll yet. Middle cerebral artery occlusion (MCAO) in male spontaneously hypertensive rats (SHR) was investigated as a model of permanent focal cerebral ischemia. Different stem/progenitor cells subpopulations from human umbilical cord blood and SHR bone marrow mononuclear cells, a T cell clone (irradiated and unable to divide) and a control (physiologycal saline) were alternatively injected ( lx l06 cells) into the tail vein 8-10 hours following MCAO. Therapeutically benefit was detected via behavioral testing (RotaRod, beanl walk and nlNSS). Iamllunotfistochemistry and digital measure- ment of lesioned area were performed after a perfusion of the animals on day 29 following stroke onset. Reactive astrocytes were detected by GFAP staining. In the group with strong behavioural benefit less glial reactivity and reduced extent of lesion were observed, while in the groups with little behavioural recovery (control T cells) reactive astrocytes were much more numerous, and the area of lesion was more extensive. It was also shown by fluorescence microscopy that in successfully treated animals the processes of the reactive astrocytes are shorter and GFAP fluorescence is less intensive as compared the to control groups. Micro- and astroglial reactions were shown by multiple fluorescence labelling and confocal laser-scamting microscopy already by day 2 after MCAO. In sunmmry, behavioural benefit in stem/ progenitor cell treated MCAO rats is associated with size reduction of the areas of lesion and less numerous reactive astrocytes indicating remodelling by reduced gliosis.

1598 World trade centre nightmares of Del~nestrafion and Suicidal Ideation following Eletriptan intake

Hart G a, Chermann J F ~, Sereni C a. 1Hdpital L~opoldBellan, Paris, France

We present a case-report of a 28 year-old female migraineur treated with eletriptan. One hour following the first administration of eletfiptan she experienced suicidal ideation with impulses of defenestration persisting for two hours accompanied by complete resolution of the migraine. Ten days later she experienced a further migraine and took eletriptan prior to sleep. Three hours later she was awakened by a nightmare during which she assisted the defenestration of people within the enflamed world trade centre. The patient had no personal or family history of psychiatric illness. The eletriptan was

subsequently replaced my almotriptan with no further recurrence of suicidal impulsions or images of defenestration at one year follow-up. In addition, the patient was treated with topiramate as migraine prophylaxis. We propose that the emergence of the suicidal ideation may be influenced by the enhanced lipophJlicity of eletriptan in comparision to almotriptan. We also suggest that the presence of topiramate may have potentialised these CNS side effects.

1599 TranSient Neurological Focal Symptoms not considered Transient Isdlemic aflacks in rural and urban Northern Portugal: incidence, risk of death and risk of stroke in a community-based study

Correia M ~, Silva M R a, Magalhges R 3, Silva MC ~. 1Servi:o de Neurologia, Hospital Germ de Santo Antdnio, Porto, Portugal," 2 Servi:o de Neurologia, Hospital de S. Pedro, tq'la Real, Portugal," 3Departa- mento de Estudos de Populaldes, lnstituto de Cidncias BiomJdicas de Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

Background: There are no community-based studies on the incidence of Transient Neurological Focal Symptoms not classified as Transient Ischemic Attacks (TNFS). This study was designed to determine the incidence of TNFS in rural and urban populations in Northeru Portugal. Methods: All suspected first stroke, TIA and TNFS occurring between October 1998 and September 2000 in 18677 residents in rural municipalities and 86023 living in the city of Porto were entered a population-based registry. TNFS not TIA were defined as acute symptoms and signs presunled to be caused by a non ischaemic focal dysfunction of the central nervous system, and lasting less than 24 hours. Comprehensive sources of infomlation were used for identification of patients that were followed-up at 3 and 12 months after the event. Results: During a 24-month period 513 first TNFS patients were registered, 73 in rural and 440 in urban areas. The crude annual incidence was 1.95 (95%CI, 0.94-3.76) and 2.56 (95%CI, 1.93-3.33) per 1000 for rural and urban populations, respectively. The global TNFS nicidence standardised to the World S~gi population was 1.58 (95% CI, 1.14-2.19). The 28-day risk of death was 0.6% (95%Cf, 0.2-1.8) and of stroke 0.4% (95%Cf, 0.1-1.6); the 12-month risk was 4.1% (95%CI, 2.6-6.3) and 2.5°,5 (95%CI, 1.4-4.4), respectively. Contusions: The incidence of TNFS is higher than that reported for TIA in conmlulaJty-based studies. The importance and clinical meaning of these conditions can only be ascertained by an adequate long-term follow-up of these patients.

1600 Giant cell arterifis a rare but hnportant cauSe of headache with C5 cervical radiculopathy

Woolmore, J A a, Leonnard, A a, Davies, M B ~. 1Department of Neurology, University Hospital of North Staffordshire, Stoke on Trent, United Kingdom

Background: Giant cell arteritis is a common, treatable cause of head- ache increasing in incidence with age. Case report: A 72 year old female presented with a month 's history of headache and diplopia. Five days before presentation the patient awoke with weakness of the right arm and inability to abduct both shoulders. Detailed clinical examination showed a bilateral radicular pattern of weakness involving C5 and C6 predominantly on the right. The ESR was raised at l l3mm/Hr and CRP at 105mg/L. A chest radiograph showed a raised fight hemidiaphragm. MRI of the brain and cervical spine, echocardiogram, electrocardiograph, lumbar puncture and blood screening were unremarkable. Temporal artery biopsy showed histological findings consistent with giant cell arteritis. Electrophysiology witlfin 10 days of symptom onset was normal. Both headache and neurological impairment improved with steroid therapy and recovery was full.