Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii

Foreword. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxvii

Foreword to the First Edition .xxix

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xxxi

SECTION 1

Foundation Issues

Section Editor: L. Michael Posey

1. Pharmacoeconomics: Principies,Methods, and Applications 6) . . . . . . . . . . . . . . . . .. 1Lisa Sanehez Trask

2. Health Outcomes and Health-Related

Quality of Life e 3

Stephen Joe/ Coons

3. Health Literacy and Medication Use CD . . . . . . . . .. 5Oralia V. Bazaldua and Sunil Kripalani

4. Cultural Competency CD . . . . . . . . . . . . . . . . . . . . . . . 7Jeri J. Sias, Amanda M. Loya, José O. Rivera,

Arthur A. Islas, and Ulysses]. Urquidi

5. Principies and Practicesof Medication Safety CD . . . . . . . . . . . . . . . . . . . . . . . . 9

Seott M. Mark, Jeffrey D. Little,Sarah E. Adkins, and Robert J. Weber

6. Evidence- Based Medicine CD 11

Elaine Chiquette and L. Miehae/ Posey

7.Documentation of Pharmacy Services (i\ . . . . . . .. 13George E. MaeKinnon III and Neil J. MaeKinnon

8. ClinicalPharmacokinetics and

Pharmacodynamics e. . . . . . . . . . . . . . . . . . . . . . .. 15

Larry A. Bauer

9. Pharmacogenetics (\\ . . . . . . . . . . . . . . . . . . . . . . . .. 17

Larisa H. Cavallari and Y. W. Francis Lam

10. Pediatrics 4' 19

Milap C. Nahata and Carol Taketomo

11. GeriatricsCD oo 21Emily R. Hajjar, Shelly L. Gray,David R.P. Guay, Catherine 1. Starner,

Steven M. Handler, and Joseph T. Hanlon

12. Palliative Care . 23

JillAstolfi

13. Pharmacoepidemiology CD . . . . . . . . . . . . . . . . . . . . 25

Andy Stergaehis,Thomas K. Hazlet,and DeniseBoudreau

14. Clinical Toxicology . . . . . . . . . . . . . . . . . . . . . . . . . . . 27

Peter A. Chyka

15. Emergency Preparedness: Identification and

Management of Biologic Exposures &. . . . . . . . . . 51

Colleen M. Terriff, Jason E. Brouillard,Lisa T. Costanigro, and Jessiea S. Oftebro

16. Emergency Preparedness: Identification and

Management of Chemical and RadiologicExposures ~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53

GreeneShepherd and Riehard B. Sehwartz

SECTION 2

Cardiovascular Disorders

SectionEditor:RobertL.Talbert

17. Cardiovascular Testing. . . . . . . . . . . . . . . . . . . . . . . . 55

Riehard A. Lange and L. David Hillis

1 8. Cardiac Arrest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83

Jeffrey F. Barletta and Jeffrey L. Wilt

19. Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101

Joseph J. Saseen and Erie ]. Maclaughlin

20. Systolic Heart Failure . . . . . . . . . . . . . . . . . . . . . . .. 137

Robert B. Parker and Larisa H. Cavallari

21. Diastolic Heart Failure and the

Cardiomyopathies . . . . . . . . . . . . . . . . . . . . . . . . . .. 173

Jean M. Nappi and Robert L. Page II

'" The completechapter,learningobjectives,and other resourcescan be found at www.pharmacotherapyonline.com.

22. Acute DecompensatedHeart Failureo o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o 191

lo EoRodgers and Craig R. Lee

23. Ischemic Heart Diseaseo . . . . ooooooooooo. . . . . . . 209

Robert L. Talbert

24. Acute Coronary Syndromes. o oo 241

Sarah Ao Spinler and Simon De Denus

25. The Arrhythmias o o o o o o o o o o o o . . . . . . o o o o o o o o o o 273

Cynthia Ao Sanoski and lerry L. Bauman

26. Venous Thromboembolismo o o o o o.. o o o o o o o o o o 0311

Daniel M. Witt, Edith AoNuteseu,and Stuart T. Haines

27. Stroke o o o o o . . o o o o o o o o o o o . . . . o . o o o o o o o o o o o o . . 353

Susan C. Fagan and David C. Hess

28. Dyslipidemiao o o o o o o o.. o. o o o o o o o o o o o o o. o. o o o o 365Robert L. Talbert

29. Peripheral Arterial Disease. . . o oo oo oo oo o . . . . . o . 389Barbara J. Hoeben and Robert L. Talbert

30. Use ofVasopressors andInotropes in the Pharmacotherapyof Shock. o o o o o o o o o o o . o o o o o o o o o o o o . . . . o o o o o o o 399

Robert Maclaren, Maria lo Rudis,

and loseph F. Dasta

31. Hypovolemic Shock. o o o o o o o o o o o... o o o o o o o o o o o 421Brian L. Erstad

SECTION 3

RespiratoryOisordersSection Editor: Robert L. Talbert

32. Introduction to PulmonaryFunctionTesting6) o o o o o o o o o o o o o o o . . . . o o o o o o 437lay l. Peters and Stephanie M. Levine

33. Asthma oo oo . . o oo o . . . . . . . . . . . o . . . . . . . . . o oo oo 439

H. William Kel/y and Christine Ao Sorkness

34. Chronic ObstructivePulmonary Disease . . o o o o o o o o o o o o o o o o o o o o . o o . 471

Dennis M. Williams and Sharya Vo Bourdet

35. Pulmonary Arterial Hypertension . o. . . . . . . . . . . 497Rebecca Moote, Rebecca L. Attridge,and Deborah 'o Levine

36. Drug- Induced Pulmonary Disease . . . . . . . . . . . . . 511

Hengameh HoRaissy, Miehel/e Harkins,and Patrieia L. Marshik

37. Cystic Fibrosis .. .. .. . ooo.. .. . .. .. .. . .. . . . . . o525

ChaninC. Wrightand YolandaY. Vera

SECTION 4

Gastrointestinal Oisorders

SectionEditor:Joseph T. DiPiro

38. Evaluation of the GastrointestinalTract. . . . . . . . . . . . . . oo. . . . . . . oooo. . . . . ooooo. . 539

Keith M. Olsen and Grant FoHutehins

39. Gastroesophageal Reflux Disease o o o o o o o . . . o . o o 549Dianne B. Williams and Robert R. Sehade

40. Peptic Ulcer Disease . . . . . o o o . . o o o o o o . . o o o o o o . 563

Rosemary R. Berardi and Randolph VoFugit

41. Inflammatory BowelDisease . . . . . . . . . . . oo. o. o. 587Brian Ao Hemstreet

42. Nausea and Vomiting o o. . . o . o oo . . . . o oo oo o . . . . 607

Cecily V. DiPiro and RobertJ. 19noffo

43. Diarrhea, Constipation, and IrritableBowelSyndrome o o o. 621

Patricia Ho Powel/ and Virginia Ho Fleming

44. Portal Hypertension and Cirrhosiso o o o o . o o o o o o o 639

lulie Mo Sease

45. Drug-Induced Liver Disease o. ooooo. . . oo. . o. . . 659

William R. Kirehain and Rondal/ E. Al/en

46. Pancreatitis. o o o o . . . o . o o o o o o . . . o o o o . . . o o o o o . . 669

Seott Bolestaand PatriciaAoMontgomery

47. Vira! Hepatitis .. .. .. . oo.. .. .. . ooo.. .. ooo.. . . 685

Paulina Deming

48. Drug Therapy Individualization inPatients with Hepatic Disease andGenetic Alterations in DrugMetabolizing Activity o. . . ooooo. o. . . . . o. . . . . . . 705YoWoFrancis Lam

49. Celiac Disease &.. o o o o o o o o.. o o o 0717

Robert Ao Mangione and Priti N. Patel

SECTION 5

Renal Oisorders

SectionEditor:GaryRoMatzke

50. Clinical Assessment of Kidney Function . . . . . . oo719

Thomas C. Dowling

51. Acute Kidney Injury . . . . . . . . . . . . o. . . . . . . . o. . . 741

William Dager and lenana Hali/ovie

52. Chronic Kidney Disease:Progression-Modifying Therapieso . o . . . o o o o o o o o 767

Vimal K. Derebail, Abhijit Vo Kshirsagar,

and Melanie Soloy

4\ The complete chapter,learningobjectives,and other resources can be found at www.pharmacotherapyonline.com.

53. Chronic Kidney Disease:Management of Complications . . . . . . . . . . . . . . . . 787

Joanna Q. Hudson

54. Hemodialysis and Peritoneal Dialysis 6) . . . 817Kevin M. Sowinski and Mariann D. Churchwell

55. Drug-Induced Kidney Disease. . . . . . . . . . . . . . . . . 819

Thomas D. Nolin and Jonathan Himmelfarb

56. Glomerulonephritis 837Alan H. Lau

57. Drug Therapy Individualization forPatients with Chronic Kidney Disease. . . . . . . . . . 861Gary R. Matzke

58. Disorders ofSodium and WaterHomeostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 873

James D. Coyle and Gary R. Matzke

59. Disorders of Calcium and PhosphorusHomeostasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 891

Amy Barton Pai

60. Disorders of Potassium and MagnesiumHomeostasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 909

Donald F. Brophy and Jane Frumin

61. Acid-Base Disorders . . . . . . . . . . . . . . . . . . . . . . . . . 923

John W. Devlin and Gary R. Matzke

-,, '., .~..

Neurologlc DisordersSection Editor: Barbara G. Wel/s

62. Evaluation ofNeurologic Illness 943Susan C. Fagan and Fenwick T. Nichols

63. Alzheimer's Disease. . . . . . . . . . . . . . . . . . . . . . . . . . 947

Patricia W. Slattum, Russell H. Swerdlow,

and Angela Massey Hill

64. Multiple Sclerosis. . . . . . . . . . . . . . . . . . . . . . . . .. . . 963

Jacquelyn L. Bainbridge and John R. Corboy

65. Epilepsy . . . . . . . . . . . . . . . . . . . . . . . . . 979Susan ]. Rogers and Jose E. Cavazos

66. Status Epilepticus. . . . . . . . . . . . . . . . . . . . . . . . . . . 1007

Stephanie]. Phelps,Collin A. Hovinga,and James w.Wheless

67. Acute Management oftheBrain Injury Patient. . . . . . . . . . . . . . . . . . . . . . . . . 1019

Bradley A. Boucher and Shelly D. Timmons

68. Parkinson's Disease. . . . . . . . . . . . . . . . . . . . . . . . . 1033

Jack]. Chen, Merlin V. Nelson,

and David M. Swope

69. Pain Management . . . . . . . . . . . . . . . . . . . . . . . . . . 1045

TerryJ. Baumann, Jennifer M. Strickland,and ChrisM. Herndon

70. Headache Disorders . . . . . . . . . . . . . . . . . . . . . . . . 1061

Deborah S. Minor

SECTION 7

psychiatric DisordersSection Editor: Barbara G. Wel/s

71. Evaluation of Psychiatric Illness . . . . . . . . . . . . .. 1077Mark E. Schneiderhan, Leigh Anne Nelson,and Stuart Munro

72. Childhood Disorders. . . . . . . . . . . . . . . . . . . . . . . . 1087

Julie A. Dopheide and StephenR. Pliszka

73. Eating Disorders 1101Steven C. Stoner

74. Substance-Related Disorders:Overview and Depressants, Stimulants,and Hallucinogens. . . . . . . . . . . . . . . . . . . . . . . . . . 1113

Paul L. Doering

75. Substance-Related Disorders: Alcohol,Nicotine, and Caffeine . . . . . . . . . . . . . . . . . . . . .. 1131

PaulL.Doeringand Robin Moorman U

76. Schizophrenia . 1147M. Lynn Crismon, Tami R. Argo,and Peter F. Buckley

77. Major Depressive Disorder 1173Christian]. Teter, Judith C. Kando,and Barbara G. Wells

78. Bipolar Disorder . . . . . . . . . . . . . . . . . . . . . . . . . . . 1191

Shannon J. Drayton

79. Anxiety Disorders 1:Generalized Anxiety, Panic,and Social Anxiety Disorders. . . . . . . . . . . . . . . . . 1)09

Sarah T. Melton and Cynthia K. Kirkwood

80. Anxiety Disorders 11:Posttraumatic Stress Disorderand Obsessive-CompulsiveDisorder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1229

Cynthia K. Kirkwood, Usa B. Phipps,and Barbara G. Wells

81. Sleep Disorders. . . . . . . . . . . .. . . . . . . . . . . . . . . .. 1241

John M. Dopp and Bradley G. Phillips

82. Disorders Associated with

Intellectual Disabilities 8 . . . . . . . . . . . . . . . . . . . 1253

Nancy Brahm, Jerry Mckee, and Douglas Stewart

. The complete chapter,learningobjectives,and other resources can be found at www.pharmacotherapyonline.com.

SECTION8

Endocrinologic DisordersSection Editor: Robert L. Talbert

83. Diabetes Mellitus. . . . . . . . . . . . . . . . . . . . . . . . . . . 1255

Curtis 1. Triplitt and CharlesA. Reasner

84. Thyroid Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . 1303

JacquelineJonklaasand Robert 1. Talbert

85. Adrenal Gland Disorders 1327

Steven M. Smith and John G. Gums

86. Pituitary Gland Disorders . . . . . . . . . 1345Amy Heck Sheehan,Jack A. Yanovski,and Karim Anton Calis

SECTION9

Gynecologic and ObstetricDlsorders

SectionEditor: Barbara C. We/ls

87. Pregnancy and Lactation:Therapeutic Considerations. . . . . . . . . . . . . . . . . . 1361Kristina E. Ward and Barbara M. O'Brien

88. Contraception . . . . . . . . . . . . . 1377Sarah P. Shrader, Kelly R. Ragucci,and VanessaA. Diaz

89. Menstruation-Related Disorders. . . . . . . . . . . . .. 1393

Elena M. Umland, Lara Carson Weinstein,and Edward M. Buchanan

90. Endometriosis . . . . . . . . . . . . . . . . 1409

Deborah A. Sturpe

91. Hormone Therapy in Women 1417Sophia N. Kalantaridou, Devra K. Dang,Susan R. Davis, and Karim Anton Calis

SECTION 10

UrologicDisordersSection Editor: L. Michael Posey

92. Erectile Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . 1437

Mary Lee

93. Benign Prostatic Hyperplasia. . . . . . . . . . . . . . . . . 1455

Mary Lee

94. Urinary Incontinence . . . . . . . . . . . . . . . . . . . . . . . 1467

Eric S.Rovner, Jean Wyman,Thomas Lackner, and David R.P. Guay

SECTION 11

Immunologic Disorders

SectionEditor:Cary e Yee95. Function and Evaluation of the

Immune System . . 1487PhilipD. Hall,NicoleWeimertPilch,and DanielH. Atchley

96. Systemic Lupus Erythematosus andOther Collagen-Vascular Disorders 1505JeffreyC.Delafuenteand KimberlyA. Cappuzzo

97. Allergic and PseudoallergicDrug Reactions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1521

Lynne M. Sylvia and Joseph T. DiPiro

98. Solid-Organ Transplantation. . . . . . . . . . . . . . . .. 1537

Heather j. Johnson and Kristine S. Schonder

~'l 3 jr'11tnlngic Disorderc;

SectionEditor:L.Michael Posey

~~ Osteoporosis and Other MetabolicBone Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1559

Mary Beth O'Connell and Sheryl F. Vondracek

00 Rheumatoid Arthritis ... . . . 1583

Arthur A. Schuna

1 01 Osteoarthritis 1599

Lucinda M. Buys and Mary Elizabeth Elliott

01. Gout and Hyperuricemia. . . . . . . . . . . . . . . . . . .. 1621Michael E. Ernst and Elizabeth C. Clark

SECTION 13

Ophthalmicand OtolaryngologicalDisordersSection Editor: L. Michael Posey

103. Glaucoma . . . . . . . 1633

Richard G. Fiscella, Timothy S. Lesar,

and Deepak P. Edward

104. Allergic Rhinitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . 1649

j. RussellMay and Philip H. Smith

SECTION 14

Dermatologic Disorders

SectionEditor:L.Michael Posey

105. Dermatologic Drug Reactionsand Common Skin Conditions.. 1661Rebecca M. Law and David T.S. Law

& The complete chapter,learningobjectives,and other resourcescan be found at www.pharmacotherapyonline.com.

1 06. Acne V ulgaris. . . . .. . . . . . . . .. . . . . . . . . . . . . . . . 1673

Debra J. Sibbald

107. Psoriasis 1693

Rebecca M. Law and Wayne P. Gul/iver

108. Atopic Dermatitis . . . . . . . . . . . . . . . . . . . . . . . . . . 1707

Rebecca M. Law and Po Gin Kwa

SECTION 15

Hematologic Disorders

Section Editor: Gory C. Yee

109. Anemias 1717

KristenCook,BeataA. lneck,and William1. Lyons

11O.Coagulation Disorders . . . . . . . . . . . . . . . . . . . . . . 1741Betsy Bickert Poon, Char Witmer, and Jane Pruemer

111. SickleCell Disease . . . . . . . . . . . . . . . . . . . . . . . . .. 1765

C. Y. Jennifer Chan and Reginald Moore

112. Drug-Induced HematologicDisorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1781

Christine N. Hansen and Amy F. Rosenberg

SECTION16

Infectious Diseases

SectionEditor:Joseph T.DiPiro

113. Laboratory Tests to Direct AtimicrobialPharmacotherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . 1797

Michael J.Rybak, Jeffrey R. Aeschlimann,

and Kerry 1. Laplante

114. Antimicrobial Regimen Selection. . . . . . . . . . . . . 1813

David S. Burgess

115. Central Nervous System Infections. . . . . . . . . . . . 1825

Isaac F. Mitropoulos, Elizabeth D. Hermsen,

and John C. Rotschafer

116. LowerRespiratory Tract Infections . . . . . . . . . .. 1845

Martha G. Blackford, Mark 1. Glover,and Michael D. Reed

117. Upper Respiratory Tract Infections . . . . . . . . . .. 1867Christopher Frei, Bradi Frei, and George Zhanel

118. Influenza. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1881

Jessica C. N)oku and Elizabeth D. Hermsen

119. Skin and Soft- Tissue Infections. . . . . . . . . . . . . .. 1893

Douglas N. Fish, Susan 1. Pendland,

and Larry H. Danziger

120. Infective Endocarditis. . . . . . . . . . . . . . . . . . . . . . . 1913

Angie Veverka and Michael A. Crouch

121. Tuberculosis. .. . . . . . . . . . . . . . . . . . . . . .. . . . . . . 1931

CharlesA. Peloquinand Rocsanna Namdar

122. Gastrointestinal Infections and

Enterotoxigenic Poisonings . . . . . . . . . . . . . . . . . . 1951

Steven Martin and RoseJung

123. Intraabdominal Infections . . . . . . . . . . . . . . . . . . . 1969

Joseph T. DiPiro and Thomas R. Howdieshell

124. Parasitic Diseases. . . . . . . . . . . . . . . . . . . . . . . . . . . 1981

J. V. Anandan

125. Urinary Tract Infections and Prostatitis . . . . . . . 1995

Elizabeth A. Coyleand Randall A. Prince

126. Sexually Transmitted Diseases. . . . . . . . . . . . . . . . 2011

Leroy C. Knodel

127. Bone and Joint Infections . 2029

Edward P. Armstrong and Allan D. Friedman

128. SevereSepsis and Septic Shock. . . . . . . . . . . . . . . 2041S. Lena Kang-Birken and Karla Killgore-Smith

129. Superficial Fungal Infections . . . . . . . . . . . . . . . . . 2055Thomas E. R. Brown, Linda D. Dresser, andThomas W. F. Chin

130. Invasive Fungal Infections . . . . . . . . . . . . . . . . . . . 2073

Peggy 1. Carver

131. Infections in ImmunocompromisedPatients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2105

Douglas N. Fish

132. Antimicrobial Prophylaxis in Surgery . . . . . . . . . 2131Salmaan Kan)i

133. Vaccines, Toxoids, and Other

Immunobiologics. . . . . . . . . . . . . . . . . . . . . . . . . . . 2147MaryS.Hayney

134. Human Immunodeficiency Virus Infection . . . . 2169Peter 1. Anderson, Thomas N. Kakuda,

and Courtney V.Fletcher

SECTION17

Oncologic Disorders

Sedion Editor:GoryC. Yee

135. Cancer Treatment and Chemotherapy .2191Patrick J. Medina and Stacy S. Shord

136. Breast Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2229

Laura Boehnke Michaud, Chad M. Barnett,and Francisco J. Esteva

137. Lung Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2271DeborahA. Friezeand ValR.Adams

& The complete chapter,learningobjectives,and other resourcescan be found at www.pharmacotherapyonline.com.

138. Colorectal Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . 2287

Lisa E. Davis, Weijing Sun, and PatrickJ. Medina

139. Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2319

LeAnn B. Norris and Jill M. Ko/esar

140. Lymphomas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2333

A/exandreChanand GaryC. Yee

141. Ovarian Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2361

JudithA. SmithandJudithK. Wolf

142. Acute Leukemias . . . . . . . . . . . . . . . . . . . . . . . . . . . 2377

Betsy Bickert Poon and Dianne M. Brundage

143. Chronic Leukemias . . . . . . . . . 2401

Christopher A. Fause/ and Patrick ]. Kie/

144. Multiple Myeloma . . . . . . . . . . . . . . . . . . . . . . . . . . 2417

Timothy R. McGuire and CaseyB. Williams

145. Myelodysplastic Syndromes .. . . . . . . . . . . . . . . 2431

Julianna A. Burzynski and Tracey Wa/sh-Choco/aad

146. Renal Cell Carcinoma" . . . . . . . . . . . . . . . . . . . . 2433Christine M. Wa/ko, Ninh M. La-Beck.and Mark D. Wa/sh

147. Melanoma. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2435

Cindy 1. O'Bryant and Jamie c. Poust

148. Hematopoietic Stem CellTransplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2455Janelle B. Perkins and Gary C. Yee

Nutntional Oisorders

Section Editor:Gary R. Matzke

149. Assessment ofNutrition Status,and Nutrition Requirements . . . . . . . . . . . . . . . . . 2473Katherine Hammond Chessman

and Vanessa]. Kumpf

150. Medication Administration Considerations

with Specialized Nutrition Support . . . . . . . . . . . 2493Ro/and N. Dickerson and Gordon S. Sacks

151. Parenteral Nutrition . . . . . . . . . . . . . . . . . . . . . . . . 2505ToddW.Mattoxand CatherineM. Crill

J52. Enteral Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . 2527

Vanessa ]. Kumpf and Katherine Hammond Chessman

153. Nutritional Considerations in MajorOrgan Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2545

Brian M. Hodges and Mark DeLegge

154. Obesity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2567Judy T. Chen, Amy Heck Sheehan,JackA. Yanovski, and Karim Anton Calis

Glossary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2585

Index 2613