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2204/19/23
Bunyaviridae Bunyaviridae
Structure Classification Multiplication Clinical manifestations Epidemiology Diagnosis Control
Baron’s Web Site
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Structure Spherical enveloped particles
– 90-100 nm virus encoded transcriptase 2 external glycoproteins multipartite - 3 segments of
SS RNA– antisense - SS RNA
C=122
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Classification Genera
–Bunyaviruses– Phlebovirus–Nairovirus–Uukuvirus–Hantavirus
Immunologically– 35 serogroups– 300 types &
subtypes
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BunyaViruses ARthropod BOorne viruses
–Phlebovirus–Nairovirus–Uukuvirus–Hantavirus
ROdent BOrne Viruses
–Bunyaviruses
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Bunyavirus ReplicationBunyavirus Replication
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+ mRNA
+ ssRNA
- ss RNA
Virus RNA transcriptase
Cytoplasm
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Genetic Reassortment
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Serious Bunya Virus Diseases
Crimean Congo Hemorrhagic Fever Virus
Rift Valley Fever Virus La Crosse Virus Hanta Virus
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Pathogenesis Early
– fever & viremia Late
– encephalitis– retinitis– renal involvement
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Epidemiology Determined by distribution of
vector and mammalian host Humans: accidental dead end
hosts
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Diagnosis
Presumptive febrile illness geographic site of
exposure Sean vectors
Confirmation virus isolation Virus specific IgM Rise in antibody
titer
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Control Control Vectors
– arthropods– rodents
Vaccination– Humans: Crimean Congo– Sheep & Cattle : Rift Valley
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Crimean Congo Hemorrhagic Fever Virus
Headache pain in limbs bleeding from multiple orifices
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Rift Valley Fever Virus Explosive potential Egypt 1977 200,000 cases 600 deaths
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La Crosse Virus Fever convulsions drowsiness focal neurological signs
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Hanta Virus
Rodents - transmission to humans via aerosolized excretions and bites. A wide variety of biting insects.
Hanta virus Web site
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Hanta Virus Lipid envelope
– susceptible to most disinfectants.
– Need to lower pH < 5
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Hanta Virus tripartite negative-
sense RNA – L,>>viral
transcriptase– M>> envelope
glycoproteins– >. nucleocapsid
protein
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Hantavirus Pulmonary Syndrome
febrile prodrome followed by
– non-cardiogenic pulmonary edema,
– hypotension – shock
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Hantavirus
Four corners New Mexico – May 1993 8 deaths
April 5, 199468 cases in 17 states– Deermouse in New Mexico - principal
reservoir do not cause infections - found in saliva, urine, feces and is shed sporadically
-infected animals - blood, organs, saliva feces, urine.
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Hanta virus ...continued
– Humans visiting holding areas for animals can become infected in five minutes.
– outbreaks of this and associated diseases have been observed in
Baltimore, MarylandSoeul, KoreaBelgiumEngland
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DONE!!!
