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Supplementary table 1. The corresponding values of each marker with respect to endoscopic Mayo score in ulcerative colitis
Mayo 0(N=14)
Mayo 1(N=9)
Mayo 2(N=11)
Mayo 3(N=6)
P value (between groups)
P value (within groups)
FCT (ug/g) 74 ±18
114 ±31
626 ±132
755 ±116
<0.001 all <0.001 except 0.726 (0 vs 1) and 0.342 (2 vs 3)
FIT (ug/g) 16 ±1 35 ±20 57 ±20 112 ±31
0.007 0 vs 1: 0.4060 vs 2: 0.0640 vs 3: 0.0011 vs 2: 0.3671 vs 3: 0.0112 vs 3: 0.055
CRP (mg/dL)
0.38 ±0.04
0.42 ±0.08
0.74 ±0.17
1.38 ±0.46
0.003 0 vs 1: 0.8580 vs 2: 0.1090 vs 3: 0.0011 vs 2: 0.2011 vs 3: 0.0022 vs 3: 0.023
ESR (mm/hour)
12 ±1 30 ±5 46 ±8 41 ±13 0.001 0 vs 1: 0.0010 vs 2: <0.0010 vs 3: 0.0021 vs 2: 0.1371 vs 3: 0.4002 vs 3: 0.737
Albumin (g/L)
44 ±1 45 ±1 40 ±2 36 ±3 0.005 0 vs 1: 0.5260 vs 2: 0.0930 vs 3: 0.0031 vs 2: 0.0381 vs 3: 0.0012 vs 3: 0.094
Platelet count ( x109/L)
250 ±13
260 ±29
555 ±84 484 ±52
<0.001 0 vs 1: 0.7230 vs 2: <0.0010 vs 3: <0.0011 vs 2: 0.0071 vs 3: 0.0012 vs 3: 0.565
Hemoblogbin (g/L)
13.7 ±0.4
13.3 ±0.4
12.1 ±0.6
11.5 ±0.8
0.026 0 vs 1: 0.5420 vs 2: 0.0250 vs 3: 0.0091 vs 2: 0.1391 vs 3: 0.0492 vs 3: 0.440
CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test
Supplementary table 2. The corresponding values of each marker with respect to SES-CD in Crohn’s disease
SES-CD 0-3 (remission)(N=17)
SES-CD 4-6(mild activity)(N=1)
SES-CD ≥7(moderate to severe activity)(N=8)
P value (between groups)
P value (within groups)
FCT (ug/g) 307 ±96 1000 ±N/A
930 ±69 0.001 remission vs mild: 0.108remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.747
FIT (ug/g) 23 ±3 69 ±N/A 98 ±21 <0.001 remission vs mild: 0.04remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.669
CRP (mg/dL) 0.50 ±0.09 0.35 ±N/A
2.73 ±0.76 0.001 remission vs mild: 0.712remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.330
ESR (mm/hour)
18 ±3 7 ±N/A 37 ±7 0.021 remission vs mild: 0.325remission vs moderate/ severe: 0.011mild vs moderate/ severe: 0.208
Albumin (g/L) 45 ±1 48 ±N/A 39 ±2 0.008 remission vs mild: 0.530remission vs moderate/ severe: 0.003mild vs moderate/ severe: 0.216
Platelet count ( x109/L)
255 ±13 139 ±N/A 394 ±30 <0.001 remission vs mild: 0.051remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.026
Haemoblogbin (g/dL)
13.9 ±0.2 13.7 ±N/A
12.8 ±0.6 0.183 remission vs mild: 0.847remission vs moderate/ severe: 0.069mild vs moderate/ severe: 0.658
CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test, SES-CD: simple endoscopic score for Crohn’s disease
Supplementary table 3. Clinical parameters of patients in endoscopic remission and non-
remission
Parameters PatientsEndoscopic
remission
Endoscopic non-
remissionP value
FCT (ug/g)
All patients* 182 ± 282 764 ± 352 <0.001
UC** 90 ± 81 672 ± 388 <0.001
CD*** 307 ± 96 938 ± 185 <0.001
FIT (ug/g)
All patients 23 ± 30 83 ± 68 <0.001
UC 24 ± 38 77 ± 73 0.005
CD 23 ± 14 95 ± 59 <0.001
CRP (mg/dL)
All patients 0.44 ± 0.28 1.48 ± 1.56 0.002
UC 0.40 ± 0.18 0.97 ± 0.84 0.003
CD 0.50 ± 0.38 2.47 ± 2.16 0.001
ESR (mm/hour)
All patients 19 ±13 41 ± 25 <0.001
UC 19 ± 14 44 ± 27 <0.001
CD 18 ± 11 34 ± 21 0.034
Albumin (g/L)
All patients 45 ± 3 39 ± 6 <0.001
UC 44 ± 2 39 ± 7 0.002
CD 46 ± 3 41 ± 6 0.010
Platelet count (x
109/L)
All patients 254 ± 59 473 ± 213 <0.001
UC 254 ± 65 529 ± 234 <0.001
CD 255 ± 54 366 ± 117 0.003
Haemoglobin
(g/dL)
All patients 13.7 ± 1.2 12.7 ± 1.9 0.002
UC 13.6 ± 1.3 11.9 ± 1.9 0.004
CD 13.9 ± 1.1 12.9 ± 1.7 0.079
CD: Crohn’s disease, CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test, UC: ulcerative colitis
*All patients: Total number = 66. Endoscopic remission = 40; Endoscopic non-remission = 26**UC: Total number = 40. Endoscopic remission = 23; Endoscopic non-remission = 17***CD: Total number = 26. Endoscopic remission = 17; Endoscopic non-remission = 9
Supplementary figure 1. AUROC values of each marker in UC vs. CD patients
Supplementary figure 2. Sensitivity and specificity of blood indices in all IBD patients
Supplementary figure 3. Sensitivity and specificity of different biomarkers in UC
Supplementary figure 4. Sensitivity of combinations of fecal and blood biomarkers for endoscopically active UC
Supplementary figure 5. Specificity of combinations of fecal and blood biomarkers for
endoscopically active UC
Supplementary figure 6. Sensitivity and specificity of different biomarkers in CD
Supplementary figure 7. Sensitivity of combinations of fecal and blood biomarkers for endoscopically active CD
Supplementary figure 8. Specificity of combinations of fecal and blood biomarkers for endoscopically active CD