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ITS-DNAHPLCsyringaldehydeJournal of Nature Products

HPLCsyringaldehydecaffeic acidchlorogenic acidquercetinGlut4 2013

45

- 56

67100-1.2.3--aB101-1.2.2--a7

78 OGTT

89

9 10

10 2013()11

-11 2013()12

--12 2013 13

13 2013 14

20131415 (1)(2) (3)

15 ()syringaldehydecaffeic acidchlorogenic acidquercetin

(lignans) (Phenylpropanoids(polyphenol) (triterpenoids)

161617lignin triterpenoid, phenylpropanoid estersphenolicMyriceric acid Hibicusin(7S,8S)-Demethylcarolignan Eerythro-Carolignan EBoehmenanMansonone H Myriceric acid B/CUncarinic acid A (A549MCF-7 )Syringaresinol (human breast cancer cellsP- Glycoprotein )(P -)cleomiscosin-A (antileukemia )syringic acid, Vanillic Acid ()scoparoned () 9,9-O-Ferulolyl-()-secisolaricinresinol, uncarinic acid (HIV)() phenylpropanoids dihydrodehydrodiconifenyl alcohol ( NGF) ()17Journal of Natural Products 18

2012 Journal of Natural Products syringaldehyde 1819

19 20

1H-NMR

Mass20 ()21

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22 23

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A54924A549 25

A549A5491224A549Myriceric acid(7S,8S)-Demethylcarolignan EHibicusinHibiscone CHibicuslide Cerythro-Carolignan EBoehmenanMansonone HMyriceric acid B/CA549

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A549 cell

26Flow cytometry12hrA549cell cycle S phaseA54915.625 ug/ml (3%)250 ug/ml (18.5%)

26()27

2728Hibiscus Taiwanese()A549BCCA54962.5g/ml27%125g/ml82%

BCC31.25g/ml25%62.5g/ml70%125 g/ml90%

2828 29

2930Anti-Inflammatory and Analgesic Effects

Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 132859, 13 pages doi:10.1155/2012/1328593031

3132

A(PGE2) 150300g/mlPGE2

B() 2

3233COX-2PGiNOSCOX-2COX-2

3334

HIV

188020051153551HIV(8) 3435

Bioorganic & Medicinal Chemistry

200412 Bioorganic & Medicinal ChemistryEC 50 values of 1.8 and 3.9g/mL (7) 3536 (I~III)

(Hibiscus taiwanensis)(Malvaceae)

lignans 1532 naphthoquinones 1016 40naphthalene 5 oleanoic acids 282930 31

hydroxyl groupmethoxyl group cinnamic acid or ester110(6) 3637 1 2

Met3738

138

393940

40 ()

414142 ()

...

4243

4344 -

109(90/) 3

14323

1 2 3

4445 ()1 Ans

2Ans

3Ans

4546()4 Ans

5Ans

6Ans 1-3

4647

4748

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48Chart11000096.82295.51172.43317.31112.32225.144

Hibiscus Taiwanese (ug/ml)Cell ViabilityvA549

Sheet1100096.8295.5172.4317.3112.3225.14Control15.62531.2562.5125250500

Sheet1000022011033011022044

Hibiscus Taiwanese (ug/ml)Cell ViabilityA549

Sheet2

Sheet3

Chart110000912276113144113310441355

Hibiscus Taiwanese (ug/ml)Cell V iab ilityBCC

Sheet11000912761314113104135Control15.62531.2562.5125250500

Sheet1000022011044033044055

Hibiscus Taiwanese (ug/ml)Cell ViabilityBCC (Basal Cell Carcinoma)

Sheet2

Sheet3