2nd EuropeanTeaching Course - on Neurorehabilitation

2nd European Teaching Course on Neurorehabilitationin conjunction with

1st Congress of the Romanian Society for Neuropsychological Rehabilitation24 - 26 APRIL 2012 | GRAND HOTEL ITALIACLUJ-NAPOCA | ROMANIA

Final Program andAbstract Book

2nd European Teaching Course on Neurorehabilitation 24 - 26 APRIL 2012CLUJ-NAPOCA | ROMANIA

Neuropsychological Rehabilitation1st Congress of the Romanian Society for in conjunction with

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Volker Hömberg

Head Dept. NeurologySRH Health Center Bad Wimpfen, Germany

Dept. Neurology Heinrich Heine University Düseldorf

Secretary General World Federation Neurorehabilitation (WFNR)

Secretary General European Federation of Neurorehabilitation Societies (EFNRS)

Board member and former President and Vice President German Society of Neurorehabilitation (DGNR)

Heinrich Binder

President of Austrian Society for Neurorehabilitation

President of European Federation NeurorehabilitationSocieties

Head of the Neurological Center, Otto Wagner Hospital, Vienna

Dafin F. Mureşanu

Professor of Neurology, Chairman Department of Neurosciences, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania

President of the Society for the Study ofNeuroprotection and Neuroplasticity (SSNN)

PROGRAM COORDINATORS



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FACULTY/in alphabetical order

Mihai Berteanu / Romania Heinrich Binder / AustriaDana Boering / GermanyAngelo Bulboacă / Romania Delia Cinteză / Romania Sanda Deme / Romania Volker Hömberg / GermanyDafin F. Mureșanu / Romania Adriana Nica / Romania Ioan Onac / RomaniaLăcrămioara Perju Dumbravă / RomaniaDaiana Popa / RomaniaBogdan O. Popescu / Romania C. D. Popescu / Romania Cristina Tiu / RomaniaJean-Luc Truelle / FranceKlaus von Wild / Germany



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LOCALCOMMITTEE/in alphabetical order

Ovidiu Băjenaru / RomaniaMihai Berteanu / RomaniaAngelo Bulboacă / Romania Anca Buzoianu / RomaniaLăcrămioara Perju Dumbravă / RomaniaIoan Ștefan Florian / RomaniaAlexandru Irimie / RomaniaIoan Mărginean / Romania Ioan Onac / RomaniaGelu Onose / RomaniaSanda Patrichi / RomaniaC. D. Popescu / Romania



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Grand Hotel Italia *****

Cluj-Napoca (RO)Str. Trifoiului - Vasile Conta400478 Cluj-Napoca (RO)Tel. +40 364 111333 - Fax +40 364 118080

The Grand Hotel Italia rises majestically above Cluj-Napoca welcoming you in the serenity of the nature while offering you a panoramic view of the entire city. It is the ideal place to dis-cover the delightful charm of Transylvania and at the same time to benefit from the high class services throughout your stay. The hotel is lo-cated just 5 minutes from the historical centre of the town and 20 minutes from Cluj-Napoca International Airport. The Grand Hotel Italia blends elegance and de-sign offering 209 confortable rooms, an Ameri-can Bar that will delight you with international cocktails and musical entertainments, 2 res-taurants with exquisite food, a Congress Cen-tre with modern technical facilities and a SPA to find physical and spiritual balance.

CONGRESS VENUE



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The Society for the Study of Neuroprotection and Neuroplasticitywww.ssnn.ro

International School of Neurolgy RoSNeRa

World Federation for NeuroRehabilitationwww.wfnr.co.uk

“Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Romaniawww.umfcluj.ro

Academia de Ştiinţe Medicaledin Româniawww.adsm.ro

Department of Neurosciences University of Medicine and Pharmacy Cluj-Napoca, Romania

European FederationNeurorehabilitation Societies

ORGANIZERS



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MAINSPONSOR

SPONSORS

EVER Neuro Pharmahttp://www.everpharma.com

Medisonhttp://www.medison.co.il/

Takeda Pharmaceuticals Internationalhttp://nycomed.com/

Wörwag Pharmahttp://www.woerwagpharma.de/

Procardiahttp://www.procardia.ro/



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GENERAL INFORMATION

Congress Secretariat

Ovidiu Selejan

Secretary General SSNN, Event and Logistic Manager / [email protected] for the Study of Neuroprotection and NeuroplasticityCluj-Napoca, Romania, 33A Teleorman Street, Office phone: +40264431924E-mail:[email protected]

CONGRESS REGISTRATION DESKAll materials and documentation will be available at the registration desk located at SSNN booth. The staff will be pleased to help you with all enquiries regarding registration, materi-als and program. Please do not hesitate to contact the staff members if there is anything they can do to make your stay more enjoyable.

All congress materials and documentation will be available at the SSNN booth. The congress staff will be pleased to help you with all enquiries regarding registration, congress materials and program. Please do not hesitate to contact the staff members if there is something they can do to make your stay more enjoyable.

CongressRegistrationDesk

Tuesday - 24th of April: 08:00 - 19:00Wednesday - 25th of April: 08:30 - 18:00Thursday - 26th of April: 08:30 - 17:00

Opening Hours



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The Society for the Study of Neuroprotection and Neuroplasticity Cluj-Napoca, Romania33A Teleorman StreetOffice phone: +40264431924E-mail:[email protected]

ScientificSecretariate

The registration fee is 250 Euro.

Beneficiary Address:

PERFECT TRAVEL

Cluj-Napoca, Str. Teleorman nr. 33/ARomaniaBank account: RO20DAFB101700118466EU03Bank name: BANK LEUMI ROMANIA - CLUJ BRANCHBIC: DAFBRO22XXXBank Adress: Cluj-Napoca, P-ta Unirii nr. 15, Romania

If you need further information regard-ing payment details, please contact: Doria [email protected]: +40757 096 111

RegistrationFees

PaymentOptions

Contact

Admission to all scientific sessions during the congress Conference materials (delegate bag, final program and abstract book etc.)Admission to Lunches, Dinners and Coffee Breaks

Participants Registration Fee Includes:



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On-site registration will be processed on a first-come, first-served basis. Priority will be given to pre-registered delegates. Depending on the number of on-site registered delegates, availability of congress bags may be limited.

The organizers cannot assume liability for any changes in the congress program due to external or unforeseen circumstances.

The congress language is English. Simultaneous translation will not be provided.

Participants are kindly requested to wear their name badge at all times during the congress.The badge constiutes admission to the scientific sessions, coffee breaks and lunches.

If you need further information regarding technical details, please contact: Ovidiu Selejan/e-mail/[email protected] For updates and details please visit our website/www.ssnn.ro

On-Site Registration

Changes In Program

Congress Language

Name Badges

Contact



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APRIL 23RD

20:00 -23:00 DINNER

APRIL 24TH

11:00 - 11:30 COFFEE BREAK 14:00 - 15:00 LUNCH

17:00 - 17:30 COFFEE BREAK

20:00 -23:00 WELCOME RECEPTION

APRIL 25TH


13:00 - 14:00 LUNCH


20:00 - 22:30 DINNER

APRIL 26TH


12:40 - 13:30 LUNCH


20:00 - 22:30 DINNER

Coffee Breaks,Lunches & Dinners



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SCIENTIFIC PROGRAM 2nd European Teaching Course on Neurorehabilitation



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Tuesday, April 24th, 2012

08:45 – 09:00 Welcome Address / Alexandru Irimie (Romania), Ioan Ștefan Florian (Romania), Anca Buzoianu (Romania)

09:00 – 09:15 Opening remarks / Dafin F. Mureşanu (Romania), Volker Hömberg (Germany), Heinrich Binder (Austria) 09:15 – 11:00 Basic Course in Neurological Clinical Examination / Volker Hömberg (Germany)

11:00 – 11:30 Coffee Break

MODULE I. Basic structure of rehabilitation. Goal finding and monitoring processes and the health model of rehabilitation

11:30 – 12:30 The Comprehensive Approach of Rehabilitation Medicine, Ethical and Legal Aspects / Volker Hömberg (Germany)

12:30 – 13:30 The Bio-Psycho-Social Paradigm of Disease Understanding and ICF / Volker Hömberg (Germany)

13:30 – 14:00 Discussions 14:00 – 15:00 Lunch

15:00 – 16:00 The Organization of the Rehabilitation Team / Dana Boering (Germany)

16:00 – 17:00 Goal Finding and Monitoring of the Neurorehabilitation Process & The Concepts of Evidence Based Medicine and Design for Clinical Studies / Volker Hömberg (Germany)


17:30 – 18:30 Definition of Rehabilitation Outcomes / Heinrich Binder (Austria)

18:30 – 19:00 Discussions

20:00 – 23:00 Welcome Reception



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Wednesday, April 25th, 2012

MODULE II. Principles of Reorganisation and Recovery of the Nervous System and Ways to Influence these Processes, Elementary Assessment Tools and Epistemology of Neurorehabilitation

09:00 – 10:00 The Neurobiology of Neurorecovery and Concept of Neuromodulation / Dafin F. Mureşanu (Romania)

10:00 – 11:00 Basic Principles of Learning / Volker Hömberg (Germany)



12:00 – 13:00 Basic Mechanisms of Brain Plasticity and Hypothesis Driven Neurological Rehabilitation / Dana Boering (Germany)

13:00 – 14:00 Lunch

14:00 – 14:20 Understanding Disability – an Updated WHO Perspective / Mihai Berteanu (Romania)

14:20 – 14:40 Non-Pharmacologic Treatment of Neuropathic Pain / Adriana Nica (Romania)

14:40 – 15:00 Neurorehabilitation in Multiple Sclerosis / Angelo Bulboacă (Romania)





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Wednesday , April 25th, 2012

15:40 – 16:00 Prognostic and Diagnostic Value of Transcranian Magnetic Stimulation in Motor Disfunctions of Central Origin / C. D. Popescu (Romania)

16:00 – 16:20 The Importance of Pain Assessments in the Neurorehabilitation of Parkinson’s Disease / Lăcrămioara Perju Dumbravă (Romania)

16:20 – 16:40 Functional Electric Stimulation in Neurological Rehabilitation / Delia Cinteză (Romania)


20:00 – 22:30 Dinner



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SCIENTIFIC PROGRAM 1st Congress of the Romanian Society for Neuropsychological Rehabilitation



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Thursday, April 26th, 2012

09:15– 09:30 Welcome Address C. D. Popescu (Romania), Dafin F. Mureşanu (Romania)

09:30 – 10:10 Key note lecture / Klaus von Wild (Germany)

Vocational Rehabilitation Following Brain and Spinal Cord Lesions

10:10 – 10:30 Neurological Diagnostic Tools (Neurophysiological, Neurosonological Imaging) for Prognosis and Goal Definition in Neurorehabilitation / Heinrich Binder (Austria)

10:30 – 10:50 Assessment Tools for Special Nursing Problems / Dana Boering (Germany)



11:40 – 12:00 The Role of Neuroplasticity in Normal and Pathological Behavior / Dafin F. Mureşanu (Romania)

12:00 – 12:20 Mood and Behavior Disorders After Traumatic Brain Injury in Adults: Pathophysiology, Symptoms and Management / Jean-Luc Truelle (France)


12:40 – 13:30 Lunch



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Thursday, April 26th, 2012

13:30 – 13:50 Mobility Impairments in Multiple Screlosis / C. D. Popescu (Romania)

13:50 – 14:10 Post Stroke Rehabilitation: Facts and Fiction / Cristina Tiu (Romania)

14:10 – 14:30 Robotic Assisted Gait Training in Stroke Rehabilitation / Daiana Popa (Romania)



15:20 – 15:40 Right Hemisphere Stroke Syndrome (RHSS). Acute and Long-Term Recovery Impairment / Sanda Deme (Romania)

15:40 – 16:00 Rehabilitation in Disk Herniation Sciatica / Ioan Onac (Romania)

16:00 – 16:20 Stem Cell Therapy in Neurological Diseases – Pitfalls and Hopes / Bogdan O. Popescu (Romania)


20:00 – 22:30 Dinner



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ABSTRACTS



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More than 1 billion peaple in the world have some form of disability, of whom nearly 200 million experience considerable difficulties in functioning. In the following years disability will be a even greater concern because its prevalence is increasing due to ageing populations and the higher risk of disability in older people as well as the global increase in chronic health conditions such as: cardiovascular disease, diabetes, cancer, etc.

Accross the world, people with disabilities have poorer health outcomes, lower educa-tion, less economic participation and higher rates of poverty than people without dis-abilities because, among others disabled persons experience barriers in accessing ser-vices that many of us take for granted: education, employment, transport, information.

The WHO and the World Bank Group have jointly produced the first World Report on Disability to provide the evidence for innovative policies and programmes that can improve the lives of people with disabilities and facilitate implementation of the UN Convention on the Rights of Persons with Disabilities, which came into force in May 2008. This landmark international treaty reinforced our understanding of disability as a Human Rights and Development priority.

This Report makes a major contribution to our understanding of disability and its im-pact on individuals and society. It highlights the different barriers that people with disability face: attitudinal, physical and financial. It also makes recommendations for action at local, national and international levels.

It is a most valuable tool for policy-makers, researchers, practitioners, advocates and other peaple involved in disability, and will mark a turning point for inclusion of people with disability who should be central to these endeavors.

UNDERSTANDING DISABILITY – AN UPDATED WHO PERSPECTIVE

MIHAI BERTEANU

UMF ,,Carol Davila “ BucurestiRomania



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The applicability of neurological diagnostic tools (electrophysiological, neuro-sonological, imaging) for prognosis and goal definition in neurorehabilitation” Purpose of neurorehabilitation is to reintegrate adequately patients with disability re-sulting of neurological illness into and her social and also adequately occupational con-text. Condition for it is an analytic as well as synthetic consideration and approach. Both the rehabilitation doctor must master. Decisions must be dripped whether in which magnitude and how the recognized deficits can be removed or be reduced. Mea-sures and purpose reaching are to be accompanied by suitable controls and measur-ing instruments. On the one hand these measuring instruments enclose indispensable clinically neuropsychiatric and neuropsychologic examination including various scores. On the other hand there is a row on electrophysiologic and neuroimaging investigations which are aimed on morphology as well as function. Both are indispensable if it is about detailed questions of patients condition and necessary rehabilitation process. However, a critical view of the results is required in relation on the final goal of the aimed reha-bilitation success because the information won thereby are only stones of a whole. The right estimation and synthesis is the challenge of neurorehabilitation.

NEUROLOGICAL DIAGNOSTIC TOOLS (NEUROPHYSIOLOGICAL, NEUROSONOLOGICAL IMAGING)

FOR PROGNOSIS AND GOAL DEFINITION IN NEUROREHABILITATION

HEINRICH BINDER

Head of the Neurological Center, Otto Wagner Hospital, ViennaAustria



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At the outset of rehabilitations stands the rehabilitation potential and at the end the rehabilitation outcome. It is nearly impossible to predict the end at the beginning and still we try it over and over again. And how often the result outreaches or belie the ex-pectations. In these times particular it poses a great challenge to explore all individual possibilities in the beginning of the rehabilitation process and to develop an individually tailored program to accomplish an at that time realistic goal. But who can say what is realistic? There are different aspects from plenty persons as for instance the person affected, the relatives and different parts of medical staff. Therefore the acceptance of the outcome may differ tremendously. Nevertheless the success depends at the end from concordance of prediction starting from goal setting and outcome and not at least from the measures justified subsequently by the resultat.

DEFINITION OF REHABILITATION OUTCOME

HEINRICH BINDER

Head of the Neurological Center, Otto Wagner Hospital, ViennaAustria



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Neurological rehabilitation differs from other medical disciplines in being primarily an educational process of the disabled person, who is involved in setting goals that are important to his/her own current situation. It is not a process done to but a process done by the disabled person under the guidance of a wide range of professionals.Re-habilitation is also going beyond the narrow confines of physical disease, dealing with the psychological consequences of the disability and the social milieu a disabled person has to function in.

A key aspect of neurological rehabilitation is that it cannot be carried out by medical practitioners alone; it requires the active participation of a whole range of professionals in an interdisciplinary approach: the rehabilitation team.

Main organizational aspects of the work in an interdisciplinary team will be pointed out: what is interdisciplinarity, which are the aspects that foster the stability of a team, which are those which promote innovation and progress, what is the role of leadership and of hospital culture within this complex process.

THE ORGANIZATION OF THE REHABILITATION TEAM

DANA BOERING

St. Mauritius Therapieklinik Meerbusch Meerbusch, Germany



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Since the introduction of the term plasticity by William James more than hundred years ago, plasticity grew to a main field of neuroscience research.

This could be explained on the one hand by the fact that plasticity is not an occasional state of the nervous system but a normal ongoing state of the brain throughout the life span, on the other hand by the growing evidence that knowledge gained in the field of learning induced plasticity and post-lesional basic neural repair mechanisms can broad-ly be used to shape and enhance plasticity during postacute neurological rehabilitation.The talk will focus on general aspects of plasticity, motor learning related cortical plas-ticity mechanisms in animals and humans, plasticity in the setting of brain injury con-sidering cortical rewiring, changes in the balance of cortical excitability and alteration of interhemispheric interactions,crossmodal activation circuits andthe role of white matter lesions in recovery.

Furthermore the talk will light out hypothesis driven approaches to neurorehabilitation: behavioral modulation techniques, pharmacological manipulation to enhance arousal and learning during training ,electrical cortical stimulation to increase/decrease the excitability of target cortical areas, manipulation of somatosensory input, combined cortical/peripheral electrical stimulation,virtual reality, robotics. A summary outlook on possible future developments will close it.

BASIC MECHANISMS OF BRAIN PLASTICITY AND HYPOTHESIS DRIVEN NEUROLOGICAL REHABILITATION

DANA BOERING

St. Mauritius Therapieklinik Meerbusch Meerbusch, Germany



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Multiple sclerosis (MS) is an extremely disabling disease, with variable and complex physical and social consequences.The mechanisms of disability are poorly understood. Effective overall management of the disease therefore requires a long-term and proac-tive approach beginning at the time of diagnosis and continuing throughout the pa-tient’s life .The neuro-rehabilitation (NR) should be incorporated throughout the course of the disease to address the key needs of MS patients. We used for our MS patients a short-term intensive inpatient neuro-rehabilitation pro-gram (3 weeks) involving a multidisciplinary team. The primary objective was to evalu-ate the tolerability of this program, in patient with moderate level of disability. Second-ary outcome evaluate the recovery of disability , fatigue and the quality of life. Physical therapy aims at improvement of motor functions as: co-ordination, fine movements, balance, gait and reduction of spasticity. Conclusion. Our experience (over 10 years) demonstrated a good tolerability and safety of 3-weeks intensive inpatient neuro-rehabilitation program in Ms patients with mod-erate disability. Timing and mode of rehabilitation measures should be selected indi-vidually depending on disease phase and personal needs. Today we have good evidence that neuro-rehabilitation measures are effective in MS improving disability.

NEUROREHABILITATION IN MULTIPLE SCLEROSIS

ANGELO BULBOACĂ

University ofMedicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania



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The therapeutic approach of the patients with sequels after neurological diseases by means of physical medicine is particularly focused on the re-training of motor skills. Most of the physical and rehabilitation medicine methods` were directed toward main-taining and regaining selective movements by treating mainly the weakness or the ab-normal tonus of a muscle or group of muscles, or developing coordination and equilib-rium etc. During the time, new therapeutic approaches as the practice of goal-oriented functional tasks, has developed, based on the neuroplasticity and neuromodulation thesis.

The adaptation and functional substitution mechanisms of the central nervous system could need help of external aids from the physical and rehabilitation medicine meth-ods. Functional neurostimulation may sometimes be the better method from all other forms, by a neurally mediated functional substitution.

There are two broadly kinds of electric neurostimulation:- therapeutic stimulation – it has clinical effects, for example reduced spasticity, improved muscle strength etc- functional stimulation – the aims is to generate movements which realize functional activities

The effect of functional stimulation can be modified by changing the parameters of electrical current, in order to safely deliver the correct stimulation currents to the right tissues; the stimulating circuits and electrodes can be used to realize some special devices, named neuroprosthesis. These devices have a unique potential for artificially substituting some impaired sensory and motor functions. Yet, more studies are neces-sary to assess the effectiveness and to determine the optimal methodology for this kind of neurological rehabilitation method.

FUNCTIONAL ELECTRIC STIMULATION IN NEUROLOGICAL REHABILITATION

DELIA CINTEZĂ

National Institute of Rehabilitation, Physical Medicine and Balneoclimatology,

Bucharest, Romania



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For most people, the right hemisphere is the nondominant hemisphere, responsible for speech and language. Those individuals who are right hemisphere dominant are either left handed or ambidextrous. (Only about 15% of left handed persons are right hemi-sphere dominant for speech and language.) Because the right hemisphere usually plays only a secondary role in language processing, patients were not routinely treated by speech-language pathologists until recently.

Right hemisphere syndrome (RHS) represents a group of disorders occurring follow-ing lesions of the right cerebral hemisphere, including visual and spatial dysfunction, disturbances of body schema (anosognosia or asomatognosia), attention disorders (uni-lateral spatial neglect, motor impersistence, confusion), emotional changes(aprosodia, indifference to environment) conjugate eye deviation to the right, or right grasp reac-tion, and writing disorders (hypergraphia).

According to Myers (1994), impairments of perception and attention are the underly-ing causes of the extra-linguistic, linguistic and nonlinguistic deficits manifested by patients with right hemisphere damage. According to Love and Webb (2001), neglect, inattention and denial are three major characteristics of right hemisphere syndrome. They are also characteristics of executive function difficulty ( Marshall et al., 1998).

There are two basic approaches to cognitive training: (1) impairment training and (2) task specific training.

Impairment training addresses impairments common to a number of tasks and attempts to offer a general benefit to all of the tasks at once. Task specific training focuses on the impairments that arise in a single task and attempts to improve performance on that task. Impairment training of spatial disorders following right hemisphere stroke has shown some success when curricula are properly designed. The success, however, is quite limited because of normal cognitive constraints and those occurring after brain damage. Task specific training in conjunction with the combined application of various cognitive principles appears more promising, but as yet, only a few studies exist. The neurologic factors are likely to be the same factors that influence recovery. The factors that influence trainability are lesion topography (size and location of the focus plus premorbid atrophy), lesion chronicity, and the presence of additional cognitive impair-ments (anosognosia, confusion, and abulia). Other interventions that may be beneficial, even for training resistant patients, include behavior modification, cognitive prosthe-ses, and drugs.

Right hemisphere (RH) stroke may critically reduce the capability to perceive, internally represent, and process spatially-distributed, global information, as well as the ability to activate automatic visuospatial response systems. These consequences of RH stroke

RIGHT HEMISPHERE STROKE SYNDROME (RHSS). ACUTE AND LONG-TERM RECOVERY IMPAIRMENT

SANDA MARIA DEME

Neurology Department, Western Vasile Goldis University of Arad, Arad, Romania



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and visuospatial impairment are established in the neuroscience literature, but cur-rent visuospatial behavioral treatments do not integrate these concepts. Translating our knowledge of the cognitive neuroscience of visuospatial disability into behavioral techniques may increase the impact of treatment on the high cost of stroke in acute rehabilitation care and functional disability.

The research aims to a promising treatment for visuospatial deficits in RH stroke sur-vivors to clinical application in training RH stroke survivors with visuospatial deficits. Optimized standard visuospatial rehabilitation after RH stroke may require 1) specific training in global visual organization, and 2) practicing verbal self-instructions. Lastly, 3) training must transfer to functional task performance to improve disability. This ap-plication aims to integrate the three elements of successful therapy into a strategy for visuospatial rehabilitation, to be applied clinically and used in treatment trials. In the proposed research, we will examine whether teaching organizational strategies to increase global processing improves recall of a standard neuropsychological test of vi-suospatial impairment, the Rey-Osterrieth complex figure in stroke survivors with RH stroke, whether verbal instruction further augments this effect, and whether training effects generalize to everyday visuospatial tasks. Visuospatial deficits are linked to im-peding rehabilitation outcomes, increasing clinical morbidity, and inducing problems with dressing, driving, shopping, sports, computer/internet use, and other activities of daily living. The significance of the proposed research is to establish effective treat-ments for visuospatial deficits in right hemisphere stroke survivors so that functional disability and cost of rehabilitation care will be reduced.

The right hemisphere seems to be crucially involved in the control of many other as-pects of emotions, including the ability to show appropriate emotional concern, to regulate autonomic response to emotional stimuli, to recognize emotion through tone of voice and to produce facial expressions of emotion and emotional tone of voice. Studies of the breakdown or preservation of each of these functions in individual right hemisphere patients could provide very valuable evidence as to whether the different aspects of emotion are indivisible or are organized as autonomous modules. In the right hemisphere, have been found advantages for the recognition of spatial configurations and for faces in particular; an increasing body of research suggests that the recognition of faces and the recognition of facial expressions of emotion are separate processes.

Motor recovery of the patients with RHS is identical with that utilized to the patients with left hemispheric damages. In precocious recovery, difficulties occur due to emo-tional disorders, the patient’s indifference; the impossibility to create images makes communication difficult, even if language is preserved.



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In acute medicine there is a clear nosological definition of a disease followed by a set of diagnostic procedures leading to a treatment approach directed towards the known properties of this disease. Threfore the entire treatment process is centered around the diagnosis and nosological entity and in some sense monodimensional.

In contrast in rehabilitation medicine a much more comprehensive multi- facetted ap-proach has to be used. The entire social and environmental circumstances and tradition in which the individual patient is embedded in has to be taken into account. Treatment is not marshalled according to a particular diagnosis but rather oriented on the balance between what the patients is able to do and is not able to do in particular domains of behavior. These domains today can be described by the use of the international clas-sification of functions (ICF) (see module 2). Therefore rehabilitation needs a specialized way of looking at the necessary assessment of the patient, describing the patient’s needs and goals and try to find a compromise what goals can be achieved in a particular condition and giving a particular behavior repertoire the patient has access to.

In this module furthermore legal and ethical aspects will be described as well as short overview will be given about different structure of rehabilitation approaches in neurology across Europe. In this respect it is also important to define the relative roles of physicians in neurology and physical medicine/ rehabilitation contributing to the definition of neurorehabilitation procedures.

THE COMPREHENSIVE APPROACH OF REHABILITATION MEDICINE, ETHICAL AND LEGAL ASPECTS

VOLKER HÖMBERG

Dept of Neurology,Heinrich HeineUniversityDuesseldorfGermany



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Medicine today uses a standardized international classification of diseases (ICD). In acute medicine treatment and diagnoses of a particular disease entities,which are de-fined nosologically are the most important points.

As already mentioned in module 1 in rehabilitation medicine the problem is some dif-ferent: Here in the foreground of interest of physicians and patients is the ability of the patient to do particular things i.e. to find descriptors for the actual abilities, function and chances of participation for the patient. To make also such a classification comparable on an international level and find sort of a “micro language” to describe such differences in function and abilities the world health organization (WHO) has suggested to use a standardized international clas-sification of function (ICF).

The ICF differentiates 1. Body functions and structures 2. Activities 3. Participation

In the course of rehabilitation there is a transition from the acute medical treatment of body structures and body functions towards a more functional activity and participa-tion related view. Within the ICF nine chapters of different activities can be differenti-ated from elementary mobility to major live areas as social, civic and religious actvities. Within each domain ( e.g. mobility) activities can be further sub defined into sub cat-egories:

It will be demonstrated how ICF classification can be institute to describe rehabilitation process. Furthermore it is critically discussed in how far the micro language of ICF re-ally reflects the patients ambitions and needs in the rehabilitation process.It is important to note to that the ICF tries to reflect a bio- psycho- social model of disease rather than a pure biological understanding.

THE BIO –PSYCHO – SOCIAL PARADIGM OF DISEASE UNDERSTANDING AND ICF

VOLKER HÖMBERG




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As a mentioned in the earlier modules the International Classification of Functions ( ICF ) has become sort of a gold standard for the classification of functions,activities and participation . In this module practical exercises will be done how to extract from the ICF a reasonable matrix for the definition of rehabilitation goals.

It is important in the process of rehabilitation that goals can be clearly and operation-ally defined in the interaction between physicians and the patient as well as relatives. An attempt will be made to give real live oriented examples for definition of goals for various domains within the ICF framework.

Historically the concept of evidence based medicine going back to the French encyclo-pedist of the 18th century and the first medical application of such an approach will be shown. The different levels of evidence will be introduced and the general properties of randomized controlled trials as a key element of the modern concept of evidence based medicine will be demonstrated.

In addition a critical epistemiological l discussion about the usefulness of this concept of evidence based medicine in neuro rehabilitation in contrast to concepts of indi-vidualized medicine will be presented and the design of Number of 1 studies as an alternative to groip designs will be introduced. Finally a systematic review of treat-ments based on evidence based medicine which today are widely used in neurologic rehabilitation will be reviewed.

GOAL FINDING AND MONITORING OF THE NEUROREHABILITATION PROCESS

& THE CONCEPTS OF EVIDENCE BASED MEDICINE AND DESIGN FOR CLINICAL STUDIES

VOLKER HÖMBERG




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For the rehabilitation of motor function an elementary understanding about the pro-cesses of motor learning is important. Within the last decade there has been a dramatic change in the paradigm of motor rehabilitation concepts and techniques.

In this module elementary aspects of motor learning especially of learning by repeti-tion and feedback will be demonstrated.Also the key behaviorial and psychological basic science elements contributing to our modern understanding of motor learning will be described. Furthermore the neurobiological foundation of motor learning process as well as the brain areas involved in learning by doing, imagery and imitation will be discussed.

Finally examples will be given in how far knowledge about motor learning principles in general over the last two decades has been implemented into reasonable motor re-training strategies such as the forced use approach or the use of auditory pacing ( e.g. neurological music therapy).

Students will also be invited to practical exercises in designing “new” possible motor rehabilitation strategies based on elementary knowledge about motor learning.

BASIC PRINCIPLES OF LEARNING

VOLKER HÖMBERG




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In this course the art of a rational neurological examination will be taught:More than in any other clinical discipline the history and examination in neurology are the most informative source of information for the clinician.This is of course due to the fact that structure and function of central and peripheral nervous system are clear and informative.

Clinical skills for optimal examination of cranial nerves,motor and sensory functions and screeningapproaches for cognitive and linguistic analysis will be presented .So the students will soon learn that neurologic examination is much more than just looking at “reflexes”

Also fields notoriously estimated as being difficult (such as eye movements ,nystagmus ,diplopia etc )will not be spared but elucidated in an “easy to understand and remem-ber” mode.

BASIC COURSE IN NEUROLOGIC CLINICAL EXAMINATION

VOLKER HÖMBERG




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This presentation briefly reviews some of the mechanisms involved in the pathogenesis of neurological diseases, i.e. damage mechanisms, and their interactions and overlap with protection and reparatory processes (i.e., endogenous defense activities). A re-lationship between damage mechanism (DM) and endogenous defense activity (EDA) regarding therapy principles will also be described.

Currently, it is difficult to find the correct therapeutic approach for brain protection and recovery, especially because we do not fully understand all of the endogenous neuro-biological processes, the complete nature of the pathophysiological mechanisms and the links between these two categories. Moreover, we continue to use a simplistic and reductionist approach in this respect.

Endogenous neurobiological processes, such as neurotrophicity, neuroprotection, neu-roplasticity and neurogenesis, are central to protection and recovery and represent the background of EDA.

The biological reality of the nervous system is far more complex. In fact, there is an endogenous holistic process of neuroprotection and neurorecovery that should be ap-proached therapeutically in an integrated way.

The current tendency to exclusively frame drug activity in terms of single mechanisms and single focus effect might distract from other paradigms with greater explanatory power and hinder the development of more effective treatment strategies. A change of concept is required in pharmacological brain protection and recovery. This presentation will also highlight some prospective considerations including an integrated pharmaco-logical approach, focusing on drugs with multimodal activity and pleiotropic neuropro-tective effect which are biological drugs, rather than single mechanism drugs, which usually are chemical drugs.

THE NEUROBIOLOGY OF NEURORECOVERY AND CONCEPT OF NEUROMODULATION

DAFIN F. MUREȘANU

Department of Neurosciences, University ofMedicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania



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Neuroplasticity is the term used to describe the brain’s ability to change already exist-ing structures, in response to environmental stimulus, such as learning or experiencing something new or to an injury.Neuroplasticity means also the brain’s ability to restruc-ture itself after training or practice and mediates the transition from early learning to automatic responding.

Specific networks involving the basal ganglia are the neural substrate of affective, cognitive, motor and behavioural (actions and habits) activities.These are described as parallel-projecting, partially segregated reentrant circuits.

Limbic input projects to ventromedial zones, sensorimotor input to dorsolateral zones and associative input to the region in between ventromedial and dorsolateral zones.

This presentation will highlight how neuroplasticity is permanently reshaping these circuitries during normal and pathological behavior.

THE ROLE OF NEUROPLASTICITY IN NORMAL AND PATHOLOGICAL BEHAVIOR

DAFIN F. MUREȘANU

Department of Neurosciences, University ofMedicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania



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Neuropathic pain is a very special and complex type of pathology being included in the syndrome categories group. As a complex phenomenon it express the sensory experi-ence in connection with allodynia, hyperpathia or dysesthesia and other specific or non-specific symptoms. In spite of classic and new pharmacologic opportunities focus on neuropathic pain a lot of patients complain and develop special chronic scenaries of neuropatic pain, in connection with pathological background and psycho-behavioral compounds and emotional experience.

Modern medicine encourages pacients to contribute to their own strategy for control-ling and modulating the evolution of neuropathic pain in context of cronicity. Clinic and functional background is associated with fear, sleep disturbances, secondary muscu-loskeletal and cognitive consequences, with disability and also with quality of life and socio-economic effects. So, after performing an educational training on neuropathic pain in order to understand much better the aims , therapeutic and side effects of drug therapy there can be introduced also non-pharmacologic strategies for physical and psyho-behavioral modulation of neuropathic pain.

The assessment of neuropathic pain has multidimentional aspects and also it requires a multidisciplinary team for diagnose and treatment. First step starts with a complex clinic and functional evaluation from subjective and objective point of view including diagnostic tools for neuropathic pain. The evaluation adreses the presence of charac-theristics of neuropathic pain criteria and uses evaluation tools like: DN4, the LANSS Pain scale, s-LASS, VAS. The neuropathic pain is frequently associated with different types of pathology such as: diabetic neuropathy, central post stroke pain, multiple scle-rosis, polineuropathy, phantom limb pain, post-herpetic neuralgia, brachial plexus avul-sion, HIV associated neuropathy, spinal surgery, cancer, low back pain, CRPS, s.o.Non-pharmacologic therapy adresses two directions: conservative interventions and surgical decision.

Non-pharmacologic conservative interventions include:

- neuromodulation (spinal cord stimulation, puls radiofrequency) - physiotherapy with different types of pasive physical modalities: local, seg mental or reflex thermotherapy applications (cold - cryotherapy, heat), elec trotherapy (TENS, PENS, other modalities), therapeutic analgetic massage and active specific kinetotherapy program (postures, relaxation, movement, manipulation, special technics) - occupational therapy, splinting - psychotherapy and cognitive therapy (individual /group), laughter, hypnosis, musicotherapy - acupuncture - social and vocational support.

NON-PHARMACOLOGIC TREATMENT OF NEUROPATHIC PAIN

ADRIANA SARAH NICA

UMF ,,Carol Davila “ BucurestiRomania



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Neuropathic pain is a special complex cause of morbidity and a syndrome with long-term effects on individual and societal level. The complex multimodal treatments in-cluding also non-pharmachologic conservatory modalities must offer an adequate therapeutic program offering different alternative solutions, with a high rate o benefice for the pacient. It also avoids the invasive procedures and the side effects of long term pharmacological therapy.



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Lumbar sciatica represents a form of clinical manifestation of a peripheral motor neu-ron syndrome in the low back pain, most frequently having a mechanic disc etiology, characterized by dermatome distribution aggravated by flexion and Valsalva maneuver, with monoradicular neurologic deficit in 50% of cases. Annual costs of treatments are impressive, ranging at billions of Euros/US dollars annually. Properly treated it has a high healing potential within 3 month from beginning (60-80%), untreated it is prone to chronic pain. Severe forms with ponytail syndrome require neurosurgical treatment. Current guidelines recommend positive diagnosis of sciatica in the presence of a typical radicular pain, lower limb irradiated and at least one neurological test (sign) indicating nerve root damage or characteristic neurological deficit, excluding warning signs (“ red flags “) , both anamnesis and physical examination.

Computer tomography (CT) and magnetic resonance imaging (MRI) have both the needed accuracy for the diagnosis of disc herniation.

Initial treatment is conservative, with a major focus on patient education (see the clinic guide of the Dutch College of General Practitioners). It recommends relative rest with continuing normal activity, combined with drug therapy (NSAIDs, analgesics, muscle relaxants, general corticotherapy or paravertebral , epidural, infiltration, sedatives).

Surgical treatment (discectomy ‘the golden standard’ in the herniated disc) is reserved for severe cases with ponytail syndrome or if clinical symptoms persist after 6-8 weeks of treatment.

Regarding the optimal treatment and application timing, no definite conclusion was reached yet.

No significant differences appeared in the evolution of patients treated surgically com-pared with those treated conservatively, on the long term of 1-2 years.

REHABILITATION IN DISK HERNIATION SCIATICA

IOAN ONAC

University ofMedicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania



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Pain a part of the spectrum of non-motor symptoms of Parkinson’s disease patients. This presentation will focus on the assessment of pain and its importance in the reha-bilitation of PD patients.

Pain is defined according to the International Association for the Study of Pain (IASP) as unpleasant sensory and emotional experiences with actual or potential tissue damage or described in terms of such damage. Pain in PD can be classified according to different criteria. The most used classification is the one proposed by Ford and co, who separate pain into: musculoskeletal, radicular-neuropathic, dystonic, central or primary pain and akathisia.

Pain prevalence in the general population in different countries is difficult to compare because of different study designs and inclusion criteria. Variations in pain prevalence in PD have been described in the literature, ranging from 38% to 85%.

In order to alleviate pain one has to assess pain and find factors that might influence its course and progression. One method would be to determine the pain threshold, by one of the following methods: thermal stimulation, pressure pain threshold, RIII noci-ception flexion reflex. Another method is represented by evaluation scales: Brief Pain Inventory (BPI), Visual Analogue Scale (VAS).

Current studies state that pain is associated with higher depression scores, female gender, earlier age at PD onset, and a lower level of education.

The management of pain consists of medication and rehabilitation therapy. The first and most evident measure is to maximally reduce motor symptoms with anti-parkin-sonian medication. When the pain fluctuates in parallel with the motor changes, this pain may respond to modifications in anti-parkinsonian therapy, which can be far more effective than conventional analgesic treatments. PD patients receiving analgesics re-ported only a partial relief of their painful symptoms (decrease of pain intensity with only 32,98%) which highlights the need for a different approach for the management of pain in PD. Physical intervention as part of the neurorehabilitation process represents a very effective way for treating painful symptoms in PD patients.

There are nonetheless a few limitations for applying physical therapy to PD patients: the lack of international available guidelines for everyday clinical practice, loss of initia-tive of patients, maybe caused by the neurodegenerative process itself, and few physi-cal therapists specialized in the rehabilitation of PD patients.

THE IMPORTANCE OF PAIN ASSESSMENTS IN THE NEUROREHABILITATION OF PARKINSON’S DISEASE

LĂCRĂMIOARA PERJU-DUMBRAVĂ

University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Romania



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Stroke is one of the leading cause of disability in adult population. More than a half of stroke survivors are not able to walk and requires a period of rehabilitation to achieve a functional level of ambulation. Effective rehabilitation intervention provided in a spe-cialized setting and initiated early after stroke can enhance the recovery and minimize the level of disability. Recent studies reported that the type of training strategy imple-mented in rehabilitation can affect the patient’s locomotor recovery. Repetitive move-ment and sensory stimulation play an important role in the gait rehabilitation of the patients with functional deficits due to neurological conditions, as stroke or spinal cord injury. The current evidence indicates that intensive task specific therapy produces the highest level of recovery of motor function, even in the case of sever impairment. In the past, the gait rehabilitation of those patients relied on technics that focused on the compensatory approach of these deficits. Movement therapy studies on stroke and spi-nal injuries, show that the recovery is better as far as the the therapy is administrated earlier, longer and more intensively. Nowadays, the latest clinical studies show that the new concept of neural plasticity can be applied effectively to the rehabilitation process of such patients, leading to improved outcomes and enhanced functional abilities. An intensive functional locomotion therapy regimen, assisted by the therapist is demand-ing, requires sufficient staff and allows only relatively short training session. On this respect, new robotic assistive technologies was developed, aimed to enable functional movements with dynamic training regimen which exceed human capacity and allows monitoring of exercise variables. Modern assisted devices for gait training combine dy-namic body support with functional electrical stimulation, augmented feedback tech-nics and virtual reality, enabling patients to practice repetitive functional tasks which will force use-dependent plasticity in order to enhance neural repair process. Using bio-medical robotic devices, functional limitation, considered until recently not revers-ible, can be successfully overcome, thus offering to these patients the opportunity to improve physical capacities, including gait, functional independence and quality of life.

Key words: stroke, gait rehabilitation, robotic assisted devices, neural plasticity

ROBOTIC ASSISTED GAIT TRAINING IN STROKE REHABILITATION

DAIANA POPA

Rehabilitation Hospital Felix-SpaRomania



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Many neurological diseases remain devastating nervous system diseases, due to limited treatment options. In stroke, Alzheimer’s disease, Parkinson’s disease or multiple scle-rosis, disease modifying therapies are needed and searched to be validated by clinical trials. In ischemic stroke, a short time window for intervention and bleeding risks are associated with rt-PA treatment. In contrast to thrombolysis, the use of stem cells for neurorestoration looks promising from experimental studies done so far. Stem cells derived from different tissues have the capability to stimulate neurogenesis, angiogen-esis, remyelination and synaptic plasticity. Interestingly, it seems that their mechanism of action is not mainly based on cell replacement but on inhibition of inflammation and other deleterious stroke-related pathogenic pathways. Brain regeneration after stroke takes a long period of time and therefore the use of stem cells might have the ad-vantage of a large therapeutic window which would increase the access to treatment beyond the first hours after the onset. However, the cell-based therapies in stroke need more exploration of proliferation, cell signaling, integration and migration both from bench work and early clinical trials. In Alzheimer’s disease, neurogenesis is not functional due to amputation of differentiation phase. However, specific neurotrophic factors seem to be able to stimulate neural stem cell differentiation. In Parkinson’s disease neurorestoration studies resulted in untreatable dyskinesias so far. Even though the current state of art in the field is not linked to validated clinical applications, neu-rorestoration remains an insufficiently explored intervention.

AcknowledgementThis paper is supported by the Sectorial Operational Programme Human Resources De-velopment (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract number POSDRU/89/1.5/S/64109.

STEM CELL THERAPY IN NEUROLOGICAL DISEASES – PITFALLS AND HOPES

BOGDAN O. POPESCU

Department of Neurology, University Hospital, Bucharest, ‘Carol Davila’ University of Medicine and Pharmacy Bucharest, Bucharest, Romania



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Multiple sclerosis is a chronic disabilitating disease, typically diagnosed in young people between ages 20 and 40. One of the most disruptive - physically and emotionally - aspects of MS is mobility impairment, which can be influenced by other various defi-cits and symptoms associated with the disease. The importance given to walking and mobility by MS patients is immense. Thus, recent studies shows that between 64% and 85% of patients with MS report walking difficulty and 70% of MS people who ex-perience difficulty walking report it to be the most challenging aspect of their disease, with a great influence on their quality of life. The impact of mobility impairment on employment is also very significant. Also, a study conducted in the United Kingdom found that people with MS consider the ability to walk as the most important function in both early and late stages of the disease, followed in importance by visual function and thinking/memory. Assessing mobility and the effect of interventions on mobility is an important part of MS patient approach. A combination of simple walking tests and validated questionnaires, in addition to a complete history and examination, is the most efficient way of monitoring mobility in a clinical settings. Various tests are used to measure mobility impairment in patients with MS – clinically rated or patient reported. Early recognition of mobility impairment and subsequently early intervention can improve patient mobility, work retention and quality of life.

MOBILITY IMPAIRMENTS IN MULTIPLE SCRELOSIS

C. D. POPESCU

Department ofNeurology, Universityof Medicine andPharmacy“Gr.T. Popa”Iasi, Romania



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Neurorehabilitation is an open field for a team game. A game which involves different professional categories, doctors, nurses, speech and language therapists, occupational therapists, psychologists, physiotherapists, social workers and others, and has a guar-anteed winner: the patient. Neurological diseases have an important disabling poten-tial; the last 20 years have transformed our way of thinking, focusing our activities not only for saving the patient`s life, but also for saving the quality of this life. Romania has an increasing prevalence of stroke, and in the same time occupies an undesired place three, in the hierarchy of highest stroke mortality in the world. The need for re-habilitation services for stroke survivors is resented acutely, although small steps were done in creating specialized services for this category of patients. Stroke patients raise special problems, since stroke is a consequence of vascular or cardiac diseases, some-times very severe, which impose some limits for the degree of effort expected from the patients. Disabilities determined by stroke can be very complex: motor deficits, speech problems, cognitive impairment, post stroke depression, swallowing problems, vision problems and others. In addition, we have ischemic and hemorrhagic strokes, which at least in the post-acute period necessitate different approaches. Neurorehabilitation must address all these, in the attempt to help the patient to regain independence or to improve the quality of his daily living. Looking toward specialized structures, with multidisciplinary teams and complex devices, we must not forget that in some cases we can achieve our goals with very simple means.

POST STROKE REHABILITATION : FACTS AND FICTION

CRISTINA TIU

University Hospital Bucharest, Department of Neurology, Romania



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Behavioural disorders are the main factor of handicap after severe Traumatic Brain In-jury (TBI). They reflect three interfering etiological dimensions: neuropsychological (or lesional), psychopathological, social or environmental.

The evaluation takes into account the complaints of the patient and, moreover, the relative’s opinion, the pre and post-traumatic history, a semi-structured interview, the observation, the way of life and the handicap. The main disorders are: loss of initiative, loss of emotional control, somatic complaints, depression and anxiety, family conse-quences and the hard process of handicap acceptance and identity reconstruction. The pharmacological treatment is poorly assessed. In addition to individual and family ori-ented psychotherapies, care is based on holistic and multidisciplinary “resocialisation” programs.

Keywords: Traumatic Brain Injury, Behavioural Disorders, Mood, Psychopathology

MOOD AND BEHAVIOR DISORDERS AFTER TRAUMATIC BRAIN INJURY IN ADULTS:

PATHOPHYSIOLOGY, SYMPTOMS AND MANAGEMENT

JEAN-LUC TRUELLE1

Montreuil M.2

1. Department of Physical Medicine and Rehabilitation, University Hospital, Garches, France

2. National Council of the Universities,Laboratoire de psychopathologie et de neuropsychologie, université Paris, Saint-Denis, France



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Vocational rehabilitation (VR) is aimed at engaging or re-engaging individuals with work participation and employment. The International Classification of Functioning, Disabil-ity and Health (ICF) by the World Health Organization can be operationalized in the context of VR. The same has been demonstrated in comparison with the QOLIBRI as-sessment tool for HRQOL following TBI. With regard to TBI when sustained earlier in life this impact may cause permanent sequelae in specific domains of cognitive func-tioning and that it might attenuate the age-related decline in cognitive functioning. Most striking, however, was that these deficits were reported not perceiving as a limit-ing factor in everyday life, which suggests that coping strategies may be important. In general QOLIBRI analysis has shown that after one year the mental cognitive and neurobehavioral deficits become dominated by neuropsychiatric signs and symptoms. These will become the limiting factors for social reintegration in case adequate social- medical- and psychiatric counselling / support are not provided or available at all.

With regard to SCI, a systematic review of functioning in vocational rehabilitation us-ing the WHO-ICF ( by the Swiss Paraplegic Research Centre, Zürich) has demonstrated a great diversity in the ICF contents of the measures used in different VR settings and study populations indicating the complexity of VR. Citation from Escorpizo R, et al : J Occup Rehabil. 2011 Feb 17. [Epub ahead of print]: “ Methodes:648 measures which contained 10,582 concepts that were linked to the ICF which resulted in 87 second-level ICF categories. 31 (35.6%) were related to body functions, 43(49.4%) to activities and participation, and 13 (14.9%) were related to environmental factors. No category was related to body structures. “End of citation.

Conclusions: Mental- cognitive and behavioural disabilities are more persistent and constitute more of a handicap than do focal neurological signs. New concepts for long term neurorehabilitation and specialized teams are needed to meet with the individuals needs following CNC damages and, at the same time, to take the challenge for help-ing- assisting- supporting to reconstruct the human life.

VOCATIONAL REHABILITATION FOLLOWING BRAIN AND SPINAL CORD LESIONS

KLAUS VON WILD

Tobias von Wild1, Dafin F. Mureșanu2, Cornel Cătoi3

1. Department of Plastic Reconstruc-tive& Hand Surgery, Univ. Hospital UK--SH, Luebeck, D

2. Department of Neuroscience, University of Medicine and Pharmacy, Cluj-Napoca, RO

3. Faculty of Veteri-nary Medicine, Univ. of Agricultural Sci-ence and Vet. Med. Cluj-Napoca, RO

4. Faculty of Medi-cine, W.W. University Münster, D

Professor H.C. of Physical Rehabilita-tion, Al Azhar University Cairo, EG



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CURRICULUM VITAE



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TITLE- Professor at the University of Medicine “Carol Davila” Bucharest- Chief of Dept. Physical and Rehabilitation Medicine, University Hospital ELIAS- Senior consultant in Physical and Rehabilitation Medicine (PRM)- PhD -cum laudae.- European Board certified in PRM

STUDIES- 1969-1980 German School Bucharest- 1981-1987 General Medicine at the University of Medicine “Carol Davila” Bucharest,- 1987 MD License

POSTGRADUATE EDUCATION- Complementary studies in: Electromyography (2000), Pain Therapy(2000), Home-opathy (1994), Management of Health Services (2003), Hospital Management (2006)- Multiple national and international courses: in EMG (2001), Train the trainers (2002),Entrepreneurship (2002), European Practicum on Clinical Exercise Testing (2010)- Clinical exchange in: Bruxelles (1997), Berlin (1998), Angers (2001), Washington (2000), Innsbruck (2000), Winterthur (2004), Barcelona (2006), etc.

STIINTIFIC ACTIVITY- Author or coauthor in over 250 papers, chapters in textbooks, etc., published nation-ally and internationally- Keynote speaker in international congresses: Sao Paulo (2005), Hong Kong (2006),Antalya (2005), Athens (2006), Porto (2008), etc.- PhD –CUM LAUDAE: Value of Electromyographic Biofeedback in Rehabilitation of Voluntary Movement, increase of Muscle Force and Treatment of Spasticity. 2003- European Board certified since 2005.

PATENTS- 5 patents with medical applicationRESEARCH- Partner in 6 national grants- Partner in 2 international grantsMANAGEMENT ACTIVITIES- Medical Director , University Hospital ELIAS 2006-2010- Manager University Hospital ELIAS 2010

MEMBER OF INTERNATIONAL- ISPRM Int. Society of Physical & Rehabilitation Medicine. Board member (since 2004)- WFNR World Federation of Neurological Rehabilitation. Board member (2001-2006)- AAPM&R American Academy of Physical Medicine and Rehabilitation. Member.- UEMS European Union of Medical Specialists PRM section, National Delegate (since2004)- UEMS, President of the Professional Practice Committee (since 2010)- Bone and Joint Decade – National Delegate. (since 2002)- WHO-ICF delegate since 2002NATIONAL- President of the Commission of PRM in the Ministry of Health- President of the Romanian Society of PRM. (1998-2008 Secretary General)- Council and Senate of the University of Medicine “Carol Davila” Bucharest

MIHAI BERTEANU/ROMANIA



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EDUCATION:

1965 - 1972 Faculty of Medicine at the University Vienna MD since (promotion on) 1972, June 6th

1972 - 1978 University Hospital for Neurology, graduated in Medical Specialist for Neurology and Psychiatry

9/1982 Docent for neurology, a title corresponding to PhD

since 1988 Professor for Neurology, University Vienna founding member of the Austrian Society for Neurorehabilitation

5/1989 Head of the Neurological Hospital “Maria Theresien-Schlössel”

1994-2007 Head of Ludwig Boltzmann Insitute for Restorative Neurology and NeuromodulationSince 2008 Deputy Head of Landsteiner Institute for Neurorehabilitation and Space Medicinesince 2002 Head of the Neurological Center, Otto Wagner Hospital, Vienna. Main focus: Patients with severe neurological/ neuropsychological deficits and invasive neurorehabilitation methodscurrently President of • AustrianSocietyforNeurorehabilitation(OEGNR)• EuropeanFederationNeuroRehabilitationSocieties(EFNRS)Member of • ManagementCommitteeoftheWorldFederationNeuroRehabilitation(WFNR)• ManagingBoardoftheInternationalDanubeSymposium• EditorialBoardof”JournalofMedicineandLife”:Chairman of • SpecialInterestGroup/WFNR“SpinalCordInjury”• SpecialInterestGroup/WFNR“EarlyRehabilitation”• Scientificpanel/EFNS“BrainrecoveryandRehabilitation”• SpecialBranch/InternationalDanubeSymposium:“NeuroRehabilitation”

Main topic of research: Neurorehabilitation, brain injury, spinal cord injury, vegetative state/ apallic syndrome (more than 140 publications)

HEINRICH BINDER/ AUSTRIA



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EDUCATION:

1. Secondary School I. Slavici Arad, Romania2. Medical School: Facultatea de medicina si Farmacie I.M.F. Cluj- Napoca, Romania

ACADEMICAL QUALIFICATIONS:

1. Dr. medic : I.M.F. Cluj Napoca 19812. German acknowledgement as Dr. med. 19873. Specialty qualification: Neurologist 19944. Further specialty qualification: Neurorehabilitationist 2001, Neurophysiologist 2002

EMPLOYMENT:

St. Mauritius Therapieklinik Meerbusch since 2002Professional appointments, scientifical activities:1994-2002 Collaboration with the University of Essen in the field of plasticity after stroke, with an emphasis on the role of theerebellum in motoric learning tasksSince 2002 Collaboration with the University of Düsseldorf in the field of plasticity after stroke2009 Collaboration with the Coma Science Group Liege/Belgium2010 Collaboration with the Neuroradiology of the Wake University Winson- Salem U.S.A. in a study on network properties of DOC patients

DANA BOERING/GERMANY



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Head of neurological rehabilitation departmentCoordinating department`s activitiesNational Institute of Rehabilitation, Physical Medicine and Balneoclimatology, Bucharest, Romania 2, Sf. Dumitru Str., Bucharest, RomaniaHealth, research and medical education

From 2005Associate professorTeaching and research activitiesCarol Davila University of Medicine and Pharmacy, 37, Dionisie Lupu Str, Bucharest, Romania

Education and research General sonography Musculoskeletal sonography Electromyography Doppler ultrasound for peripheral vessels Laser Biostimulation Health Service Management- Project manager and partner project manager for National Research Program projects- Main investigator for international multicentric studies General sonography Musculoskeletal sonography Electromyography Doppler ultrasound for peripheral vessels Laser Biostimulation Health Service Management

Project manager and partner project manager for National Research Program projects: 1. Method and software for the determination and interpretation of plantar footprint- CALIST Program, 2004-2006;INRMFB2. Forming a network of integrated research methods and equipment for determin-ing calorie consumption and patterns of dynamics during gait in patients with chronic diseases of the locomotor system –CEEX Partnerships Program 4 - Contract 35/2005 CALORCRO., 2005-2007, UMFCD3. Detection and monitoring of somatic and psycho-behavioral deficiencies in children and adolescents (10-18 years), pilot study CEEX Partnerships Program 4 - Contract 106/2006 DEMODEF, 2006-2008, INRMFB4. Equipment and computerized monitoring and diagnosis for the treatment of trau-matic disorders and postoperative recovery- CEEX Partnerships Program 4 - Contract 68/2006 INFOREC, 2006-2008, INRMFB5. Upgrading of research infrastructure in order to test the therapeutic ability of natural factors of immunological studies spas, cell biology and physiology made by specialized laboratories of the Institute for Rehabilitation, Physical Medicine and Balneoclimatol-ogy - Program 2 Capacity, Module 1 - Contract no. 34/2007 Spa, 2007-2010, INRMFB Main investigator for international multicentric studies:1. International multicenter clinical trial, double blind, placebo-controlled for analyzing the effectiveness of new therapies to treat neuropathic pain – 2006-20072. Duloxetine 60 mg once daly versus placebo in the treatment of patients with osteo-arthritis knee pain – 2009 – 2010

DELIA CINTEZĂ/ROMANIA



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3. A 12-week randomized double-blind placebo controlled trial to evaluate yhe efficacy and safety of prucalopride in subjects with chronic non-cancer oain suffering from opi-oid induced constipation – 2010-2011 Participant in some national and international research program and projects:1. ICF Core Sets multicenter validation study: Validation of the ICF Core Sets for chronicLow back pain (International program)2006-20072. ICF Core Sets multicenter validation study: Validation of the ICF Core Sets for chronicwidespread pain from the perspectives of physicians (international program)2007-200083. Medical and biological study for innovative therapeutical use of natural factors in cave and saline mines - Studiu complex medico-biologic in vederea utilizarii inovative a factorilor potential terapeutici de mediu din saline si pestera in sanatate si turism balneoclimatic; soluţii de modelare a acestora”- Partnerships Program2, Contract no 42120 CEFACTERMEDSUB, 2008-2011, INRMFB



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Deme Sanda Maria, MD, PhD, is Associate Professor of Neurology, Head of the Neurol-ogy Department, Faculty of Medicine, Western University of Arad “Vasile-Goldis” - Ro-mania, member of the European Neurological Society (ENS), member of the Society for the Study of Neuroprotection and Neuroplasticity (SSNN). She was the organizer of the first Neurorehabilitation International Conference- WEST NEUROREHAB, 6-8 Novem-ber 2008, ARAD, ROMANIA (in collaboration with the University ”Iuliu Hateganu” Cluj). She is the collaborator for the Grant with the title “Diagnosis and recovery of apha-sic Romanian speaking patients, following an ischemic stroke”, in collaboration with the Department of Neurology, University of Medicine and Pharmacy “Victor Babes” Timisoara, and coordinator in the implementation of the project “Building of the joint International Institution for Gerontological Prevention (IIGP)”, approved by the Joint Steering Committee of the Hungary-Romania Cross-border Co-operation Programme 2007 – 2013. She obtained her MD degree in 1985 from the University of Medicine and Pharmacy “Victor Babes” Timisoara, and completed 4 years of doctoral-research in neurology - thematic neuropsychology, right hemisphere damage in stroke. In 2002, she was appointed Associate Professor and Head of the Department of Neurology at Western University of Arad “Vasile-Goldis”. Her activity and research has been focused on understanding the Neuropsycology and also on understanding the cognitive neuro-recovery after right hemisphere stroke. She has also published numerous articles and study researches in national and international medicine journals. In 2009 she was hon-ored with the Outstanding Abstract Award in CONy Congress, Prague with the abstract “Silent strokes and cognitive impairment linked to metabolic syndrome in middle age adults”, and also with the Academic Gala Awards, UVVG, Arad for exceptional merit, and for the published research activity.

SANDA MARIA DEME/ROMANIA



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MEDICAL DIRECTOR St. Mauritius Therapy Hospital Meerbusch

PERSONAL DATA Born 25 July 1954 Married to Priv.-Doz. Dr. Kristina Müller, paediatric neurologist

MEDICAL CAREER

1973 - 1980 School, Universities of Düsseldorf and Freiburg; Elective in Neurology at Boston City Hospital, Boston, Mass.; National Hospital for Nervous Diseases, Londonsince 1975 Junior researcher in the Department of Neuropsychology at the C. & O. Vogt Institute for Brain Research, Düsseldorf and the Department of Neurology, Freiburg (Prof. R. Jung)1980 - 1981 Research fellow in the Department of Neuropsychology (Prof. G. Grünewald) at the C. & O. Vogt Institute for Brain Research, Düsseldorfsince 1981 Clinical training in the Department of Neurology (Prof. H.-J. Freund), Heinrich- Heine-University Düsseldorfsince 1985 Senior registrar in the Department of Neurology, Heinrich-Heine- University Düsseldorfsince 1987 Senior investigator for the German Research Council Special Task Force in Neurology at Heinrich-Heine-University (SFB 200 and SFB 194)1987-2005 Medical director of the Neurological Therapy Center (NTC), Heinrich-Heine-University Düsseldorfsince 1988 Board examiner for Neurology at the local examination board (Ärztekammer Nordrhein)1989-1997 Vice president of the German Society for Neurological Rehabilitation1993 Habilitation in Neurology, Heinrich-Heine-University Düsseldorfsince 1995 Board examiner for physical medicine and rehabilitation (Ärztekammer Nordrhein)1997-2005 Medical director of the Neurological Therapy Center, Cologne1998-2004 President of the German Society for Neurological Rehabilitationsince 2000 Medical director and head of neurology, St. Mauritius Therapy Hospital, Meerbuschsince 2003 Secretary General World Federation for NeuroRehabilitation (WFNR)since 10/2004 Vice president of the German Society for Neurological Rehabilitationsince 2005 Panel-Chairman Neurorehabilitation for European Federation Neurological Societies (EFNS)

VOLKER HÖMBERG/GERMANY



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Mureșanu Fior Dafin, MD, PhD, MBA, is Professor of Neurology, Chairman of the Neu-rosciences Department, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, member of the Academy of Medical Sciences, Romania. He is also President of the Society for the Study of Neuroprotection and Neuroplasticity. In these roles, he acts as coordinator in international educational programs of European Master type (European Master in Stroke Medicine, University of Krems), organizer and co-organizer of European and international schools and courses (Eastern European Neurology Sum-mer School for Young Neurologists - www.ssnn.ro, European Stroke Organisation Sum-mer School, Danubian Neurological Society Teaching Course). His activity includes his involvement in many clinical studies and research projects, his membership in the ex-ecutive board of many national and international societies, participations as invited speaker in national and international congresses, and a significant portfolio of scientific articles, contributions in monographs and books published by prestigious international publishing houses. Prof. Dr. Muresanu has been honoured with the Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca “Octavian Fodor Award” for the best scientific activity of the year 2010 and the 2009 Romanian Acad-emy of Medical Sciences “Gheorghe Marinescu Award” for advanced contributions in Neuroprotection and Neuroplasticity.

DAFIN F. MUREȘANU/ROMANIA



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Current position

- Professor in Physical Medicine, Rehabilitation and Balneoclimatology at the University of Medicine “Carol Davila”, Bucharest- Head of Rehabilitation Department - University of Medicine “Carol Davila”, Bucharest - PhD- Chief of University Rehabilitation Department III – National Institute of Reha-bilitation, Physical Medicine and Balneoclimatology- European Board certified in PRM- Senior consultant in Physical Medicine and Rehabilitation

Medical Career

1978 – MD at the Faculty of Medicine – University of Medicine “Carol Davila”, Bucha-rest 1982 – University assistant and resident doctor – Balneoclimatology, Sport Medicine and Physical Medicine – University of Medicine “Carol Davila”, Bucharest 1985 – Specialist in Balneoclimatology, Sport Medicine and Physical Medicine – Uni-versity of Medicine “Carol Davila”, Bucharest, confirmed by the Ministery of Health of Romania1992 – Lecturer – Balneoclimatology, Sport Medicine and Physical Medicine – Univer-sity of Medicine “Carol Davila”, Bucharest1997 – PhD at the University of Medicine “Carol Davila”, Bucharest1998 – Ass. Professor of Balneoclimatology, Sport Medicine and Physical Medicine – University of Medicine “Carol Davila”, Bucharest 2002 – 2004 – Medical Director of National Institute of Rehabilitation, Physical Medi-cine, Balneoclimatology, Bucharest, Romania2003 – Professor of Rehabilitation, Physical Medicine and Balneoclimatology

Post-graduated training and fields of interest in scientific research

1.ICF Workshop –Oct. 2011, Notvill, Switzerland2.Musculoskeletal Ultrasound Course, October 10-12, 2008, Bucharest3.Project “Postgraduate Training in Romania; Competence in Public Health Administra-tion and Management”, Bucharest, 22.06.20074.“4th Symposium - Discussion Platform for Pain, Surgery and Rehabilitation Aspects”, Bodrum, Turkey, 30.04-3.05.2007 5.“ISCD Bone Densitometry Course & Workshop”, Bucharest, March 1-3, 20076.“Project Management in Clinical Research”, Wien, February 19-21, 20077.“Introduction to Good Clinical Practice”, Wien, December 12-13, 2006 8.“ EMG Course”, “UMF Carol Davila”, Bucharest, 20069.“Research in Robotics Technology and Virtual Reality Applyed in Physiotherapy”, Bucharest, October 3, 200610.“Hospital Management”, Bucharest, September 18.- November 17, 2006 11.The Second International Course for Hand Surgery and Hand Therapy”, Cluj-Napoca, September 22-24, 200612.“35th Congress of the International Society of Medical Hydrology and Climatology”, Istanbul Turkey, June 6-10, 200613.External Auditory Course - Sistem of Quality Management SR EN ISO 9001/2001, SR EN ISO 19011/2003”, Bucharest – SIMTEX, february 6-10 200614.Future Perspectives of Thermalism an its Legislation in Europe and in Different Geo-

ADRIANA SARAH NICA/ROMANIA



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graphical Areas”, 9th World Days of Thermalism - 39th International SITH Congress - the Quality Systems, Levico Terme, 14-16.10.200515.“The First International Course for Hand Surgery and Hand Therapy”, Cluj-Napoca, September 23-25 , 200516.“Seminar on pathology of the Hand”, organised by UEMS SOROT si EFFORT, Cheile Gradistei, September 8-10, 200517.”Internal Auditory Course - Sistem of Quality Management SR EN ISO 9001/2001, SR EN ISO 19011/2003”, Bucharest – SIMTEX, August 10-12, 2005 18.Standards SR EN ISO 9001/2001”, seminary, Bucharest – SIMTEX, August 9, 200519.“Electrostimulation of the innervated and denervated skeletal muscle”, during the 14th European Congress of Physical and Rehabilitation Medecine, Wien, Austria, May 12-15, 200420.”Management of Educational Project”, Ministry of Health– CNPPMFA, June 9-13, 200321.“Training Trainers and Evaluators for Testing and Checking Laboratories”, 16-20 June 2003 – Certificate of Training RENAR22.ERASMUS Program – “Actualities in Biomecanic and Gate Analysis”, European School Marseille, France, June 1-11 200323.“4th Congress of Hand Surgery”, “5th National Congress of Reconstructive Micro Surgery”, 15-16.10.2002, Bucharest24.“International Workshop for Hand Rehabilitation”, Bucharest, 15-16 .10.2002 25.“Course of General Echography”, Competence in Ecography, UMF Carol Davila, June 28, 2002, Bucuresti 26.“Course for Training Trainers” – Diploma of Instructor Trainer in Rehabilitation, Physical Medicine and Balneoclimatology , Ministry of Health, May 200227.“5th ESRA WORKSHOP “NEURAL BLOCKADES ON CADAVERS” – Institute of Anat-omy, University of Innsbruck / Austria, February 21-23, 200228.,, Electromyography Testing, Evoked Potentials and EEG”, UMF ,,Carol Davila”, March 6-31, 200129.Competence in Pain Therapy”- National Institute for Traing of Pyisicians and Phar-macists, 4.12.200130.,,Paliative Medicine – An Compulsory Part of Today’s Medicine” -International Course of Romanian Society of Paliative Medicine and Tanatology”, Sinaia, oct 28-30, 199931.Building a Strong Foundation in Medical Rehabilitation, May 31–June 2, 1999, CARF – The Rehab. Accreditation Commission LUND, Sweden32.Competence in Biostimulation of Laser Therapy33.Competence in Pain Therapy34.« Reeducation Fonctionelle » Postgraduate training in Rehab, December 1991 – March 1992, Secretariat d’Etat Aux Handicapes et Accidentes de la Vie, Nancy, France35.“New Priorities for Health Care”– Management in Heath Sciences, Salzburg, June 199136.“Homeopathy” (1986-1988), “Acupuncture” (1983)

Scientific activity

Author of 4 booksChapters in published books - 9 chapters Author or coauthor of more than 200 papers published in national and international issuesResearch: project manager in 6 national projects, partner in 1 international projectKeynote speaker in international congresses and conferences: Verona (1995), Florence



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(2008), Bucharest (2007, 2008)Delegate of ISPRM WRD Commitee for ICF, 2011

Organiser of Scientific events

1. Monthly medical meetings of Department Rehabilitation, Physical Medicine, Balneoclimatology, Bucharest, University of Medicine and Pharmacy “Carol Davila” and Romanian society of Rehabilitation, Physical Medicine, Balneoclimatology, 2000-20122. ARSD Yearly National Symposia (Calimanesti 1996, Medias 1998, Sinaia 2000, Bucuresti 2002, Bucuresti 2004, Bucuresti 2006, 2007, 2008, 2010)3. Organising of International Course on ,,Pain Management” 2001, IASP –ARSD 4. Organising “Training of trainers in Rehabilitation” in partnership with National Centre for Training in Medicine and Health Sciences, 2001 Bucuresti5. Organising “Project management” Courses in partnership with Romanian Phy-sicians Colledge, 20036. Organising interdisciplinary symposia in connection with “Family Medicine – Rehabilitation” (1998, 1999, 2000, 2001); Orthopaedics – Rehabilitation (1999, 2000, 2006), Geriatrics – Rehabilitation (1997, 1999, 2001, 2003, 2007).7. Organising CEEPA Symposion, Praga, March 9-12, 20068. Organising Courses of “Project Management and Bioethic Issues in Research” in partnership with faculty of Medicine Oradea February 29- March 2,2008

Affiliation

- Romanian Association of Physical Medicine and Rehabilitation ISPRM (International Society of Physical & Rehabilitation Medicine (Board member since 2010)- Romanian Association for the Study of Pain (Past President) - Romanian Rheumatological Association- Romanian Association for Osteoporosis- Romanian Association for Laser- Romanian Association for Psycho-neuro-endocrinology- Romanian Association for Geriatry- I.A.S.P. - Fellow of Seminar Salzburg Society- EFIC (Councellar of the Board of European Federation International Corner Committee for Romania – 2006 - 2012)- Romanian Termography Medical Association (President)- Member of the PRM Commision in the Ministry of Health



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Education:Oct 1974 – June 1980 UMF “Iuliu Haţieganu”-Cluj, General practitioner1982 – prezent UMF “Iuliu Haţieganu”-Cluj, Project Manager, physician on rehabilita-tion, physical medicine, balneologyDegree : Doctor of Medicine Degree, Project Manager

Working experience: 24 years1982 – present Chair of Balneophysical Therapy and Medical Rehabilitation, UMF “Iuliu Haţieganu”-Cluj, Lecturer1982 – present Rehabilitation and Physical Medicine department, Clinical Rehabilita-tion Hospital, Head of DepartmentPresent working status and position: Clinical Rehabilitation Hospital, General Direc-tor, Head of DepartmentExperience in medical field : 22 years;Elaborated and/ or published research: most important projects:5 scientific projects: VIASAN, project participant, no. 128/2004

BOOKS, MONOGRAPHIES1.Alexandrina Nicu, I. Onac, Luminiţa Pop, Rodica Ungur, Laszlo Irsay, Liviu Pop/ sub redacţia Conf. Dr. Liviu Pop: Evaluare clinică articulară şi musculară, University Medical Publishing House „Iuliu Haţieganu” – Cluj, 2002.173 pages, B5 format, ISBN 973-8385-39-32.L. Irsay, L. Pop: Masajul medical clasic, suport DVD, ISBN 973-693-127-7, DACIN SARA 1060/2005, University Medical Publishing House „Iuliu Haţieganu” – Cluj, 20053.I.Onac: Masajul medical, University Medical Publishing House „Iuliu Hatieganu” Cluj-Napoca, 2009.13. Member of profesional associations: Romanian Society of Physical and Rehabilita-tion Medicine, European Society of Physical and Rehabilitation Medicine .14. Language knowledge: english, french.15. Other core copetences:16. Specialisation and qualification: physician, rehabilitation, physical medicine, balne-ology17. Cumulated experience other national/international programmes:

Active grants:1.PN-II-ID-PCE-2008-2 Grant, no.ID- 2623 /2008Studiul efectelor ultrasonoterapiei asupra balantei oxidanti/antioxidanti la pacientii artroziciRole : Member

Past grants:1.VIASAN Grant no.362/2004,2005-2006:Eficientizarea tratamentului artrozelor prin demonstrarea utilitatii condroprotectoare-lor pe plan clinico-functional, biologic si radiologicRole: Member2.CNCSIS Grant no. 1415/2006, 2006-2008:Ameliorarea calitatii vietii femeilor cu osteoporoza prin asocierea la medicatia os-teoporotica a metodelor balneofizioterapeutice si a unor practici de management, marketing socialRole:Member

IOAN ONAC/ROMANIA



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Lăcrămioara Perju-Dumbravă, MD, PhD is Professor of Neurology within the Neurosci-ences Department, Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Chairman of the First Neurology University Clinic, Cluj-Nap-oca, Romania. Her academic status includes her position as member of the Board of the Faculty of Medicine and of the University’s Senate, as well as Doctorate coordinator in the field of MEDICINE. Her prestigious activity includes: publishing of 3 monographs, co-authorship in other 7 speciality books, 168 scientific papers published in medical journals, chairman and speaker at annual national congresses and conferences, inter-national conferences and membership in editing committees and professional societies, involvement in several clinical studies, her expertise being sought by national medical councils and committees. LĂCRĂMIOARA

PERJU-DUMBRAVĂ/ROMANIA



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DAIANA POPA/ROMANIA

Personal data: Born in Cluj, in 1963 married,2 children Summary of qualification Senior Consultant in Physical and Rehabilitation MedicineSpecialist Registrar in Management and Public HealthPh.D Studies High School of Science, Cluj -NapocaUniversity of Medicine and Pharmacy Cluj, Faculty of General MedicineMD Bachelor Degree: 1988 Postgraduate studies Complementary studies in Acupuncture, Musculoskeletal Ultrasonography, Paleative Care, Occupational Therapy, Learning Disabilities, Project Management, Osteoporosis (International Certification in Osteo-densitometry), Health Services Management, Neuro-rehabilitation.International Exchange in The Netherlands, Germany, Austria, Portugal, Hungary Present Appointment Head of Dept. in Rehabilitation Hospital Felix Spa

Past Appointment 1988- 1991 : Attending Physician in Fundeni Hospital, Bucharest1991 - 1994: Resident in Physical and Rehabilitation Medicine - University Hospital Bucharest1994: certified as Specialist Registrar1996: lecturer in Oradea University, Faculty of Physical Therapy1994- 1998 : Junior Researcher in National Institute of Physical Medicine, Balneology and Rehabilitation1998 – present - Senior Consultant in Rehabilitation Hospital Felix Spa2007 – 2009 Medical Director of the Rehabilitation Hospital Felix Spa

Scientific Activity 8 papers published in International Journals (indexed in ISI)40 papers published in National Journals2 monographs2001: Ph.D Thesis “ Occupational Dexterity Assessment in Rheumatoid Arthritis” - University of Medicine and Pharmacy Cluj - Napoca2003 – 2006: Regional leader in International Project: “Facilitation and Participation of Young People With Disabilities in an Enlarged Europe” – Joint Action Project, Euro-pean Commission no. 113161 JA-1-2003) 2009 – 2013: Partner in the Cross-border Cooperation Project „Bihar County’s Health Care Contribution”

Professional memberships ISPRM (International Physical and Rehabilitation Medicine)WFOT (World Federation of Occupational Therapist)SRMFR (Romanian Society of Physical and Rehabilitation Medicine)OSART (Osteo-Arthrology Foundation)ASPOR (Romanian Osteoporosis Association)Commission of PRM in the Ministry of HealthEditorial Board of The Romanian Journal of Rheumatology and Romanian Journal of Physical and Rehabilitation Medicine



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Bogdan O. Popescu graduated the School of Medicine at ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, in 1996. Since 1997, he works as neurologist at the University Hospital Bucharest. Since 2004, Bogdan O. Popescu is the head of Molecu-lar Medicine Laboratory at ‘Victor Babes’ National Institute of Pathology in Bucharest. He graduated two PhDs, in Bucharest, in 2001, and in Stockholm, Sweden (Karolinska Institute) in 2004, with theses regarding apoptosis and cell signaling in neurodegen-eration. His scientific contribution refers mainly to mechanisms of neurodegenerative diseases (Alzheimer’s and Parkinson’s). He published 25 papers in ISI high impact factor journals, being cited more than 200 times in international publications and having a Hirsch index of 11. He is member of ENS, EFNS, MDS, ESO, Romanian Society of Neu-rology and National Society of Neuroscience. He was honored with the ‘Victor Babeș’ award for medical research by the Romanian Academy in 2007. In the last 10 years he served as General Secretary of the Romanian Society of Neurology and as Executive Editor of the Romanian Journal of Neurology.

BOGDAN O. POPESCU/ROMANIA



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Cristian Dinu POPESCU is a professor of Neurology at the University of Medicine and Pharmacy “Gr. T. Popa” Iasi. He graduated from the same University in 1975 and holds a PhD from 1991. He is the head of the Neurology Clinic in The Clinical Rehabilitation Hospital in Iasi, Romania, where he conducts his clinical and scientific activity.

Since 2008 he is chief of the Neurology Department and also the chief of the VI th Medical Chair of the Iasi Medical University.

He is a member of national and international professional associations (vice president of the Romanian Society of Neurology, member of the Society for Study of Neuropro-tection and Neuroplasticity, Society of Parkinson’s Disease and Movement Disorders, European Council of Neurological Rehabilitation, Balcanian Medical Union).

He was an invited speaker in most of the important national neurology scientific events during the last years.

He is a local coordinator for MS immunomodulatory treatment. He initiated and coor-dinated the organization of the National Multiple Sclerosis Conferences during the last 5 years.

He has authored or coordinated 5 books and took part in writing of 12 other books as coautohor, and more than 150 papers.His main fields of interest have been aging of the brain and its vascular system, multiple sclerosis, rehabilitation in stroke and other neurological diseases. Neurorehabilitation and neuroplasticity are among the main topics of concern, both in current clinical prac-tice and regarding the research activities.

His group was among the first to use functional electrical stimulation in Romania - current research targets applications and effects of FES in stroke, MS and Parkinson’s disease.

He is the coordinator of one of the first groups in our contry to use transcranian mag-netic stimulation in neurology – both in clinical practice (diagnostic and therapeuthical TMS) and for research (cortical neuroplasticity and neuromodulation).

C. D. POPESCU/ROMANIA



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I always considered myself an optimistic person but still there are certain things which Ifind depressing, and a CV is one of those things. Suddenly it is not about you anymore,but about a person who had a number of achievements which are rarely the things youfind interesting about yourself, and all your life is compressed in half a page.

I have graduated the University of Medicine and Pharmacy “Carol Davila” in Bucharestin 1987 and I started my career in neurology in 1991, as a resident in the Departmentof Neurology of the University Hospital Bucharest, the same place where now I am Associated

Professor and Head of the Stroke Unit. I have two favorite domains: vascularpathology and multiple sclerosis. My main interest is in cerebrovascular diseases, I amcoordinating a teaching course for cervical and cerebral ultrasonography and I followedthe European Master in Stroke Medicine Programme in Austria.

My involvement in MS field started in year 2000, when the first patients in Romaniawere treated with DMTs due to a constant effort (read fight) of three people: Prof. IoanPascu, Prof. Alexandru Serbanescu and Prof. Ovidiu Bajenaru. Since then, I have fol-lowed- up hundreds of patients with MS, and I am now the coordinator of the UniversityHospital Bucharest Center for the National Programme for treating the Patients withMultiple Sclerosis. I have participated, together with my colleagues in the majority ofthe main International Clinical Trials in MS in the last decade and we had also severaloriginal scientific work related to clinical aspects of MS patients. I am one of the tworepresentatives of the Romanian Society of Neurology in the Board of ECTRIMS.

In the end of my half page, I am looking forward to future goals: development of basicresearch in MS in Romania, a National MS Registry, better drugs, a better education forpatients and doctors, a better me…

CRISTINA TIU/ROMANIA



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Born on July 6th 1939, married, 3 children

1967 Diploma of neurophysiology (Faculty of Sciences, Paris)1970 Assistant, Hôpital de la Salpêtrière (Paris)1976 Professor of Neurology : University of Angers1977 Member of the French Society of Neurology1982 Assessor to the Dean : Medical Faculty of Angers1986 Head of Neurology Department : Foch Hospital (Paris-Suresnes)1987 Medico-legal Expert to the Court of Versailles1989 Founder of the European Brain Injury Society (E.B.I.S.); European Commission Research Contract on “ Traumatic Brain Injury Evaluation, Epidemiology and Service Delivery”

1990 Founder of Association Arceau-Anjou (TBI re-entry facilities) and of France Traumatisme Crânien (French National Association on TBI)1991 Editorial Board of Clinical Rehabilitation, Neuropsychological Rehabilitation, Brain Injury, the neurolaw letter, Acta Neuropsychologica1992 Expert to the World Health Organization1996 Creating the U.E.R.O.S.: 32 French Transitional Units for Evaluation, Retraining, and Social-Vocational re-entry for Persons with Acquired Brain Injury 2000 President of the International Joint Congress “Traumatic Brain Injury” organised by IBIA (International Brain Injury Association), EBIS (European Brain Injury), EMN (Euroacademia Multidisciplinaria Neurotraumatologica), SOFMER (French Society of Rehabilitation) and FTC (France Traumatisme Crânien) in Paris

2001 President of the jury : consensus conference « Traumatic Brain Injury : from coma to awareness » 20022002 Chairman of the QOLIBRI Task Force on TBI quality of life2003 Vice-President of EMN, EBIS and France Traumatisme Crânien2005 Project leader : Mild Traumatic Brain Injury (French Ministry of Health) ; Medical Adviser of ADEF-résidences for Facilities devoted to TBI, scientific council of IRME( Research Institute on spinal cord and brain injury), La Braise (Brussels) and Mulhouse Rehabilitation Centre; member of the jury of the consensus conference on TBI Re-entry and of the “Mosaïco” project in Verona. 2006 University diploma on mediation (Catholic University, Paris)CNRS (French National Centre for Scientific Research) associate member: unit « ce-rebral dysfunction, development and plasticity »; teacher in 5 university courses ( TBI, forensic medicine) 2011 Professor of mediation in health (University Diploma, Catholic University, Paris)

JEAN-LUC TRUELLE/FRANCE



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PRESENT APPOINTMENT

Professor (apl) for Neurosurgery Medical Faculty Westphalia Wilhelms- University ofMünster,Professor (apl) for Neurorehabilitation and Re-engineering of Brain and Spinal CordLesions,International Neuroscience Institute, INI, Hannover, Institute at Otto-von-Guericke University, Medical Faculty, Magdeburg, GermanyVisiting professor Armed Force and Rheumatic Rehabilitation Hospital EL AGOUZAMilitary Hospital Centre, Cairo, Egypt; China Rehabilitation Research Centre, CRRC,Beijing, PRCh

MEDICAL EDUCATION - QUALIFICATIONS:

1966 Graduation from the Medical Faculty of the J.W.Goethe-University Frankfurt/ Main1968 M.D.1975 Specialist Neurosurgeon, Department of Neurosurgery, Head Prof. Hugo Ruf1977 Postdoctoral lecture qualification (Habilitation), Dr.med. habil., in Neurosurgery1977- 1984 Assistant Professor Med. Faculties of the Universities of Frankfurt and Hanover Consultant Neurosurgical Department Academic Public Hospital Nordstadt, Director Prof Madjid Samii, Hanover1982- 2002 Director Neurosurgical Clinic Clemens Academic Hospital, Med. Faculty Muenster1984 Professor Medical Faculty University Münster, North Rhine Westphalia, Germany1993- 2002 Founder & Head Special Department for Early Neurorehabilitation in Neurosurgery, Licence for education and board examination for neurosurgeons of the medical association in Neurosurgical intensive care, Clinical laboratory medicine in neurosurgery, Neuroradiology, Electroencephalography, Treatment of Pain, Physical Training Dr von Wild has personally performed more than 5000 major operations of CNS and PNS lesions with special interest in pituitary adenomas & tumours of the sella region & the cavernous sinus , CPA tumours , tumours of the spinal cord, brain stem cavernomas; Intramedullary tumours of the spinal cord; all kind of spinal surgery. Birth traumatic spinal cord and brachial plexus lesions;transdisciplinary neurotraumatology and functional reconstruction in cooperation with Reconstructive trauma-, Earnose and through-, Head and Neck, Thoracic-, Maxilla facial, and Eye surgeons.At present: Functional restoration of locomotion in paraplegics by FES implanted neuroprosthesis and via central nervous system- peripheral nervous system (CNS_PNS) by pass grafting procedure following SCI; Neuro modulation of patients in coma and VS State

KLAUS VON WILD/GERMANY



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CLINICAL RESEARCH:

Organizer & President of numerous national and international congresses, workshopsand coursesGuidelines On Quality management in neurotraumatology, functionalneurorehabilitation, and outcome:

The German Coma Remission Scale (CRS) In Schmidek, HH (ed) 2000: Operative neurosurgical techniques, 4th edition, Vol. 1, Saunders Comp, Philadelphia, US, pp 45-60 Guidelines on Early Neurological-Neurosurgical Rehabilitation See Acta Neurochir Suppl. 79, 11-19, 2001 Guidelines on Management of Poly -traumatised Patients . See The German Interdisciplinary Association for Intensive Care Medicine (DIVI) 1998, only in German Guidelines on Mild Traumatic Brain Injury, European J. Neurology, 2002, No 9,207-219) Revised Guidelines on MTBI Early Management, See EFNS MTBI Taskforce in EFNS Hand book of neurology 2006, Guidelines on quality management for AS/VS European Journal of Trauma Emerg Surg. 2007, No3:268-292 The QOLIBRI : Quality of Life after traumatic brain injury assessment tool See von Steinbüchel N et al 2005 in Acta Neurochirurgica Supp.93, pp 43-49

PRESET

Quality management of multidisciplinary neurotraumatology and brain protectionQuality management and amelioration of patients in long-lasting coma and AS/VSNeuromodulation in paraplegics after SCI; Exernal audit for cell-transplantationNeuroethics; Long term outcome, HRQoL, and social re-entry following TBI

DISTINCTION

Professor honoris causa (h..c.) for Neurorehabilitation and Reconstructive Neurosurgery Faculty of Physical Rehabilitation at Al Azhar University, Cairo, EgyptDoctor honoris causa (Dr.h.c.) at the Faculty of Medicine and Pharmacology, „Iuliu Hatiegau“ University, Cluj- Napoca, Romania Honorary (& founding) President EMN, Euroacademy, and AMN, World Academy of Multidisciplinary neurotraumatology;Honorary President Romanian Society of Neurorehabilitation RoSNeRa ; Corresponding Fellow The Cuban Society ofNeurophysiology (SCNFC); Honorary Chair-man WFNS Committee Neurorehabil. & Reconstructive Neurosurgery; Honorary Chair-man EFNS Panel NeurotraumatologyHonorary Member (former President)German Soc. Neurotraumatology & Neurorehab.Honorary Member of the Austrian Society , the Lithunian Society, the Polish, the Ro-manian Society of Neurosurgery, the Russian Federation of Neurosurgical Societies; The Cuban Neurological Society, Egyptian and Pan Arab Societies for Neurorehabilitation, the Japanese Society for Neural Repair and Neurorehabilitation



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SCIENTIFIC SOCIETIES / PRESENT DUTIES

Since 2001 WFNR Executive Board , World Federation for Neurorehabilitation,Since 2009 EBIS 1st Vice-President , European Brain Injury Society,IANR Scientific Executive Board, International Association of NeurorestoratologySince 2008/9 Treasurer (Founding Member) International QOLIBRI Society, CNM,International Society for Clinical Neuromusicology, EFNR Europ. Federation Neurore-habilitationSince 2003 AMN Secretary General, World Academy of Multidisciplinary Neurotrau-matology,Director (CEO) kvw neuroscience consulting GmbH Muenster, DFounding Member & Member of the Presidium: ISRN International Society ofReconstructive Neurosurgery ;MASCIN, Madjid Samii Congress of International Neurosurgeons; ESCRI Europ.Spinal Cord Research Institute Giorgio Brunelli Foundation, Brescia, Italy;Founding Member . DANC/GANS German Academy of Neurosurgery; BDNC, German Social Professional organisation of neurological surgeons.



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Documents

2nd EuropeanTeaching Course - on Neurorehabilitation