public talk

“Memory in Aging with and without

Parkinson’s Disease”Speaker:Tazrina Alrazi (PhD student at the PCAN Lab) University of CalgaryCumming School of MedicineClinical Neuroscience Department

Dr. James Parkinson

Parkinson’s Disease (PD)

Epidemiology of Parkinson’s Disease

• Parkinson’s disease (PD) is the second most common

neurodegenerative disorder in the world

• In North America, the prevalence of PD is 107-187 per 100,000

population

• The most alarming non-motor PD complication is dementia (PDD)

Epidemiology of Parkinson’s Disease Dementia

• PDD can affect up to 50% of patients 10 years after diagnosis and over 80% by 20

years

• Dementia risk is almost six times higher in PD patients than in age-matched healthy

controls

• Severely affects quality of life, independent activities of daily living, and

interpersonal relationships

Mild Cognitive Impairment (MCI)Normal Cognition

Mild Cognitive ImpairmentDementia:-Alzheimer’s dementia-Lewy body dementia-Frontotemporal dementia-Parkinson’s dementia-Vascular dementia

Mild Cognitive Impairment (MCI)MCI encompasses all 5 cognitive domains

Executive functions

Attention

Visuo-spatial and visuo-perceptual functions

Language

Memory

Epidemiology of Mild Cognitive Impairment in Parkinson’s Disease

• 26.7% (range 18.9–38.2%) of non-demented PD patients have PD-MCI

• Janvin et al. found 62% of PD-MCI patients

converted to PDD over a 4-year period

Pathophysiology of Cognitive Impairment in PD

Associative Memory

Associative memory tasks demand high efficiency of the medial temporal lobe

Associative Memory Task•FAST (FACE ASSOCIATED SCENE TASK)

Our Volunteers (Study Groups) Participants:

Parkinson’s disease, no mild cognitive impairment PD (non-MCI) (35)Parkinson’s disease with mild cognitive impairment PD-MCI (65)Mild cognitive impairment, no Parkinson’s disease MCI (non-PD-MCI)

(65)Healthy Controls (age-matched to patients) HC (35)

Importance of This Research

Pioneering research

Lets Test Memory

Memorizing Phase Begins

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Decision Making Phase Begins

Do you recall seeing these pictures?

Together

GREAT JOB!!!!!