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“Memory in Aging with and without
Parkinson’s Disease”Speaker:Tazrina Alrazi (PhD student at the PCAN Lab) University of CalgaryCumming School of MedicineClinical Neuroscience Department
Dr. James Parkinson
Parkinson’s Disease (PD)
Epidemiology of Parkinson’s Disease
• Parkinson’s disease (PD) is the second most common
neurodegenerative disorder in the world
• In North America, the prevalence of PD is 107-187 per 100,000
population
• The most alarming non-motor PD complication is dementia (PDD)
Epidemiology of Parkinson’s Disease Dementia
• PDD can affect up to 50% of patients 10 years after diagnosis and over 80% by 20
years
• Dementia risk is almost six times higher in PD patients than in age-matched healthy
controls
• Severely affects quality of life, independent activities of daily living, and
interpersonal relationships
Mild Cognitive Impairment (MCI)Normal Cognition
Mild Cognitive ImpairmentDementia:-Alzheimer’s dementia-Lewy body dementia-Frontotemporal dementia-Parkinson’s dementia-Vascular dementia
Mild Cognitive Impairment (MCI)MCI encompasses all 5 cognitive domains
Executive functions
Attention
Visuo-spatial and visuo-perceptual functions
Language
Memory
Epidemiology of Mild Cognitive Impairment in Parkinson’s Disease
• 26.7% (range 18.9–38.2%) of non-demented PD patients have PD-MCI
• Janvin et al. found 62% of PD-MCI patients
converted to PDD over a 4-year period
Pathophysiology of Cognitive Impairment in PD
Associative Memory
Associative memory tasks demand high efficiency of the medial temporal lobe
Associative Memory Task•FAST (FACE ASSOCIATED SCENE TASK)
Our Volunteers (Study Groups) Participants:
Parkinson’s disease, no mild cognitive impairment PD (non-MCI) (35)Parkinson’s disease with mild cognitive impairment PD-MCI (65)Mild cognitive impairment, no Parkinson’s disease MCI (non-PD-MCI)
(65)Healthy Controls (age-matched to patients) HC (35)
Importance of This Research
Pioneering research
Lets Test Memory
Memorizing Phase Begins
Do you like the pair?
Unsure
Unsure
Decision Making Phase Begins
Do you recall seeing these pictures?
Together
GREAT JOB!!!!!
