NIH: A Time of Unprecedented Opportunity Senate Appropriations Subcommittee on Labor/HHS/Education...

NIH: A Time of Unprecedented Opportunity

Senate Appropriations Subcommitteeon Labor/HHS/Education

Elias A. Zerhouni, M.D.Director

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Preem

ptiveThe Future Paradigm: The 4 P’s

Transform Medicine from Curative to Preemptive

Normal Gene FunctionHealthy StateA

E

D

C

BA

B

CD

E

A

E

D

BA

B

CD

E

Disrupted Gene FunctionDisease StateA

E

D

C

B

CC

C

A

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D

BA

B

D

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Disrupted Gene FunctionDisease State

CC

D

A E

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Manolio, Brooks, Collins, Manolio, Brooks, Collins, J Clin Invest J Clin Invest 2008; 118:1590-625.2008; 118:1590-625...

200520062007 first quarter2007 second quarter2007 third quarter2007 fourth quarter2008 first quarter

Toward a New Era in Medicine:Genome-wide Association Discoveries

Second quarter 2008

Type 2 Diabetes10 years ago: 0 genes5 years ago: 2 genes

Today: 16 genes

AutismLast week: 6 new genes discovered

Credit: Arthur Toga/UCLA/Photo Researchers Inc.

Goal: To systematically explore the entire spectrum of genomic changes involved in human cancer

Current study: Lung, glioblastoma, and ovarian cancers

Finding: Three new genes discovered mutated in glioblastoma

Glioblastoma

Opportunities in Cancer Research:New Genomic Clues

Initial Genome-Wide Association StudyClues

Analyzing More Populations and More GenesLeads

Understanding the BiologyTargets

Translation

Diagnostics Therapeutics

What Are the Next Steps?How Do Scientists Unravel the Mystery?

Prevention Strategies

NIH Transforming medicine and health through discovery