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NIH: A Time of Unprecedented Opportunity Senate Appropriations Subcommittee on Labor/HHS/Education Elias A. Zerhouni, M.D. Director. The Future Paradigm: The 4 P’s Transform Medicine from Curative to Preemptive. Personalized. Predictive. Preemptive. Participatory. A. B. C. D. E. - PowerPoint PPT Presentation
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NIH: A Time of Unprecedented Opportunity
Senate Appropriations Subcommitteeon Labor/HHS/Education
Elias A. Zerhouni, M.D.Director
PersonalizedP
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Participatory
Preem
ptiveThe Future Paradigm: The 4 P’s
Transform Medicine from Curative to Preemptive
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Disrupted Gene FunctionDisease StateA
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Manolio, Brooks, Collins, Manolio, Brooks, Collins, J Clin Invest J Clin Invest 2008; 118:1590-625.2008; 118:1590-625...
200520062007 first quarter2007 second quarter2007 third quarter2007 fourth quarter2008 first quarter
Toward a New Era in Medicine:Genome-wide Association Discoveries
Second quarter 2008
Type 2 Diabetes10 years ago: 0 genes5 years ago: 2 genes
Today: 16 genes
AutismLast week: 6 new genes discovered
Credit: Arthur Toga/UCLA/Photo Researchers Inc.
Goal: To systematically explore the entire spectrum of genomic changes involved in human cancer
Current study: Lung, glioblastoma, and ovarian cancers
Finding: Three new genes discovered mutated in glioblastoma
Glioblastoma
Opportunities in Cancer Research:New Genomic Clues
Initial Genome-Wide Association StudyClues
Analyzing More Populations and More GenesLeads
Understanding the BiologyTargets
Translation
Diagnostics Therapeutics
What Are the Next Steps?How Do Scientists Unravel the Mystery?
Prevention Strategies
NIH Transforming medicine and health through discovery