Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM...

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Molecular testing in NSCLC.

P.Pauwels (UZA/UZG)

EGFR

• Exist as monomers

• Binds ligand, changes shape and homo/hetero-dimerize

• Autophosphorylation of tyrosine residues

• Recruitment of adaptor/signaling molecules

• Downstream signalingPao & Miller JCO 2005;23:2556-2568

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