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Molecular testing in NSCLC. P.Pauwels (UZA/UZG)

Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …

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Page 1: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …

Molecular testing in NSCLC.

P.Pauwels (UZA/UZG)

Page 2: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 3: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 4: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 5: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 6: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 7: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 8: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 9: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …

EGFR

• Exist as monomers

• Binds ligand, changes shape and homo/hetero-dimerize

• Autophosphorylation of tyrosine residues

• Recruitment of adaptor/signaling molecules

• Downstream signalingPao & Miller JCO 2005;23:2556-2568

Page 10: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 11: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 12: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 13: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 14: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 15: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 16: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 17: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 18: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 19: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 20: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 21: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 22: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 23: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 24: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 25: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 26: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 27: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 28: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 29: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 30: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 31: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 32: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 33: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 34: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 35: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 36: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 37: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …
Page 38: Molecular testing in NSCLC....PM->EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS? AP2A1 …

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