Introduction Controlling Laboratory Biorisks Training Course International Biological Threat...

Introduction

Controlling Laboratory Biorisks Training CourseInternational Biological Threat Reduction Program

Global Security Programs

Sandia National Laboratories

Albuquerque, NM USA

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SAND No. 2008-0480PSandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company,

for the United States Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.

Sandia National Laboratories Provides innovative, science-based, systems-engineering solutions

to the most challenging national and international security problems

Physics 8%

Other Fields 11%

Other Engineering

14%

Mechanical Engineering

15% ElectricalEngineering

25%

Biology 6%

Computing 11%

Chemistry7%Math 3%

• Over 8,500 employees• Over 1,500 PhDs• Over 2,500 MS/MA• Over 1,000 on-site

contractors• Annual operating

budget ~$2 billion

Sandia’s Global Security Center Reduces current and emerging proliferation and terrorism threats

by creating sustainable system solutions through international cooperation

US/Russia Nuclear SecurityReducing the risk of theft or diversion of Russian nuclear weapons, materials, and related expertise

Nuclear Nonproliferation/International Physical SecurityPreventing the proliferation of weapons of mass destruction by enhancing International Safeguards,and promoting the peaceful usesof nuclear technology

Border SecurityDetecting, deterring, and interdicting

nuclear smuggling acrossinternational borders

Regional SecurityDeveloping technical solutions

to regional security problems

Biological/ChemicalThreat ReductionReducing biological and chemical threats globally by focusing on safety and security of legitimate materials

Sandia’s International Biological Threat Reduction

• IBTR’s mission: To enhance United States and international security by reducing biological threats worldwide

• IBTR’s highest goals• Enhance safety, security, and containment of

dangerous biological agents in bioscience facilities

• Strengthen capacities to detect and control dangerous biological agents

• Improve understanding and mitigation of biological threats

IBTR Technical Program Areas

Laboratory Biosafety, Biosecurity, and Biocontainment

Infectious Disease Diagnostics and Control

Training and Workshops

Policy, Regulatory, and Guidelines Support

Assessments and Analysis

Extensive collaboration with

US Government agencies

Extensive collaboration with international organizations

• •

Course Overview

• Biorisk Management

• Assessment• Mitigation• Performance

• Lectures• Case studies• Guided class discussions• Lab activities• Group presentation• Course assessments

• Pre-course assessment• Daily quizzes • Post-course assessment

Case Studies

• Case studies will be done in the same small groups for the week• You will complete all case studies as a member of the “Facility

Biorisk Committee”• Biorisk officer• Laboratory manager• Principal investigator• Facilities, operations & maintenance representative

• Through the series of case studies, the “Facility Biorisk Committee” is tasked with doing a risk assessment and developing a risk mitigation plan

• On Day 5, your “Facility Biorisk Committee” will present your risk assessment and risk mitigation plan

Pre-Course Test

Group Exercise #1

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In your group take 10 minutes to discuss and answer the following question:

What are the risks of working in a laboratory with biological materials?

Report your answers to the class.

Group Exercise #2

In your group, take 10 minutes to discuss and answer the following three questions:

• How did you identify these risks?

• Which steps do you take to minimize these risks?

• How do you know these steps are working?

Use post-it notes to write down your answers and post them on the empty board.

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Group Exercise #3

Let’s get organized…

Take the post-it notes and place them under one of the following columns:

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Assessment PerformanceMitigation

Biorisk

• The risk associated with biological materials in the laboratory has a safety and a security component.

• The concept of Biorisks encompasses both Biosafety and Biosecurity.

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What are Laboratory Biosafety and Biosecurity?

• Biosafety Risk• The risk of accidental exposure to or

release of a biological hazard

• Biosecurity Risk• The risk of intentional removal (theft)

of a valuable biological material

• How do we best manage these Biorisks?

Yersinia pestis

Francisella tularensis

Key Components of Biorisk Management

• Biorisk Management has three key components:

• Risk Assessment

• Risk Mitigation

• Performance / Quality Control

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Biorisk Management: The AMP Model

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Next Steps…

During the next sessions we will refer back to the AMP model and individually address the three components

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