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Introduction
Controlling Laboratory Biorisks Training CourseInternational Biological Threat Reduction Program
Global Security Programs
Sandia National Laboratories
Albuquerque, NM USA
PhysicalSecurity
Personnel
Security
Material C
ontrol
& Accountabilit
yTransport
Security
Info
rmat
ion
Sec
urity
SAND No. 2008-0480PSandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company,
for the United States Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.
Sandia National Laboratories Provides innovative, science-based, systems-engineering solutions
to the most challenging national and international security problems
Physics 8%
Other Fields 11%
Other Engineering
14%
Mechanical Engineering
15% ElectricalEngineering
25%
Biology 6%
Computing 11%
Chemistry7%Math 3%
• Over 8,500 employees• Over 1,500 PhDs• Over 2,500 MS/MA• Over 1,000 on-site
contractors• Annual operating
budget ~$2 billion
Sandia’s Global Security Center Reduces current and emerging proliferation and terrorism threats
by creating sustainable system solutions through international cooperation
US/Russia Nuclear SecurityReducing the risk of theft or diversion of Russian nuclear weapons, materials, and related expertise
Nuclear Nonproliferation/International Physical SecurityPreventing the proliferation of weapons of mass destruction by enhancing International Safeguards,and promoting the peaceful usesof nuclear technology
Border SecurityDetecting, deterring, and interdicting
nuclear smuggling acrossinternational borders
Regional SecurityDeveloping technical solutions
to regional security problems
Biological/ChemicalThreat ReductionReducing biological and chemical threats globally by focusing on safety and security of legitimate materials
Sandia’s International Biological Threat Reduction
• IBTR’s mission: To enhance United States and international security by reducing biological threats worldwide
• IBTR’s highest goals• Enhance safety, security, and containment of
dangerous biological agents in bioscience facilities
• Strengthen capacities to detect and control dangerous biological agents
• Improve understanding and mitigation of biological threats
IBTR Technical Program Areas
Laboratory Biosafety, Biosecurity, and Biocontainment
Infectious Disease Diagnostics and Control
Training and Workshops
Policy, Regulatory, and Guidelines Support
Assessments and Analysis
Extensive collaboration with
US Government agencies
Extensive collaboration with international organizations
• •
Course Overview
• Biorisk Management
• Assessment• Mitigation• Performance
• Lectures• Case studies• Guided class discussions• Lab activities• Group presentation• Course assessments
• Pre-course assessment• Daily quizzes • Post-course assessment
Case Studies
• Case studies will be done in the same small groups for the week• You will complete all case studies as a member of the “Facility
Biorisk Committee”• Biorisk officer• Laboratory manager• Principal investigator• Facilities, operations & maintenance representative
• Through the series of case studies, the “Facility Biorisk Committee” is tasked with doing a risk assessment and developing a risk mitigation plan
• On Day 5, your “Facility Biorisk Committee” will present your risk assessment and risk mitigation plan
Pre-Course Test
Group Exercise #1
9
In your group take 10 minutes to discuss and answer the following question:
What are the risks of working in a laboratory with biological materials?
Report your answers to the class.
Group Exercise #2
In your group, take 10 minutes to discuss and answer the following three questions:
• How did you identify these risks?
• Which steps do you take to minimize these risks?
• How do you know these steps are working?
Use post-it notes to write down your answers and post them on the empty board.
10
Group Exercise #3
Let’s get organized…
Take the post-it notes and place them under one of the following columns:
11
Assessment PerformanceMitigation
Biorisk
• The risk associated with biological materials in the laboratory has a safety and a security component.
• The concept of Biorisks encompasses both Biosafety and Biosecurity.
12
What are Laboratory Biosafety and Biosecurity?
• Biosafety Risk• The risk of accidental exposure to or
release of a biological hazard
• Biosecurity Risk• The risk of intentional removal (theft)
of a valuable biological material
• How do we best manage these Biorisks?
Yersinia pestis
Francisella tularensis
Key Components of Biorisk Management
• Biorisk Management has three key components:
• Risk Assessment
• Risk Mitigation
• Performance / Quality Control
14
Biorisk Management: The AMP Model
15
Next Steps…
During the next sessions we will refer back to the AMP model and individually address the three components
16