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7/24/2019 HO Kuliah 3 - Innate Immune System - Cellular
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Dr. Ongko Susetia Totoprajogo MNs, Sp.GK
Jurusan D IV gizi
Poltekes Kemenkes
Malang
!"#
Innate immune s$stem
%&ellular '
(e)ture *
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The Purpose of this lectureStudents will understand :
1) The cellular immune system as a part of innate immune system.
2) Innate immune system consists of : Physico chemical barrier,
circulating molecule (complement) , cell (Macrophage, Natural
killer cell, monocyte, and granulocyte)and soluble mediators
(cytokines).
3) Phagocytosis proses inoling : Toll li!e receptor, opsonin, "ntigen
presenting cell ("P#) and cyto!ine production.
$) "ntigen presenting cell "P#) to T lymphocyte through the role of
ma%or histocompatibility comple& ('#) and #luster of
differentiation (#).
*) The role of natural !iller cells (+-cells).
) The relationship bet/een innate 0 adaptie immune system.
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Outline
1. Introduction.
2. Innate immune system
3. Innate to adaptie immune system
$. Phagocytosis
". Toll li!e receptor
. psoniation
#. #omplement 4 ne&t lecture
i. 'embrane attac! comple& ('"#) - ne&t lecture
ii. Pore formation - ne&t lecture
*. "ntigen presenting cell ("P#)
. 'a%or histocompatibility comple& ('#) 5 uman leucocyte
antigen (6")
7. +atural !iller cell (+ cell)
8. Innate to adaptie immune response.
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Immune system
Innate Adaptive
(Acquired)Physico chemicalbarrier
Skin
Mucous membrane
Lysozyme
Stomach acid
Commensal bacteria
Cutaneous & mucosalimmune system (!AL"#MAL"# ect)
Antibodies in mucosal
secretionsSecretory I$A%
#irculating molecules Complement Antibodies
#ells !ranulocytes
Monocytes macropha$e
'atural killer cells
Lymphocytes ( and ")
9oluble mediators Macropha$e derivedcytokines
Lymphocytes derivedcytokines
Gibney. M.J; 2003; Nutrition & metabolism; page: 285
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Adaptive(Specifc)
2line o deenseProtects/
re-exposure
HumoralComponents
Innate(onspecifc)
!line o deense
CellularComponents
CellularComponents
HumoralComponents
ImmuneS"stem
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&ellular immune s$stem + one marro-
origin
%Stem )ell origin'
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Immune cells description
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Innate immune system
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Skin
Mucose in GI tract
HCl in gaster
Complement
Leucocytes
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Mu)us + &iliate epit/elial )ells
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Pago!ytosis : "e pro!ess o# internali$ation antigen by Pago!yti! !ells
% Mononu!lear !ells: Mono!yte ma!ropage;
Polymorponu!lear: Granulo!ytes' intera!ting (it
!omplement & spe!i#i! immune system.
)psonisation : substrate tat #a!ilitate te pago!ytosis pro!ess.
%*omplement *+rea!ti,e protein- *P antibo/y'.
*ytoines : Pepti/e or Gly!oprotein me/iators ranging #rom 1.000 to 10.000
ilo/altons mole!ular (eigt tat a!t as inter!ellular signals.
Pro/u!e/ by " & ympo!ytes %ympoines'; by Mono!ytes
emopoeti! *4s inter#erons !onne!ti,e tissue gro(t #a!tors
%Monoines'.
efinitions
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Immune system
Innate Adaptive
(Acquired)Physico chemicalbarrier
Skin
Mucous membrane
Lysozyme
Stomach acid
Commensal bacteria
Cutaneous & mucosalimmune system (!AL"#MAL"# ect)
Antibodies in mucosalsecretions
Secretory I$A%
#irculating molecules Complement Antibodies
#ells !ranulocytesMonocytes macropha$e
'atural killer cells
Lymphocytes ( and ")
9oluble mediators Macropha$e derivedcytokines
Lymphocytes derivedcytokines
Gibney. M.J; 2003; Nutrition & metabolism; page: 285
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P/ago)$tosis
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Toll like re)eptor %T(0'
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O li
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Outline
1. Introduction.
2. Innate immune system
3. Phagocytosis
". Toll li!e receptor
. psoniation
#. #omplement 4 ne&t lecture
i. 'embrane attac! comple& ('"#) - ne&t lecture
ii. Pore formation - ne&t lecture
$. "ntigen presenting cell ("P#)
*. 'a%or histocompatibility comple& ('#) 5 uman leucocyte
antigen (6")
. +atural !iller cell (+ cell)
7. Innate to adaptie immune response.
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P/ago)$tosis
6ire!t
In+6ire!t
7ntibo/y
4ur#a!e re!eptor
4ur#a!e antigen
Killi i t/ / P/ t i
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Killing mi)roes t/roug/ P/ago)$tosis pro)ess
1
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P/ago)$tes 1 )$tokines prou)tion
uring in2lammation
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Complement
3ill e is)use on t/e ne4t le)ture
5 ti ti ll 5P&
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5ntigen presenting )ell 6 5P&
P/ t i l 5 ti ti
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P/ago)$tosis + l$sosome + 5ntigen presenting
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Major /isto7)ompatiilit$ )omple4 6 M8&
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M8& 6 8(5
3/at is &D
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3/at is &D
In molecular biology,
C!(cluster of differentiation$)
is a glycoproteinfound on the surface of
immune cells such as :
1. T helper cells,
2. monocytes,
3. macrophages, and$. dendriticcells.
#$ is a co-receptorthat assists the T cell receptor(T#)
in communicating /ith an antigen-presenting cell.
Pat/-a$ to antigen presentation
http://en.wikipedia.org/wiki/Molecular_biologyhttp://en.wikipedia.org/wiki/Cluster_of_differentiationhttp://en.wikipedia.org/wiki/Glycoproteinhttp://en.wikipedia.org/wiki/T_helper_cellhttp://en.wikipedia.org/wiki/Monocyteshttp://en.wikipedia.org/wiki/Macrophageshttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Co-receptorhttp://en.wikipedia.org/wiki/T_cell_receptorhttp://en.wikipedia.org/wiki/Antigen-presenting_cellhttp://en.wikipedia.org/wiki/Antigen-presenting_cellhttp://en.wikipedia.org/wiki/T_cell_receptorhttp://en.wikipedia.org/wiki/Co-receptorhttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Dendritic_cellshttp://en.wikipedia.org/wiki/Macrophageshttp://en.wikipedia.org/wiki/Monocyteshttp://en.wikipedia.org/wiki/T_helper_cellhttp://en.wikipedia.org/wiki/Glycoproteinhttp://en.wikipedia.org/wiki/Cluster_of_differentiationhttp://en.wikipedia.org/wiki/Molecular_biology7/24/2019 HO Kuliah 3 - Innate Immune System - Cellular
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Pat/-a$ to antigen presentation
M8& 6 8(5 )lass " 1 )lass
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M8& 6 8(5 )lass " 1 )lass
&D 9 1 &D#
MHC " C$ C ll killi
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MHC " # C$ # Cell killing
Ma)rop/age 7 5P& + M8& II -it/ &D # T + l$mp/o)$te
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Ma)rop/age 7 5P& + M8& II -it/ &D # T + l$mp/o)$te.
Macrophage T lymphocyte
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Natural killer )ell
Target cell
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%atural killer cell%& cell
&iller cellTarget cell
'infected with a (irus
Target orientedgranules
eath of )othinfected cell * (irus
Surface contact
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Innate to adaptie immune system.
2
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(eu)o)$te mo:ement 2rom loo :essel
Intra (ascular
Innate to aapti:e immune s$stem
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Innate to aapti:e immune s$stem
"P#
Complement system
Mem)rane attackcomple+ 'M,C-
Cell lysis
Innate
5apti:e
T/e kineti)s o2 t/e innate 1 aapti:e immune response
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p p
(ater response T l$mp/o)$te
a)ti:ation
Initial response
&ellular
P/$si)o7)/emi)al
arrier
&ir)ulating
mole)ule
&ir)ulating
mole)ule
&ellular
Immune system
0esume;
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y
Innate Immune system "daptie immune system
#ellular#irculating molecule(Next lecture)
'acrophage
"P#
endrit cell
cell
T lymphocyte 4 Th;
Th 2Th 1
cell
MHC I -II
CD4 -8
0esume;
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