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hepatitis D
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Hepatitis D
Hepatitis DEpidemiologi Spread most commonly by percutaneous or permucosal exposure- Perinatal transmission reported but rare More prevalent in Mediterranean countries, Romania, some isolatedareas in the Amazon River basin Clinical Features Coinfection with HBV- Fulminant hepatitis more common (2-20%)- Less commonly become HBsAg carriers Superinfection in chronic HBV- More likely to develop chronic HDV infection- 70% develop cirrhosis (2-5 times more frequent thanwith HBV alone) Incubation period probably the same as HBVSerologic Diagnosis1. IgM anti-HDV is present transiently in most with acute HDV infectiona. 40-50% positive within 2 weeks of infectionb. Persists at a low level in chronic HDV infection2. IgG anti-HDV develops in both co-and superinfected cases
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