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Molecular–cellular mechanisms of adrenal and sex glands hormones action. Eucosanoids: prostoglandins, tromboxans, leucotriens. EPINEPHRINE GLANDS. Two parts : - cortex - medulla. Hormones of medulla - catecholamines. Epinephrine , norepinephrine and DOPA - PowerPoint PPT Presentation
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Molecular–cellular mechanisms of adrenal and sex glands hormones action. Eucosanoids: prostoglandins,
tromboxans, leucotriens.
EPINEPHRINE GLANDS Two parts:
-cortex-medulla
Hormones of medulla - catecholamines
Epinephrine, norepinephrine and DOPA Nature – derivatives of tyrosine Excretion is regulated by sympathetic
nervous system and brain cortex
Norepinephrine Epinephrine
Stress and The Adrenal Glands
Functions:Stress hormones. Contraction of vessels,
increase the blood pressure, accelerate pulse. Contraction of uterus muscles. Epinephrine relaxes the muscles of bronchi and intestine.
On carbohydrate metabolism:-activates the decomposition of glycogen in liver
and muscles-activates glycolysis, PPC, TAC and tissue
respirationOn protein metabolism-accelerate the decomposition of proteinsOn lipid metabolism-activates lipase, mobilization of lipids and their
oxidation
Hormones of cortex - corticosteroids
There are more than 50 corticosteroids Nature – steroids Are synthesized from cholesterol
Two groups-glucocorticoids (protein, carbohydrate
and lipid metabolism)-mineralocorticoids (mineral metabolism)
Glucocorticoids
Most important: corticosteron, cortison, hydrocortison
Synthesis is regulated by ACTHAre transported combined with proteinsHalf-life time – till 1 hourIn the decomposition17-ketosteroids
are formed (excretion with urine). Diagnostic significance – index of the function of cortex of epinephrine glands and testis
Adrenals
Kidney
Posterior Pituitary Gland
Hypothalamus
AnteriorPituitary Gland
ACTH
Stress Circadian
rhythm
CRH
(-)
Glucocorticoids, Catecholamines, etc..
Glucocorticoids, Catecholamines, etc..
Muscle: Net loss of aminoAcids (glucose)
Liver: Deamination of
proteins into amino acids,
gluconeogenesis (glucose)
Fat Cells: Free fatty
acid mobilization
Heart rate: Increased
Immune system: altered
Hypothalamopituitary adrenal (HPA) axis: Negative Feedback
Glucocorticoid Analogues
Functions
• Antiinflammatory, antiallergic, antiimmune
• Adaptive effect• Maintain the blood pressure• Maintain the volume of extracellular
liquid
Effect on protein metabolism
• Stimulate catabolic processes in connective, lymphoid and muscle tissues
• Activate protein synthesis in liver• Stimulate amino transferases• Stimulate the urine biosynthesis
Effect on the carbohydrate metabolism
Increase the glucose level• Activate gluconeogenesis• Inhibit hexokinase (glycolisis)
Effect on the lipid metabolism
• Activate lipolysis• Activate the conversion of FA
into carbs
MineralocorticoidsThe most important hormone:
aldosteronExcretion is controlled by rhenin-
angiothensin systemFunctions:-activate the
reabsorption of Na, water and Cl in kidney canaliculi
- Promotes the excretion of К ions via the kidneys, skin and saliva
Aldosteron
Disorders of the function of epinephrine gland
cortexInsufficiency: Addison disease
(bronze disease)Causes: -injury of epinephrine gland cortex-insufficient production of ACTHBlood pressure
decrease, loss of weight, weakness, anorexia.Hyperpigmentation - bronze skin
Hyperproduction: Kushing syndromCauses: hypeplasia or tumor of
epinephrine gland cortexObesity, particularly of the trunk and face (“moon face“) with sparing of the limbs; striae (stretches of the skin)Proximal muscle weaknessHirsutism (facial male-pattern hair growth)Insomnia, impotence, amenorrhoea, infertilityHeart diseases, hypertensionPolyuria, hypokalemia hyperglycemia, glucosuria (steroid diabetes) Kidney bonesDepression, anxietyHyperpigmentation
Aldosterone hyperproductionCauses: -aldosteroma
Symptoms:-hypokaliemia-hypernatriemia-hyperchloremia-hypervolemia-edema,
hypertension
A little amount of female sex hormones is formed in male organism and vice versa.
Female – estrogens, progesteron.
Male – androgens.
Sex hormones
Are synthesized in:-sex glands-placenta-cortex of epinephrine
glands
• Androgens – testosterone – dehydroepiandrosterone (DHEA) – dehydroepiandrosterone sulfate (DHEAS) – androstenedione – dihydrotestosterone (DHT)
• Estrogens – estradiol – estrone – estriol
• Progestagens – progesterone
Estradiol
Cholesterol
Pregnenolone
Progesterone
Corticosterone
11-Desoxy-corticosterone
18-Hydroxy- corticosterone
ALDOSTERONE
17-α- Hydroxy pregnenolone
11- Desoxy- cortisol
17- Hydroxy progesterone
21,β hydroxylase
CORTISOL
11,β hydroxylase
Dehydro-epi androsterone
Andro-stenedione
Oestrone
Oestriol
TESTOSTERONE OESTRADIOL
ACTH
EstrogensNature: steroidsEstradiol – is formed in follicles of
ovariumEstron and estriol – are formed in liver
and placenta in the metabolism of estradiol
Estradiol estriol
Functions of estrogensDevelopment of the female reproductive
system organs Ability to fertility in reproductive period
Biochemical functions of estrogens
Anabolic action on the tissues of reproductive organs
Inhibit the exit of Ca from bones (osteoporosis in menopause)
ProgesteronNature: steroidIs formed in corpus luteum, placenta
and epinephrine glands
Functions of progesteronPrepares the endometrium of uterus to
implantation of ovumInhibits the uterus contraction during
pregnancyStimulates the growth of mammary
glands
AndrogensTestosteron
Nature: steroidIs formed in the interstitial cells of
testisIs excreted as 17-кetosteroids
Functions of testosteroneDevelopment of the primary sex
featuresDevelopment of the secondary sex
featuresStimulates spermatogenesis
Biochemical functions of testosterone
Strong anabolic action (stimulates the synthesis of NA, proteins, phospholipids) – increases the mass of muscles
Keeps the Ca and P in organism
Derivatives of androgens – active anabolics
Major Classes of EicosanoidsMajor Classes of Eicosanoids
• Prostaglandins
• Thromboxanes
• Prostacyclins
• Leukotrienes
Precursors of EicosanoidsPrecursors of Eicosanoids
• Arachidonic acid (ω6)• Eicosatrienoic acid (-linolenic acid, ω6)
• Eicosapentaenoic Acid (ω3)
Prostaglandins – Structural FeaturesProstaglandins – Structural Features
CYCLO-OXYGENASE CYCLO-OXYGENASE PATHWAY PATHWAY
PG and TX synthesisPG and TX synthesis
2GSH
2GSSG
PGF2a
PGE 9-keto reductase
PGI2PGI synthase
TXA2TXA synthase
LipoxygenaseLipoxygenase pathway pathway
Mechanism of Aspirin ActionMechanism of Aspirin Action
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