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ElectroEncephaloGraphy (EEG) Capabilities
Discovery Research
Discovery Research Suven Life Sciences Ltd
Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad-500034, India.
Contacts: info@suven.com, nvsrk@suven.com
2
Contents
S. No Title Page No
1 Overview 3-5
2 Sleep/Wake Profile in Rats 6-7
3 Cognitive Biomarkers in Rats 8
4 Evaluation of Seizure Inducing Potential 9
5 Contacts 10
3Company Confidential Copyright © 2018 Suven Life Sciences Limited
Telemetry Systems with Implantable Telemetry- Data Sciences International (DSI)
Acquisition Platform- Ponemah
Data Analysis Software- NeuroScore v3.2.1 with automated sleep scoring, seizure detection and
video synchronization
Grass S88 stimulator for stimulating specific regions of brain in anesthetized animals
Sleep/ wake activity Temperature and wake promoting activity Total EEG power Power analysis in frequency bands Seizure evaluation potential assessment Assessment of cognitive biomarkers (Theta and Gamma Activity) Simultaneous power analysis in animal performing behavioral task Orexin-SAP induced chemical lesion model for narcolepsy
Infrastructure
Evaluations
EEG in RodentsOverview
Company Confidential Copyright © 2018 Suven Life Sciences Limited
EEG, EMG, Video, Activity and Temperature
Neuroscience
Wake Sleep
Data Acquisition Coupled with Behavioral Monitoring
EEG in RodentsOverview: Multi-Channel Recording using Telemetry
4
Company Confidential Copyright © 2018 Suven Life Sciences Limited
EEG in RodentsOverview: Sleep Analysis using NeuroScore
5
6Company Confidential Copyright © 2018 Suven Life Sciences Limited
Results Generated at Suven
Edger and Seidel, 1997*p<0.05, **p<0.01, ***p<0.001 Vs Vehicle
Results Generated at Suven are Comparable to Literature Report
EEG in RodentsSleep/Wake Profile in Rats: Modafinil
***p<0.001 Vs vehicle
REM Sleep
Wake NREM Sleep
EEG in RodentsSleep/Wake Profile in Rats: Caffeine
Summary
Caffeine Produced Significant Increase in Wakefulness with Significant Decrease in Slow Wave Sleep
Company Confidential Copyright © 2018 Suven Life Sciences Limited 7
Company Confidential Copyright © 2018 Suven Life Sciences Limited
-30 -20 -10 0 10 20 300
255075
100125150175200
Vehicle (n=8)Donepezil 0.3 mg/kg, i.v. (n=8)Donepezil 1.0 mg/kg, i.v. (n=9)
Time (min)
Rela
tive
Thet
a Po
wer (
%)
-30 -20 -10 0 10 20 300
25
50
75
100
125
150
175
200Vehicle (n=8)
Scopolamine 0.1 mg/kg, i.v. (n=6)
Time (min)
Rela
tive
Thet
a Po
wer
(%)
EEG in RodentsCognitive Biomarkers in Rats
-90 -60 -30 0 30 60 90 120 150 180 210 240 270 300 330 36020304050607080
30-50 Hz
Time (min)
Gam
ma
Pow
er
-90 -60 -30 0 30 60 90 120 150 180 210 240 270 300 330 36020
40
60
8030-50 Hz
Time (min)
Gam
ma
Pow
er
-90 -60 -30 0 30 60 90 120 150 180 210 240 270 300 330 36020
40
60
8030-50 Hz
Time (min)
Gam
ma
Pow
er
Quantitative EEG can be effectively used as a tool for monitoring efficacy of cognitive enhancers
Theta Modulation Gamma Modulation
Donepezil
PQCA
Scopolamine
Treatments are indicated as open circle (vehicle) and open square (donepezil, PQCA or scopolamine) for gamma modulation.
8
Company Confidential Copyright © 2018 Suven Life Sciences Limited
EEG in RodentsEvaluation of Seizure Inducing Potential
Pre-dose recording
Myoclonic Jerks Clonic Convulsions Tonic Convulsions
EEG recording can evaluate the seizure inducing potential of test compound
PTZ
9
Company Confidential Copyright © 2018 Suven Life Sciences Limited
Contacts
Venkat JastiChairman & CEOE-mail:info@suven.com
Ramakrishna NirogiVice President, Discovery ResearchE-mail: nvsrk@suven.com
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