Early Life Experiences - RCCN · Kate Tillingl, Steve Horvath3'4 Sonja Kunze5, Annette Peters...

Early Life Experiences

Dr. Frances A. ChampagneDepartment of Psychology

Poverty

Environmental Influences During Infancy & Childhood

Social & Physical Environment

Childhood Abuse & Neglect

Epigenetic Control of Gene Activity

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10 20 30 40 50

epigenetic age

chro

no

logi

cal a

ge

Epigenetic age during pregnancy

epigenetic age acceleration

Epi-AA in adolescent males

Epi-AA at birth in ceasarean

Epi-AA at birth with maternal smoking

Walsh et al. (2019) PNAS

Preterm Birth and Maternal Stress

Walsh et al. (2019) PNAS

Elevated 2nd Trimester PSS Score “masculinizes” aromatase profile in females

Fetal Exposure to Testosterone

Firestein et al. in preparation

ASD RISK

Impact of prenatal exposures on the maternal brain

Conceptual model depicting hypothesized mediational

pathways and moderators linking childhood maltreatment to

risk for MCI and AD

Thanks

Canadian Institutes

of Health ResearchNIH Director's

New Innovator

Award

Centers for Children's Environmental

Health & Disease Prevention Research

Columbia University

Rahia Mashoodh

Cate Jensen

Emily Jordan

Marija Kundakovic

Kathryn Gudsnuk

Becca Franks

Morgan Firestein

Columbia Center for

Children’s Environmental

Health

Rachel Miller

Frederica P. Perera

Columbia University

Catherine Monk

Ben Tycko