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Early Life Experiences
Dr. Frances A. ChampagneDepartment of Psychology
Poverty
Environmental Influences During Infancy & Childhood
Social & Physical Environment
Childhood Abuse & Neglect
Epigenetic Control of Gene Activity
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10 20 30 40 50
epigenetic age
chro
no
logi
cal a
ge
Epigenetic age during pregnancy
epigenetic age acceleration
Epi-AA in adolescent males
Epi-AA at birth in ceasarean
Epi-AA at birth with maternal smoking
Walsh et al. (2019) PNAS
Preterm Birth and Maternal Stress
Walsh et al. (2019) PNAS
Elevated 2nd Trimester PSS Score “masculinizes” aromatase profile in females
Fetal Exposure to Testosterone
Firestein et al. in preparation
ASD RISK
Impact of prenatal exposures on the maternal brain
Conceptual model depicting hypothesized mediational
pathways and moderators linking childhood maltreatment to
risk for MCI and AD
Thanks
Canadian Institutes
of Health ResearchNIH Director's
New Innovator
Award
Centers for Children's Environmental
Health & Disease Prevention Research
Columbia University
Rahia Mashoodh
Cate Jensen
Emily Jordan
Marija Kundakovic
Kathryn Gudsnuk
Becca Franks
Morgan Firestein
Columbia Center for
Children’s Environmental
Health
Rachel Miller
Frederica P. Perera
Columbia University
Catherine Monk
Ben Tycko