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BIO 345 001 - PATHOPHYSIOLOGY SPRING, 2020
Tuesday/Thursday 8:45–10:00 AM
Luther Bonney 510, Portland Campus
Credit Hours: 3
Tracy Anne Filler, VMD MS
Best form of Contact is Email: Tracy.Filler@Maine.edu
You may also leave a message for me at the Biology Department (207-780-4260)
Office hours: Available upon Request.
I am willing to meet with students in the lounge of Luther Bonney or if we need a
more private setting the adjunct office connected to the Department of Biology’s
Main Office, USM Science Building 107.
Mandatory Text and Materials:
Essentials of Pathophysiology, Concepts of
Altered States, 4th edition
By: Carol Porth; ISBN 9781451190809
Access to BLACKBOARD is required for this class.
Please check your USM email account for Blackboard announcements
regularly. I will be updating this site during the semester. Use your
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USM email account for all correspondences. It is the student’s
responsibility to keep informed of ALL changes and assignments via
email, announcements, and Blackboard posts.
Course Description: Pathophysiology is the study of the genetic
physiological, biochemical and anatomical pathways of non-infectious
diseases. This web-based class will consist of lecture sessions and
assignments on blackboard.
Prerequisites: Bio 109 or Bio 113 or Bio 223. These are the pre-
requisites as established by the university. This is an upper level
science course it is recommended that you have completed two
semesters of Anatomy & Physiology.
Course Objectives & Learning Outcomes: Pathophysiology is the
study of how normal body function is altered by disease. Most of the
people in this class have had a recent (or not so recent) course in
Anatomy & Physiology. This should provide an excellent background in
the basic form and function of the normal body.
In this course we will explore normal function in greater detail and go
on to discuss abnormalities in function caused by disease. We will begin
by discussing some general concepts of pathophysiology and will then
focus on genetic diseases, cancer, immune disturbances, cardiovascular
disease, respiratory disease, GI disease, renal disease, hepatobiliary
disease, and endocrine disease (including diabetes). By the end of this course you should be able to:
1) Expand your understanding of normal body function, and to use this understating as the basis for gaining an appreciation of the physiological basis for some important diseases.
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2) Provide a basic understanding of how the body reacts to disease and compensates for some important diseases, and
3) Explore the physiological basis for the treatment of some important diseases.
4) Be able to communicate said concepts and terminology of pathophysiology and disease utilizing terminology of a clinical professional.
Student Responsibilities:
Attend ALL lectures.
Take careful notes during lecture.
Keep up with all assignments, Blackboard postings and readings.
Stay current with your readings from the text book.
Participate actively in lectures.
Ask questions to help clarify any assignments or material that is
confusing and unclear.
Turn in all assignments on time. Late assignments will be
penalized. Do not get behind on you assignments.
Turn in college level work that is respectful. No slang
terminology, profanity or abbreviations are accepted.
Contact the professor if you have any questions. Do not be afraid
to ask for help.
Be respectful to your professor and all of your fellow classmates.
Review the USM honor code. It is imperative to uphold the
integrity and decorum of an USM student.
And finally-have fun!!! Yes this can be an intense course but I
assure you if you plan on pursuing a career in science or medicine
this class is imperative to your future. You are here to learn and I
will be the guide.
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Course Outline of Topics
Here is a list of the chapters we will complete this semester.
CHAPTER TOPIC
1 Introduction and Terminology
2 Cells Respond to Stress
4 Cell Proliferation & Tissue Repair
6 Genetic and Congenital Diseases
7 Neoplasia
8 Fluid, Electrolyte & Acid-Base Balances
15 Normal Immunity
16 Disorders of Immunity
18 Disorders of Blood Flow and Pressures
19 Disorders of Cardiac Function
20 Disorders of Heart Failure and Shock
23 Disorders of Gas Exchange and Ventilation
26 Kidney Disease
29 Disorders of GI Function
30 Hepatobiliary Disease
32 Endocrine Disorders
33 Diabetes Mellitus
Technology: You are permitted to bring laptops and tablets to class.
However I ask that all cell phones be turned off and placed away. Cell
phones are a distraction, if you need to take a call please step out into
the hall during lecture.
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Below is how your performance will be assessed in our class.
ASSIGNMENT % of GRADE
DESCRIPTION
Homework Assignments per
Chapter
100 points total
Questions to review material discussed in class
will be available for a certain period of time on
Blackboard.
Examinations- Three exams during the semester. The final exam will be
administered during final exam period
300 points (each exam 100 points)
Exams are utilized to measure your
understanding of the assigned material from both lab and lecture. There will be an exam
every five weeks.
Case Discussions 100 points Group Project
Student groups lead discussion about a chosen topic that ties in with the lecture schedule for the
week.
TOTAL POINTS AVAILABLE
500 points
Grading Scale & Description of Assignments
A 93-100 B 83-86 C 73-76 D 60-66
A- 90-92 B- 80-82 C- 70-72 F < 60
B+ 87-89 C+ 77-79 D+ 67-69
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Attendance Policy: Attendance will not be recorded but is expected
during the semester. Attendance is especially important when case
discussion are scheduled. The path to success begins with good
attendance.
How to Contact the Professor: The best way to contact me is by
USM email. I will respond to your questions within 24 hours during the
week and within 36-48 hours during the weekend. Please include your
name and the course code in the subject line. Please be professional
and clear with your questions.
Please note that I am only campus Tuesdays and Thursdays for class. I
am unavailable on Wednesdays, Fridays and Saturdays during the
semester due to my other employment.
Inclement Weather Policy: Class will be closed if USM closes or
delays due to inclement weather. If we miss class time due to
inclement weather I will contact the entire class via email with the
updated schedule and plan. If we miss an exam day, we will hold the
exam on the next regularly scheduled class day. If we miss the final,
plan to take the exam on the Tuesday following finals week.
End-of-Course Evaluation: USM is now using an Electronic Course
Evaluation (ECE) system and this course is included in the project.
During the last week of classes, students will receive an email notice
that asks you to complete your course evaluation online. This email will
include a direct link to the course evaluation, and you will log-in by
using your Mainestreet ID and password.
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Your ratings on the evaluation would be very useful to your instructor if
you answer thoughtfully and honestly. The responses you give are
confidential and will be collected by the Office of Academic
Assessment. After the final grades are posted, your instructor will
receive a summary report of the student responses. All student
feedback is valued and is being used for course and program
improvement purposes. Thanks, in advance, for your participation.
USM Course Policies
Accommodations: If you need course adaptations or accommodations
because of a disability, please Contact the Disabilities Services Center,
242 Luther Bonney Hall, Portland campus. You can call them at 780-
4706 to arrange an appointment with the Coordinator of DSC. This is in
accordance with the ADA.
Title IX statement: The University of Southern Maine is committed to
making our campuses safer places for students. Because of this
commitment, and our federal obligations, faculty and other employees
are considered mandated reporters when it comes to experiences of
interpersonal violence (sexual assault, sexual harassment, dating or
domestic violence, and stalking). Disclosures of interpersonal violence
must be passed along to the University’s Deputy Title IX Coordinator
who can help provide support and academic remedies for students who
have been impacted.
More information can be found by contacting Sarah E. Holmes at
sarah.e.holmes1@maine.edu or 207-780-5767online at
http://usm.maine.edu/campus-safety-project. If students want to
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speak with someone confidentially, the following resources are
available on and off campus:
University Counseling Services (207-780-4050)
24 Hour Sexual Assault Hotline (1-800-871-7741)
24 Hour Domestic Violence Hotline (1-866-834-4357)
Add-Drop & Withdrawal: USM establishes the policy for grading
when a student drops a course. A student may receive a grade of “W” if
s/he withdraws before 60% of the course is completed. Withdrawals
do not affect your GPA. They do affect your course completion rate.
Failure to attend or ceasing to attend class does not constitute
withdrawal from the course. If you fail to come to class after the after
the withdrawal period, the grade is “F.” It is important that students
understand that this is a University policy. I cannot give grades of “W”
to students who leave a class after the set date no matter how much I
may wish to. There is no refund associated with withdrawal.
I do, of course, understand that circumstances beyond the control of a
student (for example, health or family emergencies) may arise late in
the semester and that these circumstances may make it impossible for
a student to complete a course. If you are passing this course and an
emergency arises that makes it impossible for you to finish, please
contact me to discuss a grade of “Incomplete.” I will consider requests
for an incomplete when:
1) A legitimate emergency exists.
2) The student is passing at the time of the request.
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3) The student has a realistic plan to complete the course work by the
end of the following semester.
4.) The student has talked to the head of the department and their
advisor to confirm the acceptance of an ‘Incomplete”.
Plagiarism and other forms of Cheating
Academic honesty is of the utmost importance in all classes because it
maintains the integrity of the entire educational process. Everyone
associated with USM is expected to adhere to the principles of
academic integrity central to the function of the University. Breech of
these policies represents a serious offense. Plagiarism, cheating, and
falsification of information are violations of academic integrity that will
not be tolerated in this class. Adherence to ethical academic standards
is obligatory.
Cheating is a serious offense, whether it consists of taking credit for
work done by another person or doing work for which another person
will receive credit. Taking and using the ideas or writings of another
person without clearly and fully crediting the source is plagiarism and
violates the academic code as well as the Student Code of Conduct.
Please check the USM Office of Community Standards website for
official definitions of these practices. Evidence of a violation of the
academic integrity policy will normally result in disciplinary action. A
copy of this policy may be obtained from the office of Community
Standards and Mediation by calling 207-780-5245 or online at
USM.maine.edu.
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You can also get a copy of the policy through the Office of Student
Judicial Affairs. If you are in doubt concerning the requirements, please
consult me before you complete any assignment so that we can discuss
what is not acceptable.
If it is suspected that a student in any course in which s/he is enrolled
has knowingly committed a violation the instructor has the authority to
review the alleged misconduct and determine the grade that the
student should receive for the assignment and the course. The
instructor may assign a failing grade for the assignment or course and
may require the student to complete additional work for the course.
The instructor may also consult with the department chair faculty
member and/or the College’s chief academic officer prior to making
such decisions.
This is a web-enhanced course. Many of the assignments and
examinations are on-line and completed outside the classroom. It is of
vital importance that all students adhere to USM’s honor code. This
means that no one is permitted to have assistance for any exam or to
have another person take the exam in their place. If for any reason
during the semester the instructor feels that this policy is being
violated I reserve the right to stop on-line assignments and begin in-
class, closed book homework.
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PATHOPHYSIOLOGY BIO 345 SPRING, 2020
SCHEDULE OF LECTURES & ASSIGNMENTS
DATE CHAPTER ASSIGNMENTS 1/21 Syllabus Review and
Terminology Welcome to our class
1/23 Chapter 2 Cells Response to Stress
& Chapter 4 Cell Proliferation &
Tissue Repair
1/28
Chapter 6 Genetic & Congenital
Diseases
1/30
Chapter 6 Genetic & Congenital
Diseases
Homework due
Syllabus, Chapter 2 & 4 2/4 Chapter 7
Neoplasia Case Discussion-
Genetics/Congenital
2/6 Chapter 7 Neoplasia
Homework due Chapter 6
2/11 Chapter 8 Fluid, Electrolyte & Acid-Base Balances
Case Discussion
Neoplasia
2/13 Chapter 8
Fluid, Electrolyte & Acid-Base Balances
Homework due
Chapter 7
2/18 Test #1 Intro, Ch. 2, 4, 6, 7, & 8
Homework due Chapter 8
2/20 Chapter 15 Normal Immunity
2/25 Chapter 16 Disorders of Immunity
2/27 Chapter 16 Disorders of Immunity
Case Discussion Autoimmune Disease
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DATE CHAPTER ASSIGNMENTS
3/3
Chapter 18 Disorders of Blood Flow
& Pressure
Homework due Chapter 15 & 16
3/5
Chapter 18 Disorders of Blood Flow
& Pressure
Case Discussion Blood Pressure
3/10
Chapter 19 Disorders of Cardiac
Function
Homework due
Chapter 18
3/12 Chapter 19
Disorders of Cardiac Function
Case Discussion Cardiac Disease
3/16-3/20
SPRING BREAK Happy & Safe SPRING BREAK
3/24
Chapter 20 Disorders of Heart
Failure & Shock
Homework due
Chapter 19
3/26 Chapter 20
Disorders of Heart Failure & Shock
Case Discussion
Congestive Heart Failure
3/31 Chapter 23
Disorders of Gas Exchange & Ventilation
Homework due
Chapter 20
4/2 Chapter 23
Disorders of Gas Exchange & Ventilation
Case Discussion
Pulmonary Disease 4/7 Test #2
15, 16, 18, 19, 20 & 23 Homework due
Chapter 23 4/9 Chapter 26
Kidney Diseases
4/14 Chapter 29 Disorders of GI Function
Homework Chapter 26 Case Discussion Kidney Disease
4/16 Chapter 30 Hepatobiliary Diseases
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DATE CHAPTER ASSIGNMENTS
4/21 Chapter 32 Endocrine Disorders
Homework due Chapter 29 & 30
4/23 Chapter 32 Endocrine Disorders
Case Discussion GI/Liver Disease
4/28 Chapter 33 Diabetes Mellitus
Homework due Chapter 32
4/30 Chapter 33 Diabetes Mellitus
Case Discussion Endocrine Disease
5/5 No Class
Homework due Chapter 33
5/7 Final Exam 8:00 AM – 10:00 AM
Test #3 Ch. 26, 29, 30, 32, 33
Please note that this schedule is TENTATIVE. It may change based on weather,
illness, and the pace of our class. After all this is Maine in winter. I am asking all of you to
be flexible with adaptions during the semester. For instance if there are numerous snow
days we may need to bump the presentations to May 5th.
Make sure that you are comfortable with blackboard. I will be posting
assignments such as the quizzes, lecture slides and discussions on this site. I will also
have announcements here and via email concerns class schedules during the semesters.
IT IS THE RESPONSIBILITY OF THE STUDENT TO KEEP ABREAST OF ALL ASSIGMENTS AND
CHANGES IN THE SCHEDULE.
Here is to an exciting semester in Pathophysiology.
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