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ACCELERATING
REGENERATIVE MEDICINE
Follow Fujifilm Life Sciences at
We’re applying our photographic film innovations to help advance
new treatments in the revolutionary field of regenerative medicine.
Over the last 80-plus years, we’ve developed advanced technology
that controls complex chemical reactions in photographic film
that’s a mere 20 microns(*1) thick. And today, that technology is
being applied to research and the world’s first clinical trial(*2)
of medical treatments that use high-quality iPS cells.
And in the future, we’ll strive to help those suffering
from a range of medical conditions, such as those
of the eyes, nerves, heart and more. Of course,
the challenges are endless, but so are the
possibilities. Which is why we’ll never stop
accelerating regenerative medicine to help
build a stronger, healthier future for all.
*1 Thickness of layers excluding the base.
*2 Fujifilm’s iPS cells are being utilized in the world’s first clinical trial using iPS cells
conducted in the UK by the Australian company Cynata.
FUJIFILM and Fujifilm Value from Innovation are trademarks of FUJIFILM Corporation.
©2019 FUJIFILM Corporation. All rights reserved.
Meeting program and online registration are available.
AAAS, publisher of Science, thanks the sponsors and
supporters of the 2020 Annual Meeting.
As of November 25, 2019
aaas.org/meetings #AAASmtg
ANNUAL MEETINGSeattle, WA February 13–16, 2020
European Union
Host University
Since opening its doors in 2015, the Beijing Advanced Innovation Center
for Structural Biology (ICSB) at Tsinghua University has quickly gained
a reputation for producing prolific amounts of high-quality research in
the life sciences.
In four years, the center has published 50 high-impact research
papers in Nature, Science, and Cell, and helped define and develop this
rapidly developing field in China, says Yigong Shi, director of the ICSB.
The former dean of the School of Life Sciences at Tsinghua University
dramatically advanced the field of molecular biology with his ground-
breaking discoveries about spliceosomes, the cellular machines that
make all of the proteins our bodies need to function. Shi explains that
the senior faculty at the center are training the next generation of
exceptional scientists while simultaneously producing world-leading
basic and translational research.
“The institute put itself on the map when my team published
the first near-atomic-resolution structure of the spliceosome. Some
scientists have called this discovery one of the holy grails of structural
biology,” says Shi, who won China’s foremost science award, the Future
Science Prize, in 2017. “Our research improved our understanding of basic
biological processes and should help to identify new drug targets in
the future.”
Dreaming of breakthroughsWhen Shi returned from studying in the
United States in 2007, he began to
envision a new center based in
Beijing that could conduct
advanced research of
structural biology. Over
the following decade, Shi
encouraged
Chinese
scientists to
join him at
Tsinghua,
and those 15 scientists helped him lay the intellectual foundations for
ICSB. Now, the center has 23 independent laboratories that house more
than 40 postdoctoral fellows and 200 graduate students. The young and
creative team has an average age of 40 years.
Shi’s mission is to ensure that ICSB produces the next generation of
top-level molecular biologists who can integrate traditional scientific
approaches with new technologies and research methods. In order
to ensure that the pipeline of talent never runs dry, and cultivate the
talents of early-career structural biologists, the center has established
a training program. The Advanced Innovation Fellow program selects
trainees to work on risky, difficult research and engineering projects.
After completing this two-year program, the most outstanding
researchers are given the opportunity to join the center as senior
researchers.
“We have recruited more than 20 postdocs in our program,” says Shi.
“Some of them have made significant achievements and shown their
great potentials in structural biology.”
For example, Xuerui Wan, who entered the program in 2018, was
elected as one of the four winners of the Science & SciLifeLab Prize for
Young Scientists in the same year.
“She is a rising star in structural biology of the spliceosome, and her
research has given important insights into the mechanism of pre-RNA
splicing,” says Shi.
A collaborative approachThe field of structural biology demands a cross-disciplinary approach,
and the ICSB has poured resources into creating a team of scientists, from
areas such as computing, electronics, mechanical engineering, chemistry,
physics, maths, and biology, that can work together with biophysicists,
structural biologists, and cell biologists to work on key problems and
produce major breakthroughs.
Hongwei Wang, who earned his undergraduate degree and Ph.D. at
Tsinghua University, researches cryo-electron microscopy (cryo-EM)—a
tool that can help researchers examine the structures of macromolecules
at extremely high resolutions. According to Wang, one of the greatest
challenges in his field of research is to build a team with a wide enough
disciplinary background to handle the challenges posed by the projects.
“I have built strong collaborations with scientists in nano-material
science and scientists in precision instrument implementation to tackle
the major technical challenges, such as cryo-EM specimen preparation
and cryo-EM structural analysis throughput,” he says.
Most recently, Wang and his team helped set a world record for the
smallest protein (52 kDa streptavidin) to be solved at atomic resolution
using single-particle cryo-EM reconstruction. Using cryo-EM, he and his
team hope to solve a wide range of drug target macromolecules
in their relative native states without crystallization, which
could lead to more efficient drug discoveries.
Tsinghua scientists see the bigger biological picture
Advertorial
PH
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QU
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Designs on healthWhile researchers at the ICSB are devoted to unraveling the mysteries
of life at an atomic level, they are also keen to see their work solve real-
life problems in the future.
Haitao Li researches the biological mechanisms that switch genes
on or off at the chromosomal level—a field called epigenetics—and
explores how drugs can be developed to treat medical conditions, such as
cancer, heart diseases, and diabetes, which are influenced by epigenetic
dysfunction.
For example, his laboratory has recently identified how the YEATS
domain proteins relate to the development of leukemia and developed
compounds that can be used in ENL gene-targeted therapy. Li works
closely with hospitals across China and thinks there will be many
opportunities to translate his basic research into applications for the
benefit of patients, given the strong support he receives from the
ICSB.
Scientists at the center benefit from state-of-the-art facilities, such
as high-end cryo-EM machines, and proteomic and imaging core facilities,
he says. In addition, there is an ethos of intellectual curiosity that enables
groundbreaking work.
“The mission of the center is to resolve the mystery of biological
structures in diverse functional systems of life,” he says. “We are given
the freedom to choose our projects, aim high, and think deeply.”
Xinquan Wang, a biophysicist, agrees that these factors will help
scientists at ICSB translate research that can benefit the health of
Chinese citizens. His group is researching the structure of the interleukin 1
family of cell-surface receptors. Wang hopes their study will enable the
development of antibodies that are able to modulate the activities of
these receptors, which are linked to inflammation in the body.
He uses cutting-edge X-ray crystallography and cryo-EM tools in his
work, but adds that he and his team need to combine structural biology
methods with other functional techniques to gain more insights into the
scientific questions.
“Collaboration is also important for our study, especially for applying
the knowledge from our research to the development of agents with
potential therapeutic applications,” he says.
Looking to the futureShi has his sights set on new avenues of scientific enquiry that will
open up possibilities for cellular research at ICSB and Tsinghua University.
For instance, he is interested in how biological systems interact with
electromagnetic waves.
“On the pragmatic side, the applications of this kind of research
could be enormous,” he says. “For example, if electromagnetic waves of a
longer wavelength can induce a specific interaction in cells, which leads
to cell death in cancer cells, then that could be used as a therapy to treat
cancer patients.”
The prize-winning scientist highlights that there are many forces
interacting with our bodies that are unknown to us.
“There are many things we don’t know because we don’t see them.
Using state-of-the-art tools, we can gain a glimpse into this process,”
he says. “To me, this is an enormously interesting area that has not been
explored by many scientists.”
An international outlook
As the ICSB enters its fifth year, its international reputation continues
to grow.
Since its establishment, the ICSB has welcomed scientists from all
over the world, including Nobel Prize–winning chemist Brian Kobilka,
says Shi. Such collaborations ensure that the center will continue to grow
as an international hub for world-leading research in the life sciences.
Sponsored by
AdvertorialP
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Produced by the Science/AAAS
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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this
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Whatever projects you’re working
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all known diseases, you can count
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reliable, cutting-edge lab and
production materials, we are always
expanding and perfecting our global
portfolio. So we’ll be right there
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from impossible dream to reality.
To find out more, visit:
SigmaAldrich.com/UnleashTheImpossible
Unleashthe impossible
The Life Science Business of
Merck operates as MilliporeSigma
in the US and Canada.
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