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1-P1-01
BARP regulates the dynamics of voltage-dependent Ca2+ channelcomplexes at dendritic spine
Yoshihiro Matsunaga1, Akito Nakao1, Mizuki Omori1, Taketoshi Kajimoto1,2, Yasuo Mori1
1Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ., 2Div. Biochem. Kobe Univ. Grad. Sch. Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-02
Presynaptic inhibition of GABA release from striatal medium spiny neuronsonto cholinergic interneurons in young-adult mice.
Etsuko Suzuki, Toshihiko Momiyama
Department of pharmacology, Jikei university school of medicine
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-03
Involvement of NO cascade in AT1 receptor mediated effects of angiotensin IIon excitatory synaptic transmission in the rat nucleus tractus.
Yoshiaki Ohi, Daisuke Kodama, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-04
Evaluation of the effect of levetiracetam on methamphetamine-inducedhyperactivity in Sv2aL174Q rats
Saki Shimizu, Yui Mimaki, Sayaka Jinno, Shiho Taruya, Tadao Serikawa, Yukihiro Ohno
Dept. Pharmacol., Osaka Univ. Pharm. Sci.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-05
Effect of estradiol on behavioral selection for pups and synaptictransmission in the rhomboid nucleus of the bed nucleus of the striaterminalis
Kiyoshiro Fukui, Keiichiro Sato, Masabumi Minami, Taiju Amano
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-06
Lysophosphatidylethanolamines with different fatty acid lengths stimulateneurite outgrowth in cultured cortical neurons through distinct signalingcascades
Yoshida Hironori1,3, Kazutoshi Hisano2,3, Shiori Kawase4, Tetsuhiko Mimura2,3, Hisao Haniu3,Tamotsu Tsukahara5, Taiga Kurihara6, Yoshikazu Matsuda7, Naoto Saito3, Takeshi Uemura3,4
1Grad. Sch. of Sci. Tech., Shinshu Univ., Nagano, Japan, 2Grad. Sch. of Med., Sci. Tech., Shinshu Univ.,Nagano, Japan, 3IBS-ICCER., Shinshu Univ., Nagano, Japan, 4Div. of Gene Res., Res. Cent. for Supports toAdvanced Sci., Shinshu Univ., Nagano, Japan, 5Dept. Pharmcol. Therap. Innov., Nagasaki Univ., inst. Biomed. Sci.,Nagasaki, Japan, 6Div. Microbiol. & Mol. Cell. Biol., Nihon Pharmaceutical Univ., Saitama, Japan,7Div. of Clin.Pharm. & Pharmaceut., Nihon Pharmaceutical Univ., Saitama, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-07
Alteration of parvalbumin expression and perineuronal nets formation in theanterior cingulate cortex of Fabp3 KO mice
Yui Yamamoto1,2, Yuji Owada2, Kohji Fukunaga3, Keiju Kamijo1
1Dept. Anatomy, Tohoku Med. and Pharm. Univ.,2Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med.,3Dept.Pharmacology, Tohoku Univ. Grad. Sch. Pharm.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-08
E3 Ubiquitin Ligase HRD1 regulates the Serotonin Transporter Function
Taguchi Kei1, Masayuki Kaneko3, Serika Motoike2, Kana Harada1, Izumi Hide1, Shigeru Tanaka1,Norio Sakai1
1Department of Molecular and Pharmacological Neuroscience, 2Department of Dental Anesthesiology GraduateSchool of Biomedical and Health Sciences, Hiroshima University, 3Department of Pharmacology and TherapeuticInnovation, Nagasaki University Graduate School of Biomedical Sciences
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-09
Regulation of nicotine-induced tremor by the dopaminergic nervous system
Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Chihiro Takashima, Kana Tsujimura,Kazuya Horikawa, Yukihiro Ohno
Dept. Pharmacol., Osaka Univ. Pharm. Sci.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-10
Applying Ca2+ Image Sensor to visualize extracellular Ca2+ dynamics inhippocampus.
Parajuli Bijay1, Hideo Doi3, Eiji Shigetomi1,2, Youichi Shinozaki1,2, Toshihiko Noda3,4,Kazuhiro Takahashi3, Kazuaki Sawada3, Schuichi Koizumi1,2
11Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi,Yamanashi, Japan, 2Yamanashi Interdisciplinary Brain-Immune Research Center (YiBIC), University of Yamanashi,Yamanashi, Japan, 3Integrated Biosensor. MEMS group, Department of Electrical and Electronic InformationEngineering,, 4Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) Toyohashi University ofTechnology
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-11
Human excitatory amino acid transporters (EAATs) were functional in thehuman induced pluripotent stem cell (hiPSC)-derived human neuralnetworks
Kanako Takahashi1, Kaori Chujo1, Ikuro Suzuki2, Kaoru Sato1
1Lab. Neuropharmacol., Div. Pharm., Nat. Inst. Hlth. Sci.,, 2Dept. Electro., Grad. Sch. Engineering, Tohoku Inst.Tech.,
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-12
Expanding the repertoire of the genetically-encoded fluorescent transmittersensors
Daisuke Ino
Dept. Cell Biol Histol., Grad. Sch. Med., Kanazawa Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-13
Degradation of oligomeric α-Synuclein in brain pericytes is enhanced bycyclosporin A
Shinya Dohgu1, Miki Yokoya1, Fuyuko Takata1, Junichi Matsumoto1, Takuro Iwao1,Kazunori Sano2, Yasufumi Kataoka1
1Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Dept. Physiol. & Pharmacol., Fac.Pharmaceut. Sci., Fukuoka Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-14
Brain pericytes increase sodium-dependent glutamate uptake in astrocytes.
Fuyuko Takata1, Kenta Sakai1,2, Takuro Iwao1,2, Junichi Matsumoto2, Yasufumi Kataoka1,Atsushi Yamauchi2, Shinya Dohgu1
1Department of Pharmaceutical Care and Health Sciences, 2Department of Pharmaceutical Care and HealthSciences
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-15
Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice
Koichi Kawahara, Yukina Kojima, Natsuki Kumakura, Masaaki Sano, Kota Hosokai,Takumi Yamada, Takuya Hasegawa, Takehiko Maeda
Dept. Pharmacol., Fac. Pharm. Sci., Niigata Univ. Pharm. Appl. Life. Sci.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-16
Cholesterol induced calcium oscillation found in astrocytes
Adachi Chihiro, Takafumi Inoue
Dept. Life. Sci. & Med. Biosci. Waseda Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-17
Zinc-aggravated M1 microglia suppress astrocytic engulfing activity viaP2X7 receptors
Youichirou Higashi1, Takaaki Aratake1,2, Tomoya Hamada1, Takahiro Shimizu1, Shogo Shimizu1,Suo Zou1, Masaki Yamamoto1, Rina Nakamura1, Toshifumi Akizawa1, Motoaki Saito1
1Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., 2JSPS Research Fellow
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-18
Prostaglandin E2 increases the expression of cyclooxygenase-2 protein inmicroglia.
Takayuki Nagano, Naohiko Tsuda, Kenichi Fujimura, Yuji Ikezawa, Yuki Higashi, Shinya KimuraH., Motohiko Takemura
Dept. Pharmacol., Hyogo Coll. Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-19
Study of immunocytochemistry in expression of nucleoside transporterENT3 in astrocytes
Koh-ichi Tanaka1,2,3, Wataru Suzuki1, Kento Igarashi1,2, Kazuo Tomita1,2, Nobue Kitanaka3,Junichi Kitanaka3, Tomoaki Sato2, Motohiko Takemura3
1Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Applied Pharmacol., KagoshimaUniv. Grad. Sch. Med. & Dent. Sci., 3Dept. Pharmacol., Hyogo Col. Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-20
An in vivo macroscopic Ca2+ imaging method for analysis of astrocytic Ca2+
activities in neurodegenerative disease model mice
Yuki Motegi, Masamitsu Iino, Kazunori Kanemaru
Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-21
Three-dimensional co-culture model using human iPSCderived brain organoid and microglia-like cells
Mayuko Takata, Kaneyasu Nishimura, Kazuyuki Takata
Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-22
The role of nicotinic acetylcholine receptors on differentiation of iPSC-derived macrophages and dopaminergic neurons
Koki Harada1, Takeshi Kato1, Kaneyasu Nishimura1, Masahiro Hirao1, Shun Shimohama2,Kazuyuki Takata1
1Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan, 2Dept. Neurol., Sapporo Med. Univ. Sch. of Med.,Sapporo, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-23
Robust induction of nigro-striatal neurons from human induced pluripotentstem cells by small compound-based signal controlling
Kaneyasu Nishimura, Naoya Amimoto, Takeshi Kato, Masahiro Hirao, Kazuyuki Takata
Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-24
Toward the generation of thalamic organoids from human inducedpluripotent stem cells
Masatoshi Nishimura1, Nao Morimoto1,2, Fumitaka Osakada1,2,3
1Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan,2Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University, Japan,3Institute of Nano-Life-Systems, Institutes for Innovation for Future Society, Nagoya University, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-25
Generation of cortical organoids with axial polarity from marmosetembryonic stem cells
Tomoki Kodera1, Taiki Hara1,2, Nao Morimoto1,3, Fumitaka Osakada1,3
1Lab. of Cell. Pharmacol., Grad. Sch. of Pharmaseut. Sci., Nagoya Univ., 2Mitsubishi Tanabe Pharma Corp., 3Lab.of Neural Info. Processing, Inst. for Adv. Res., Nagoya Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-26
Astrocyte-microglia interaction promotes rotenone-induced dopaminergicneurotoxicity
Ikuko Miyazaki1, Ryo Kikuoka1, Nami Isooka1, Shinki Murakami1, Chiharu Sogawa2,Norio Sogawa3, Yoshihisa Kitamura4, Masato Asanuma1
1Dept. of Medical Neurobiology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci.,2Dept. of DentalPharmacology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., 3Dept. of Dental Pharmacology,Matsumoto Dental Univ., 4Dept. of Pharmaceutical Care and Health Sciences, Sch. of Pharmacy, Shujitsu Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-27
Inhibitory effect of neurite outgrowth via glycer-AGEs dependent β-tubulinabnormal aggregation
Ryuto Nasu1, Furukawa Ayako1, Masayoshi Takeuchi2, Yoshiki Koriyama1
1Grad. Sch. of Pharm. Sci., Suzuka Univ. of Med. Sci., 2Dept. of Adv. Med., Kanazawa Med. Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-28
Construction of PDGFRβ activation system using optogenetics.
Kimura Yuna, Masatoshi Inden, Hisaka Kurita, Isao Hozumi
Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-29
High glucose enhances oxidative stress-induced cell death in culturedneuronal cells
Yuki Ishimaru, Reina Miura, Akinori Tanimura, Tokiyo Yamaguchi, Akiko Yamamuro,Yasuhiro Yoshioka, Sadaaki Maeda
Lab. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-30
Effects of the Alzheimer's disease drug rivastigmine on nerve growth factorvia sigma receptor
Matsushima Yukari1, Kazuki Terada2, Kaoru Umehara1, Iwao Sakakibara1
1Department of Kampo and Natural Product Chemistry, Faculty of Pharmaceutical Sciences,Yokohama Universityof Pharmacy, 2Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, FukuokaUniversity
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-31
Effect of forest bioresources for amyloid-β protein and working memoryperformance
Iwasa Kensuke1, Kei Maruyama1, Masashi Asai2, Kuniyoshi Shimizu3, Keisuke Yoshikawa1
1Dept. Pharmacol., Saitama Med University., 2Dept. Faculty of Pharmacy, Yokohama University of Pharmacy.,3Dept. agro-environmental sciences, Faculty of Agriculture, Graduate School of Kyushu University.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-32
Neuropathological analysis of Niemann-Pick disease type C using patient-derived iPSCs
Ryo Saito1,2, Takashi Miyajima1,3, Chen Wu1,3, Arif Hossain Mohammad1,2, Miyo Munakata1,Ken Suzuki1, Takeo Iwamoto2, Takumi Era4, Yoshikatsu Eto1,5
1Adv. Clin. Res. Ctr., Southern Tohoku Res. Inst. for Neurosci.,2Core Res. Facilities for Basic Sci., The Jikei Univ.Sch. of Med., 3Rare disease res. ctr., AnGes Inc.,4Dept. of Cell Modulation, IMEG, Kumamoto Univ., 5The JikeiUniv. Sch. of Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-33
D-Cysteine regulates chaperone-mediated autophagy and microautophagythrough the generation of hydrogen sulfide.
Ueda Erika1, Takahiro Seki1,2, Ayumu Konno3, Hirokazu Hirai3, Yuki Kurauchi1,2, Hiroshi Katsuki1,2
1Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, 2Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci,Kumamoto Univ, 3Dept Neurphysiol Neural Rep, Gunma Univ Grad Sch Med
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-34
Increased glutathione via NOVA1 by administration of an inhibitor of themicroRNA miR-96-5p
Chisato Kinoshita1, Nobuko Matsumura1, Koji Aoyama1, Toshio Nakaki1,2
1Dept. Pharmacol., Teikyo Univ. Sch. Med.,2Fac. Pharma-Sci., Teikyo Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-35
Involvement of cochlear macrophages in the loss of inner hair cell synapsesby noise exposure
Taro Yamaguchi, Yusuke Onaka, Masanori Yoneyama
Lab. Pharmacol. Sci., Sestunan Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-36
Establishment of a new tri-culture system for elucidating crosstalkmechanisms between brain microvascular endothelial system and centralnervous system in Alzheimer’s disease brains
Tomoya Sasahara1,2, Minako Hoshi1,3
1Depart. Brain and Neurodegener Dis Res, Institute of Biomedical Research and Innovation, Foundation forBiomedical Research and Innovation at Kobe, 2Research & Development Division, TAO Health Life Pharma,3Depart. Anat and Dev Biol, Graduate School of Medicine, Kyoto Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-37
Hypercholesterolemia may attenuate cerebral aneurysm
Kazuya Hokamura1,3, Hiroshi Makino2, Takayuki Iwaki1, Ryou Imai2, Tetsuro Kimura2,Yoshiki Nakajima2, Kazuo Umemura1
1Dept. Pharm., Hamamatsu Univ. Sch. of Med., 2Dept., Anesth., Hamamatsu Univ. Sch. of Med., 3Medical Edu.,Hamamatsu Univ. Sch. of Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-38
CUD003, a novel synthetic derivative of curcumin, can mitigate middlecerebral artery occlusion (MCAO)-induced ischemic injury by suppressinginflammation in rats
Hirokazu Matsuzaki1, Nazuki Sekine1, Hayato Sato1, Azumi Horikoshi2, Takashi Asano1,Naohiro Iwata3, Xuan Meiyan2, Jun Takayama2, Yuan Bo1, Yasihide Hibino3, Takeshi Sakamoto2,Mari Okazaki1
1Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., 2Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.,3Immunobiochem., Fac. Pharm. Sci., Josai Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-39
Effect of traditional Japanese medicine, ninjin’yoeito, on cerebral blood flowin urethane-anesthetized mice
Nobuhiro Watanabe, Kaori Iimura, Harumi Hotta
Dep. Auton. Neurosci., Tokyo Metro. Inst. Gerontol.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-40
Effects of IL-6 family cytokines on blood-brain barrier function
Sho Hamada, Natsuko Hitora-Imamura, Masabumi Minami
Department of Pharmacology, Hokkaido University
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-41
Transport of docosahexaenoic acid across the blood–brain barrier isdecreased in aged mice
Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yasufumi Kataoka, Shinya Dohgu
Fukuoka University
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-42
Reptiles, sleep, and the claustrum
Norimoto Hiroaki1, Lorenz Fenk1, Hsing-Hsi Li1, Maria Tosches1,2, Tatiana Tatiana1, David Hain1,Sam Reiter1,3, Riho Kobayashi1,4, Gilles Laurent1
1Max Planck Institute for Brain Research, 2Columbia University Department of Biological Sciences,3Computational Neuroethology Unit, 4Nagoya City University Graduate School of Pharmaceutical Sciences
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-43
Influence of circadian rhythm on the delayed recovery from isofluraneanesthesia induced by hypnotics in mice
Yoshinori Iba, Atsunobu Sugano, Hiroki Murai, Syunpei Horiguchi, Yuki Amano
Dept. Life Sci., Fac. Sci. and Engineering, Setsunan Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-44
Real time recording of Period1 gene in the central and peripheral tissues ofthe freely moving streptozotocin-treated diabetic mouse.
Nagasawa Koki1, Yuki Ishii1, Ryosuke Sato1, Mizuki Nakaya1, Juri Hayashi1, Yukina Yoshida1,Masayori Ishikawa2, Michitaka Ozaki3, Kazuko Hamada1, Toshiyuki Hamada1
1IUHW.Dept.Phamaceut, 2Hokkaido.Uni.Fac.Health Sci, 3Hokkaido.Uni.Fac.Health Sci
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P1-45
The analysis of Period1 gene expression in freely moving mouse usingmicro PMT system.
Yuki Ishii1, Juri Hayashi1, Mizuki Nakaya1, Ryosuke Sato1, Yukina Yoshida1, Kouki Nagasawa1,Masayori Ishikawa2, Michitaka Ozaki3, Kazuko Hamada1, Toshiyuki Hamada1
1IUHW.Dept.Phamaceut, 2Hokkaido,Uni.Fac.Heaith Sci., 3Hokkaido,Uni.Fac.Heaith Sci.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-01
Moxifloxacin exacerbate aortic aneurysm and aortic dissection by increasingosteopontin protein expressions
Koshun Inada1, Mitsuhisa Koga2, Atsushi Yamauchi3
1Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 2Dept. Drug Design and DrugDelivery., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 3Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci.,Fukuoka Univ.,
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-02
Role of tissue type plasminogen activator in a murine model of type IIahuman familial hypercholesterolemia
Arakawa Tomohiro1, Takayuki Iwaki1, Masamitsu Takaba2, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Third Div., Dept. Intern. Med., Hamamatsu Univ. Sch. Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-03
Effect of pretreatment with diltiazem on mast cell degranulation byadrenaline treatment in anaphylactic rats.
Sawano Mayu, Wakana Takatsu, Seiichiro Kano
Fac.Pharm.Sci.,Hokkaido Univ of Sci.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-04
Development and functional analysis of novel PCSK9/LDLR interactioninhibitors for hypercholesterolemia treatment
Takumi Yokoyama1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-05
Effect of uridine triphosphate and uridine diphosphate on vascular functionin the carotid arteries of spontaneously hypertensive rats
Katome Tomoki, Takayuki Matsumoto, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi,Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-06
Activation of transient receptor potential vanilloid 4 channels dilates the ratretinal arterioles via the production and release of nitric oxide and theactivation of large-conductance Ca2+-activated K+ channels in vivo
Asami Mori1,2, Kazuki Takeda1, Kenji Sakamoto1,2, Tsutomu Nakahara1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-07
Endothelial Function in Coronary Arteries from Pneumonia-Infected Pigs
Masashi Tawa, Katsuya Nakano, Qiang He, Takayoshi Masuoka, Takaharu Ishibashi
Dept. Pharmacol., Kanazawa Med. Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-08
Benzodiazepines and non-benzodiazepine drugs have direct vasorelaxanteffects
Satomi Kagota1, Kana Morikawa1, Hirotake Ishida2, Junko Chimoto2, Kana Fumoto1,Shizuo Yamada,2, Kazumasa Shinozuka1
1Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ,2Centr. for Pharm-Food Res, Univ. ofShizuoka
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-09
Apelin attenuated advanced glycation end products-induced cell death inmouse endothelial cell line bEnd.3.
Yasuhiro Yoshioka, Haruku Yamamoto, Shigenori Yoshizawa, Akiko Yamamuro, Yuki Ishimaru,Sadaaki Maeda
Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., Osaka 573-0101, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-10
Effects of gas phase extract of cigarette smoke generated from heatedtobacco and burned cigarette on human vascular endothelial cells
Takahiro Horinouchi1, Yuichi Mazaki1, Soichi Miwa2
1Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ. Sapporo 060-8638, Japan., 2Toyooka Gen. Hosp., Hyogo668-8501, Japan.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-11
Microvascular endothelial model that can predict the inflammatoryresponses in human microvessels with high reproducibility: Culture modelof an hCMEC/D3 cell line fabricated in a collagen vitrigel membrane chamber
Miaki Uzu, Toshiaki Takezawa
Vitrigel Project, Institute of Agrobiological Sciences, NARO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-12
Retinoic acid promotes barrier functions in human iPS cell-derived intestinalepithelium
Shigeru Yamada1,2, Yasunari Kanda1
1Div. Pharmacol, NIHS, 2PEIJ
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-13
Maintenance of intestinal homeostasis by NAD metabolism
Yaku Keisuke, Takashi Nakagawa
Dept. of Mol. and Med. Pharmacol., Fac. of Med., Univ. of Toyama
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-14
Oral administration of 5,6-DiHETE attenuates DSS-induced colitis in mice
Shinya Takenouchi, Daiki Imai, Koji Kobayashi, Tatsuro Nakamura, Nanae Nagata,Takahisa Murata
Dept. Animal Radiology, Univ. Tokyo
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-15
Role of TRPM2 expressed in macrophages in TNBS-induced colonic fibrosisin mice
Nakamoto Tomohiro1, Kenjiro Matsumoto1, Hiroyuki Yasuda1, Yasuo Mori2, Shinichi Kato1
1Dept. of Pharmacol. and Exp. Therap., Kyoto Pharmaceut. Univ., 2Dept. of Synthetic Chem. and Biological Chem.,Grad. Sch. of Eng., Kyoto Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-16
Assessment of the effects of docosahexaenoic acid (DHA) andeicosapentaenoic acid (EPA) on the contractile responses of guinea piglower gastrointestinal (LGI) tracts
Keisuke Obara, Keyue Xu, Guanghan Ou, Rikako Inaba, Mirai Kawakita, Ayana Kawaguchi,Rena Kudo, Akari Kurata, Kento Yoshioka, Fumiko Yamaki, Yoshio Tanaka
Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-17
Daikenchuto attenuates visceral pain and suppresses eosinophil infiltrationin inflammatory bowel disease in murine models
Kogure Yoko1, Hirosato Kanda1,2,3, Shenglan Wang1,4, Satoshi Yamamoto1, Koichi Noguchi3,Yi Dai1,2,3
1Dept. Pharm. Sch. Pharm. Hyogo Univ. Health Sci., 2Tral Med. Res. Ctr, Chn Med. CI at Hyogo Col. Med.,3Dept.Anat. Neurosci., Hyogo Col. Med., 4Sch. Acup-Mox Tuina, Beijing Univ. Chn Med.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-18
Lacking dietary fiber enhances sensitivity to inflammatory stimuli, thatresults in intestinal hyper-permeability.
Haruki Usuda, Syoma Kanda, Takayuki Okamoto, Koichiro Wada
Dept. Pharmaco., Fac. Med., Shimane Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-19
Effect of oyster extract on gastrointestinal and myeloid toxicity of 5-FU inrats
Noriyuki Yamazaki1, Suzuki Kohtaro1, Keita Saitoh1, Kohei Araki1, Yuki Ishida1, Hiroki Morikawa1,Takuma Nakajima1, Tohru Nonomura1, Makoto Konno1, Tatsuya Ishida2, Hiroyuki Matsui2,Yoshikazu Matsuda2
1New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-20
Effect of oyster extract on toxicity and pharmacological action of steroids inrats
Makoto Konno1, Hiroki Morikawa1, Masaharu Igarashi1, Masumi Kikuta1, Hitoshi Goto1,Noriyuki Yamazaki1, Katsura Matsuda2, Tatsuya Ishida2, Hiroyuki Matsui2, Yoshikazu Matsuda2
1New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-21
Prenylated quinolinecarboxylic acid compound-18 prevents sensory nervefiber outgrowth through inhibition of the interleukin-31 pathway
Masato Ogura, Kumiko Endo, Toshiyuki Suzuki, Yoshimi Homma
Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-22
Loss of skeletal muscle mass influences immune homeostasis andaccelerates the disease progression of lupus nephritis
Shuang Liu1, Takeshi Kiyoi2, Masaki Mogi1
1Dept. Pharmacol., Grad. Sch. Med., Ehime Univ., 2ADRES, Ehime Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-23
Activated coagulation factors induce histamine release of human skin mastcells and peripheral basophils through activation of complement system
Yuhki Yanase1, Yoshimi Matsuo2, Tomoko Kawaguchi2, Kaori Ishii2, Koichiro Ozawa1,Michihiro Hide2
1Dept. of Parmacotherapy, Hiroshima University, 2Dept. of Dermatology, Hiroshima University
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-24
Anti-inflammatory mechanism of Nrf2-ARE activator in chronic contacthypersensitivity model mice
Mana Nonoguchi1, Yuki Takada-Takatori1, Risa Imai1, Namiko Shouno1, Yasuhiko Izumi2,3,Akinori Akaike2,4, Toshiaki Kume2,5, Katsuharu Tsuchida1, Kei-ichi Ozaki1
1Fac. Pharmaceut. Sci., Doshisha Women's Coll., 2Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.,3Kobe Pharmaceut. Univ., 4Wakayama Med. Univ.,5Dept. Appl. Pharmacol., Grad. Sch. Medicinal and Pharmaceut.Sci., Univ.Toyama
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-25
A Discussion on the Mechanism of Actions of a gold compound, Auranofin
Masamichi Yamashita
Dept. Biosci. Daily Life, Coll. Biores. Sci., Nihon Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-26
The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13-induced STAT6 phosphorylation in phorbol 12-myristate 13-acetate-stimulated THP-1 cells
Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Shinya Yamamoto, Kazuhito Tsuboi
Kawasaki Med. Sch.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-27
Upregulation of P2X7 receptor signaling by interleukin-33 in mouse bonemarrow-derived mast cells
Kazuki Yoshida, Yuu Ishida, Masaaki Ito, Isao Matsuoka
Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-28
P2Y receptor activation and PI3K(δ) enhance human-derived mast celldegranulation
Haruhisa Nishi1, François Niyonsaba2,3
1Dept. Pharmacol., Sch. Med., Jikei Univ. Sch. Med., 2Atopy Res. Cent., Grad. Sch. Med., Juntendo Univ., 3Fac.International Liberal Arts
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-29
Development and functional analysis of novel IL-6R/IL-6 interactioninhibitors for autoimmune disease treatment
Yukio Takamori1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-30
Development and functional analysis of novel TNF-alpha/TNFR interactioninhibitors for autoimmune disease treatment
Keita Tsukamoto1, Takehiro Ando1, Yukio Takamori1, Daisuke Fuji2, Mizuki Yamamoto3,Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ,5JST, PRESTO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-31
Transrepression-selective liver X receptor (LXR) ligands regulateinflammasome activation
Sayaka Takahashi1, Kaori Umeda-Endo2, Makoto Makishima2, Hashimoto Yuichi3,Toshiaki Ishizuka1, Minoru Ishikawa4
1National Defense Medical College, 2Nihon University School of Medicin, 3Institute for Quantitative Biosciences,The University of Tokyo, 4Graduate School of Life Sciences, Tohoku University
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-32
Risk management of L-Asparaginase-induced allergy: focusing on theinfluence of cyclophosphamide
Ai Nogami-Hara1, Yuta Hori1, Chie Mitsuhata1, Koji Kajiyama1, Kentaro Susuki1, Akira Shimada2,Mitsunobu Mio1
1Lab. Pharmacol., Sch. Pharm., Shujitsu Univ., 2Dept. Pediatr. Hematol. Oncol., Okayama Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-33
Pharmacological evaluation in atopic dermatitis models induced by miteantigen in mice
Nagayama Manami, Ayaka Yamaguchi, Ryota Yagi, Kumiko Kitta, Atsuko Ichikawa, Jun-ichi Fuchikami, Yasuki Akie
CMIC Pharma Science Co., Ltd.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-34
FK506-binding protein contributes to tacrolimus distribution in red bloodcells
Naoki Yoshikawa1, Ayako Matsuo2, Tsubasa Yokota1, Tomomi Iwakiri1, Ryuji Ikeda1
1Dept. Pharm., Univ. Miyazaki Hosp., 2Dept. Respiratory Med., Univ. Miyazaki Hosp.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-35
Exploring the mechanism of action of maoto, a traditional Japanesemedicine, on acute systemic inflammation induced by polyI:C administration
Keisuke Ogura, Ayumi Kadota, Akinori Nishi, Akiko Nakayama, Hitomi Kannno, Yoshiki Ikeda
Tsumura Kampo Research Laboratories, Tsumura and Co.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-36
Investigation of genetic variants in SARS-CoV-2-interacting molecules ofACE2, TMPRSS2 and TLR3/7/8 across populations
Lee Ji-Won1, In-Hee Lee2, Sek Won Kong2,3, Tadahiro Iimura1
1Dept. Pharmacol., Grad. Sch., Hokkaido Univ., 2Boston Children’s Hospital,3Harvard Med. Sch.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-37
Development and functional analysis of novel HER3/HRG interactioninhibitors for cancer treatment
Takehiro Ando1, Takumi Yokoyama1, Rina Iwamoto1, Daisuke Fuji2, Mizuki Yamamoto3,Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-38
Development and functional analysis of novel VEGFR2/VEGF interactioninhibitors for angiogenesis inhibition
Horiuchi Daisuke1, Takehiro Ando1, Fuji Daisuke2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Gred. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-39
Development and functional analysis of novel PD-L1/PD-1 interactioninhibitors for cancer immunotherapy
Iwamoto Rina1, Takehiro Ando1, Daisuke Horiuchi1, Daisuke Fuji2, Mizuki Yamamoto3,Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-40
Cytotoxic effects of mushroom extracts banked in FMRC
Kenji Takahashi1,2, Atsushi Ishihara2, Toshio Ohta1,2
1Tottori Univ. Joint Dep Vet Med. Vet Pharmacol.,2Tottori Univ. Fac. Agr. FMRC
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-41
Molecular and Functional Analysis of Choline Transporters and AntitumorEffects of Choline Transporter-Like Protein 1 Inhibitors in HumanHepatocellular Carcinoma Cells
Masato Inazu1,2, Akane Hase1, Kaho Hirai1, Saiichiro Watanabe1, Kaoru Shibata1,Tsuyoshi Yamanaka2
1Inst. Med. Sci., Tokyo Med. Univ.,2Dept. Mol. Preventive Med., Tokyo Med. Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-42
Dysfunction of DUSP22 induces synthetic lethality in poly(ADP-ribose)glycohydrolase (PARG) knocked down lung cancer cell lines.
Yuka Sasaki1,2, Hiroaki Fujimori2, Takae Onodera1,2, Tadashige Nozaki1,3, Fumiaki Koizumi1,4,Mitsuko Masutani1,2
1Dept. Molecular and Genomic Biomedicine, Grad. Sch. Biomed. Sci. & CBMM, Nagasaki Univ., 2Natl. Cancer Ctr.Res. Inst., 3Dept. Pharmacol. Osaka Dent. Univ.., 4Div. Clin. Res. Support, Komagome Hosp.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-43
Study of Anti-proliferative Effects of Chaga Mushroom and PanaxNotoginseng-containing Traditional Chinese Medical Supplement, Shibe-riaon Dog Bladder Cancer Stem Cells
Yuta Shinohara1,2, Yomogi Sato1, Mohamed Elbadawy1,3, Megumi Yamanaka1, Yuta Goto1,Kimika Hayashi1, Amira Abugomaa1, Tatsuya Usui1, Kazuaki Sasaki1
1Dept. Vet Med., Fac. agr., Tokyo Univ of Agr and Tech.,2Division. Pet Health and Food., Iskara Industry CO.,LTD., 3Dept. Pharm., Fac. Vet med., Benha Univ.
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-44
Development of an anti-cancer drug sensitivity test using a urine sample-derived organoid culture for dog bladder cancer
Mori Masahiro, Yomogi Sato, Mohamed Elbadawy, Tatsuya Usui, Kazuaki Sasaki
Lab. of Veterinary Pharmacology, Dept of Veterinary Medicine, Fac. of Agriculture, Tokyo Univ. of Agriculture andTechnology
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-45
Establishment of a culture method of the human bladder cancer organoidusing the urine sample
Kodai Fujisaka1, Mohamed Elbadawy1,2, Yomogi Sato1, Haru Yamamoto1, Hiroaki Matsumoto3,Hideyasu Matsuyama3, Masahiro Kaneda4, Tatsuya Usui1, Kazuaki Sasaki1
1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, TokyoUniversity of Agriculture and Technology,2Department of Pharmacology, Faculty of Veterinary Medicine, BenhaUniversity, 3Department of Urology, Graduate School of Medicine, Yamaguchi University,4Laboratory of VeterinaryAnatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture andTechnology
Poster Sessions
Copyright © The Japanese Pharmacological Society
1-P2-46
Establishment of a culture method of the dog lung cancer organoid
Sato Yomogi1, Mohamed Elbadawy1,2, Daigo Azakami3, Masahiro Kaneda4, Tatsuya Usui1,Kazuaki Sasaki1
1Lab. Veterinary Pharmacol., Dept. Veterinary Medic., Fac. Agri., Tokyo University of Agri. and Tech.,2Benha Univ,Fac. Veterinary Med., Dept. Pharmacol., 3Lab. Veterinary Clin. Oncology, Dept. Veterinary Medic., Fac. Agri.,Tokyo University of Agri. and Tech.,4Lab. Veterinary Anatomy., Dept. Veterinary Medic., Fac. Agri., TokyoUniversity of Agri. and Tech.
Poster Sessions
Copyright © The Japanese Pharmacological Society
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