1-P1-01 Poster Sessions BARP regulates the dynamics of ... · Ueda Erika1, Takahiro Seki 1,2, Ayumu Konno3, Hirokazu Hirai3, Yuki Kurauchi1,2, Hiroshi Katsuki 1Dept Chemico-Pharmacol

1-P1-01

BARP regulates the dynamics of voltage-dependent Ca2+ channelcomplexes at dendritic spine

Yoshihiro Matsunaga1, Akito Nakao1, Mizuki Omori1, Taketoshi Kajimoto1,2, Yasuo Mori1

1Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ., 2Div. Biochem. Kobe Univ. Grad. Sch. Med.

Poster Sessions

Copyright © The Japanese Pharmacological Society

1-P1-02

Presynaptic inhibition of GABA release from striatal medium spiny neuronsonto cholinergic interneurons in young-adult mice.

Etsuko Suzuki, Toshihiko Momiyama

Department of pharmacology, Jikei university school of medicine

Poster Sessions


1-P1-03

Involvement of NO cascade in AT1 receptor mediated effects of angiotensin IIon excitatory synaptic transmission in the rat nucleus tractus.

Yoshiaki Ohi, Daisuke Kodama, Akira Haji

Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.

Poster Sessions


1-P1-04

Evaluation of the effect of levetiracetam on methamphetamine-inducedhyperactivity in Sv2aL174Q rats

Saki Shimizu, Yui Mimaki, Sayaka Jinno, Shiho Taruya, Tadao Serikawa, Yukihiro Ohno

Dept. Pharmacol., Osaka Univ. Pharm. Sci.

Poster Sessions


1-P1-05

Effect of estradiol on behavioral selection for pups and synaptictransmission in the rhomboid nucleus of the bed nucleus of the striaterminalis

Kiyoshiro Fukui, Keiichiro Sato, Masabumi Minami, Taiju Amano

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan

Poster Sessions


1-P1-06

Lysophosphatidylethanolamines with different fatty acid lengths stimulateneurite outgrowth in cultured cortical neurons through distinct signalingcascades

Yoshida Hironori1,3, Kazutoshi Hisano2,3, Shiori Kawase4, Tetsuhiko Mimura2,3, Hisao Haniu3,Tamotsu Tsukahara5, Taiga Kurihara6, Yoshikazu Matsuda7, Naoto Saito3, Takeshi Uemura3,4

1Grad. Sch. of Sci. Tech., Shinshu Univ., Nagano, Japan, 2Grad. Sch. of Med., Sci. Tech., Shinshu Univ.,Nagano, Japan, 3IBS-ICCER., Shinshu Univ., Nagano, Japan, 4Div. of Gene Res., Res. Cent. for Supports toAdvanced Sci., Shinshu Univ., Nagano, Japan, 5Dept. Pharmcol. Therap. Innov., Nagasaki Univ., inst. Biomed. Sci.,Nagasaki, Japan, 6Div. Microbiol. & Mol. Cell. Biol., Nihon Pharmaceutical Univ., Saitama, Japan,7Div. of Clin.Pharm. & Pharmaceut., Nihon Pharmaceutical Univ., Saitama, Japan

Poster Sessions


1-P1-07

Alteration of parvalbumin expression and perineuronal nets formation in theanterior cingulate cortex of Fabp3 KO mice

Yui Yamamoto1,2, Yuji Owada2, Kohji Fukunaga3, Keiju Kamijo1

1Dept. Anatomy, Tohoku Med. and Pharm. Univ.,2Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med.,3Dept.Pharmacology, Tohoku Univ. Grad. Sch. Pharm.

Poster Sessions


1-P1-08

E3 Ubiquitin Ligase HRD1 regulates the Serotonin Transporter Function

Taguchi Kei1, Masayuki Kaneko3, Serika Motoike2, Kana Harada1, Izumi Hide1, Shigeru Tanaka1,Norio Sakai1

1Department of Molecular and Pharmacological Neuroscience, 2Department of Dental Anesthesiology GraduateSchool of Biomedical and Health Sciences, Hiroshima University, 3Department of Pharmacology and TherapeuticInnovation, Nagasaki University Graduate School of Biomedical Sciences

Poster Sessions


1-P1-09

Regulation of nicotine-induced tremor by the dopaminergic nervous system

Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Chihiro Takashima, Kana Tsujimura,Kazuya Horikawa, Yukihiro Ohno

Dept. Pharmacol., Osaka Univ. Pharm. Sci.

Poster Sessions


1-P1-10

Applying Ca2+ Image Sensor to visualize extracellular Ca2+ dynamics inhippocampus.

Parajuli Bijay1, Hideo Doi3, Eiji Shigetomi1,2, Youichi Shinozaki1,2, Toshihiko Noda3,4,Kazuhiro Takahashi3, Kazuaki Sawada3, Schuichi Koizumi1,2

11Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi,Yamanashi, Japan, 2Yamanashi Interdisciplinary Brain-Immune Research Center (YiBIC), University of Yamanashi,Yamanashi, Japan, 3Integrated Biosensor. MEMS group, Department of Electrical and Electronic InformationEngineering,, 4Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) Toyohashi University ofTechnology

Poster Sessions


1-P1-11

Human excitatory amino acid transporters (EAATs) were functional in thehuman induced pluripotent stem cell (hiPSC)-derived human neuralnetworks

Kanako Takahashi1, Kaori Chujo1, Ikuro Suzuki2, Kaoru Sato1

1Lab. Neuropharmacol., Div. Pharm., Nat. Inst. Hlth. Sci.,, 2Dept. Electro., Grad. Sch. Engineering, Tohoku Inst.Tech.,

Poster Sessions


1-P1-12

Expanding the repertoire of the genetically-encoded fluorescent transmittersensors

Daisuke Ino

Dept. Cell Biol Histol., Grad. Sch. Med., Kanazawa Univ.

Poster Sessions


1-P1-13

Degradation of oligomeric α-Synuclein in brain pericytes is enhanced bycyclosporin A

Shinya Dohgu1, Miki Yokoya1, Fuyuko Takata1, Junichi Matsumoto1, Takuro Iwao1,Kazunori Sano2, Yasufumi Kataoka1

1Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2Dept. Physiol. & Pharmacol., Fac.Pharmaceut. Sci., Fukuoka Univ.

Poster Sessions


1-P1-14

Brain pericytes increase sodium-dependent glutamate uptake in astrocytes.

Fuyuko Takata1, Kenta Sakai1,2, Takuro Iwao1,2, Junichi Matsumoto2, Yasufumi Kataoka1,Atsushi Yamauchi2, Shinya Dohgu1

1Department of Pharmaceutical Care and Health Sciences, 2Department of Pharmaceutical Care and HealthSciences

Poster Sessions


1-P1-15

Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice

Koichi Kawahara, Yukina Kojima, Natsuki Kumakura, Masaaki Sano, Kota Hosokai,Takumi Yamada, Takuya Hasegawa, Takehiko Maeda

Dept. Pharmacol., Fac. Pharm. Sci., Niigata Univ. Pharm. Appl. Life. Sci.

Poster Sessions


1-P1-16

Cholesterol induced calcium oscillation found in astrocytes

Adachi Chihiro, Takafumi Inoue

Dept. Life. Sci. & Med. Biosci. Waseda Univ.

Poster Sessions


1-P1-17

Zinc-aggravated M1 microglia suppress astrocytic engulfing activity viaP2X7 receptors

Youichirou Higashi1, Takaaki Aratake1,2, Tomoya Hamada1, Takahiro Shimizu1, Shogo Shimizu1,Suo Zou1, Masaki Yamamoto1, Rina Nakamura1, Toshifumi Akizawa1, Motoaki Saito1

1Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., 2JSPS Research Fellow

Poster Sessions


1-P1-18

Prostaglandin E2 increases the expression of cyclooxygenase-2 protein inmicroglia.

Takayuki Nagano, Naohiko Tsuda, Kenichi Fujimura, Yuji Ikezawa, Yuki Higashi, Shinya KimuraH., Motohiko Takemura

Dept. Pharmacol., Hyogo Coll. Med.

Poster Sessions


1-P1-19

Study of immunocytochemistry in expression of nucleoside transporterENT3 in astrocytes

Koh-ichi Tanaka1,2,3, Wataru Suzuki1, Kento Igarashi1,2, Kazuo Tomita1,2, Nobue Kitanaka3,Junichi Kitanaka3, Tomoaki Sato2, Motohiko Takemura3

1Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Applied Pharmacol., KagoshimaUniv. Grad. Sch. Med. & Dent. Sci., 3Dept. Pharmacol., Hyogo Col. Med.

Poster Sessions


1-P1-20

An in vivo macroscopic Ca2+ imaging method for analysis of astrocytic Ca2+

activities in neurodegenerative disease model mice

Yuki Motegi, Masamitsu Iino, Kazunori Kanemaru

Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine

Poster Sessions


1-P1-21

Three-dimensional co-culture model using human iPSCderived brain organoid and microglia-like cells

Mayuko Takata, Kaneyasu Nishimura, Kazuyuki Takata

Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan

Poster Sessions


1-P1-22

The role of nicotinic acetylcholine receptors on differentiation of iPSC-derived macrophages and dopaminergic neurons

Koki Harada1, Takeshi Kato1, Kaneyasu Nishimura1, Masahiro Hirao1, Shun Shimohama2,Kazuyuki Takata1

1Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan, 2Dept. Neurol., Sapporo Med. Univ. Sch. of Med.,Sapporo, Japan

Poster Sessions


1-P1-23

Robust induction of nigro-striatal neurons from human induced pluripotentstem cells by small compound-based signal controlling

Kaneyasu Nishimura, Naoya Amimoto, Takeshi Kato, Masahiro Hirao, Kazuyuki Takata

Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan

Poster Sessions


1-P1-24

Toward the generation of thalamic organoids from human inducedpluripotent stem cells

Masatoshi Nishimura1, Nao Morimoto1,2, Fumitaka Osakada1,2,3

1Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan,2Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University, Japan,3Institute of Nano-Life-Systems, Institutes for Innovation for Future Society, Nagoya University, Japan

Poster Sessions


1-P1-25

Generation of cortical organoids with axial polarity from marmosetembryonic stem cells

Tomoki Kodera1, Taiki Hara1,2, Nao Morimoto1,3, Fumitaka Osakada1,3

1Lab. of Cell. Pharmacol., Grad. Sch. of Pharmaseut. Sci., Nagoya Univ., 2Mitsubishi Tanabe Pharma Corp., 3Lab.of Neural Info. Processing, Inst. for Adv. Res., Nagoya Univ.

Poster Sessions


1-P1-26

Astrocyte-microglia interaction promotes rotenone-induced dopaminergicneurotoxicity

Ikuko Miyazaki1, Ryo Kikuoka1, Nami Isooka1, Shinki Murakami1, Chiharu Sogawa2,Norio Sogawa3, Yoshihisa Kitamura4, Masato Asanuma1

1Dept. of Medical Neurobiology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci.,2Dept. of DentalPharmacology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., 3Dept. of Dental Pharmacology,Matsumoto Dental Univ., 4Dept. of Pharmaceutical Care and Health Sciences, Sch. of Pharmacy, Shujitsu Univ.

Poster Sessions


1-P1-27

Inhibitory effect of neurite outgrowth via glycer-AGEs dependent β-tubulinabnormal aggregation

Ryuto Nasu1, Furukawa Ayako1, Masayoshi Takeuchi2, Yoshiki Koriyama1

1Grad. Sch. of Pharm. Sci., Suzuka Univ. of Med. Sci., 2Dept. of Adv. Med., Kanazawa Med. Univ.

Poster Sessions


1-P1-28

Construction of PDGFRβ activation system using optogenetics.

Kimura Yuna, Masatoshi Inden, Hisaka Kurita, Isao Hozumi

Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ.

Poster Sessions


1-P1-29

High glucose enhances oxidative stress-induced cell death in culturedneuronal cells

Yuki Ishimaru, Reina Miura, Akinori Tanimura, Tokiyo Yamaguchi, Akiko Yamamuro,Yasuhiro Yoshioka, Sadaaki Maeda

Lab. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.

Poster Sessions


1-P1-30

Effects of the Alzheimer's disease drug rivastigmine on nerve growth factorvia sigma receptor

Matsushima Yukari1, Kazuki Terada2, Kaoru Umehara1, Iwao Sakakibara1

1Department of Kampo and Natural Product Chemistry, Faculty of Pharmaceutical Sciences,Yokohama Universityof Pharmacy, 2Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, FukuokaUniversity

Poster Sessions


1-P1-31

Effect of forest bioresources for amyloid-β protein and working memoryperformance

Iwasa Kensuke1, Kei Maruyama1, Masashi Asai2, Kuniyoshi Shimizu3, Keisuke Yoshikawa1

1Dept. Pharmacol., Saitama Med University., 2Dept. Faculty of Pharmacy, Yokohama University of Pharmacy.,3Dept. agro-environmental sciences, Faculty of Agriculture, Graduate School of Kyushu University.

Poster Sessions


1-P1-32

Neuropathological analysis of Niemann-Pick disease type C using patient-derived iPSCs

Ryo Saito1,2, Takashi Miyajima1,3, Chen Wu1,3, Arif Hossain Mohammad1,2, Miyo Munakata1,Ken Suzuki1, Takeo Iwamoto2, Takumi Era4, Yoshikatsu Eto1,5

1Adv. Clin. Res. Ctr., Southern Tohoku Res. Inst. for Neurosci.,2Core Res. Facilities for Basic Sci., The Jikei Univ.Sch. of Med., 3Rare disease res. ctr., AnGes Inc.,4Dept. of Cell Modulation, IMEG, Kumamoto Univ., 5The JikeiUniv. Sch. of Med.

Poster Sessions


1-P1-33

D-Cysteine regulates chaperone-mediated autophagy and microautophagythrough the generation of hydrogen sulfide.

Ueda Erika1, Takahiro Seki1,2, Ayumu Konno3, Hirokazu Hirai3, Yuki Kurauchi1,2, Hiroshi Katsuki1,2

1Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, 2Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci,Kumamoto Univ, 3Dept Neurphysiol Neural Rep, Gunma Univ Grad Sch Med

Poster Sessions


1-P1-34

Increased glutathione via NOVA1 by administration of an inhibitor of themicroRNA miR-96-5p

Chisato Kinoshita1, Nobuko Matsumura1, Koji Aoyama1, Toshio Nakaki1,2

1Dept. Pharmacol., Teikyo Univ. Sch. Med.,2Fac. Pharma-Sci., Teikyo Univ.

Poster Sessions


1-P1-35

Involvement of cochlear macrophages in the loss of inner hair cell synapsesby noise exposure

Taro Yamaguchi, Yusuke Onaka, Masanori Yoneyama

Lab. Pharmacol. Sci., Sestunan Univ.

Poster Sessions


1-P1-36

Establishment of a new tri-culture system for elucidating crosstalkmechanisms between brain microvascular endothelial system and centralnervous system in Alzheimer’s disease brains

Tomoya Sasahara1,2, Minako Hoshi1,3

1Depart. Brain and Neurodegener Dis Res, Institute of Biomedical Research and Innovation, Foundation forBiomedical Research and Innovation at Kobe, 2Research & Development Division, TAO Health Life Pharma,3Depart. Anat and Dev Biol, Graduate School of Medicine, Kyoto Univ.

Poster Sessions


1-P1-37

Hypercholesterolemia may attenuate cerebral aneurysm

Kazuya Hokamura1,3, Hiroshi Makino2, Takayuki Iwaki1, Ryou Imai2, Tetsuro Kimura2,Yoshiki Nakajima2, Kazuo Umemura1

1Dept. Pharm., Hamamatsu Univ. Sch. of Med., 2Dept., Anesth., Hamamatsu Univ. Sch. of Med., 3Medical Edu.,Hamamatsu Univ. Sch. of Med.

Poster Sessions


1-P1-38

CUD003, a novel synthetic derivative of curcumin, can mitigate middlecerebral artery occlusion (MCAO)-induced ischemic injury by suppressinginflammation in rats

Hirokazu Matsuzaki1, Nazuki Sekine1, Hayato Sato1, Azumi Horikoshi2, Takashi Asano1,Naohiro Iwata3, Xuan Meiyan2, Jun Takayama2, Yuan Bo1, Yasihide Hibino3, Takeshi Sakamoto2,Mari Okazaki1

1Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., 2Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.,3Immunobiochem., Fac. Pharm. Sci., Josai Univ.

Poster Sessions


1-P1-39

Effect of traditional Japanese medicine, ninjin’yoeito, on cerebral blood flowin urethane-anesthetized mice

Nobuhiro Watanabe, Kaori Iimura, Harumi Hotta

Dep. Auton. Neurosci., Tokyo Metro. Inst. Gerontol.

Poster Sessions


1-P1-40

Effects of IL-6 family cytokines on blood-brain barrier function

Sho Hamada, Natsuko Hitora-Imamura, Masabumi Minami

Department of Pharmacology, Hokkaido University

Poster Sessions


1-P1-41

Transport of docosahexaenoic acid across the blood–brain barrier isdecreased in aged mice

Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yasufumi Kataoka, Shinya Dohgu

Fukuoka University

Poster Sessions


1-P1-42

Reptiles, sleep, and the claustrum

Norimoto Hiroaki1, Lorenz Fenk1, Hsing-Hsi Li1, Maria Tosches1,2, Tatiana Tatiana1, David Hain1,Sam Reiter1,3, Riho Kobayashi1,4, Gilles Laurent1

1Max Planck Institute for Brain Research, 2Columbia University Department of Biological Sciences,3Computational Neuroethology Unit, 4Nagoya City University Graduate School of Pharmaceutical Sciences

Poster Sessions


1-P1-43

Influence of circadian rhythm on the delayed recovery from isofluraneanesthesia induced by hypnotics in mice

Yoshinori Iba, Atsunobu Sugano, Hiroki Murai, Syunpei Horiguchi, Yuki Amano

Dept. Life Sci., Fac. Sci. and Engineering, Setsunan Univ.

Poster Sessions


1-P1-44

Real time recording of Period1 gene in the central and peripheral tissues ofthe freely moving streptozotocin-treated diabetic mouse.

Nagasawa Koki1, Yuki Ishii1, Ryosuke Sato1, Mizuki Nakaya1, Juri Hayashi1, Yukina Yoshida1,Masayori Ishikawa2, Michitaka Ozaki3, Kazuko Hamada1, Toshiyuki Hamada1

1IUHW.Dept.Phamaceut, 2Hokkaido.Uni.Fac.Health Sci, 3Hokkaido.Uni.Fac.Health Sci

Poster Sessions


1-P1-45

The analysis of Period1 gene expression in freely moving mouse usingmicro PMT system.

Yuki Ishii1, Juri Hayashi1, Mizuki Nakaya1, Ryosuke Sato1, Yukina Yoshida1, Kouki Nagasawa1,Masayori Ishikawa2, Michitaka Ozaki3, Kazuko Hamada1, Toshiyuki Hamada1

1IUHW.Dept.Phamaceut, 2Hokkaido,Uni.Fac.Heaith Sci., 3Hokkaido,Uni.Fac.Heaith Sci.

Poster Sessions


1-P2-01

Moxifloxacin exacerbate aortic aneurysm and aortic dissection by increasingosteopontin protein expressions

Koshun Inada1, Mitsuhisa Koga2, Atsushi Yamauchi3

1Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 2Dept. Drug Design and DrugDelivery., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 3Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci.,Fukuoka Univ.,

Poster Sessions


1-P2-02

Role of tissue type plasminogen activator in a murine model of type IIahuman familial hypercholesterolemia

Arakawa Tomohiro1, Takayuki Iwaki1, Masamitsu Takaba2, Kazuo Umemura1

1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Third Div., Dept. Intern. Med., Hamamatsu Univ. Sch. Med.

Poster Sessions


1-P2-03

Effect of pretreatment with diltiazem on mast cell degranulation byadrenaline treatment in anaphylactic rats.

Sawano Mayu, Wakana Takatsu, Seiichiro Kano

Fac.Pharm.Sci.,Hokkaido Univ of Sci.

Poster Sessions


1-P2-04

Development and functional analysis of novel PCSK9/LDLR interactioninhibitors for hypercholesterolemia treatment

Takumi Yokoyama1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5

1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Poster Sessions


1-P2-05

Effect of uridine triphosphate and uridine diphosphate on vascular functionin the carotid arteries of spontaneously hypertensive rats

Katome Tomoki, Takayuki Matsumoto, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi,Tsuneo Kobayashi

Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.

Poster Sessions


1-P2-06

Activation of transient receptor potential vanilloid 4 channels dilates the ratretinal arterioles via the production and release of nitric oxide and theactivation of large-conductance Ca2+-activated K+ channels in vivo

Asami Mori1,2, Kazuki Takeda1, Kenji Sakamoto1,2, Tsutomu Nakahara1

1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.

Poster Sessions


1-P2-07

Endothelial Function in Coronary Arteries from Pneumonia-Infected Pigs

Masashi Tawa, Katsuya Nakano, Qiang He, Takayoshi Masuoka, Takaharu Ishibashi

Dept. Pharmacol., Kanazawa Med. Univ.

Poster Sessions


1-P2-08

Benzodiazepines and non-benzodiazepine drugs have direct vasorelaxanteffects

Satomi Kagota1, Kana Morikawa1, Hirotake Ishida2, Junko Chimoto2, Kana Fumoto1,Shizuo Yamada,2, Kazumasa Shinozuka1

1Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ,2Centr. for Pharm-Food Res, Univ. ofShizuoka

Poster Sessions


1-P2-09

Apelin attenuated advanced glycation end products-induced cell death inmouse endothelial cell line bEnd.3.

Yasuhiro Yoshioka, Haruku Yamamoto, Shigenori Yoshizawa, Akiko Yamamuro, Yuki Ishimaru,Sadaaki Maeda

Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., Osaka 573-0101, Japan

Poster Sessions


1-P2-10

Effects of gas phase extract of cigarette smoke generated from heatedtobacco and burned cigarette on human vascular endothelial cells

Takahiro Horinouchi1, Yuichi Mazaki1, Soichi Miwa2

1Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ. Sapporo 060-8638, Japan., 2Toyooka Gen. Hosp., Hyogo668-8501, Japan.

Poster Sessions


1-P2-11

Microvascular endothelial model that can predict the inflammatoryresponses in human microvessels with high reproducibility: Culture modelof an hCMEC/D3 cell line fabricated in a collagen vitrigel membrane chamber

Miaki Uzu, Toshiaki Takezawa

Vitrigel Project, Institute of Agrobiological Sciences, NARO

Poster Sessions


1-P2-12

Retinoic acid promotes barrier functions in human iPS cell-derived intestinalepithelium

Shigeru Yamada1,2, Yasunari Kanda1

1Div. Pharmacol, NIHS, 2PEIJ

Poster Sessions


1-P2-13

Maintenance of intestinal homeostasis by NAD metabolism

Yaku Keisuke, Takashi Nakagawa

Dept. of Mol. and Med. Pharmacol., Fac. of Med., Univ. of Toyama

Poster Sessions


1-P2-14

Oral administration of 5,6-DiHETE attenuates DSS-induced colitis in mice

Shinya Takenouchi, Daiki Imai, Koji Kobayashi, Tatsuro Nakamura, Nanae Nagata,Takahisa Murata

Dept. Animal Radiology, Univ. Tokyo

Poster Sessions


1-P2-15

Role of TRPM2 expressed in macrophages in TNBS-induced colonic fibrosisin mice

Nakamoto Tomohiro1, Kenjiro Matsumoto1, Hiroyuki Yasuda1, Yasuo Mori2, Shinichi Kato1

1Dept. of Pharmacol. and Exp. Therap., Kyoto Pharmaceut. Univ., 2Dept. of Synthetic Chem. and Biological Chem.,Grad. Sch. of Eng., Kyoto Univ.

Poster Sessions


1-P2-16

Assessment of the effects of docosahexaenoic acid (DHA) andeicosapentaenoic acid (EPA) on the contractile responses of guinea piglower gastrointestinal (LGI) tracts

Keisuke Obara, Keyue Xu, Guanghan Ou, Rikako Inaba, Mirai Kawakita, Ayana Kawaguchi,Rena Kudo, Akari Kurata, Kento Yoshioka, Fumiko Yamaki, Yoshio Tanaka

Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.

Poster Sessions


1-P2-17

Daikenchuto attenuates visceral pain and suppresses eosinophil infiltrationin inflammatory bowel disease in murine models

Kogure Yoko1, Hirosato Kanda1,2,3, Shenglan Wang1,4, Satoshi Yamamoto1, Koichi Noguchi3,Yi Dai1,2,3

1Dept. Pharm. Sch. Pharm. Hyogo Univ. Health Sci., 2Tral Med. Res. Ctr, Chn Med. CI at Hyogo Col. Med.,3Dept.Anat. Neurosci., Hyogo Col. Med., 4Sch. Acup-Mox Tuina, Beijing Univ. Chn Med.

Poster Sessions


1-P2-18

Lacking dietary fiber enhances sensitivity to inflammatory stimuli, thatresults in intestinal hyper-permeability.

Haruki Usuda, Syoma Kanda, Takayuki Okamoto, Koichiro Wada

Dept. Pharmaco., Fac. Med., Shimane Univ.

Poster Sessions


1-P2-19

Effect of oyster extract on gastrointestinal and myeloid toxicity of 5-FU inrats

Noriyuki Yamazaki1, Suzuki Kohtaro1, Keita Saitoh1, Kohei Araki1, Yuki Ishida1, Hiroki Morikawa1,Takuma Nakajima1, Tohru Nonomura1, Makoto Konno1, Tatsuya Ishida2, Hiroyuki Matsui2,Yoshikazu Matsuda2

1New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd

Poster Sessions


1-P2-20

Effect of oyster extract on toxicity and pharmacological action of steroids inrats

Makoto Konno1, Hiroki Morikawa1, Masaharu Igarashi1, Masumi Kikuta1, Hitoshi Goto1,Noriyuki Yamazaki1, Katsura Matsuda2, Tatsuya Ishida2, Hiroyuki Matsui2, Yoshikazu Matsuda2

1New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd.

Poster Sessions


1-P2-21

Prenylated quinolinecarboxylic acid compound-18 prevents sensory nervefiber outgrowth through inhibition of the interleukin-31 pathway

Masato Ogura, Kumiko Endo, Toshiyuki Suzuki, Yoshimi Homma

Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan

Poster Sessions


1-P2-22

Loss of skeletal muscle mass influences immune homeostasis andaccelerates the disease progression of lupus nephritis

Shuang Liu1, Takeshi Kiyoi2, Masaki Mogi1

1Dept. Pharmacol., Grad. Sch. Med., Ehime Univ., 2ADRES, Ehime Univ.

Poster Sessions


1-P2-23

Activated coagulation factors induce histamine release of human skin mastcells and peripheral basophils through activation of complement system

Yuhki Yanase1, Yoshimi Matsuo2, Tomoko Kawaguchi2, Kaori Ishii2, Koichiro Ozawa1,Michihiro Hide2

1Dept. of Parmacotherapy, Hiroshima University, 2Dept. of Dermatology, Hiroshima University

Poster Sessions


1-P2-24

Anti-inflammatory mechanism of Nrf2-ARE activator in chronic contacthypersensitivity model mice

Mana Nonoguchi1, Yuki Takada-Takatori1, Risa Imai1, Namiko Shouno1, Yasuhiko Izumi2,3,Akinori Akaike2,4, Toshiaki Kume2,5, Katsuharu Tsuchida1, Kei-ichi Ozaki1

1Fac. Pharmaceut. Sci., Doshisha Women's Coll., 2Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.,3Kobe Pharmaceut. Univ., 4Wakayama Med. Univ.,5Dept. Appl. Pharmacol., Grad. Sch. Medicinal and Pharmaceut.Sci., Univ.Toyama

Poster Sessions


1-P2-25

A Discussion on the Mechanism of Actions of a gold compound, Auranofin

Masamichi Yamashita

Dept. Biosci. Daily Life, Coll. Biores. Sci., Nihon Univ.

Poster Sessions


1-P2-26

The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13-induced STAT6 phosphorylation in phorbol 12-myristate 13-acetate-stimulated THP-1 cells

Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Shinya Yamamoto, Kazuhito Tsuboi

Kawasaki Med. Sch.

Poster Sessions


1-P2-27

Upregulation of P2X7 receptor signaling by interleukin-33 in mouse bonemarrow-derived mast cells

Kazuki Yoshida, Yuu Ishida, Masaaki Ito, Isao Matsuoka

Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare

Poster Sessions


1-P2-28

P2Y receptor activation and PI3K(δ) enhance human-derived mast celldegranulation

Haruhisa Nishi1, François Niyonsaba2,3

1Dept. Pharmacol., Sch. Med., Jikei Univ. Sch. Med., 2Atopy Res. Cent., Grad. Sch. Med., Juntendo Univ., 3Fac.International Liberal Arts

Poster Sessions


1-P2-29

Development and functional analysis of novel IL-6R/IL-6 interactioninhibitors for autoimmune disease treatment

Yukio Takamori1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5


Poster Sessions


1-P2-30

Development and functional analysis of novel TNF-alpha/TNFR interactioninhibitors for autoimmune disease treatment

Keita Tsukamoto1, Takehiro Ando1, Yukio Takamori1, Daisuke Fuji2, Mizuki Yamamoto3,Takashi Kawakami4,5

1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ,5JST, PRESTO

Poster Sessions


1-P2-31

Transrepression-selective liver X receptor (LXR) ligands regulateinflammasome activation

Sayaka Takahashi1, Kaori Umeda-Endo2, Makoto Makishima2, Hashimoto Yuichi3,Toshiaki Ishizuka1, Minoru Ishikawa4

1National Defense Medical College, 2Nihon University School of Medicin, 3Institute for Quantitative Biosciences,The University of Tokyo, 4Graduate School of Life Sciences, Tohoku University

Poster Sessions


1-P2-32

Risk management of L-Asparaginase-induced allergy: focusing on theinfluence of cyclophosphamide

Ai Nogami-Hara1, Yuta Hori1, Chie Mitsuhata1, Koji Kajiyama1, Kentaro Susuki1, Akira Shimada2,Mitsunobu Mio1

1Lab. Pharmacol., Sch. Pharm., Shujitsu Univ., 2Dept. Pediatr. Hematol. Oncol., Okayama Univ.

Poster Sessions


1-P2-33

Pharmacological evaluation in atopic dermatitis models induced by miteantigen in mice

Nagayama Manami, Ayaka Yamaguchi, Ryota Yagi, Kumiko Kitta, Atsuko Ichikawa, Jun-ichi Fuchikami, Yasuki Akie

CMIC Pharma Science Co., Ltd.

Poster Sessions


1-P2-34

FK506-binding protein contributes to tacrolimus distribution in red bloodcells

Naoki Yoshikawa1, Ayako Matsuo2, Tsubasa Yokota1, Tomomi Iwakiri1, Ryuji Ikeda1

1Dept. Pharm., Univ. Miyazaki Hosp., 2Dept. Respiratory Med., Univ. Miyazaki Hosp.

Poster Sessions


1-P2-35

Exploring the mechanism of action of maoto, a traditional Japanesemedicine, on acute systemic inflammation induced by polyI:C administration

Keisuke Ogura, Ayumi Kadota, Akinori Nishi, Akiko Nakayama, Hitomi Kannno, Yoshiki Ikeda

Tsumura Kampo Research Laboratories, Tsumura and Co.

Poster Sessions


1-P2-36

Investigation of genetic variants in SARS-CoV-2-interacting molecules ofACE2, TMPRSS2 and TLR3/7/8 across populations

Lee Ji-Won1, In-Hee Lee2, Sek Won Kong2,3, Tadahiro Iimura1

1Dept. Pharmacol., Grad. Sch., Hokkaido Univ., 2Boston Children’s Hospital,3Harvard Med. Sch.

Poster Sessions


1-P2-37

Development and functional analysis of novel HER3/HRG interactioninhibitors for cancer treatment

Takehiro Ando1, Takumi Yokoyama1, Rina Iwamoto1, Daisuke Fuji2, Mizuki Yamamoto3,Takashi Kawakami4,5


Poster Sessions


1-P2-38

Development and functional analysis of novel VEGFR2/VEGF interactioninhibitors for angiogenesis inhibition

Horiuchi Daisuke1, Takehiro Ando1, Fuji Daisuke2, Mizuki Yamamoto3, Takashi Kawakami4,5

1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ.,2Dept. Biotechnol., Fac. LifeEnviron. Sci., Yamanashi Univ.,3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., YamanashiUniv., 4Fac. Life Environ. Sci., Gred. Fac. Interdiscip. Res., Yamanashi Univ.,5JST, PRESTO

Poster Sessions


1-P2-39

Development and functional analysis of novel PD-L1/PD-1 interactioninhibitors for cancer immunotherapy

Iwamoto Rina1, Takehiro Ando1, Daisuke Horiuchi1, Daisuke Fuji2, Mizuki Yamamoto3,Takashi Kawakami4,5


Poster Sessions


1-P2-40

Cytotoxic effects of mushroom extracts banked in FMRC

Kenji Takahashi1,2, Atsushi Ishihara2, Toshio Ohta1,2

1Tottori Univ. Joint Dep Vet Med. Vet Pharmacol.,2Tottori Univ. Fac. Agr. FMRC

Poster Sessions


1-P2-41

Molecular and Functional Analysis of Choline Transporters and AntitumorEffects of Choline Transporter-Like Protein 1 Inhibitors in HumanHepatocellular Carcinoma Cells

Masato Inazu1,2, Akane Hase1, Kaho Hirai1, Saiichiro Watanabe1, Kaoru Shibata1,Tsuyoshi Yamanaka2

1Inst. Med. Sci., Tokyo Med. Univ.,2Dept. Mol. Preventive Med., Tokyo Med. Univ.

Poster Sessions


1-P2-42

Dysfunction of DUSP22 induces synthetic lethality in poly(ADP-ribose)glycohydrolase (PARG) knocked down lung cancer cell lines.

Yuka Sasaki1,2, Hiroaki Fujimori2, Takae Onodera1,2, Tadashige Nozaki1,3, Fumiaki Koizumi1,4,Mitsuko Masutani1,2

1Dept. Molecular and Genomic Biomedicine, Grad. Sch. Biomed. Sci. & CBMM, Nagasaki Univ., 2Natl. Cancer Ctr.Res. Inst., 3Dept. Pharmacol. Osaka Dent. Univ.., 4Div. Clin. Res. Support, Komagome Hosp.

Poster Sessions


1-P2-43

Study of Anti-proliferative Effects of Chaga Mushroom and PanaxNotoginseng-containing Traditional Chinese Medical Supplement, Shibe-riaon Dog Bladder Cancer Stem Cells

Yuta Shinohara1,2, Yomogi Sato1, Mohamed Elbadawy1,3, Megumi Yamanaka1, Yuta Goto1,Kimika Hayashi1, Amira Abugomaa1, Tatsuya Usui1, Kazuaki Sasaki1

1Dept. Vet Med., Fac. agr., Tokyo Univ of Agr and Tech.,2Division. Pet Health and Food., Iskara Industry CO.,LTD., 3Dept. Pharm., Fac. Vet med., Benha Univ.

Poster Sessions


1-P2-44

Development of an anti-cancer drug sensitivity test using a urine sample-derived organoid culture for dog bladder cancer

Mori Masahiro, Yomogi Sato, Mohamed Elbadawy, Tatsuya Usui, Kazuaki Sasaki

Lab. of Veterinary Pharmacology, Dept of Veterinary Medicine, Fac. of Agriculture, Tokyo Univ. of Agriculture andTechnology

Poster Sessions


1-P2-45

Establishment of a culture method of the human bladder cancer organoidusing the urine sample

Kodai Fujisaka1, Mohamed Elbadawy1,2, Yomogi Sato1, Haru Yamamoto1, Hiroaki Matsumoto3,Hideyasu Matsuyama3, Masahiro Kaneda4, Tatsuya Usui1, Kazuaki Sasaki1

1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, TokyoUniversity of Agriculture and Technology,2Department of Pharmacology, Faculty of Veterinary Medicine, BenhaUniversity, 3Department of Urology, Graduate School of Medicine, Yamaguchi University,4Laboratory of VeterinaryAnatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture andTechnology

Poster Sessions


1-P2-46

Establishment of a culture method of the dog lung cancer organoid

Sato Yomogi1, Mohamed Elbadawy1,2, Daigo Azakami3, Masahiro Kaneda4, Tatsuya Usui1,Kazuaki Sasaki1

1Lab. Veterinary Pharmacol., Dept. Veterinary Medic., Fac. Agri., Tokyo University of Agri. and Tech.,2Benha Univ,Fac. Veterinary Med., Dept. Pharmacol., 3Lab. Veterinary Clin. Oncology, Dept. Veterinary Medic., Fac. Agri.,Tokyo University of Agri. and Tech.,4Lab. Veterinary Anatomy., Dept. Veterinary Medic., Fac. Agri., TokyoUniversity of Agri. and Tech.

Poster Sessions


Documents

1-P1-01 Poster Sessions BARP regulates the dynamics of ... · Ueda Erika1, Takahiro Seki 1,2, Ayumu Konno3, Hirokazu Hirai3, Yuki Kurauchi1,2, Hiroshi Katsuki 1Dept Chemico-Pharmacol