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Уравнение Липперта
lcII
Nk
eII
dlIkcdI
lkc
O
T
A
ε
ε
=
=
=
=
−
0
''
lg
/2300
'
[ ]( ) [ ]( )
( )[ ] [ ]
[ ]
[ ] ( ) [ ]QKKKKQ
K
QK
QKKQKK
QKQK
SDSDapp
app
SDSD
SD
++=
−=
+=
=+++=
++=
11
1
1
11
0
20
0
ϕϕ
ϕϕ
ϕϕ
COOH
NH2
COOH
NH2HO N
H
NH2
COOH
OP
O
O
HO
P
O
O
HO
O
H2COH
OH
N
N
NN
H2N
OHOHOH
N
N
N
N
O
O
H3C
H3C
N
H HC
H2C
OH OHO
OP
O
O
OH
PO
O
OH
OCH2
OH OH
N
NN
N
NH2
NH2
O
NH+
CH3
OH
CH2
H2C
OP
-O
O
O-
H2N
NH+
CH3
OHH2C
O H
OP
-O
O
O-
3 Пиридоксаль, связанный с фосфорилазой b в виде Шиффова основания
2
1
Дрожжевая tRNA
OO
COOH
OH
N C S
O(H3C)2N+
COOH
N(CH3)2
NCS
NH3C CH3
SO3Cl
( ) 6/12450 1079.8 knJqR D
−−×=
( ) ( )( )∫
∫=λλ
λλλλε
df
dfJ
D
DA4
( )22 coscos3cos ADDAk θθθ −=
D
Da
D
Da
IIE
ττ
−=
−= 11
HIGH THROUGHPUT SCREENINGPOPULATION SCREENING
DRUG DESIGN
CATEGORIZED MICROPARTICLES
Categories Dansyl Fluorescein1 - -2 low -3 high -4 - low5 low low6 - high
С.ПаркерФотолюминесценция растворов«Мир», Москва, 1972
Экспериментальные методы химической кинетики.Под ред. Н.М.Эммануэля и Г.Б.Сергеева«Высшая школа», 1980
Дж.ЛаковичОсновы флуоресцентной спектроскопии«Мир», Москва, 1979
J.LakowiczPrinciples of fluorescent spectroscopySecond ed.Kluwer Academic/Plenum Publishers, New-York, 1999
R.HaglandHandbook of fluorescent probes and research chemicals.Molecular Probes, Inc. http://www.probes.com
M.ZimmerGreen Fluorescent Protein (GFP): Applications, Structure and Related Photophysical BehaviorChemical Review, 2002
P.SelvinThe renaissance of fluorescence resonance energy transfer.Nature structural biology. V.7, number 9, pp.73-04, 2000
R.RiglerFluorescence correlation, single molecule detection and large number screening. Applications in biotechnologyJ.Biotechnol., V.41, pp. 177-186, 1995
Evident Nanocrystals Catalog http://www.evidenttech.com
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