jean-pierre-valentin documents

Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines
Documents Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines
Reducing QT liability and proarrhythmic risk in drug discovery and development
Documents Reducing QT liability and proarrhythmic risk in drug discovery and development
Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs
Documents Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs
A HESI consortium approach to assess the human predictive value of non-clinical repolarisation assays
Documents A HESI consortium approach to assess the human predictive value of non-clinical repolarisation assays
A preliminary evaluation of the predictive value of non-clinical data for drug-induced QT-prolongation: A collaborative approach
Documents A preliminary evaluation of the predictive value of non-clinical data for drug-induced QT-prolongation: A collaborative approach
Relationship between block of the cardiac sodium channel and drug-induced prolongation of the QRS complex
Documents Relationship between block of the cardiac sodium channel and drug-induced prolongation of the QRS complex
A framework to assess the translation of safety pharmacology data to humans
Documents A framework to assess the translation of safety pharmacology data to humans
Safety and secondary pharmacology: Successes, threats, challenges and opportunities
Documents Safety and secondary pharmacology: Successes, threats, challenges and opportunities
Potential value of zebrafish (Danio rerio) larvae as a front-loaded in vivo screen to assess safety pharmacology endpoin
Documents Potential value of zebrafish (Danio rerio) larvae as a front-loaded in vivo screen to assess safety pharmacology endpoin
Alternative mechanisms of drug-induced QT prolongation: hERG and beyond
Documents Alternative mechanisms of drug-induced QT prolongation: hERG and beyond
Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A
Documents Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A
Influence of the endothelium and nitric oxide on the contractile responses evoked by 5-HT1D receptor agonists in the rabbit isolated saphenous vein
Documents Influence of the endothelium and nitric oxide on the contractile responses evoked by 5-HT1D receptor agonists in the rabbit isolated saphenous vein
Nitric oxide regulation of TP receptor-mediated pulmonary vasoconstriction in the anesthetized, open-chest rat
Documents Nitric oxide regulation of TP receptor-mediated pulmonary vasoconstriction in the anesthetized, open-chest rat
Emerging trends and approaches in safety pharmacology
Documents Emerging trends and approaches in safety pharmacology
Introduction to safety pharmacology
Documents Introduction to safety pharmacology