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BioContact Presentation | Fall 2008www.therapurebio.com

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13/ of all newproducts

The future of medicine

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$51B

$87B

$25B

$89B

2001

Protein therapeutic market

2005 2010 2010

Worldwide mobile technology market

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You discovered a protein with blockbuster potential

Specific

Safe

Targeted

Efficacious

Novel

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Ultimately, to get your product approved you will invest…

You are working hard to develop it

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11 years 5 clinical trials 2,000 patients 39 patents ~$1 billion

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What about manufacturing?

What about manufacturing?

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Discovery Development

Marketing Manufacturing 7

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Scaling up is not easy

Simple

Quick

Inexpensive

Milligrams

commercialbench

Complex

Long lead times - 4-5 years

Expensive -

$150+ million

Kilograms

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Therapure Biopharma:Overcoming the manufacturing barrier

Complex We know protein purification

Long lead times Ready to go now

Quality cGMP compliant

Expensive Established Meadowpine Facility

Regulated We have 8 INDs under our belts

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your trusted partneryour trusted partner

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for protein manufacturin

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for protein manufacturin

g

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Therapure Biopharma Focus

Provide clients accessto our biomanufacturing capabilities

– Product development– Protein purification – Cell culture– Formulation– Fill– Lyophilization – Finishing

Advance our pipeline• TBI 301

Post-liver transplant & acute and chronic HCV

• TBI 302 Hepatocellular carcinoma & metastatic colorectal cancer

• TBI 303 Proprietary protein modification technology

• TBI 304 Chemotherapy-induced anemia

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Experienced Management Team

• Thomas Wellner President and CEO

• Dirk AlkemaVice President, Operations

• Peter Winkley Vice President Finance and Chief Financial Officer

• David Bell Vice President, Drug Development and Chief Scientific Officer

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About Us

Therapure Biopharma Inc. Canadian-based privately held biopharmaceutical company wholly owned by Catalyst Fund Limited Partnership II and management.

Catalyst Fund Limited Partnership IIA private equity fund with over $1B U.S. in capital that is managed by The Catalyst Capital Group Inc., a Toronto based private equity fund manager.

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Ideally located

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90 minute flight to

60% of the U.S. population15

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Our Unique and Flexible

Biomanufacturing Facility

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130,000 square feet

5,700 sq.ft. of research laboratories

6,300 sq.ft. of QC labs

30,000 sq.ft. clean room manufacturing

28,000 sq.ft. controlled cGMP warehouse

2,200 sq.ft. GMP clinical pilot suites

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Large Volume Protein Purification

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Large Scale Processing Capabilities

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Large Volume Storage Capacity

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Central Service Chase

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CIP Units For Process Equipment

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Water For Injection

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Purified Water System

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Clean Rooms and Access Pointsto Meet cGMP Requirements

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QC Laboratories

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Sterile Fill Suite

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Support Beyond Manufacturing

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Biomanufacturing In-licensing Equity partnerships

• Late-stage products

• Approved products in new indications

• Possible targeted investment

Joint development• Innovative financing

• Product co-development

• Process development

• Formulation

• Protein purification

• Fill & finishing

Fee for service

Enhanced partnerships

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Therapure(manufacturing)

Therapure(finance)

$$ (seed capital)

$$ (development fees)

protein product

interest/options

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Biotech

Equity Partnership

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partnership

Biotech

Therapure Biopharma

Product IP/development

Manufacturing IP/development

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Joint Development

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Therapure Biopharma Inc.

• Unique and Flexible– Scale of production– Range of production

• Expertise– Scientific– Manufacturing– Regulatory

• Financing opportunities

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LetLet

bring your biopharmaceutical to the world!

bring your biopharmaceutical to the world!

www.therapurebio.com