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Ramesh Durvasula, Pistoia Alliance board member, discusses the Pistoia Alliance mission and recaps activities in 2011-12, with particular emphasis on the successful completion of the Sequence Squeeze Competition and Sequence Services Phase 2. The presentation was delivered at BioITWorld in Boston in April 2012.
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http://pistoiaalliance.org @PistoiaAlliance
The Pistoia AllianceUpdate on Strategy & Progress
Presentation to #BioIT12
Ramesh Durvasula, PhDDirector, Informatics, Bristol-Myers Squibb Board Member of the Pistoia Alliance
Agenda
• Industry Drivers• The Origins of Pistoia• The Mission and Strategy of
Pistoia• The Initiatives of Pistoia
Rapidly Evolving Info Ecosystem
Big Life Science
Company
Yesterday Today Tomorrow
Yesterday Today Tomorrow
Innovation Model
Innovation inside Searching for InnovationHeterogeneity of collaborations.
Part of the wider ecosystem
IT Internal apps & dataStruggling with change
Security and TrustCloud/Services
Data Mostly inside Inside Outside Distributed
Portfolio Internally driven and owned
Partially shared Shared portfolio
What is Needed: Glue between Nodes
ProprietarycontentproviderPublic
contentprovider
Academicgroup
Software vendor
CRO
Service provider
Regulatoryauthorities
The Mission of the Pistoia Alliance
Lowering the barriers to innovation
by improving the interoperability of R&D business processes
via pre-competitive collaborations
Pistoia Alliance MembershipDec 2011
Chemistry Externalization Processes
Potential Projects
COLLABORATION BACKBONE
ORDERING/REQUESTING SERVICES
COLLABORATION
BROKERING ANIMLSIGNPO
ST
HOSTED ELN
SAMPLE MGT
HOSTED REGISTRATI
ON
Pistoia-Led Successes
• Sequence Services– Phase 1 (2011): 4 proofs of concept– Phase 2 (2012): 3 demos at Pistoia
Conference
• Semantic Enrichment of Scientific Literature– Transfer to IMI’s OpenPHACTS
• Sequence Squeeze– $15K prize for best new NGS compression
algorithm
www.sequencesqueeze.org
All source code from entries available on SourceForge under BSD-2 license
Sequence Squeeze Results & Winner
James BonfieldWellcome Trust Sanger Institute
A recent innovation attributed to Pistoia
• ODDT (Open Drug Discovery Teams) – an iPad app for rare and neglected disease collaboration that is chemistry-aware and uses social media
• Launched April 12, 2012• Presented @ ACS• Idea-innovation, 2 months
Pistoia Conference (24 April 2012)
• Twitter: #PistoiaCon12 @PistoiaAlliance
• Dragon’s Den, pitching new projects
• Review output of Sequence Services– Cycle Computing & Eagle Genomics– HP– Constellation Technologies & Genestack
Pistoia Alliance Publications
1. “The Pistoia Alliance - The Sequence Services Project” - Simon Thornber et al. - G.I.T. Laboratory Journal 1-2/2011
2. “Need for Collaborative Technologies in Drug Discovery” - Chris L. Waller et al. Book Chapter in “Collaborative Computational Technologies for Biomedical Research” – Edited by Sean Ekins et al. Wiley May 2011
3. “What are the obstacles to innovation in the Pharmaceutical Industry? The Pistoia Alliance responds” – The Pistoia Alliance – Drug Discovery World
4. “Empowering Industrial Research With Shared Biomedical Vocabularies” – Lee Harland et al - Drug Discovery Today in press
5. “ELNs - An Essential Productivity Tool – But Which One to Use” – John Wise - European Pharmaceutical Review - Issue 4, 2011
Pistoia Projects in the Pipeline
• Vocabulary standards• Biomarker exchange standards• Screening Data Standards • Canonical models for large molecules• Disease explorer• Data exchange with CROs
For more info, visit http://www.pistoiaalliance.org
A Reality Check: Setting Expectations
VS.
VS.
Our industry needs a Disruptive Innovation. That Disruption...is Pistoia
IF YOU WANT TO GO FAST, GO ALONEIF YOU WANT TO GO FAR, GO TOGETHER
www.pistoiaalliance.org
Twitter: @PistoiaAlliance
