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Recognition of ORI (Originof replication)
Helicase
DNA unroll
DNA polymerase
DNA replicateReparation of
DNA
Mutation
Conservation and transmition of the DNA
Trypanosoma brucei it’s a parasite type
kinetoplastia, wich have the mtDNA encapsulated in
the mithocondrion with many copies of the
mitochondrial genome. This parasite cause African
sleeping sickness.
Taken from: http://www.microbiologyonline.org.uk/about-
microbiology/introducing-microbes/protozoa
Taken from:
http://www.parasitemuseum.com/trypanosome/
DNA circlesDNA
polymeraseCopy the
information
Daughter
cells
Relationship withreplicating kDNA
molecules
ExperimentInmunofluorescence
DNA polymerase ID
Localization of DNA polymerase ID
This parasites cant be eradicate with antibiotics by the
complex mitochondrial genome and the only way to kill
them is using toxics. This research proposed a alternative
treatments more effectivs and less agresives.
Meier-Gorlin
syndrome : it is
characterized for
severe growth
defects, skeletal
abnormalities and
small brain size.
Taken from
http://abbottgenetics.wordpress.com/2009/03/09/
why-the-littlest-angel-was-so-little-by-bryan-cooke/
ORC recognize the ORI to start the DNA
replication and coordinate that the
genetic material duplicate just once. Also
ensure the correct duplication of the
genetic material through centrosome.
Taken from: http://www.intechopen.com/books/dna-replication-current-
advances/the-silencing-face-of-dna-replication-gene-repression-mediated-by-
dna-replication-factors
pre-RC recognize theORI
DNA replicaction
Regulation of thecentrosome
Orc1-encoding gene is mutated
Reduplication of the centrosome
alteration of the cell cycle and cell signaling
Knowing the causes of the disease allow us
treat this mutation before its expression,
through genetic therapy with the objective
to prevent the damage and in a future
decrease the number of kids with Meier
Gorlin syndrome.
Taken from: http://www.fedaes.es/FOLLFA/B14-TERA.htm
This research expose us alternative
treatments to diseases as complicated as
those caused by parasites, African sleeping
sickness, Chagas disease and leishmaniasis
and understand the cellular processes that
take place in these diseases.
The genetic diseases have increased with the
pass of the years, they are misunderstood
because the cause of them are unknown in the
most part of cases and the treatment are very
limited, so as a doctors is very important inform
about this diseases and exposed our patients the
alternatives treatments and the explain them all
about this diseases.
Taken from:
http://www.sitiosespana.com/notas/2010/mayo/oligof
renia.htm
MARTINEZ, Lina; Biologia molecular, Vol 6.
ed. UPB, 2011. Paginas 74-81.
Secrets of Parasites' Replication Unraveled;
Sciencedaily; july 9 2012;
http://www.sciencedaily.com/releases/2012
/07/120710141940.htm
Protein Involved in DNA Replication,
Centrosome Regulation Linked to Dwarfism,
Small Brain Size; Sciencedaily; July 31 2012;
http://www.sciencedaily.com/releases/2012
/07/120731200628.htm