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Network pharmacology, comparing protein pharmacology networks built from Ligand based approach (Similarity Ensemble Approach) with those built from BioAssay response data.
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Network Pharmacology: From
BioAssay Response Data to Network
Bin Chen, Nikil Wale, Kevin McConnell
and Eric Gifford
Cite: Bin Chen, Kevin McConnell, Nikil Wale, David Wild, Eric Gifford, Comparing Bioassay Response and Similarity Ensemble Approaches to Probing Protein Pharmacology, Bioinformatics
Network of top 2% most highly correlated pairs by BARD using Spearman (Node presents assay, two nodes are linked if their similarity reaches certain
threshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashed
red oval.
Network of top 2% most highly correlated pairs by BARD using SEA (Node presents assay, two nodes are linked if their similarity reaches certain
threshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashed
red oval.
5-HT7 & D1common active 536spearman 0.571TC=0.84SEA: 1.2e-25
