Markets for Smart Antimicrobial Coatings and Surfaces–2015 2022 Slides

Markets for Smart Antimicrobial Coatings and Surfaces–2015-2022

Nano-841

Issued September 2015

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Markets for Smart Antimicrobial Coatings and Surfaces 2015-2022

Smart antimicrobial coatings and surfaces represent an important element of the smart materialsspace. The market for smart antimicrobial coatings and surfaces is driven by the need to selectivelycombat new threats from bacteria, viruses and fungi. Also important to the future of smartantimicrobial coatings is the mandate to reduce hospital-acquired infections. But, the opportunity forantimicrobial surfaces extends well beyond healthcare facilities. In a growing number of cases, the nextgeneration of antimicrobial coatings and surfaces will be smart enough to kill harmful microbes whileleaving the beneficial ones, or will combine antimicrobial action with the ability to self clean.

In this report, n-tech discusses the latest products and R&D in smart antimicrobials from a businessperspective and how large specialty chemical and pharma companies, as well as start-ups aredeveloping their strategies to take advantages to smart antimicrobial opportunities.

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Materials and Technology

This report provides complete coverage of the latest materials used to create effective antimicrobial coatings and surfaces. It alsodiscusses the technologies that are evolving that will make such products truly smart. Among the topics analyzed are:

• Silver and nanosilver• Copper• Hydrogels• Chitosan• Silanes• Sulfates• Graphene and carbon nanotubes• Role of biomaterials and biotechnology• Combining antimicrobial action with self-cleaning and self-healing• Target specificity• Time release mechanisms• Safety, biocompatibility and environmental/toxicity concerns• Coating requirements for different kinds of surface

Included in this analysis is discussion of how these technologies and materials are being commercialized to produce smart antimicrobial coatings and surfaces.

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Applications and Markets for Smart Antimicrobial Coatings and Surfaces

This report also includes an analysis of the application areas where we see smart antimicrobials surfaces and coatings generating significant revenues in the next decade. These include:

• Healthcare facilities• Medical implants, surgical equipment and laboratory equipment• Kitchens, restaurants and appliances• Agriculture and veterinary• Other residential, commercial and public buildings• Consumer electronics• Clothing and textiles

Eight-Year Forecasts

This report contains detailed forecasts of the antimicrobial surfaces and coatings market:• Revenue ($ Millions)• Volume (square meters)• By application• By materials and technology

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Strategic profiles

In this report n-tech also examines the product/market strategies of the firms to watch in this space including their current R&D programs. Coverage includes

Aeris, AK Coatings, Allied Biosicence, Applied Sciences, BASF, BigSky Technologies, Bio-Gate, BioSuMa, BioTech International, BlueSky, Clariant, Corning, DiFusion Technologies, Dow Chemical, DSM Biomedical, Dunmore, DuPont, Evonik, FlowCrete, Gelest, Green Earth Nano Science, Johnson Controls, Less EMF, Life Material Technology, Microban, Nolla, Optical Coatings Technologies, Parker Hannefin, Parx Plastics, Plastics Color Corp., Polygeine, Poly One, PPG, Ras Materials, Rochling, SABIC, Sciessent, Sharklet Technologies, Specialty Coatings Systems, TiFiber and Vesteagen.

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This report is divided into five chapters

The Executive Summary is intended to pinpoint the market opportunities that n-tech sees emerging in the smart antimicrobials space over the coming years. In that chapter, we provide a summary of our forecasts and analysis, along with a listing of which companies we think will shape the market.

Chapter One is intended to set the scene for the rest of the report, including both setting out how the report is structured and providing an introductory essay setting out why metamaterials is a commercially interesting area.

Chapter Two of this report analyzes the materials—emerging and commercialized—that are used for smart antimicrobials. It also examines other related technological issues such as the role of time-release mechanisms and relevant coating and patterning technologies.

Chapter Three and Chapter Four of this report include analysis and forecasts of the smart antimicrobials market. Chapter Three examines the market for these materials in the medical/healthcare, while Chapter Four covers other markets.

Report Plan


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Chapter Three: Antimicrobial Coatings and Surfaces in Healthcare3.1 Antimicrobial Action: Where the Medical Surfaces Are3.2 Drivers for New Antimicrobial Approaches in Healthcare Facilities3.3 Options for Medical/Healthcare-specific Smart Antimicrobial Coatings and Surfaces3.4 Targets for Smart Antimicrobials3.5 Challenges and Opportunities3.6 Eight-Year Forecasts of Smart Antimicrobials in Healthcare Markets3.7 Companies to Watch in Smart Antimicrobial Materials in Medical/Healthcare3.8 Key Points from This Chapter

Chapter Four: Smart Antimicrobials in Non-Medical Applications4.1 Beyond Healthcare: Where Can Smart Antimicrobials be Sold?4.2 Smart Antimicrobials in Consumer Electronics and Appliances: Clean Touch4.3 Clothing and Textiles: A Need for Smarts?4.4 Links in a Supply Chain: Smart Antimicrobials in Food, Water, and Agriculture4.5 Smart Antimicrobial Applications in Buildings4.6 Transportation: Cars, Boats and Planes4.7 Military and Smart Antimicrobials: A Wide Net4.8 Companies to Watch4.9 Key Points from This ChapterAcronyms and Abbreviations Used In this ReportAbout the Authors

Top Level Table of Contents


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Executive SummaryE.1 Smart Antimicrobials: Technology DirectionsE.2 Healthcare: First Target for Smart AntimicrobialsE.3 Smart Antimicrobials in non-Healthcare MarketsE.4 Summary of Eight-Year Forecasts of Smart AntimicrobialsE.5 Seven Companies to Watch in the Smart Antimicrobial Market

Chapter One: Introduction1.1 Background to this Report1.2 Objectives and Scope of this Report1.3 Methodology for this Report1.4 Plan of this Report

Chapter Two: Smart Antimicrobial Technology Trends2.1 Antimicrobial Materials Trends: Impact on the Need for Smart Antimicrobials2.2 The Selective Killing of Microbes: A Role for Smart Materials2.3 Smart Polymers and Smart Antimicrobials Together at Last2.4 Self-Cleaning Antimicrobials2.5 Antimicrobials and Super-hydrophobic Materials2.6 Nanotechnology and Antimicrobials: Advanced Functionality, Smartness and Competition2.7 Key Points from this Chapter

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Table of Figures


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Exhibit E-1: Future Opportunities for Smart AntimicrobialsExhibit E-2: Eight-Year Forecast of Smart Antimicrobial Surfaces by Application ($ Million)Exhibit E-3: Eight-Year Forecast of Smart Antimicrobial Surfaces by Material Type ($ Million)Exhibit 2-1: Classes of Smart Antimicrobials and their Selling PropositionsExhibit 2-2: Smart Antimicrobial FunctionalitiesExhibit 2-3: Role of Nanotechnology in Smart AntimicrobialsExhibit 3-1: Selected Use Cases for Smart Antimicrobials in Medical EnvironmentsExhibit 3-2: Silver-based Antimicrobials for Medical ApplicationsExhibit 3-3: Research Projects and Trends in the Antimicrobial/Bioactive Coatings SegmentExhibit 3-4: Medical Equipment and Devices: Need for Smart AntimicrobialsExhibit 3-5: Eight-Year Forecast of Smart Antimicrobial Medical Surfaces by Surface Area (Square Meters)Exhibit 3-6: Eight-Year Forecast of Smart Antimicrobial Medical Surfaces by Market Value ($ Millions)Exhibit 3-7: Eight-Year Forecast of Smart Antimicrobial Medical Surfaces by Type of Antimicrobial–Market Share (%) and Revenues ($ Million)Exhibit 4-1: Non-Healthcare Applications for Smart AntimicrobialsExhibit 4-2: Eight-Year Forecast of Smart Non-Medical Antimicrobial Surfaces by Application – Surface Area (Square Meters) and Revenue ($ Millions)Exhibit 4-3: Eight-Year Forecast of Non-Medical Smart Antimicrobial Surfaces by Type of Antimicrobial–Market Share (%) and Revenues ($ Millions)Exhibit 4-4: Requirements for Antimicrobials Used on Clothing and TextilesExhibit 4-5: Identifying Opportunities for Smart Antimicrobial Coatings in Buildings

• The silver-based smart antimicrobials market will continue togrow, reaching US$913 million by 2020, but will be hurt by theappearance of more effective smart antimicrobials such aspeptides as well as environmental concerns about silver itself.

• There will also be a strong trend towards combining smartantimicrobials with additional self-cleaning and self-healingfunctionality. Self-cleaning adds to the antimicrobial effect bywashing away microbes while self-repair of cracks gives microbesno place to hide. By 2020 smart multifunctional coatings andsurfaces are expected to generate are around US$120 million

• Sales of smart antimicrobials will focus on medical equipmentand medical uniforms. Growing the market for smartantimicrobials into non-healthcare markets will be a challenge;life and death concerns will be hard to evoke as part of abusiness case. However, n-tech still sees important nichesoutside of medical markets where smart antimicrobials are likelyto sell well. These include high-use and high-traffic areas inbuildings, and clothing and textiles. The interior surfaces of cars,truck, aircraft and marine vessels present additionalopportunities for smart antimicrobial surfaces.

• By 2020, we expect the market for smart antimicrobial coatingsand surfaces in non-healthcare markets to reach US$225 milliongoing on to reach US$500 million by the 2022.

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Market Forecast


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0

500

1,000

1,500

2,000

2,500

3,000

2015 2016 2017 2018 2019 2020 2021 2022

© n-tech Research 2015

Smart Antimicrobial Surfaces by Material Type ($ Millions)

SilverSmart antimicrobial polymersPeptidesHydrophobic and self-cleaningSelf-healing

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Opportunities & Challenges


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Future Opportunities and Challenges for Smart Antimicrobials

Type of Material Opportunities Challenges

Antimicrobial peptides (AMPs) Opportunity to address strain-resistant microbes selective, especially in highly vulnerable

medical environments; implants and surgical tools. Another smart aspect of AMPs is

that they can self-assemble

Actively being developed by many research teams, although much of this work is focused

on peptide drug development

Expensive to make—will these materials be able to be sold outside of

environments where only the best antimicrobials will do?

There is also work to be done to make peptide materials more stable

Smart polymers Antimicrobial polymers are mature technology and well adapted to being used on

surfaces. They may also prove cost effective

There are at least three ways to make them smarter—embedded antimicrobial delivery

mechanisms, additional self-cleaning capability and self-healing capabilities.

Relatively little research in this area as yet. There are antimicrobial polymers,

but it is sometimes hard to say whether they are really smart or not

Silver including nanosilver Already widely commercialized and smart by virtue of its inherent time release

mechanism and self-assembling properties

No one fully understands the antimicrobial mechanism of silver and there are

healthcare issues that has sometimes produced a regulatory reaction

Super-hydrophobic materials This is an important R&D direction within the smart materials sector and antimicrobial

action is just one opportunity among several. Also, self-cleaning capabilities are more or

less built in.

Super-hydrophobic materials are not yet all that durable, although surfaces

created with the nano-patterning of steel surfaces may solve this problem

Self-cleaning antimicrobials Self-cleaning adds to the antimicrobial effect and combo products can be created using

photocatalytic materials. Or in some other way

Immature technology with addressable market that is not yet well specified

Self-healing functionality Self-healing materials can self-repair cracks, which can be an important part of reducing

the danger from microbes. Smart polymers may have a self-healing capability

Limitations on the size of the “hole” that can be fixed

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Six Companies to Watch


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BASF BASF already has several antimicrobial polymer products in its HyGentic line which use integrated silver ions. In addition, it has a presence in self-cleaning and self-healing coatings, and also has invested in SLIPS Technologies which is developing an "omniphobic" coating as a surface lubricant.

The SLIPS investment suggests to us that BASF has a strong interest in smart materials and we note that this company has always been at the forefront of value-added materials markets. While the company may or may not take on smart antimicrobials, it does seem to have many of the technology components that it will need to effectively compete in this space.

Dow Chemical Dow Chemical’s current entry into the smart antimicrobial space is Silvadur, a patented silver-technology introduced in 2012 that delivers silver ions to fabric surfaces and activates them in the presence of undesirable bacteria.

According to Dow, Silvadur’s smartness is based on its ability to "react with itself and with the surface to provide its own cross-linked polymer on the surface," binding the silver directly and releasing ions only when needed. The company says Silvadur outperforms particle silver and quat silane-based products common in the textile industry.

There’s not much to see here really in terms of smartness. However, it is a place to start for Dow, which has huge marketing and financial resources which could ultimately make it a force to be reckoned with in the smart antimicrobials space.

DSM Biomedical

DSM Biomedical provides early examples of how antimicrobial coatings use of self-assembly and hydrophilic technology may emerge:

The company's ComfortCoat and VitroStealth smart coatings have hydrophilic and non-biofouling properties, respectively. ComfortCoat ensures the lubricity and maneuvering capability of devices such as cardiovascular and urology catheters and short-term implanted devices.

VitroStealth remains permeable to biologically beneficial molecules such as glucose and oxygen, and also prevents the accumulation of unwanted proteins and other cellular particles on the surface of various devices ranging from biosensors to capillary tubes.

As n-tech sees it, such materials are just one step away from being smart antimicrobials and it would not be a surprise to see these materials evolve into microbe killers. This might occur if they (1) also exuded an antimicrobial substance, or (2) were redesigned in a clever way that killed microbes in some other way.

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Six Companies to Watch


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Life Material Technology

Life Material Technology has explicitly targeted smart antimicrobials as an opportunity and describes itself as having developed “a portfolio of smart materials with applications in numerous industries.” The company’s core activity is incorporating antimicrobial additives into a variety of solid materials and coatings, including plastics, textiles, ceramics, and paper.

Life Materials’ core materials technology is compounded into pellet polymer carrier systems which can be mixed with plastic resin and molded into plastic products or extruded into fibers.

Microban Microban is probably the best-known antimicrobial coating, found in over 1,000 products from 250 worldwide manufacturers in 30 countries. The firm has cast a very wide net for its antimicrobial coatings for surfaces in practically every corner of consumer and commercial use, from sinks to textiles to vacuums and gym equipment.

This is again another company at the early stages of making antimicrobials smart. Probably the Microban product that comes closest to smartness is the company’s silver product SilverShield. However, if Microban takes on more smartness in its products, we see it as being extremely well established to gain a significant market share. Its well-established strategy is to adopt an “Intel inside” approach—pushing their own brand within the products of well-known consumer products firms. These currently include Moen, Rubbermaid, Bissell, DuPont, Oakley, Sharp, Kimberly Clark, Sherwin-Williams, and Medline, just to name a few.

Sciessent This is another one of the few companies that has embraced the label of "smart" for its products. At the same time, it has embraced a branding strategy similar to Microban.

Sciessent’s Agion antimicrobial products incorporate silver, copper and other elemental ions into a zeolite carrier. The ions exchange with other positive ions (often sodium) from the moisture in the environment, effecting a release of the antimicrobial elements “on demand.” The company's Curb durable water repellent finish can be combined with the Agion antimicrobial technology. Like Microban, Sciessent has built up a business through partnerships to embed its technologies into a wide range of products, from AK Coatings to DuPont to Vygon.

Nolla This company's technology uses a highly viscous liquid ionic polymer as the carrier and distribution agent for ionic silver. This, it claims, opens up many applications from fiber coatings to cosmetics and beyond.

Importantly, Nolla claims several significant benefits vs. silver nanoparticles including that it is more reactive and powerful, as well as stable when exposed to various stimuli (heat, UV light, many chemicals). Nolla is researching various areas of improvement, from showing better skin compatibility compared to alcohol-based disinfectants to use with coated cottons and viscose fibers.

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