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Fostering New Sources of Mo-99
for International Nuclear Medicine Needs
IAEA CRP on Mo-99 Production Using LEU or Neutron Activation
Ira N. Goldman, Natesan Ramamoorthy, Pablo Adelfang
International Atomic Energy Agency
2008 RERTR International Meeting
October 5 - 9, 2008
Washington, DC
RERTR 2008IAEA Mo-99 CRP
Outline
• Background and History
• Participants
• Recent Activities and Progress
• Training/Technical Support and Procurements
• Near-Term Plans
• Conclusion
RERTR 2008IAEA Mo-99 CRP
Background
• 99mTc reigns as the most used diagnostic tracer; 75-80% of all imaging >25 million studies/year
• Weekly 99Mo requirements: ~450000 GBq (12000Ci, ‘6-day curies’) at reference time (~50% for USA). Well over 95% of 99Mo is produced using HEU targets (~50 kg)
• Efforts to shift production of medical isotopes away from use of HEU (through RERTR, DOE/USA)
• Some Member States (MS) of IAEA are seeking to become small scale, indigenous producers of 99Mo
• Need to encourage and provide access to LEU technology or neutron activation (NA) methods as HEU is phased out from commercial use
RERTR 2008IAEA Mo-99 CRP
Objectives
• Assist member states with adoption of LEU Cintichem (foil targets) or neutron activation (gel moly) technology.
• Further demonstrate efficacy of LEU production of 99Mo• Advance intnl coopn for non-proliferation and nuclear
security objectives, promote sustainable development.• Foster capacity building for local/regional self-
sufficiency to meet 99Mo needs• Not Aimed: Engaging the large-scale industrial
producers (but some are participating/contributing)
www.iaea.org/OurWork/ST/NE/NEFW/nfcms_researchreactors_Mo99.html
RERTR 2008IAEA Mo-99 CRP
History
• November 2004 - Project Design Consultancy, Vienna • February 2005 - CRP approved• May 2005 - Potential Mo-99 Producer’s Workshop, Buenos
Aires, Argentina• December 2005 – 1st RCM, Vienna, Austria• March 2006 – Foil Targets Workshop, Serpong, Indonesia• November 2006 - Workshop on Operational Aspects of Mo-
99 Production, Vienna, Austria• April 2007 – 2nd RCM, Bucharest and Pitesti, Romania• 2007-2008 – Various training activities in Argentina, Chile,
India, and Indonesia; equipment procurement, process installation, testing
• Oct 13-16, 2008: 3rd RCM, MURR, Columbia, Mo, USA
RERTR 2008Mo-99 CRP
Participants
• Contract Holders:
-Chile/CCHEN - LEU foil targets fission moly-Egypt/EAEA – fission moly and gel generators-Kazakhstan/INP - gel moly portable generators-Libya/DRETC - LEU foil targets fission moly-Pakistan/PINSTECH - LEU foil plate targets fission moly-Romania/IFIN-HH Magurele - gel moly-Romania/INR Pitesti - LEU foil targets fission moly
RERTR 2008Mo-99 CRP
Participants
• Agreement Holders:
-Argentina/CNEA-India/BARC-BRIT-Indonesia/BATAN-Korea/KAERI-Poland/POLATOM-US/ANL-US/MURR
RERTR 2008IAEA Mo-99 CRP
Recent Progress/Activities
• KAERI LEU foils sent to Poland, U.S. (ANL and MURR), October 2007• Further calculation and analytical work (Chile, Egypt, Libya, Pakistan)• Annular foil target assembly and testing (Chile, Romania2)• R&D LEU foil plate target and LEU electro-deposition (Pakistan)• Hot cell modifications and preparations (Chile – new manipulators;
Libya, Romania2, MURR)• Development of processing procedures, cold run (Chile, MURR,
Romania2)• Development of QA procedures (Chile, MURR, Romania2)• Substantial intra-participant training and HR development (next slide)• Gel moly development and implementation (Kazakhstan, Romania1)
RERTR 2008IAEA Mo-99 CRP
Fostering Provision of Materials, Information Exchange
• Aluminium tubing shipped from ANL (03/06)• KAERI supply of test foils with IAEA facilitation for transfers.
LEU foils delivered to 4-5 participants (2007)• Glassware procured by IAEA with DOE funding; received
by late 2006/early 2007• ANSTO safety documentation distributed (early 2007)• MURR assistance in performing and evaluating thermal
hydraulics calculations• BRIT/BARC assistance with gel generator know-how• CRP website increasingly important tool with several
technical reports posted
RERTR 2008IAEA Mo-99 CRP
Training/Technical Assistance and Procurements
• BRIT (India), February 2008, 1 Kazakhstan SV re: portable gel moly generator technology
• BATAN, March 2008 - 1 Chilean, 2 Libyan Fellows LEU ingot rolling process, foil target fabrication, waste treatment
• CNEA, June 2008 - 1 Libyan SV, QC for Mo-99 production• CCHEN, August 2008 - 1 Poland SV, LEU annular target
fabrication equipment design, assembly, welding (2 Libyans unable to reach Chile)
• Additional aluminum tubes procured by ANL for Chile and Poland
• Bids for Cintichem laboratory equipment and supplies for Libya; evaluation underway
RERTR 2008: IAEA Mo-99 CRP Progress Status and Perspectives
• Several groups in the CRP will advance to demonstrating 99Mo production using LEU
• Objective findings on all related aspects: feasibility to adaptability – scope, requirements
• Possible role of a few groups significant: (i) MURR, USA to establish compliance of LEU moly for generator use; (ii) 4 groups already handling generator production, thus well placed to use local LEU moly
• 2 other groups will show the scale of applicability of gel moly system
RERTR 2008IAEA Mo-99 CRP
Future Activities
• 3rd RCM, 13-16 October, MURR• Provision of fabricated annular targets to Libya • 1 Poland Fellowship to MURR (1 month, Oct-Nov. 2008)• Extension of CRP for an additional two years• Irradiation of LEU targets and processing of hot targets• Irradiation of Mo oxide and preparation of ‘moly Mo-99 gel
powder for gel column generators• Compare, assess, and interpret results, provide follow-up,
and suggest adaptive changes • Review compliance with specifications and purity
requirements• Document/publish results
RERTR 2008IAEA Mo-99 CRP
Other Activities
• Participated in Global Initiative (GI) for Preventing Proliferation Workshop on Mo-99 Production, Sydney, December 2007
• Maintain contact/input to NAS Mo-99 Study• Participated in DOE Isotopes Workshop, August 2008• Respond to many inquiries regarding research reactors and
Mo-99 production.• Encouraging RR networking, collaboration for isotope
production (and other activities) under IAEA Research Reactor Coalitions Initiative.
Sydney Workshop on theProduction of 99Mo using LEU
• GICNT: NNSA, DOE/USA and ANSTO; Sydney Dec 2-5, 2007; 50 participants from 14 countries
• IAEA invited to, (I) join Executive Committee; (ii) present a talk; (iii) chair a Session
• Practically all stakeholders sat together!
• Workshop report: key issues, challenges (technical; economic; political) and path forward
• Formal report to GI plenary in summer 2008
RERTR 2008IAEA Mo-99 CRP
Other influencing events
• Vulnerability of Mo-99 supplies: Fall 2007 Canadian event; Summer 2008 European scenario
• May 2008: Closure of MAPLE reactor project announced• NAS Mo-99 Study complete; Report awaited• Follow-up on DOE Isotopes Workshop held in August 2008• Enquiries regarding the IAEA help: research reactor
availability and Mo-99 production• Progress in additional production plans and identifying
potential possibilities
RERTR 2008IAEA Mo-99 CRP
Conclusion
• Many CRP participants continue to make excellent progress.• Increasing technology transfer between the contract holders. • Participants are developing physical and human resource infrastructure
to carry out successful trial irradiation and processing.• Recent events have demonstrated the fragility of the global Mo-99
supply infrastructure. • Medium term outlook for global Mo-99 supply highly uncertain due to
aging isotope production reactors, lack of planned replacements.• Several participants have significant facilities that could be utilized in
addressing global Mo-99 requirements.• Partnerships, joint ventures, or other commercial arrangements needed
to further develop such potential alternative producers.• IAEA prepared to provide a forum to bring together all
stakeholders for an objective analysis of requirements and to consider options for path forward.
Acknowledgements
• DOE/NNSA – primary project funding
• NTI: project management finances
• Government of Norway – financial support
• ANSTO, KAERI, CERCA: in-kind support
Thank you all for your [email protected]