Taxonomies Crossing Boundaries: Thomson Reuters Life Sciences Taxonomy Use Cases

THOMSON REUTERSLife Sciences Taxonomy Software Solutions

November 2015

AGENDA• Thomson Reuters Life Sciences annotation services

and use cases• Taxonomy Management System – Synaptica KMS

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THOMSON REUTERSThe world's leading source of intelligent information for businesses and professionals

Tax & Accounting

Financial & Risk

Thomson Reuters Tax & Accounting is the leading global provider of integrated tax compliance and accounting information, software and services for professionals in accounting firms, corporations, law firms and government.

Intellectual Property & Science

Legal

Thomson Reuters Intellectual Property & Science is the leading provider of comprehensive intellectual property (IP) and scientific information, decision support tools, and services that enable pharmaceutical companies, governments, academia, publishers, corporations and law firms to discover, develop and deliver innovations.

Thomson Reuters Legal is the leading provider of critical information, decision support tools, software and services to legal, investigation, business and government professionals around the world. We offer a broad range of online services that utilize our databases of legal, regulatory, news and business information.

Thomson Reuters Financial & Risk is the leading provider of regulatory and operational risk management solutions. These solutions deliver critical news, information and analytics, enable transactions, and bring together communities that allow trading, investing, financial and corporate professionals to connect.

Reuters News2,800 journalists reporting in 20 languages from bureaus around the world

Reuters is the world’s largest international news organization

INTELLECTUAL PROPERTY & SCIENCESupporting the R&D community

SCIENTIFIC & SCHOLARLY RESEARCH

LIFE SCIENCES

IP SOLUTIONS

Our Mission: Helping Our Customers Bring Ideas and Innovations to the World

Reliable content, analytics and services that improve Pharma R&D productivity

World-class solutions to manage, protect and capitalize on IP assets

Research data and tools to identify, evaluate and

promote the best research

15,000 Customers representing over 20 Million users

LIFE SCIENCES-Supporting the R&D community

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We are trusted for the decisions that matter most, empowering decision-makers to act with confidence in a complex world

THOMSON REUTERS LIFE SCIENCES SERVICES- Annotation services• Thomson Reuters provides manual and automated

searches for our customers:– Biomedical literature– Customer documents– Databases– Websites

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Sources of relevant information. Search and annotation manually or with automated technologies

or

THOMSON REUTERS LIFE SCIENCES SERVICES- Automated annotation• Thomson Reuters automated annotation services

are powered by taxonomies, custom algorithms and domain experts.

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Taxonomies Rules and Algorithms Domain experts

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Thomson Reuters annotation services- Use cases

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THOMSON REUTERS ANNOTATION SERVICE- Use cases• Product use monitoring• Competitive intelligence• Adverse Event monitoring• Portfolio management

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Customer terminology

Public terminology Custom

terminology

Final terminology

Secure storage of taxonomies

Edit taxonomies

Map taxonomies

Automated access to taxonomies

Domain specific terminology

PRODUCT USE AND ADVERSE EVENT MONITORING USE CASE

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Data Approach Results• Monitoring of 50 products using

automated approaches• Indexing includes: indication,

dose, adverse effects, demographics, hot topics

• Output in client’s terminology to match their in-house library database

• Thomson Reuters literature collection

• Customer drug list• Customer

taxonomy

Goal: Due to growth in number of articles and products marketed, an innovative solution to literature monitoring for in-house database maintenance is needed.

• Automated search and indexing of the biomedical literature.

• Map customer thesaurus to public and Thomson Reuters’ taxonomies for a more robust final text-mining ontology source.

• Identify unique terms not found in the client’s taxonomy and recommend to the client.

Manual

Mixed

Text Mining

$$Time and volume

Client taxonomy

Public taxonomy

Thomson Reuters’

taxonomy

Unique terms

PORTFOLIO MANAGEMENT USE CASE

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Data Approach Results

Automated search of the biomedical literature. Link genes/protein terms to immunoassay terms.

Article counts per month for gene/protein used in a specific immunoassay.

Monthly report with month-to-month analytics

Raw data

>2 million gene/protein and synonym terms +

immunoassay and synonym terms

Goal: Monitor >70,000 human, mouse and rat genes/proteins in the biomedical literature linked to immunoassays to confirm a current portfolio content, as well as identify the new up-and-coming needs for a life sciences reagent company.

Confidence score based on natural language, complexity, case, context clues (‘anti-’), proximity of terms

Tumor protein p53

p53

TP53

BCC7

LFS1

Cellular tumor antigen p53

Phosphoprotein p53

Antigen NY-CO-13

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How Synaptica KMS Enables THOMSON REUTERS Annotation Services

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How Synaptica KMS Enables THOMSON REUTERS Annotation Services

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Public terminology Custom

terminology

Final terminology


Edit taxonomies

Map taxonomies



Review of Thomson Reuters Use Cases

Collaboration, Import, Linked Data, and Term Creation

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Public terminology

Custom terminology


• Collaborative Work Spaces allow for team effort development

• Public and Enterprise term sets may be imported via various source formats (CSV, TXT, XLSX, XML)

• Linked Data technologies provide access to public and private resources across organizations throughout the world (Coming Soon)

• Enable the customer to create new controlled vocabularies, metadata fields, and new terms on the fly and on demand

Taxonomy Management, Mapping and Distribution

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Final terminology


Edit taxonomies

Map taxonomies


• Provide interface for editing new and existing terms along with their governance and lifecycle characteristics.

• Both automated and manual mapping features to provide alignment between public, internal, and external controlled vocabularies.

APIs and Web Services for direct integration with external applications

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APIs / Web Services

Synaptica GUICloud Based orLocally Hosted

Editors

Administrators / Modelers

Reviewers / Stakeholders

End Users

Database – Data and Model

Database APIStored Procedures

3rd Party Applications

Vocabulary Distributionvia Scheduled Export

Import / Export FilesFull and Incremental

via WebService

via ScheduledDB Job

For More Information Please Contact Us!

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Elizabeth Sweeney, PhDSenior Research ScientistThomson Reuters

[email protected]

Jim SweeneyProduct ManagerSynaptica, LLC

[email protected]

mailto:[email protected]

