27TH JANUARY 2015

NANOSCALE THERAPEUTIC SOLUTIONS FOR

REGENERATIVE MEDICINE

CARDIOVASCULAR DISEASE

DIABETESBED-BOUND

IMPAIRED BLOOD

CIRCULATION

COMPROMISED HEALING

CHRONIC WOUNDSDo not heal for more

than 6 weeksHigh probability of local and

systemic infection

High risk of Amputations

Frequent Treatments

Pain and Impaired Mobility

MAJOR PROBLEMS

PROBLEM & NEED

Source: MedMarket Diligence, 2013

50 million chronic wound patients worldwide

Standard care does not cure 70% of these

wounds

THE PROBLEM WE ARE ADDRESSING

PROBLEM & NEED

The first sderived gel for topic

application

N A N O i n S P I R E

The first stem cell derived gel for topic

lication in chronic wounds

What isIt is productwoundsBlood of healthpotential.ability to wound,

How can SKINHEALER Accelerated healing Less time spent in hospital

Reduced probability of Faster recovery of

N A N O i n S P I R E

m cell derived gel for topic

in chronic

What is SKINHEALER? product to treat diabetic, venous and pressure chronic

wounds. It is purified from stem cells of the of healthy donors, which confers

potential. The major component of SKINHEALERto stimulate vascularization and re

wound, rapidly stimulating the healing.

What doesSKINHEALER

chronic skin woundsdisease conditions:

caused by unrelieved pressure resulting in damage to underlying tissue;

ulcers, which develop as a result of insufficient flow of blood through veins in certain areas; diabetic ulcers

wounds occurring on the feet of diabetics

How can SKINHEALER help me?ccelerated healing, and the possibility of doing Less time spent in hospital, and lower costReduced probability of internment, infectionFaster recovery of mobility and improved quality of life

treat diabetic, venous and pressure chronic

of the Umbilical Cord , which confers to it a high regenerative

SKINHEALER has the ation and re-epithelization of the

.

does SKINHEALER do? SKINHEALER accelerates the healing of

chronic skin wounds, which result from different disease conditions: pressure ulcers, which are

caused by unrelieved pressure resulting in damage to underlying tissue; venous stasis

, which develop as a result of insufficient flow of blood through veins in certain areas; diabetic ulcers which are typically chronic

ring on the feet of diabetics, due to inefficient blood circulation.

help me? ossibility of doing self application. lower costs due to faster recovery.

infection and amputation.

improved quality of life

ing of

, which are

caused by unrelieved pressure resulting in venous stasis

, which develop as a result of insufficient flow of blood through veins in certain areas;

which are typically chronic , due to

REGENERATIVE The gel is

composed of stem cell derived

components which deliver regenerative

factors to the injured tissue.

SELF ADMINISTERED

It is the only product in the market for the

treatment of chronic wounds that can be self administered

upon medical counseling

CELL FREE ADVANCED THERAPY It is the only cell-free Advanced Therapy

Product in the market for the treatment of chronic wounds.

SELF D

roduct in the market for the

of chronic that can be

administered, upon medical counseling.

Umbilical Cord Blood

“I  have  trouble  believing  that  stem  cells  will  survive  the  harsh  environment  of  the  wound.”Professor Martins-GreenBoard of Directors of the Wound Healing Society

Patent for the use of Stem Cells in Chronic Wounds

TECHNOLOGY

In collaboration with

The first sderived gel for topic

application

N A N O i n S P I R E

The first stem cell derived gel for topic

lication in chronic wounds

What isIt is productwoundsBlood of healthpotential.ability to wound,

How can SKINHEALER Accelerated healing Less time spent in hospital

Reduced probability of Faster recovery of

N A N O i n S P I R E

m cell derived gel for topic

in chronic

What is SKINHEALER? product to treat diabetic, venous and pressure chronic

wounds. It is purified from stem cells of the of healthy donors, which confers

potential. The major component of SKINHEALERto stimulate vascularization and re

wound, rapidly stimulating the healing.

What doesSKINHEALER

chronic skin woundsdisease conditions:

caused by unrelieved pressure resulting in damage to underlying tissue;

ulcers, which develop as a result of insufficient flow of blood through veins in certain areas; diabetic ulcers

wounds occurring on the feet of diabetics

How can SKINHEALER help me?ccelerated healing, and the possibility of doing Less time spent in hospital, and lower costReduced probability of internment, infectionFaster recovery of mobility and improved quality of life

treat diabetic, venous and pressure chronic

of the Umbilical Cord , which confers to it a high regenerative

SKINHEALER has the ation and re-epithelization of the

.

does SKINHEALER do? SKINHEALER accelerates the healing of

chronic skin wounds, which result from different disease conditions: pressure ulcers, which are

caused by unrelieved pressure resulting in damage to underlying tissue; venous stasis

, which develop as a result of insufficient flow of blood through veins in certain areas; diabetic ulcers which are typically chronic

ring on the feet of diabetics, due to inefficient blood circulation.

help me? ossibility of doing self application. lower costs due to faster recovery.

infection and amputation.

improved quality of life

ing of

, which are

caused by unrelieved pressure resulting in venous stasis

, which develop as a result of insufficient flow of blood through veins in certain areas;

which are typically chronic , due to

REGENERATIVE The gel is

composed of stem cell derived

components which deliver regenerative

factors to the injured tissue.

SELF ADMINISTERED

It is the only product in the market for the

treatment of chronic wounds that can be self administered

upon medical counseling

CELL FREE ADVANCED THERAPY It is the only cell-free Advanced Therapy

Product in the market for the treatment of chronic wounds.

SELF D

roduct in the market for the

of chronic that can be

administered, upon medical counseling.

Umbilical Cord Blood

Patent for the use of Stem Cells in Chronic Wounds

TECHNOLOGY

Increase the activity

Non-Cellular Product with High

Therapeutic Activity

NIN-B101

Complete healing in 15 days

Accelerates Healing

Promotes Vascularization

Stimulates Skin Growth

CONTROL

NIN-B101

DAY 0 DAY 10

PRODUCT AND BENEFITS

100% mice respondto treatment

COMPETITORS AND DIFFERENTIATION

20% improvementcompared to

Control

Improvementfrom DAY 1

Improvementfrom DAY 5

Product features/ customer benefits Regranex Dermagraft Autologel SKINHEALER

Time to Heal + + ++ +++

Responsiveness 50% in Humans

30% in Humans

80% in Humans

100% in Animals

Safety + + +++ +++

Hipoalergenic + + + ++

Easy Application +++ + ++ +++

COMPETITORS AND DIFFERENTIATION

OVERALL

ADVANCED THERAPIES

EUROPE AND USA

• $2.5BN

• $970M

• $800M

2013 2021CHRONIC WOUNDS

$6.5BN

$3.2BN

$2.7BN

Source: MedMarket Diligence, 2013; Smith and Nephew, Global Industry Analyst Report 2007

Market growth driven by increased incidence of obesity and diabetes combined with an aging population.

MARKET

TIMELINE

TODAY

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

Investigational New Drug

Approval of Clinical Trial

Results from Clinical Trial Phase 1-2

Results from Clinical Trial Phase 3

Commercialization

PRE-CLINICAL DEVELOPMENT

€2.5M

PHASE 3 CLINICAL TRIAL€19M REVIEW AND

APPROVALPROFIT

PHASE 1-2 CLINICAL TRIAL

€5M

POSSIBLE EXIT 1

POSSIBLE EXIT 2

M€

FINANCIALS

SPECIALIZED TREATMENTS FOR ISCHEMIC DISEASES

MYOCARDIALINFARCTION

PERIPHERAL ARTERIALDISEASE

PIPELINE

IN COLLABORATION WITH:

• Joana Simões Correia, PhD

• Bsc Chemistry• PhD Human

Biology• Researcher

• Ricardo Neves, PhD

• Bsc Biology• Dphil Biology• Researcher

• Lino Ferreira, PhD

• Bsc Biochemistry• PhD

Biotechnology• Researcher

• Luísa Marques, MBA

• Bsc Management• MBA• Business

Developer

Supported by

TEAM

AND

Changing the way we treat chronic wounds, forever.

THANK YOUnanoinspire.team@gmail.com