“The Key Player in the formation of new blood vessels”

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BCAS3 antibody

BCAS3’s Function:

BCAS3 is a key player in angiogenesis as it is:1. Involved in regulating the cell polarity and directional endothelial cell migration.2. Activates and recruits CDC42. 3. Reorganizes the actin cytoskeleton at the cell leading edge.

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BCAS3’s Involvement in Disease:

A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.

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BCAS3 in Research:

“Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)”.http://www.ncbi.nlm.nih.gov/pubmed/17505058

"Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.”http://www.ncbi.nlm.nih.gov/pubmed/12378525

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"Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis.“http://www.ncbi.nlm.nih.gov/pubmed/18030336