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Details the search component of systematic review projects.
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CONSTRUCTING AND
REPORTING EXTENSIVE
LITERATURE SEARCHES
Mark MacEachern, MLIS
Overview
Search construction
Sources
PubMed, OVID MEDLINE, EMBASE, etc.
Reporting
From: Users’ Guide to the Medical Literature
(JAMA Evidence)
Evidence Pyramid
Why search?
A high-quality lit search is essential for a successful
meta-analysis
It is from the search results that data is gathered for
analysis
Failure to locate important studies can significantly affect
results
Remember the goal is to capture every relevant study
Important to report search so your methodology can be
reproduced
What to expect?
Expect 1000s of results
Expect to search multiple databases
Ovid, EMBASE, PubMed, Scopus, etc.
Expect the search process to take awhile
Expect to publish search strategy and search
methodology
Expect to consult a professional with search expertise
(health sciences librarian)
Search construction
Concept building
Boolean logic
Vocabulary
Techniques
Evaluating searches
Search construction: Concept
building
Identify major concepts of topic
PICO helps for clinical questions, but the concept can be applied in other contexts
Example: Do any olfactory identification tests predict the development of Alzheimer’s disease? ] http://www.ncbi.nlm.nih.gov/pubmed/22552846
What are the major concepts? Alzheimer disease
Olfactory tests
Predict?
People/Humans?
Search construction: Concept
building
Alternate words / Synonyms
Alzheimer, Alzheimer’s, dementia, cognition
disorders
Olfactory tests, sniffin’ sticks, b-sit, cc sit, smell
identification test
Search construction: Boolean
Logic
ANDAlzheimer’
s DiseaseOlfactory
test
DementiaAlzheimer’
s disease
AnimalsHumans
OR
NOT
Concept 2
Search construction: Boolean
Logic
Concept 1
Alzheimer
disease
dementia
ANDOR
OR
OR
OR
(alzheimer disease OR dementia) AND (olfactory identification test OR b-sit OR sniffin’
sticks OR …)
Olfactory
Identification test
B-sit
Sniffin’ Sticks
Etc.
Search construction:
Vocabulary
Keywords
Controlled
vocabularies
Search construction:
Vocabulary
Keywords
Controlled
vocabularies
What are they?
Literal search
Looks for occurrences of words
When to use?
Current topics
Not easy to describe concepts
No vocabulary exists in database
Examples
Drug names (Lipitor, Prozac)
Slang
Concepts (Swine flu, oil spill)
Search construction:
Vocabulary
Keywords
Controlled
vocabularies
What are they?
Set of words or phrases used to
describe concepts
Dictionary of accepted terms for a
database
When to use?
Searching a database that uses one
Examples
MeSH (Medical Subject Headings)
EMTREE (Embase)
Search construction:
Vocabulary
Keywords
Controlled
vocabularies
MeS
H
Search construction:
Techniques
Truncation
Wild cards
Adjacency
Phrases
Boolean
Parentheses
residen*
an?sthesiology, p?diatrics
screen* adj5 cancer*
“dental education”
“dental implants”[mh] AND “dental
restoration failure”[mh]
(“dental implants”[mh] OR
implants[title/abstract]) AND (“dental
restoration failure”[mh] OR
failure[title])
Note: Techniques vary from database to database
Search construction:
Techniques
Limits or Filters – use sparingly (language, species, pt)
Search construction:
Techniques
Exploding subject headings
Databases handle explosion differently
Search construction:
Techniques
Subheadings
“dental implants/standards”[mesh]
Search construction:
Techniques
Floating subheadings
1. exp Arthritis, Rheumatoid/
2. exp Inflammatory Bowel
Diseases/
3. cuc.tw.
4. chronic ulcerative colitis.tw.
5. crohn*.tw.
6. ibd.tw.
7. rheumatoid arthritis.tw.
8. or/1-7
9. exp Postoperative
Complications/
10. exp Perioperative Care/
11. su.fs.
12. or/9-11
13. 8 and 12
Ovid MEDLINE (extract)
("inflammatory bowel diseases"[mh] OR
"chronic ulcerative colitis”[tiab] OR cuc[tiab]
OR crohn[tiab] OR "crohn's” [tiab] OR
crohns[tiab] OR ibd[tiab] OR "rheumatoid
arthritis” [tiab]) AND ("postoperative
complications"[mh] OR "perioperative
care"[mh] OR "surgery”[subheading] OR
"post operative"[tiab] OR
"postoperative"[tiab])
PubMed (extract)
Search construction: Filters
A predefined search designed to target specific study methodologies (RCTs, Cohort, Systematic Reviews)
Use a validated filter (whenever possible)
Example: PubMed Clinical Queries – Systematic Reviews
(systematic review [ti] OR meta-analysis [pt] OR meta-analysis [ti] OR systematic literature review [ti] OR (systematic review [tiab] AND review [pt]) OR consensus development conference [pt] OR practice guideline [pt] OR cochrane database syst rev [ta] OR acp journal club [ta] OR health technol assess [ta] OR evid rep technol assess summ [ta] OR drug class reviews [ti]) OR (clinical guideline [tw] AND management [tw]) OR ((evidence based[ti] OR evidence-based medicine [mh] OR best practice* [ti] OR evidence synthesis [tiab]) AND (review [pt] OR diseases category[mh] OR behavior and behavior mechanisms [mh] OR therapeutics [mh] OR evaluation studies[pt] OR validation studies[pt] OR guideline [pt] OR pmcbook)) OR ((systematic [tw] OR systematically [tw] OR critical [tiab] OR (study selection [tw]) OR (predetermined [tw] OR inclusion [tw] AND criteri* [tw]) OR exclusion criteri* [tw] OR main outcome measures [tw] OR standard of care [tw] OR standards of care [tw]) AND (survey [tiab] OR surveys [tiab] OR overview* [tw] OR review [tiab] OR reviews [tiab] OR search* [tw] OR handsearch [tw] OR analysis [ti] OR critique [tiab] OR appraisal [tw] OR (reduction [tw]AND (risk [mh] OR risk [tw]) AND (death OR recurrence))) AND (literature [tiab] OR articles [tiab] OR publications [tiab] OR publication [tiab] OR bibliography [tiab] OR bibliographies [tiab] OR published [tiab] OR unpublished [tw] OR citation [tw] OR citations [tw] OR database [tiab] OR internet [tiab] OR textbooks [tiab] OR references [tw] OR scales [tw] OR papers [tw] OR datasets [tw] OR trials [tiab] OR meta-analy* [tw] OR (clinical [tiab] AND studies [tiab]) OR treatment outcome [mh] OR treatment outcome [tw] OR pmcbook)) NOT (letter [pt] OR newspaper article [pt] OR comment [pt])http://www.nlm.nih.gov/bsd/pubmed_subsets/sysreviews_strategy.html
Search construction: Methodologic
Filters
From PubMed Clinical Queries
Search construction: Methodologic
Filters
Sources
PubMed
Ovid MEDLINE
EMBASE
Scopus
Web of Science
PsycINFO
CINAHL
Cochrane Database of
Systematic Reviews
Conference Papers
Index
ClinicalTrials.gov
ERIC
Proquest Theses &
Dissertations
CABI
Google Scholar
Sociological Abstracts
And others…
Sources: PubMed
(pubmed.gov)
Primary biomedical
database
22+ million citations
Native interface for
MEDLINE dataset
Citations indexed with
MeSH
Sources: PubMed
Sources: Ovid MEDLINE
Different interface to search MEDLINE dataset
Heavily used for systematic reviews
Provides additional
search functionality
(adjacency)
Uses MeSH (like
PubMed)
Sources: Ovid MEDLINE
Sources: Ovid MEDLINE
Sources: EMBASE
Similar to PubMed, Ovid
Indexes man more international journals
Drug indexing is a plus
Uses EMTREE
Includes MEDLINE,
unless you NOT out
Sources: Web of Science
Citation database
Times cited & conference
proceedings
Other ISI databases:
Impact Factors
Biosis Previews
Sources: Other options
Examine the references of articles of relevance
Included studies and relevant reviews
Use cited by features
Set up email alerts
Contact authors, companies, organizations,
societies, etc
Search for ongoing studies (prelim data)
Hand search important journals (by Impact Factor,
perhaps)
Citation tracking
Reporting
Reporting
See PRISMA statement
“The aim of the PRISMA Statement is to help authors
report a wide array of systematic reviews to assess the
benefits and harms of a health care intervention. PRISMA
focuses on ways in which authors can ensure the
transparent and complete reporting of systematic reviews
and meta-analyses.”
http://www.prisma-statement.org/statement.htm
Reporting
See Cochrane Handbook
http://www.cochrane-handbook.org/
Section 6.6
“It should be borne in mind at the outset that the full
search strategies for each database will need to be
included in an Appendix of the review.”
Reporting
See Cochrane Handbook
http://www.cochrane-handbook.org/
Section 6.6
In study flow diagram:
number of unique records identified by the searches;
number of records excluded after preliminary screening (e.g. of titles
and abstracts); and
number of records retrieved in full text
Reporting
See Cochrane Handbook
http://www.cochrane-handbook.org/
Section 6.6
In abstract:
List all databases searched.
Note the dates of the last search for each database or the period
searched.
Note any language or publication status restrictions (but refer to Section
6.4.9).
List individuals or organizations contacted.”
Reporting
See Cochrane Handbook
http://www.cochrane-handbook.org/
Section 6.6
In methods:
List all databases searched.
Note the dates of the last search for each database AND the period
searched.
Note any language or publication status restrictions
List grey literature sources.
List individuals or organizations contacted.
List any journals and conference proceedings specifically handsearched
for the review.
List any other sources searched (e.g. reference lists, the internet).
Reporting
Example
Recap
Spend time developing your search
Search multiple databases
Take notes during process
Give thought to how you want to report on the data
collection
Consult an expert searcher