22
EVALUATING HARDWARE Tools and Advice for Making the Right Choice Ryan Duggan University of Chicago apted from: http://ucflow.blogspot.com/2013/07/10-tips-for-purchasing-your-next.html

Evaluating Flow Cytometry Hardware - Advice for making the right choice

Embed Size (px)

DESCRIPTION

Slide set presented Monday, May 19th at #CYTO2014 as part of the Workshop "Strategic Planning: Embracing the Business Side of SRL Management." Co-chaired by Sherry Thornton and Monica DeLay - Cincinnati Children's Hospital.

Citation preview

Page 1: Evaluating Flow Cytometry Hardware - Advice for making the right choice

EVALUATING HARDWARETools and Advice for Making the Right Choice

Ryan DugganUniversity of Chicago

Adapted from: http://ucflow.blogspot.com/2013/07/10-tips-for-purchasing-your-next.html

Page 2: Evaluating Flow Cytometry Hardware - Advice for making the right choice

10-step process

1. Define Needs

2. Query the Userbase

3. Refine Needs

4. Survey the Market

5. Navigate Marketing

6. Create the Matrix

7. Hands-on

8. Social Networks

9. Negotiate

10. Year-end deals

11. Now What?

Page 3: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Define Needs

• Create a generic specification of the needed equipment based on YOUR perception.

• What applications do you see being run immediately, near future?

Page 4: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Query the Userbase

• Survey the users to find out what they need from THEIR perspective.

• Analyze recent historical data

• Talk to key Investigators• Research current

industry trends• Ignore much of what the

users say they need.

Page 5: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Refine the Needs

• Find the middle ground• Realistic specification with “room to grow”

Page 6: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Survey the Market

• Research what’s available

• Base entry for consideration on min. spec.

• Use organizational tools like Evernote™ or ELN to track contenders.

Page 7: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Navigate the Marketing• Learn to read marketing materials• Differentiate between Technical spec (what the instrument

has) and Performance Spec (what the hardware can do).• Marketing materials are fine for listing Tech. Spec. but

NOT Performance Specification.• Samsung found itself accused of artificially (and secretly) boosting

benchmark scores on its flagship phone to ensure it would outperform the competition.” - The Verge (http://goo.gl/5vuCs9)

Page 8: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Create the Matrix• List of specifications vs. available hardware• Use marketing material tech. spec.• Include budget as a spec.

  # of Lasers (Total Avail.)

Total Detectors

Field Upgradable

Multi-well Sampler Event Rate Total

Events/FileOptical

Upgrades Avail.

Instrument A 1-3 (3) 3-8 No Yes 2,000 100,000 No

Instrument B 2-4 (7) 4-12 Yes Yes 10,000 5,000,000 Yes

Instrument C 2-6 (12) 4-18 Yes Yes 20,000 10,000,000 Yes

Instrument D 2-4 (4) 4-10 No No 20,000 2,000,000 No

Instrument E 2-5 (8) 4-14 Yes Yes 20,000 10,000,000 Yes

Instrument F 1-3 (4) 3-6 No No 2,000 100,000 No

Page 9: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Hands-on• NO CANNED DEMOS• NO EXAMPLE DATA SETS• Real data, collected by you, analyzed by you.• Create your own performance metric if none exists.• Make THIS, a high level priority that will greatly influence

your decision

Page 10: Evaluating Flow Cytometry Hardware - Advice for making the right choice

4-peak ABC beads

Unstained lymphocytes

Dimly stained capture beads

Resolution limit theoretical peak

10th %-ile ABC

Med

ian

AB

C

Median ABC values

10th %-ile ABC values

90th %-ile of AutoFluorescence = 10th %-ile of resolution limit

# of Antibodies BoundF

requ

ency

qNORM

Figure 3. Cartoon displaying how the qNORM is calculated.

Page 11: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Get Social

• Read reviews• Ask peers• Request OEM response for any negative feedback

• Avoid Gen. 0 evangelists.

Page 12: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Negotiate Purchase• Negotiate with multiple OEM’s regardless of intent to

purchase• Make sure OEMs are aware of their competition• Competitive bid may be required anyway• Get everything in writing• Include Training, extended warranty, shipping, installation,

free upgrades, etc…

Page 13: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Be Mindful of Year-end deals• If you can time it right, year-end numbers can be a

powerful bargaining chip.

Page 14: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Summary• Do your homework• Test the hardware in real-world situations• (Re)negotiate

Page 15: Evaluating Flow Cytometry Hardware - Advice for making the right choice

NOW WHAT?

Page 16: Evaluating Flow Cytometry Hardware - Advice for making the right choice

You got the instrument• Time to implement it’s usage• This isn’t the first time you’re thinking about this, is it???

Page 17: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Alert your Users • Once you’ve narrowed down the choice and made the

decision, alert your users.• Send them materials describing the capabilities of the

instrument• Ask the OEM sales rep to reach out to users.

Page 18: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Solidify the SOP• Re-work usage SOP’s specific to this instrument.• Distribute to the users• Ask for comments from oversight committee/ safety

committee/ Faculty Director, etc…

Page 19: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Getting everyone up-to-speed.

• Training of the facility staff by OEM

• Training of staff + key users by OEM.

• Seminar style intro to the technology

• Spend some time with the instrument in the first week or so to get comfortable.

Page 20: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Spread the word

• Continually update users with representative data from the instrument.

• User-derived or facility-derived.

• Boost confidence in its capabilities

• Squash problems immediately.

#supercoolflowplot

Page 21: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Summary• Implementation plan begins once you’ve decided on the

specific instrument• Provide adequate information to users ahead of time• Formulate training plan needs (replicate instrument or

brand new technology)• Share data and experiences with users often• Stay ahead of problems and misconceptions/rumors.

Page 22: Evaluating Flow Cytometry Hardware - Advice for making the right choice

Thank you