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CELL & TISSUE ENGINEERING ASSAY DEVELOPMENT COMPOUND TESTING BIOLOGICAL SAMPLE ANALYSIS BIOMARKER DISCOVERY TECHNOLOGY TRANSFER COLLABORATIVE RESEARCH RESEARCH SERVICE PROVIDER

BIOalternatives Research Service Provider

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CELL & TISSUE ENGINEERING

ASSAY DEVELOPMENT

COMPOUND TESTING

BIOLOGICAL SAMPLE ANALYSIS

BIOMARKER DISCOVERY

TECHNOLOGY TRANSFER

COLLABORATIVE RESEARCH

RESEARCHSERVICE PROVIDER

Innovation & expertise-oriented strategy:Expertise

Immune-inflammation Tissue inflammation and disorders Neurodegenerative diseases Tissue regeneration Stress and ageing Skin physiology

Scope Pharmacology Biotechnology Veterinary medicine Medical devices Cosmetics Food

Your research service provider: BIOalternatives is a Contract Research Organization specializing in cellular and molecular pharmacology.

Committed since 1996 to developing effective in vitro alternatives to animal experimentation methods, we offer a full range of solutions for research and preclinical trial sample evaluation in a non- GLP environment.

While stay true to our core values and commitments to our clients, BIOalternatives stands ready to partner with you as you explore new avenues of research in pharmaceutical, consumer and veterinary sciences. Our highly competitive and customized services matched by our state-of-the-art laboratory and study monitoring strategy will meet your most demanding research needs.

HeadquartersBIOalternatives SAS

1 bis rue des plantes - BP 5001186160 Gençay

FRANCE

Tel. +33 (0)5 49 36 11 37Mail : [email protected]

BIOalternatives, Inc. 90 Park Avenue, 17th Floor

New York, NY 10016 USA

Tel. +1 (212) 364 5115 Mail : [email protected]

Follow us on:

or on social networks:

Distributed by Toyo Science Corp

Bldg. 1-21 Nihonbashi,Muromachi 4-chome

Chuo-ku, Tokyo 103-0022JAPAN

Tel. +81 (0)3 5205 1040Mail : [email protected]

www.toyo-asia.co.jp

© 2

015

- Gra

phis

me

: ww

w.p

roce

ssus

grap

hic.

fr

Member ofWorld Trade Center Association

Europe& Worldwide North America Asia

Cell and tissue engineeringDevelopment of new or complex in vitro mammalian models:

Tissue microdissection

Primary cell isolation

Cell line construction

Co-culture model system

Organotypic explant culture

Three dimensional reconstruction

Phenotypic and functional characterization

Biological sample analysisBiological sample collection, processing, storage and information management:

Study design

Sample collection

Method development and validation (tissue microarrays, cDNAarrays, PCRarrays, immunoassays, biochemical assays)

Analysis service

Biobanking (RNA, cDNA, cells, frozen tissues, embedded tissues)

Data management

Biomarker discoveryCustomized research to highlight new biomarkers and/or biological targets:

Protein and gene expression data mining

Advanced computer-assisted biological analysis

Biomarker assay development

Compound testingCellular and molecular pharmacology assays for hit-to-lead selection of active pharmaceutical ingredients and claim substantiation of healthcare products:

Cell-based assays Screening Profiling Proof-of-concept Mechanism of action

Benchmarking Safety Testing of formulations prior

to clinical trial

Assay developmentServices for the development, customization and optimization of innovative research methods and protocols:

Literature review

Feasibility study

Protocol design

Method validation

Multiplexing, miniaturization and optimization

Technology transferTo turn our know-how into your success:

Technology transfer Assay transfer Biological material transfer Training session Out-licensing

Research framework

Innovative concept and solutions

Compound sourcing

Technology co-development

Study management

Data management

Research optimization (patent, licensing, communication)

Collaborative ResearchAs a partnering research organization, BIOalternatives can contribute the following components to your R&D project or innovative program:

Cell and tissue engineeringDevelopment of new or complex in vitro mammalian models:

Tissue microdissection

Primary cell isolation

Cell line construction

Co-culture model system

Organotypic explant culture

Three dimensional reconstruction

Phenotypic and functional characterization

Biological sample analysisBiological sample collection, processing, storage and information management:

Study design

Sample collection

Method development and validation (tissue microarrays, cDNAarrays, PCRarrays, immunoassays, biochemical assays)

Analysis service

Biobanking (RNA, cDNA, cells, frozen tissues, embedded tissues)

Data management

Biomarker discoveryCustomized research to highlight new biomarkers and/or biological targets:

Protein and gene expression data mining

Advanced computer-assisted biological analysis

Biomarker assay development

Compound testingCellular and molecular pharmacology assays for hit-to-lead selection of active pharmaceutical ingredients and claim substantiation of healthcare products:

Cell-based assays Screening Profiling Proof-of-concept Mechanism of action

Benchmarking Safety Testing of formulations prior

to clinical trial

Assay developmentServices for the development, customization and optimization of innovative research methods and protocols:

Literature review

Feasibility study

Protocol design

Method validation

Multiplexing, miniaturization and optimization

Technology transferTo turn our know-how into your success:

Technology transfer Assay transfer Biological material transfer Training session Out-licensing

Research framework

Innovative concept and solutions

Compound sourcing

Technology co-development

Study management

Data management

Research optimization (patent, licensing, communication)

Collaborative ResearchAs a partnering research organization, BIOalternatives can contribute the following components to your R&D project or innovative program:

Cell and tissue engineeringDevelopment of new or complex in vitro mammalian models:

Tissue microdissection

Primary cell isolation

Cell line construction

Co-culture model system

Organotypic explant culture

Three dimensional reconstruction

Phenotypic and functional characterization

Biological sample analysisBiological sample collection, processing, storage and information management:

Study design

Sample collection

Method development and validation (tissue microarrays, cDNAarrays, PCRarrays, immunoassays, biochemical assays)

Analysis service

Biobanking (RNA, cDNA, cells, frozen tissues, embedded tissues)

Data management

Biomarker discoveryCustomized research to highlight new biomarkers and/or biological targets:

Protein and gene expression data mining

Advanced computer-assisted biological analysis

Biomarker assay development

Compound testingCellular and molecular pharmacology assays for hit-to-lead selection of active pharmaceutical ingredients and claim substantiation of healthcare products:

Cell-based assays Screening Profiling Proof-of-concept Mechanism of action

Benchmarking Safety Testing of formulations prior

to clinical trial

Assay developmentServices for the development, customization and optimization of innovative research methods and protocols:

Literature review

Feasibility study

Protocol design

Method validation

Multiplexing, miniaturization and optimization

Technology transferTo turn our know-how into your success:

Technology transfer Assay transfer Biological material transfer Training session Out-licensing

Research framework

Innovative concept and solutions

Compound sourcing

Technology co-development

Study management

Data management

Research optimization (patent, licensing, communication)

Collaborative ResearchAs a partnering research organization, BIOalternatives can contribute the following components to your R&D project or innovative program:

CELL & TISSUE ENGINEERING

ASSAY DEVELOPMENT

COMPOUND TESTING

BIOLOGICAL SAMPLE ANALYSIS

BIOMARKER DISCOVERY

TECHNOLOGY TRANSFER

COLLABORATIVE RESEARCH

RESEARCHSERVICE PROVIDER

Innovation & expertise-oriented strategy:Expertise

Immune-inflammation Tissue inflammation and disorders Neurodegenerative diseases Tissue regeneration Stress and ageing Skin physiology

Scope Pharmacology Biotechnology Veterinary medicine Medical devices Cosmetics Food

Your research service provider: BIOalternatives is a Contract Research Organization specializing in cellular and molecular pharmacology.

Committed since 1996 to developing effective in vitro alternatives to animal experimentation methods, we offer a full range of solutions for research and preclinical trial sample evaluation in a non- GLP environment.

While stay true to our core values and commitments to our clients, BIOalternatives stands ready to partner with you as you explore new avenues of research in pharmaceutical, consumer and veterinary sciences. Our highly competitive and customized services matched by our state-of-the-art laboratory and study monitoring strategy will meet your most demanding research needs.

HeadquartersBIOalternatives SAS

1 bis rue des plantes - BP 5001186160 Gençay

FRANCE

Tel. +33 (0)5 49 36 11 37Mail : [email protected]

BIOalternatives, Inc. 90 Park Avenue, 17th Floor

New York, NY 10016 USA

Tel. +1 (212) 364 5115 Mail : [email protected]

Follow us on:

or on social networks:

Distributed by Toyo Science Corp

Bldg. 1-21 Nihonbashi,Muromachi 4-chome

Chuo-ku, Tokyo 103-0022JAPAN

Tel. +81 (0)3 5205 1040Mail : [email protected]

www.toyo-asia.co.jp

© 2

015

- Gra

phis

me

: ww

w.p

roce

ssus

grap

hic.

fr

Member ofWorld Trade Center Association

Europe& Worldwide North America Asia

CELL & TISSUE ENGINEERING

ASSAY DEVELOPMENT

COMPOUND TESTING

BIOLOGICAL SAMPLE ANALYSIS

BIOMARKER DISCOVERY

TECHNOLOGY TRANSFER

COLLABORATIVE RESEARCH

RESEARCHSERVICE PROVIDER

Innovation & expertise-oriented strategy:Expertise

Immune-inflammation Tissue inflammation and disorders Neurodegenerative diseases Tissue regeneration Stress and ageing Skin physiology

Scope Pharmacology Biotechnology Veterinary medicine Medical devices Cosmetics Food

Your research service provider: BIOalternatives is a Contract Research Organization specializing in cellular and molecular pharmacology.

Committed since 1996 to developing effective in vitro alternatives to animal experimentation methods, we offer a full range of solutions for research and preclinical trial sample evaluation in a non- GLP environment.

While stay true to our core values and commitments to our clients, BIOalternatives stands ready to partner with you as you explore new avenues of research in pharmaceutical, consumer and veterinary sciences. Our highly competitive and customized services matched by our state-of-the-art laboratory and study monitoring strategy will meet your most demanding research needs.

HeadquartersBIOalternatives SAS

1 bis rue des plantes - BP 5001186160 Gençay

FRANCE

Tel. +33 (0)5 49 36 11 37Mail : [email protected]

BIOalternatives, Inc. 90 Park Avenue, 17th Floor

New York, NY 10016 USA

Tel. +1 (212) 364 5115 Mail : [email protected]

Follow us on:

or on social networks:

Distributed by Toyo Science Corp

Bldg. 1-21 Nihonbashi,Muromachi 4-chome

Chuo-ku, Tokyo 103-0022JAPAN

Tel. +81 (0)3 5205 1040Mail : [email protected]

www.toyo-asia.co.jp

© 2

015

- Gra

phis

me

: ww

w.p

roce

ssus

grap

hic.

fr

Member ofWorld Trade Center Association

Europe& Worldwide North America Asia