Navigating Genetic Data

Privacy, Regulation and Ease of Use

Presentation @ Beyond the Genome, San Francisco, CA June 2011 DNA Guide, Inc. All rights reserved 2011

Alice Rathjen, President, Founder

alice@dnaguide.com

The Problem.. No Path to Market

Genetic Data Explosion Huge investment in

Sequencing Technologies

and Molecular Diagnostics

Personalized Medicine

R&D

Pharma /

Clinical

Trials

Consumers/

Patients IN

SU

RA

NC

E

Regulation, Privacy, Ease of Use

Health

Services

Privacy

Biometric based security allow

written consent to evolve into

“real time” consent

• Use values in DNA sample to uniquely identify

each dataset

• Store and retrieve genetic data anonymously

• Perform audits, merge data

• Re-associate information throughout a

person’s lifetime

• Have variations for different uses

Raw DNA Values

DNA Security Token

Regulation

www.DNAguide.com

Solution is to Manage Interpretation and Access Down to the Base Pair Level

DNA Guide Enables Dynamic Regulation & Compliance

Quality of Science

Medical Utility

Viewing Risk

(Graded) A,B,C,D,F

W = Withdrawn

I = Incomplete (by Scientific Community)

(by Health Care Providers/ Payers)

E = Everyone,

PG = Physician Guidance

R = Restricted

(Genetic Counselors, Ethics)

Category Rating

(Five Star Rating)

(Movie Rating)

Ease of Use

(Mitochondria)

Making the Complex - Simple

Highest Risk

Slightly Higher Risk

Normal

Lower Risk

Low Magnitude High Magnitude

Quick Risk Assessment

Converting the $1,000 Genome into the Two Minute Genome

Removing the Genetic Education Barrier

Simple Graphic’s to explain genetic variation

Color code for Drug Response Information

Stop! (check details)

Warning (check details)

Go (normal dose)

• Traditional model of laboratory services, proprietary algorithms,

legacy single chromosome browsers, no dynamic mechanism for

patient engagement.

• DNA Guide Advantages

– Patient engagement/empowerment focused mobile tools

– Leverage static nature of raw genome data vs public domain,

changing patent landscape, with ability to open up platform to

third party molecular diagnostics

– Provides foundation for patient centric health record

Competition

DNA Guide Product Modules

DNA Security

Token

DNA Compass DNA Body

Use values within the DNA

sample to uniquely identify

every dataset. Token serves

as a dynamic or static IP

address - allowing every

person to become a node on

the network.

DNA Guide provides mobile dynamic

maps of entire genomes and can

perform spatial analysis across

multiple layers of different types of

genetic data.

DNA Guide’s DNA Body will

provide expression data,

medical records, and images to

be linked to a map of the human

body and to genomic location.

Human Body Linked to Gene Expression

Electronic Health

Record

Grand SLAM

Long term plans -

expression data and

medical records

linked to a map of

persons body with

electronic health

record user account

derived from their

DNA.

Note: Image of body is

from Google body

browser but reflects DNA

Plans to incorporate map

of body as part of EMR

solution.

Go to Market Strategy

Follow the Data into the Marketplace

Large Scale

Enterprise Software

Deployments

Cloud Services

Research

Consumers/

Patients P

ayo

rs, W

eln

es

s

$120 average per user per year plus transaction fees

Health

Services,

Government

Entities

Pharma,

Clinical Trials,

Molecular

Diagnosticss

HEALTH SERVICE

PROVIDER

Assess Patient

Interact with payer to

determine eligibility

Prescribe test

Collect patient DNA sample

Submit DNA sample to lab

View lab information and

interpret results

Provide analysis and

recommendation to patient

Prescribe course of action.

Interface with pharma

regarding personalized

medicine

Interact with pharma with

clinical trial information

$120 avg per user/year subscription

PATIENT

Seeks Health Services

Submits DNA Sample

Views interpretation of results

from physician

Interact with payer regarding

reimbursement

Participation in Clinical Trials

Receives Drugs and Info from

Pharma

INSURANCE and PAYER ENTITIES

Require DNA tests for reimbursement of Rx and determine which genetic tests qualify for reimbursement

LAB

Process sample and results

Provide raw DNA data to

database storage for

interpretation

PHARMA/BIOTECH/R&D

INDUSTRY

Provide sample collection kits

and information regarding

personalized medicine

Interface with physician and

patients in clinical trials

Provide lab with new products

and services

Provide patient with retail info

DNA Guide

Genome Management Software

Information Flow

$0

$50

$100

$150

$200

$250

$300

$350

$0

$50

$100

$150

$200

$250

$300

$350

FY1 FY2 FY3 FY4 FY5

Mill

ions

US Wellness Revenue

Revenue

Cost of Goods/Sale

G&A

OperatingProfit/(Loss)

Financials

Capital Efficient – Multiple Revenue Streams

Alice Rathjen

President, Founder

William Kimmerly, Ph.D.

Chief Scientific Officer

Product Dev. Team

Xavier Thomas

Saw Yu Wai

Jeff Protentis (Sales)

ADVISOR

Mark S. Boguski, M.D., Ph.D.

Center for Biomedical Informatics

Harvard Medical School

Team

AWARD

Funding/Milestones

Milestones Completed Human Genome Map deployed and tested on all major mobile platforms (iPAD, iPhone, Android, Blackberry)

Pilot Customer Projects (CysticFibrosis.com) Secured Mark Boguski, MD, Ph.D., Harvard as advisor. Discussion on Strategic partnerships underway with industry leaders (ESRI, Microsoft) Winner Kaufman Women in Science & Engineering Business Idea Competition 2011 World DNA Day Personalized Medicine Panel – Dalian, China 2011 Selected as “technology breakthrough” for Consumer Genetics Conference, Harvard Personalized Medicine Lab Symposium, Personalized Medicine World Conference Selected for Health 2.0 San Francisco “Launch”

Seed investment Finalize agreements with initial customer

Formalize strategic partnerships Apply for government grants Build out additional features Secure Series A Funding

Series A Top-tier management team recruited

Secure Major Enterprise Software Customers

• Industry Transforming Technology

• Multiple Revenue Streams &

Capital Efficient • Visionary Team

Summary of DNA Guide Opportunity

Navigating Genetic Data Regulation, Privacy and Ease of Use

T

G

C

A

Contact: Alice Rathjen

alice@DNAguide.com