II-PIC 2017: Why did I miss that Patent? How value added databases of STN helps to find those missing patents

Why did I miss that patent?

How the value-added databases of STN® helps you to

find those missing patents

Makarand Waikar

ACSI-India

II-PIC 2017

CAS is a division of the American Chemical Society.Copyright 2017 American Chemical Society. All rights reserved.

The amount of data available today is overwhelming!

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Sometimes it feels like even though the

search may be complete, the hunt is just

beginning!


Hunting relevant information can be tricky

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Variety of sourcesVariety of sourcesComplexity of structuresComplexity of structures

Vast number of patenting countries

Vast number of patenting countries

Artfully written patentsArtfully written patents


Comprehensively retrieving chemical patents

poses challenges

▪ Patents don’t always include:

• Substance names

• Chemical structures

• Physicochemical data

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A prior art search for this anti-glaucoma substance

using only its chemical name misses WO2015117024

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2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3-[(phosphonooxy)methoxy]-, sodium salt (1:2), (3S,4R)- (CA INDEX NAME)


The name search misses the patent because the

patent provides only the compound’s structure

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Retrieve the missing patent by including its chemical

structure and/or CAS Registry Number® in your search

The CAS chemist who

analyzed this patent found

the CAS RN for this

substance and included it

in the patent’s indexing.

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What is a CAS Registry Number?

▪ A unique numeric identifier for a publicly disclosed substance

– Assigned to organic compounds, inorganic compounds,

enzymes, protein sequences, nucleotide sequences,

coordination compounds, alloys, minerals, polymers, etc.

▪ CAS created and maintains the CAS REGISTRYSM database, and

is the only organization that can provide authoritative CAS Registry

Numbers

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Is it possible to retrieve a substance of interest from

a patent which doesn’t provide its name or structure?

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Intellectual analysis by CAS scientists allows you to

retrieve the “missing” patent

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WO2002014342

• No name provided

• No structure provided

• But the synthesis and NMR

details of the “desired

product” allowed the CAS

scientist to determine the

structure of the product, and

to index its CAS RN in the

CAplusSM record for this

patent CAS RN 203796-03-6


Can you still retrieve a patent when it lacks the

substance name, structure and physicochemical data?

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▪ Searched for the substance below

as a nematocide


The patent includes a Markush table with hundreds

of substances

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Your search in CAplus retrieves the patent because

CAS analysts index the substances in the table

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1648720-74-4

1648720-70-0

1648720-71-1


Finding patents is one thing, but finding your

substance within the full text also poses a challenge

▪ Full text patents can be thousands of pages long!

▪ Substances may be difficult to find if they are: – In large tables

– Represented as structures including stereo

– In long lists of IUPAC names

– Vaguely described with terminology such as

“desired compound”

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PatentPak® on STN allows you to instantly find the

location of the substance of interest in the patent

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Searching for numeric properties is challenging

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Heat transfer rate in the heat exchanger tube is improved due to use of fin structure portion that is formed in the pipe… internal surface of fin is less than 2000 microns.

Novelty of the invention :

How can you search the “less than 2000 microns” concept?

1. Less than 2000 microns can be 100 or 110 or 120 or 126 or 500 or

700 or 1999 ….

2. The value could be also expressed in other units in the original

patent other than microns – e.g., mm, cm, inches, etc.


A text-based search would be tedious and lengthy

▪ S heat exchanger AND ((1 micron or 2 microns or 3 microns …..

100 microns or 150 microns or 200 microns or 250 microns or

230 microns or 300 microns ….500 microns or 501 microns

or…… 2000 microns or 0.1mm or 0.2mm or 0.3mm or 0.4mm

or 0.5mm …. 1mm or 1.2mm or 1.3mm or 1.5mm…. or 1.9mm

or 1.95mm or 2mm or 0.1millimeter or 0.2millimeter or

0.3millimeter or 0.4millimeter or 0.5millimeter …. 1millimeter

or 1.2millimeter or 1.3millimeter or 1.4 millimeter or

1.5millimeter …. or 1.9millimeter or 1.95millimeter or

2millimeter ) ………

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Use STN’s value-added numeric property indexing to

find relevant patents in Derwent World Patent Index®

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AB US20170106984 A1 NOV NOVELTY - The heat exchanger (100) has several ram air layers that direct air.

The each ram air layer is a single pass layer which includes several ram air fins in fluid communication with the ram air flow. The several liquid pass layers is a five pass layer includes several liquid pass fins in fluid communication with the liquid flow. The each of the several liquid pass layers is positioned adjacent to the ram air layer of several ram air layers. The liquid pass fins has a liquid pass fin height of 0.058 inches.

ADV ADVANTAGE - The heat from the liquid coolant is effectively removed fromthe liquid and transferred to the air to allow for effective PECSoperation. The enhanced heat transfer is allowed, by five pass circuitof the liquid layer. The heat exchanger is dimensioned for proper mountingwithin a desired location, and structural rigidity is provided to theliquid layers.

0.058 inches= 1473 microns0.058 inches= 1473 microns

S HEAT EXCHANGER AND 0.00-2000 MICRON/LEN


A total of 55 numeric property search fields can be

searched in 19 patent and scientific databases ▪ STN extracts, normalizes and indexes the numeric data –

adding value to patent documents

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STN offers a unique numeric property searching

solution

▪ Understands multiple units (e.g., metric and non-metric

measurements)

▪ Handles ranges of values

▪ Includes tolerances for values

▪ Allows you to search unstructured text for these values

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Challenges in searching generic compounds

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How can one search structures disclosed generically in claims?


STN has the first ever unified Markush search solution!!

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Many searches begin by looking into

exemplified structure databases

▪ A team of scientists prepared the

moiety shown for treating

gastrointestinal disorders. Is the

substance novel?

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Specific structure search results indicate all clear

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CAS Registry and Derwent Chemistry resource (DCR) gave zero hits, indicating that the structure is not disclosed specifically in any patent indexed in those databases.

CAS Registry and Derwent Chemistry resource (DCR) gave zero hits, indicating that the structure is not disclosed specifically in any patent indexed in those databases.


But Markush search results tell another story!

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MARPAT® gave 4 hits, the Derwent Markush Resource (DWPIM) gave 3.

Here methyl matches to lower alkyl (1-4 carbons).

The patent discusses substances generically as gastric secretion inhibitors.


Assembled hit structures in MARPAT can tell a more

complete story of what is hidden in a patent

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MARPAT assembled Hit Results show how the generic structure matches your query.

Original Patent


STN can help you be confident that your search

results didn’t miss an important patent

▪ Find relevant information even if the chemistry is obscured

▪ Use STN’s value-added patent databases such as CAplus and Derwent

World Patents Index to increase comprehensiveness

▪ Save time by using PatentPak to locate substances within full text patents

▪ Find substances in STN’s Markush databases, MARPAT and Derwent

Markush Resource (DWPIM)

▪ Human curated, value-added indexing also featured in databases

focused on science, technology, engineering and medicine

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CAS is a division of the American Chemical Society.Copyright 2017 American Chemical Society. All rights reserved. 28

@STN

www.stn.org

Makarand WaikarFor any additional information, please feel free to contact us at

[email protected]

Internet

II-PIC 2017: Why did I miss that Patent? How value added databases of STN helps to find those missing patents