Opioid Dose & Risk of Overdose 1.Opioid prescriptions for chronic pain and overdose: a cohort study.Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merrill JO, Sullivan MD, Weisner CM, Silverberg MJ, Campbell CI, Psaty BM, Von Korff M. Ann Intern Med. 2010 Jan 19;152(2):85-92. 2.Emergency department visits among recipients of chronic opioid therapy. Braden JB, Russo J, Fan MY, Edlund MJ, Martin BC, DeVries A, Sullivan MD.Arch Intern Med. 2010 Sep 13;170(16):1425-32. 3.Association between opioid prescribing patterns and opioid overdose-related deaths.Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, Blow FC.JAMA. 2011 Apr 6;305(13):1315-21. doi: 10.1001/jama.2011.370. 4.Opioid dose and drug-related mortality in patients with nonmalignant pain.Gomes T, Mamdani MM, Dhalla IA, Paterson JM, Juurlink DN.Arch Intern Med. 2011 Apr 11;171(7): 686-91 5.A history of being prescribed controlled substances and risk of drug overdose death. Paulozzi LJ, Kilbourne EM, Shah NG, Nolte KB, Desai HA, Landen MG, Harvey W, Loring LD. Pain Med. 2012 Jan;13(1):87-95

6. High-risk use by patients prescribed opioids for pain and its role in overdose deaths. Gwira Baumblatt JA, Wiedeman C, Dunn JR, Schaffner W, Paulozzi LJ, Jones TF. JAMA Intern Med. 2014 May;174(5):796-801. 7. Prescription Histories and Dose Strengths Associated with Overdose Deaths (pages 1187–1195) Anne Hirsch, Scott K. Proescholdbell, William Bronson and Nabarun Dasgupta Article first published online: 15 FEB 2014 | DOI: 10.1111/pme.12391 8. Risk Factors for Serious Prescription Opioid-Related Toxicity or Overdose among Veterans Health Administration Patients. Zedler B, Xie L, Wang L, Joyce A, Vick C, Kariburyo F, Rajan P, Baser O, Murrelle L. Pain Med. 2014 Jun 14. doi: 10.1111/pme. 12480. 9. The Role of Opioid Prescription in Incident Opioid Abuse and Dependence Among Individuals

With ChronicNoncancer Pain The Role of Opioid Prescription Mark J. Edlund, MD, PhD,*

Bradley C. Martin, PharmD,w Joan E. Russo, PhD,z Andrea DeVries, PhD,y Jennifer B. Braden,

PhD,z and Mark D. Sullivan, MDzClin J Pain Volume 30, Number 7, July 2014

Meta-Analyses of Opioids for CNP 1.Opioids compared to placebo or other treatments for chronic low-back pain Luis Enrique Chaparro,*, Andrea D Furlan, Amol Deshpande3, Angela Mailis-Gagnon, Steven Atlas, Dennis C Turk Editorial Group: Cochrane Back Group Published Online: 27 AUG 2013 2.Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction.Martell BA, O'Connor PG, Kerns RD, Becker WC, Morales KH, Kosten TR, Fiellin DA.Ann Intern Med. 2007 Jan 16;146(2):116-27. Review.

3. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Kalso E, Edwards JE, Moore RA, McQuay HJ. Pain. 2004 Dec;112(3):372-80. Review.

4. The Effectiveness and Risks of Long-term Opioid Treatment of Chronic Pain. Agency for

Healthcare Research and Quality.

http://www.effectivehealthcare.ahrq.gov/ehc/products/557/1947/chronic-pain-opioid-treatment-

report-draft-140731.pdf