OIS 2016

©2016 Tear Science, Inc.

• Focused on Dry Eye due to MGD

• New management team

• Proven technology

• Shifted business model

• Validated through financial results

• Privately-held company

• Completed Series D financing

• EBITDA Positive Early 2017

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Overview

Company Confidential

The Dry Eye/ MGD Market

3Company Confidential

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MGD: Large, Untapped Market in Dry Eye

**Michael A. Lemp, MD, Leslie A. Crews, PhD,† Anthony J. Bron, FRCOphth, Gary N. Foulks, MD, and Benjamin D. Sullivan, PhD- Cornea 2012

Over 30 Million Dry Eye Sufferers in USEach eye doctor’s office sees an average 8-10 MGD patient daily.

Company Confidential

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MGD: The Full Picture

Normal Function

Abnormal Function

Normal Structure

Abnormal Structure

Meibomian GlandStructure

Meibomian GlandFunction

Company Confidential

Treating MGD

6Company Confidential

The Historical Gold Standard:

Warm Compresses (since ~1900)• Daily routine• Very low compliance• 1/3 as effective as a single LipiFlow

Manual Expression (since 1888)• In Office • Uncomfortable for the patient• Time consuming for the doctor and variable results

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How is MGD Treated Today?

LipiFlow® is clinically more effective and more convenient.

Company Confidential

Vectored• Heat and pressure directed to the inner eyelid using space-age

insulation and vaulted design to protect the cornea and globe

Thermal• A maximum therapeutic temperature of 43 degrees Celsius

(109.4 Fahrenheit) is applied directly to the glands from the inner eyelid

Pulse Custom peristaltic pressure sequence and device contour

maximize safe gland clearing

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LipiFlow®: A Proven MGD Treatment

VTP Technology:A Breakthrough Inner Lid Approach

Company Confidential

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LipiFlow®: Single-Use ActivatorTherapeutic Motion

Feedback-Guided Sensors

Cornea Shield

Force Equalization

• Reactivates Meibomian Gland function

• Applies heat and pressure directly to the inner eyelid for 12 minutes–in office

• FDA-cleared and clinically proven

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LipiView® II: Dynamic Meibomian Imaging (DMI)

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LipiScan™: Rapid MGD Detection

High Definition

Portable 

Rapid Capture

Broader Market Appeal

Ease of Use

Ambient Light Filtering

NEW

Company Confidential

Contact Lenses

Cataract & Refractive Surgery

WHERE WE STARTED

Glaucoma

Digital Devices

PRE-SYMPTOM MGD

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Business Model Shift to Larger Addressable Market

Company Confidential

SEVERE MODERATE MILD

60M+

WHERE WE’RE GOING

30MDry Eye

Primary Care

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Our Technology

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LIPIFLOW®LIPIVIEW® II

Accurately Identify and Detect MGD Effectively Treat MGD

LIPISCAN™

KORB MGE ACTIVATOR

NEW

Company Confidential